Traditional Chinese medicine automatic line soft material homogenizing device

Abstract

The utility model discloses a traditional Chinese medicine automatic line soft material homogenizing device which comprises a uniform blanking device and a homogenizing device, so that the chromatography state of particle finished products is improved, the medicine carrying uniformity of particles is improved, the fine powder amount is reduced, the one-time yield is improved, the production operation cost is reduced, soft materials are not excessively mixed, and the quality of the soft materials is improved. The uniformity of the materials can be kept, the materials are quantitatively added with one lattice at most through the star-shaped lattice rotating disc, the rotating speed is controlled through quantitative driving on one side, and therefore it is ensured that the materials finally received by the granulator are consistent with the throughput capacity of the granulator, and the uniform discharging device and the homogenizing device are directly connected in a butt joint mode, so that dust generated in the conveying process can be greatly reduced; according to the uniform blanking device, the mixing end point of the front mixing equipment is adaptively ended in advance to obtain a non-uniform mixture, then the non-uniform mixture is further mixed and homogenized through the homogenizing device to obtain a more uniform soft material, and the soft material meets the dual requirements of flowability and uniformity.

Description

Technical Field

[0001] The utility model relates to the field of production and granulation of Chinese patent medicines, in particular to a soft material homogenization device for a Chinese medicine automatic line. Background Art

[0002] The granulation process of highly viscous pharmaceutical materials has always been a difficult problem in the industry. The existing technical methods can be divided into two processes: dry process and wet process according to their process characteristics.

[0003] Wet process: Chinese patent medicine (plant medicine) is used for decoction and extraction, and the extract is filtered and concentrated to obtain an extract. The dry matter content of the extract is controlled to be in the range of 50% to 70%, and the specific gravity is controlled to be in the range of 1.2 to 1.4 at the process limit temperature. It is used as one of the main raw materials, and other main raw materials are combined, and sucrose powder or starch and dextrin are added as auxiliary raw materials. Several materials are mixed and matched, and a process is obtained under certain process parameter control limits to obtain a suitable soft material, which is extruded to form particles or rubbed into particles by rotating and stirring with a shearing device, and then the particles are dried to obtain the finished product;

[0004] Dry process: dry granulation process is adopted, that is, the extract before concentration in the wet process is dried to obtain dry paste powder, a certain amount of starch and dextrin are added as auxiliary materials, and high-pressure extrusion is performed, generally not less than 5Mpa, to obtain flakes, which are then crushed and sieved to obtain the finished product.

[0005] The defects of the above two methods are that the particles obtained by the first wet process will be unstable when using the existing equipment, and most of the particles will be fine particles, commonly known as "fine powder". Therefore, screening is required to stably reach the particle size required by the pharmacopoeia. Due to drying and crushing (commonly known as whole grains) in the process, the fine powder increases, and the yield is usually not higher than 85%. The second dry process method lacks a wetting agent or adhesive and only relies on pressure to granulate. The particle size after crushing is worse than the first method, and the yield is generally not higher than 75%. In addition, the particles are angular and irregular, resulting in a very high angle of repose. Under normal distribution, the angle of repose in the 3∑ range generally reaches more than 50 degrees to 60 degrees.

[0006] Compared with the above two methods, if higher quality particles are needed, the wet process is the first choice. However, in the wet process, stirring, making soft materials and granulation processes have always been difficult problems in the industry.

[0007] The traditional method, limited by the viscosity and physical properties of the material itself, is to judge the molding of mixed soft materials through the empirical method of visual and tactile inspection. The saying "it forms a ball when you hold it, and it falls apart when you press it" is used to describe this intermediate state.

[0008] The main purpose of improving granulation has been mentioned above. The core starting points are divided into the following aspects:

[0009] How to improve the chromatography status of finished granules;

[0010] How to improve the drug loading uniformity of particles;

[0011] How to reduce the amount of fine powder, improve the first-time yield, and reduce production and operation costs;

[0012] And how to reduce dust in all logistics flow links during packaging and transportation, and increase packaging speed.

[0013] Therefore, equipment that can obtain a uniform soft material is needed so that granulation can achieve the above goals. Summary of the invention

[0014] In view of the deficiencies in the prior art, the utility model provides a soft material homogenizing device for an automatic Chinese medicine production line to solve the above problems.

[0015] In order to achieve the above objectives, the utility model is implemented through the following technical solutions.

