Constant-temperature stirring-imitating type granule dissolubility detection device
Through the constant temperature imitation stirring detection device, the problem of single data of existing equipment and the inability to quickly export unsoluble granules is solved, and the granule solubility detection and accuracy improvement under multiple conditions is achieved.
Patent Information
- Application Number
- CN202420640669.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-30
- Publication Date
- 2024-12-13
- Estimated Expiration
- 2034-03-30
AI Technical Summary
Existing granule solubility detection equipment can only be tested at fixed water temperature and stirring speed. The data is single and unsolution granules cannot be quickly derived, affecting the accuracy of the melting characteristics.
A constant temperature imitation stirring detection device is designed, including a constant temperature water bath, agitating mechanism and a transparent glass cup. Different water temperatures and stirring speeds are set by the controller, and the annular fill light and detection plate are used to achieve dissolution under different conditions. Characteristic detection and derivation of undissolved granules.
Comprehensive detection under different water temperatures and stirring conditions is achieved, the accuracy of granule solubility detection is improved, and the observation and derivation of unsoluble granules are facilitated.
Smart Images
Figure CN222166996U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of granule detection, and in particular relates to a constant temperature imitation stirring type granule solubility detection device. Background Art
[0002] Granules are granular preparations made by combining drugs with suitable excipients. They can generally be divided into soluble granules, suspension granules and effervescent granules. Granules need to be tested for solubility after they are made. They can be put into use only after the solubility test is completed and meets the standards.
[0003] There are at least the following disadvantages in the use of existing granule solubility tests: 1. In existing granule solubility tests, water and solvent are mixed for observation, but existing equipment can only measure the dissolution effect of water and solvent mixed at one water temperature and one stirring speed. The test data is single, which affects the accuracy of the dissolution characteristics of the granules. 2. In existing granule solubility tests, the effect of the granules after dissolution is obtained by observation, and it is impossible to quickly export the undissolved granules for observation. Utility Model Content
[0004] The utility model aims to provide a constant temperature imitation stirring type granule solubility detection device to solve the problems raised in the above background technology.
[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:
[0006] A constant temperature, simulated stirring, granule solubility detection device comprises a base: a support frame is fixedly connected to one side of the top of the base, a connecting frame is fixedly connected to both sides of the top of the support frame, limiting grooves are provided on both sides of the outer walls of the connecting frame, and the connecting frame is movably connected and inserted in the two limiting grooves, a stirring mechanism is installed on one side of the top of the connecting frame, a controller is fixedly connected to one end of the connecting frame, a cylinder is fixedly connected between the connecting frame and the support frame, a constant temperature device is fixedly connected to the other side of the top of the base, and a container is movably connected and inserted in the constant temperature device.
[0007] Preferably, the constant temperature device includes a constant temperature water bath, a fixing mechanism, an annular fill light, a heating tube and a perforated plate. There are three fixing mechanisms in total, and the three fixing mechanisms are fixedly connected to the inner wall of the constant temperature water bath at equal distances. The annular fill light is interspersed and connected between the three fixing mechanisms. The perforated plate is fixedly connected to the lower part of the inner wall of the constant temperature water bath. The heating tube is installed at the bottom of the constant temperature water bath. The constant temperature water bath is fixedly connected to the top of the base.
[0008] Preferably, the fixing mechanism includes a support bracket, a movable rod, a limit plate, a spring, a positioning plate and a through-slot, the through-slot is opened at one end of the support bracket, the movable rod is movably connected to one end of the support bracket, one end of the movable rod movably passes through the support bracket and is fixedly connected to the positioning plate, the limit plate is fixedly connected to the end of the movable rod away from the positioning plate, the spring is fixedly connected between the limit plate and the support bracket, and the end of the support bracket away from the through-slot is fixedly connected to the inner wall of the constant temperature water bath.
[0009] Preferably, the spring is sleeved on the outer surface of the movable rod, and the support frame is configured as a Z-shaped structure.