[0016] A soft material homogenization device for an automatic line of traditional Chinese medicine, comprising a uniform feeding device and a homogenization device, wherein the uniform feeding device is connected to the homogenization device, the homogenization device comprises a homogenization shell, a homogenization extrusion mixing device, and a homogenization driving device, wherein the homogenization driving device is fixed on the homogenization shell and connected to the homogenization extrusion mixing device, wherein the homogenization extrusion mixing device is arranged inside the homogenization shell, the homogenization extrusion mixing device comprises a powder scraping connecting plate, an extrusion column, a powder scraping connecting shaft, and an auxiliary screen, wherein the powder scraping connecting plate is evenly provided with extrusion columns, the powder scraping connecting shaft is arranged in the middle of the powder scraping connecting plate, and the end is connected to the homogenization driving device, and the auxiliary screen is arranged on the outside around the extrusion column, so that the chromatographic state of the finished particle product is improved, the drug loading uniformity of the particles is increased, and the amount of fine powder is reduced , and improve the first-time yield, reduce production and operation costs, and reduce dust in all logistics flow links during packaging and transportation, increase packaging speed, and achieve soft materials without over-mixing. While maintaining uniformity between materials, the time window problem is solved. The material is quantitatively added to a maximum of one grid through the star-shaped grid rotating disk, and the rotation speed is controlled by the quantitative drive on one side, so as to ensure that the material received by the final granulator is consistent with its own throughput. The direct connection of the uniform feeding device and the homogenizing device can greatly reduce the generation of dust during transmission. The uniform feeding device allows the mixing end point of the previous mixing equipment to be adaptively ended in advance to obtain an uneven mixture, and then through the homogenizing device, further mixing and homogenization are carried out to obtain a more uniform soft material. This soft material meets the dual requirements of fluidity and uniformity.

[0017] Preferably, the homogenizing shell is provided with a homogenizing inlet and a homogenizing outlet, and the two are respectively arranged on the upper and lower sides of the homogenizing shell.

[0018] Preferably, the opening direction of the auxiliary screen is toward the homogenization inlet.

[0019] Preferably, the auxiliary wire mesh is made of either wire mesh or galvanized wire mesh.

[0020] Preferably, the uniform feeding device comprises a feeding shell, a feeding mixing device, and a star-shaped grid quantitative device, and the feeding mixing device and the star-shaped grid quantitative device are respectively arranged at the upper and lower positions of the feeding shell.

[0021] Preferably, the feeding mixing device includes a feeding mixing connecting shaft, a feeding mixing stirring column, and a feeding mixing drive. The feeding mixing connecting shaft can be movably connected to the feeding housing, and one end is connected to the feeding mixing drive. The feeding mixing connecting shaft is also evenly provided with feeding mixing stirring columns.

[0022] Preferably, the star-shaped grid quantitative device includes a star-shaped grid rotating disk and a quantitative drive.

[0023] Preferably, the star-shaped grid rotating disk is connected to a quantitative drive.

[0024] Preferably, the rotation speed of the homogenization driving device is 85rpm-150rpm.

[0025] Preferably, the wire diameter of the auxiliary screen is 0.3 mm-0.5 mm, and the aperture is no more than 14 mesh at the highest and no less than 6 mesh at the lowest.

[0026] Compared with the prior art, the utility model discloses a Chinese medicine automatic line soft material homogenization device, including a uniform feeding device and a homogenization device, which are used in combination to play a role.

[0027] ① It improves the chromatography state of the finished granules, increases the drug loading uniformity of the granules, reduces the amount of fine powder, and increases the one-time yield, reduces the production and operation costs, reduces the dust in all logistics circulation links during packaging and transportation, increases the packaging speed, and ensures that the soft materials are not over-mixed and the uniformity between the materials is maintained, solving the time window problem;

[0028] ② The material is quantitatively added to one grid at most through the star-shaped grid rotating disk, and the rotation speed is controlled by the quantitative drive on one side, so as to ensure that the material received by the granulator is consistent with its own throughput;

[0029] ③ Direct connection between the uniform feeding device and the homogenizing device can greatly reduce the generation of dust during the transfer;

[0030] ④ The uniform feeding device allows the mixing end point of the previous mixing equipment to be adaptively ended early to obtain an uneven mixture, which is then further mixed and homogenized through a homogenizing device to obtain a more uniform soft material that meets the dual requirements of fluidity and uniformity. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a schematic diagram of the structure of the soft material homogenization device of the traditional Chinese medicine automatic line of the utility model;

[0032] Figure 2 It is a structural schematic diagram of the homogenization device of the utility model;

[0033] Figure 3 It is a schematic diagram of the structural section of the homogenizing device of the utility model;

[0034] Figure 4 This is a schematic diagram of the structure of the uniform feeding device of the utility model;

[0035] Figure 5 It is a schematic diagram of the structural section of the uniform feeding device of the utility model;

[0036] Figure 6 This is a schematic diagram of the structure of the homogenization transmission device in Example 2 of the utility model;

[0037] Figure 7 This is a schematic diagram of the overall structure of Example 2 of the utility model. DETAILED DESCRIPTION

[0038] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments.

[0039] A Chinese medicine automatic line soft material homogenization device, comprising a uniform feeding device A1 and a homogenization device A3, wherein the uniform feeding device A1 is connected to the homogenization device A3, and the homogenization device A3 comprises a homogenization shell A31, a homogenization extrusion mixing device A33, and a homogenization drive device A32, wherein the homogenization drive device A32 is fixed on the homogenization shell A31 and connected to the homogenization extrusion mixing device A33, and the homogenization extrusion mixing device A33 is arranged on the homogenization shell A31. Inside the homogenizing shell A31, the homogenizing extrusion mixing device A33 includes a powder scraping connecting plate A331, an extrusion column A332, a powder scraping connecting shaft A333, and an auxiliary screen A334. The extrusion columns A332 are evenly arranged on the powder scraping connecting plate A331, the powder scraping connecting shaft A333 is arranged in the middle position of the powder scraping connecting plate A331, and the end is connected to the homogenizing driving device A32, and the auxiliary screen A334 is arranged on the outside around the extrusion column A332.

[0040] The homogenizing shell A31 is provided with a homogenizing inlet A311 and a homogenizing outlet A312, and the two are respectively arranged on the upper and lower sides of the homogenizing shell A31. The opening direction of the auxiliary wire mesh A334 faces the homogenizing inlet A311. The auxiliary wire mesh A334 is made of either a wire mesh or a galvanized wire mesh. The uniform feeding device A1 includes a feeding shell A11, a feeding mixing device A12, and a star-shaped grid quantitative device A13. The feeding mixing device A12 and the star-shaped grid quantitative device A13 are respectively arranged on the feeding shell A11. In the lower position, the material unloading and mixing device A12 includes a material unloading and mixing connecting shaft A121, a material unloading and mixing stirring column A122, and a material unloading and mixing drive A123. The material unloading and mixing connecting shaft A121 is movably connected to the material unloading shell A11, and one end is connected to the material unloading and mixing drive A123. The material unloading and mixing connecting shaft A121 is also evenly provided with a material unloading and mixing stirring column A122. The star-shaped grid quantitative device A13 includes a star-shaped grid rotating disk A131 and a quantitative drive A132. The star-shaped grid rotating disk A131 is connected to the quantitative drive A132.

[0041] The rotation speed of the homogenization driving device A32 is 85rpm-150rpm.

[0042] The wire diameter of the auxiliary wire mesh A334 is 0.3mm-0.5mm, and the aperture is no more than 14 mesh at the highest and no less than 6 mesh at the lowest.

[0043] After research, it was found that the feed amount of the granulation process is a core parameter that affects the granulation effect. Therefore, the feed amount of the granulator needs to be controlled between 10% and 50%. If it exceeds 50%, the granulator will be blocked, and if it is less than 10%, it is easy to produce severe high temperature. When the temperature exceeds 42°C, the particles will have very strong viscosity. Further research shows that this viscosity is a characteristic of the extract, so it can only be solved by equipment.

[0044] The material is quantitatively added to a maximum of one grid through the star-shaped grid rotating disk A131, and the rotation speed is controlled by the quantitative drive A132 on one side, so as to ensure that the material received by the final granulator is consistent with its own throughput. The key to this part is that the addition of this device can make the mixing end point of the previous mixing device adaptively end in advance to obtain an uneven mixture. Then, it is further mixed and homogenized through the homogenization device A3 to obtain a more uniform soft material, which meets the dual requirements of fluidity and uniformity. A thicker steel wire or iron wire or galvanized wire mesh is used to contact and wrap the scraper tightly, and the scraper is horizontally placed and reciprocating in a circle. The homogenization device A3 receives the material sent by the belt conveyor. The material of the belt conveyor has been quantified by the quantitative device. This material is an intermediate that ends mixing in advance. The homogenization device A3 will extrude and mix the received mixed semi-finished soft material again. During the reciprocating operation, it will be cut by the wire mesh, and the soft material will reach the required final soft material state and pass through the wire mesh to be discharged.