[0010] Preferably, the container includes a glass, a detection plate, a connecting rod and a connecting ring, wherein two connecting rods are provided and the two connecting rods are fixedly connected to both sides of the top of the detection plate, the connecting ring is fixedly connected to one end of the two connecting rods away from the detection plate, the detection plate is movably connected in the glass, and the glass is movably connected between the three fixing mechanisms.
[0011] Preferably, the connecting ring is movably connected to the outer surface of the glass.
[0012] Compared with the prior art, the beneficial effects of the utility model are:
[0013] (1) By setting a constant temperature device, water is introduced into a constant temperature water bath, the water temperature is set on the controller, the heating tube generates heat, and the water in the constant temperature water bath is heated, so that the water in the constant temperature water bath is kept at a constant temperature, and then the container is inserted into the constant temperature water bath from top to bottom, supported and fixed by three fixing mechanisms, the cylinder and the stirring mechanism are started, so that the lower part of the stirring mechanism is inserted into the container to simulate manual stirring of the pharmaceutical solution, and the stirring can be clockwise and counterclockwise according to the stirring needs. The stirring speed and the number of stirring circles can be set on the controller, and the ring fill light is turned on. One side of the constant temperature water bath is set with a transparent material to facilitate the observation of the dissolution of the granules in the container. The ring fill light is used to improve the observation effect, and the dissolution characteristic detection of the pharmaceutical under different water temperatures and stirring conditions is realized, making the dissolution detection of the granules more comprehensive.
[0014] (2) By setting up a container, water and granules are introduced into a glass cup for dissolution. The glass cup is made of transparent material, which is conducive to observing the dissolution phenomenon. A detection plate is set in the glass cup. After stirring, the connecting ring is pulled, the connecting ring is separated from the glass cup and drives the connecting rod to move upward, so that the detection plate can be moved out of the glass cup. The top of the detection plate is provided with dense holes, and the undissolved granules are in the dense holes in the detection plate, which is convenient for the undissolved granules to be led out. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is one of the three-dimensional diagrams of the utility model;
[0016] Figure 2 It is a three-dimensional diagram of the thermostatic device of the utility model;
[0017] Figure 3 It is a three-dimensional diagram of the fixing mechanism of the utility model;
[0018] Figure 4 It is a connection stereogram of the container of the utility model;
[0019] In the figure: 1. base; 2. support frame; 3. connecting frame; 4. limiting slot; 5. cylinder; 6. connecting frame; 7. stirring mechanism; 8. constant temperature device; 9. container; 10. controller; 81. constant temperature water bath; 82. fixing mechanism; 83. annular fill light; 84. heating tube; 85. orifice plate; 821. supporting frame; 822. movable rod; 823. limiting plate; 824. spring; 825. positioning plate; 826. through-slot; 91. glass; 92. detection plate; 93. connecting rod; 94. connecting ring. DETAILED DESCRIPTION
[0020] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0021] Embodiment 1:
[0022] See also Figure 1 - Figure 4 As shown, a constant temperature imitation stirring type granule solubility detection device comprises a base 1: a support frame 2 is fixedly connected to one side of the top of the base 1, and a connecting frame 3 is fixedly connected to both sides of the top of the support frame 2, and the outer walls of both sides of the connecting frame 3 are provided with limiting grooves 4, and a connecting frame 6 is movably connected and inserted in the two limiting grooves 4, a stirring mechanism 7 is installed on one side of the top of the connecting frame 6, a controller 10 is fixedly connected to one end of the connecting frame 6, a cylinder 5 is fixedly connected between the connecting frame 6 and the support frame 2, and a constant temperature device 8 is fixedly connected to the other side of the top of the base 1, and a container 9 is movably connected and inserted in the constant temperature device 8.
[0023] Depend on Figure 1 - Figure 3It can be seen that the constant temperature device 8 includes a constant temperature water bath 81, a fixing mechanism 82, an annular fill light 83, a heating tube 84 and a perforated plate 85. There are three fixing mechanisms 82 in total, and the three fixing mechanisms 82 are fixedly connected to the inner wall of the constant temperature water bath 81 at equal distances. The annular fill light 83 is inserted and connected between the three fixing mechanisms 82. The perforated plate 85 is fixedly connected to the lower part of the inner wall of the constant temperature water bath 81. The heating tube 84 is installed at the bottom of the constant temperature water bath 81. The constant temperature water bath 81 is fixedly connected to the top of the base 1.
[0024] The fixing mechanism 82 includes a support frame 821, a movable rod 822, a limit plate 823, a spring 824, a positioning plate 825 and a through slot 826. The through slot 826 is opened at one end of the support frame 821. The movable rod 822 is movably inserted and connected to one end of the support frame 821. One end of the movable rod 822 movably passes through the support frame 821 and is fixedly connected to the positioning plate 825. The limit plate 823 is fixedly connected to the end of the movable rod 822 away from the positioning plate 825. The spring 824 is fixedly connected between the limit plate 823 and the support frame 821. The end of the support frame 821 away from the through slot 826 is fixedly connected to the inner wall of the constant temperature water bath 81.
[0025] As can be seen from the above, water is introduced into the constant temperature water bath 81, the water temperature is set on the controller 10, the heating tube 84 generates heat, thereby heating the water in the constant temperature water bath 81, so that the water in the constant temperature water bath 81 is kept at a constant temperature, and then the container 9 filled with water and granules is inserted from top to bottom into the constant temperature water bath 81, the outer surface of the container 9 is in close contact with the positioning plate 825, and the positioning plate 825 is pushed to move while the container 9 is pushed using the size of the container 9, the positioning plate 825 pushes the movable rod 822 fixedly connected thereto to slide in the support frame 821, the movable rod 822 pushes the limit plate 823 fixedly connected thereto to move, the limit plate 823 pulls the spring 824 fixedly connected thereto to extend, the bottom of the container 9 is in close contact with the top of the support frame 821, and the container 9 is pressed against the support frame 821 The container 9 is supported and the positioning plate 825 is clamped to the container 9 by utilizing the resilience of the spring 824, thereby improving the stability of the container 9. The air cylinder 5 and the stirring mechanism 7 are started, and the output end of the air cylinder 5 contracts and pulls the connecting frame 6 fixedly connected thereto to move downward, and the connecting frame 6 drives the stirring mechanism 7 to move downward. The lower part of the stirring mechanism 7 is inserted into the container 9, and simulates manual stirring of the pharmaceutical solution in the container 9. The stirring can be performed clockwise and counterclockwise according to the stirring needs. The stirring speed and the number of stirring circles can be set on the controller 10. The annular fill light 83 is turned on, and one side of the constant temperature water bath 81 is set to a transparent material to facilitate the observation of the dissolution of the granules in the container 9. Since the annular fill light 83 is placed directly below the cup body, it is used for the lighting needs when observing the container 9, and the observation can be made more clearly.
[0026] Preferably, the spring 824 is sleeved on the outer surface of the movable rod 822, and the supporting frame 821 is configured as a Z-shaped structure.
[0027] As can be seen from the above, by setting the spring 824 and utilizing the resilience of the spring 824, the positioning plate 825 is tightly attached to the outer surface of the container 9, thereby clamping the container 9. The support frame 821 is set to a Z-shaped structure, which can support both the container 9 and the movable rod 822, and allows the movable rod 822 to have displacement space. The constant temperature device 8 and the stirring mechanism 7 are both electrically connected to the controller 10, so that the controller 10 can control the constant temperature device 8 and the stirring mechanism 7 at the same time.
[0028] Embodiment 2:
[0029] refer to Figure 1 and Figure 4 As shown, the container 9 includes a glass cup 91, a detection plate 92, a connecting rod 93 and a connecting ring 94. There are two connecting rods 93 in total, and the two connecting rods 93 are fixedly connected to both sides of the top of the detection plate 92. The connecting ring 94 is fixedly connected to one end of the two connecting rods 93 away from the detection plate 92. The detection plate 92 is movably inserted and connected in the glass cup 91, and the glass cup 91 is movably inserted and connected between the three fixing mechanisms 82.