[0045] The rotation speed of this process is 85rpm-150rpm, the wire diameter of the wire mesh is 0.3mm-0.5mm, the aperture is currently 10 mesh, the maximum is not more than 14 mesh, and the minimum is not less than 6 mesh. The reciprocating operation cycle of the homogenizing device A3 is 1 to 5 circles.

[0046] In the General Rules 0831 and 0104 of the 2020 edition of the Chinese Pharmacopoeia, there are clear requirements for the properties of granules: the weight of granules and powders that cannot pass through the No. 1 sieve and can pass through the No. 5 sieve shall not exceed 15% of the total weight. On this basis, when enterprises produce, the internal release standards will be more stringent, and the general internal control standard is 10%. In the process, due to the limitation of production costs, enterprises have additional requirements for the one-time granulation pass rate. Various factors should be considered comprehensively, and the granulation prescription should be determined through experiments. Common granules: Isatis Root Granules, Ganmao Qingre Granules, Ganmao Ling Granules, the pharmacopoeia also includes additional particle size, properties, solubility, etc.

[0047] On this basis, further expansion and extension were carried out: the research found that the particle size should meet the following characteristics, and the properties are more stable for subsequent packaging and transportation. From the distribution point of view, it presents a normal distribution effect (as shown in Table 1). Furthermore, the fluidity of the particles should meet the requirements that the angle of repose (also known as the angle of repose) should be below 60 degrees, and above 30 degrees is the best. This parameter is more stringent than the general provisions of the pharmacopoeia.

[0048] Chinese patent medicine extract, dry matter content 60%-80%, specific gravity between 1.22 and 1.4, dynamic viscosity greater than 2000cp (20℃) and less than 40000cp (20℃), pH between 5.5 and 8;

[0049] The extract prescription ratio for this example is 32% ± 10%;

[0050] The excipients are one or both of soluble starch or dextrin (DE value less than 10), and comply with the "Chinese Pharmacopoeia 2020 Edition". According to their physical properties, there is no restriction on their combination ratio. The total proportion of excipients is 68%±10%; it is allowed to contain no more than 8% of other main raw material drug ingredients, and the temperature sensitivity range is 50℃~82℃;

[0051] To meet the above-mentioned particle characteristics, one of the core issues that needs to be solved first is the viscosity control during the mixing process. The intermediate before granulation, which is made by mixing several raw materials such as extracts and excipients during the mixing process, is called "soft material". Due to the authenticity and harvesting season of the origin of Chinese patent medicines, and the slight parameter changes in the previous extract process, the dynamic viscosity of the extract will cause huge changes. This study found that when the dry matter content of the extract is 60%-80% and the specific gravity is about 1.35 (in the specific gravity range of 1.30-1.40, a benchmark value is generally selected as the production and product process parameter), the dynamic viscosity will change from 2400cp to nearly 40000cp, a change of nearly 10 times. As shown in Table 2, the physical properties of one of the main raw materials are very unstable. In wet granulation, it is necessary to adapt to the instability of this property as much as possible from the equipment end. In order to meet the large viscosity changes of the extract, the good pre-granulation state of the soft material, commonly known as "holding a ball and pressing it, it will be scattered", is achieved. The mixing process of soft materials is a very complex kneading and penetration process, which produces drastic nonlinear rheological changes, which is similar to the molding of "kneading dough", but it needs to maintain looseness. The transition time zone from the state of "unmixed" to the state of "overmixed" is called the "time window". The current process and material conditions do not exceed 10s. Materials with high viscosity will show a shortened time, and under extreme conditions, the number of turns will be different.

[0052] Table 1 Reference experiment table

[0053]

[0054] Table 2 Reference experiment table

[0055]

[0056] In the existing production process, this project relies on "artificial responsiveness" and "experience control", and it is impossible to form fixed equipment operating parameters. If this time window is exceeded, an "over-mixing" state will occur, and the over-mixed soft material will not be able to be granulated, or the produced granules will become long strips, and ultimately the granules cannot be broken and dried. The formed material will form a compact state and the finished product cannot be obtained. Even if a small part of the granules are obtained, the required properties and solubility will not be achieved. The judgment is based on manual visual and hand feeling to determine whether the purpose has been achieved. The key is that this time is very short and there are differences between batches. Therefore, it is impossible to achieve stable granule production through batch parameter setting. Example

[0057] Based on the condition that the other technical features mentioned above remain unchanged, a homogenizing device for soft materials of traditional Chinese medicine automatic line is provided, comprising a uniform feeding device A1, a homogenizing transmission device A2, and a homogenizing device A3, wherein the homogenizing transmission device A2 is respectively connected to the corresponding uniform feeding device A1 and the homogenizing device A3, wherein the homogenizing transmission device A2 comprises a homogenizing transmission bracket A21, a homogenizing blanking dust cover A22, a homogenizing loading dust cover A23, and a homogenizing transmission belt A24, wherein both the homogenizing blanking dust cover A22 and the homogenizing loading dust cover A23 are arranged above the homogenizing transmission belt A24, and the position of the homogenizing blanking dust cover A22 corresponds to the bottom of the uniform feeding device A1, wherein the homogenizing transmission belt A24 is arranged on the homogenizing transmission bracket A21, and a uniform array spacer A241 is arranged on the surface, and the homogenizing transmission belt A24 is parallel to the material and will not cause physical property changes to the mixing termination state of the material. At the same time, the homogenization device A3 adds an intermediate state to the material processing. Although it is not as effective as direct connection in reducing dust, compared with the prior art, it not only does not change the physical properties of the material's mixing terminal state, but also adds an intermediate state to the material processing, which can greatly reduce the generation of dust.

[0058] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0059] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0060] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A Chinese medicine automatic line soft material homogenization device, characterized by: The invention comprises a uniform feeding device (A1) and a homogenizing device (A3), wherein the uniform feeding device (A1) is connected to the homogenizing device (A3), and the homogenizing device (A3) comprises a homogenizing housing (A31), a homogenizing extrusion mixing device (A33), and a homogenizing driving device (A32), wherein the homogenizing driving device (A32) is fixed on the homogenizing housing (A31) and connected to the homogenizing extrusion mixing device (A33), and the homogenizing extrusion mixing device (A33) is arranged on the homogenizing housing (A31). ) inside, the homogenizing extrusion mixing device (A33) includes a powder scraping connecting plate (A331), an extrusion column (A332), a powder scraping connecting shaft (A333), and an auxiliary screen (A334); the powder scraping connecting plate (A331) is evenly provided with extrusion columns (A332); the powder scraping connecting shaft (A333) is arranged in the middle of the powder scraping connecting plate (A331), and the end thereof is connected to the homogenizing driving device (A32); the auxiliary screen (A334) is arranged on the outside around the extrusion column (A332).

2. The Chinese medicine automatic line soft material homogenization device according to claim 1 is characterized by: The homogenizing shell (A31) is provided with a homogenizing inlet (A311) and a homogenizing outlet (A312), and the two are respectively arranged on the upper and lower sides of the homogenizing shell (A31).

3. The Chinese medicine automatic line soft material homogenization device according to claim 1 is characterized by: The opening direction of the auxiliary screen (A334) is toward the homogenization feed inlet (A311).

4. The Chinese medicine automatic line soft material homogenization device according to claim 1 is characterized by: The auxiliary wire mesh (A334) is made of either a wire mesh or a galvanized wire mesh.

5. The Chinese medicine automatic line soft material homogenization device according to claim 1 is characterized by: The uniform feeding device (A1) comprises a feeding shell (A11), a feeding mixing device (A12), and a star-shaped grid quantitative device (A13); the feeding mixing device (A12) and the star-shaped grid quantitative device (A13) are respectively arranged at the upper and lower positions of the feeding shell (A11).

6. The Chinese medicine automatic line soft material homogenization device according to claim 5, characterized in that: The material feeding and mixing device (A12) comprises a material feeding and mixing connecting shaft (A121), a material feeding and mixing stirring column (A122), and a material feeding and mixing drive (A123); the material feeding and mixing connecting shaft (A121) is movably connected to the material feeding housing (A11), and one end is connected to the material feeding and mixing drive (A123); and the material feeding and mixing connecting shaft (A121) is also evenly provided with material feeding and mixing stirring columns (A122).

7. The Chinese medicine automatic line soft material homogenization device according to claim 6, characterized in that: The star-shaped grid quantitative device (A13) comprises a star-shaped grid rotating disk (A131) and a quantitative drive (A132).

8. The Chinese medicine automatic line soft material homogenization device according to claim 7, characterized in that: The star-shaped grid rotating disk (A131) is connected to the quantitative drive (A132).

9. The Chinese medicine automatic line soft material homogenization device according to claim 1, characterized in that: The rotation speed of the homogenization driving device (A32) is 85 rpm-150 rpm.

10. The Chinese medicine automatic line soft material homogenization device according to claim 1, characterized in that: The wire diameter of the auxiliary wire mesh (A334) is 0.3mm-0.5mm, and the aperture is no more than 14 mesh at the highest and no less than 6 mesh at the lowest.

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