[0030] As can be seen from the above, water and granules are introduced into the glass cup 91 for dissolution. The glass cup 91 is made of transparent material, which is conducive to observing the dissolution phenomenon. A detection plate 92 is provided in the glass cup 91. After stirring, the connecting ring 94 is pulled, the connecting ring 94 is separated from the glass cup 91 and drives the connecting rod 93 fixedly connected thereto to move upward. The connecting rod 93 drives the detection plate 92 fixedly connected thereto to move upward in the glass cup 91, so that the detection plate 92 can be moved out of the glass cup 91. The top of the detection plate 92 is provided with dense holes, and the undissolved granules are in the dense holes in the detection plate 92, which is convenient for the undissolved granules to be led out.
[0031] Preferably, the connecting ring 94 is movably connected to the outer surface of the glass 91 .
[0032] As can be seen from the above, by providing the connecting ring 94 and the connecting rod 93 , it is convenient to guide the detection plate 92 out of the glass cup 91 .
[0033] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A constant temperature stirring type granule solubility detection device, characterized in that: The invention comprises a base (1): a support frame (2) is fixedly connected to one side of the top of the base (1); a connection frame (3) is fixedly connected to both sides of the top of the support frame (2); limiting grooves (4) are provided on both sides of the outer wall of the connection frame (3); a connection frame (6) is movably connected in the two limiting grooves (4); a stirring mechanism (7) is installed on one side of the top of the connection frame (6); a controller (10) is fixedly connected to one end of the connection frame (6); a cylinder (5) is fixedly connected between the connection frame (6) and the support frame (2); a thermostat (8) is fixedly connected to the other side of the top of the base (1); a container (9) is movably connected in the thermostat (8).
2. A constant temperature stirring-type granule solubility detection device according to claim 1, characterized in that: The constant temperature device (8) comprises a constant temperature water bath (81), a fixing mechanism (82), an annular fill light (83), a heating tube (84) and a perforated plate (85); the fixing mechanism (82) is provided with three in total, and the three fixing mechanisms (82) are fixedly connected to the inner wall of the constant temperature water bath (81) at equal distances; the annular fill light (83) is inserted and connected between the three fixing mechanisms (82); the perforated plate (85) is fixedly connected to the lower part of the inner wall of the constant temperature water bath (81); the heating tube (84) is installed at the inner bottom of the constant temperature water bath (81); and the constant temperature water bath (81) is fixedly connected to the top of the base (1).
3. A constant temperature stirring-type granule solubility detection device according to claim 2, characterized in that: The fixing mechanism (82) comprises a support frame (821), a movable rod (822), a limiting plate (823), a spring (824), a positioning plate (825) and a through slot (826); the through slot (826) is provided at one end of the support frame (821); the movable rod (822) is movably inserted and connected to one end of the support frame (821); one end of the movable rod (822) movably passes through the support frame (821) and is fixedly connected to the positioning plate (825); the limiting plate (823) is fixedly connected to one end of the movable rod (822) away from the positioning plate (825); the spring (824) is fixedly connected between the limiting plate (823) and the support frame (821); one end of the support frame (821) away from the through slot (826) is fixedly connected to the inner wall of the constant temperature water bath (81).
4. A constant temperature stirring-like granule solubility detection device according to claim 3, characterized in that: The spring (824) is sleeved on the outer surface of the movable rod (822), and the support frame (821) is configured as a Z-shaped structure.
5. A constant temperature stirring-type granule solubility detection device according to claim 1, characterized in that: The container (9) comprises a glass cup (91), a detection plate (92), a connecting rod (93) and a connecting ring (94); two connecting rods (93) are provided in total, and the two connecting rods (93) are fixedly connected to both sides of the top of the detection plate (92); the connecting ring (94) is fixedly connected to one end of the two connecting rods (93) away from the detection plate (92); the detection plate (92) is movably connected in the glass cup (91); and the glass cup (91) is movably connected in the three fixing mechanisms (82).
6. A constant temperature stirring-type granule solubility detection device according to claim 5, characterized in that: The connecting ring (94) is movably connected to the outer surface of the glass (91).