Sterile blending device for fenofibrate capsule

Abstract

The utility model belongs to the technical field of blending devices, and particularly relates to a sterile blending device for fenofibrate capsules, which is characterized in that a mixing funnel is arranged inside a blending tank body, and a stirring and mixing mechanism extends into the mixing funnel along the center of the mixing funnel; a blade arranged on the stirring and mixing mechanism is just positioned between the upper cavity and the lower cavity of the mixing funnel; a grinding and feeding mechanism extending into the blending tank body is arranged outside the blending tank body, and the feeding direction of the grinding and feeding mechanism is the position of the blade. Through the arrangement of the grinding and feeding mechanism, after various raw materials are filled from the feeding hole, the grinding and feeding mechanism can quickly feed the filled raw materials into the blades for impacting, and then the raw materials are rotationally cut through the two layers of staggered blades, so that the raw materials are quickly and finely ground.

Description

Technical Field

[0001] The utility model belongs to the technical field of blending devices, and in particular relates to an aseptic blending device for fenofibrate capsules. Background Art

[0002] Fenofibrate is one of the commonly used lipid-lowering drugs in clinical practice. It reduces cholesterol synthesis by competitively inhibiting methylhydroxyglutaryl-CoA reductase, the rate-limiting enzyme in the cholesterol synthase system. It also increases the number of low-density lipoprotein receptors and the activity of lipoproteinase to increase the clearance of very low-density lipoprotein, thereby achieving a better effect in treating hyperlipidemia. It is often the drug of choice, especially for simple hypertriglyceridemia or mixed dyslipidemia characterized by elevated triglycerides.

[0003] When fenofibrate capsules are produced, it is necessary to uniformly mix the raw materials for production, such as lactose, microcrystalline cellulose and cross-linked polyvinylpyrrolidone, such as a general raw material stirring device for solid-liquid blending of publication number CN220294588U. It includes a grinding mechanism, a powder delivery pump and a stirring tank body, wherein the grinding mechanism includes a first motor, a grinding blade and a sieve bowl, the lower end of the powder delivery pump is provided with a powder spray head, and the stirring tank body is provided with a driving mechanism and a stirring mechanism. The present application grinds the solid raw material into fine powder by the action of the first motor, the grinding blade and the sieve bowl in the grinding mechanism, reduces the difficulty of mixing the solid raw material and the liquid raw material, and then increases the surface area of ​​the powder in contact with the liquid raw material through the action of the powder delivery pump and the powder spray head, and also accelerates the mixing of the two raw materials, and finally under the action of the driving mechanism and the stirring mechanism, the mixing of the solid raw material and the liquid raw material is more uniform.

[0004] The inventors found that in the mixing device of the prior art, the grinding of the raw materials for the production of fenofibrate capsules only relies on the weight of the raw materials themselves to fall and be cut into powder by the grinding blades. However, the falling speed of the raw materials relying solely on their own weight is slow, resulting in low grinding efficiency and insufficient grinding fineness.

[0005] In view of this, the utility model provides an aseptic blending device for fenofibrate capsules to solve the above problems. Summary of the invention

[0006] The utility model aims to provide an aseptic blending device for fenofibrate capsules, aiming to solve the problem in the prior art that the filling raw materials in the mixing device fall slowly only by the weight of the raw materials themselves, resulting in low grinding efficiency and insufficient grinding fineness.

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: an aseptic blending device for fenofibrate capsules, comprising a blending tank and a stirring and mixing mechanism installed on the blending tank, wherein a mixing funnel is arranged inside the blending tank, the stirring and mixing mechanism extends into the mixing funnel along the center of the mixing funnel, and the blades staggered on the stirring and mixing mechanism are exactly located between the upper and lower cavities of the mixing funnel;

[0008] The outside of the blending tank body is provided with a grinding and feeding mechanism extending into the inside of the blending tank body, and the feeding direction of the grinding and feeding mechanism is the position of the blade.

[0009] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the blending tank body comprises: a feed port, a discharge port and supporting feet, the feed port and the discharge port are respectively arranged at the upper and lower ends of the blending tank body, and the supporting feet are obliquely connected to the bottom of the blending tank body.

[0010] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the stirring and mixing mechanism includes: a stirring motor, a mixing rod, a blade and a spiral stirring blade. The stirring motor is installed on the top of the blending tank body. The stirring motor passes through the top of the blending tank body and is fixedly connected to the mixing rod. The outer wall of the mixing rod is provided with a blade and a spiral stirring blade in sequence from top to bottom.

[0011] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the spiral stirring blade stirs spirally downward.

[0012] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the blades are arranged in at least two layers of annular arrangements, and the blades are staggeredly distributed, and the cutting radius of the blades is smaller than the opening radius between the upper and lower cavities of the mixing funnel.

[0013] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the grinding and feeding mechanism includes: a fixed seat, a feeding motor and a spiral feeding blade, the fixed seat is fixedly connected to the outside of the blending tank, the feeding motor is installed on the top of the fixed seat, and one end of the spiral feeding blade is rotatably arranged inside the fixed seat and fixedly connected to the output end of the feeding motor.

[0014] As a preferred aseptic blending device for fenofibrate capsules of the utility model, the surface of the lower cavity of the mixing funnel is provided with through holes arranged at equal intervals.

[0015] Compared with the prior art, the beneficial effects of the utility model are:

[0016] The utility model sets a grinding and feeding mechanism so that when a variety of raw materials are filled in from a feed port, the grinding and feeding mechanism can quickly feed the filled raw materials into the blade for impact, and then the two layers of staggered blades rotate and cut, thereby realizing fast and fine grinding of the raw materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0018] Figure 1 This is a schematic diagram of the main structure of the utility model;

[0019] Figure 2 This is a structural schematic diagram of another viewing angle of the utility model;

[0020] Figure 3 It is a cross-sectional three-dimensional structural schematic diagram of the utility model;

[0021] Figure 4 It is a schematic diagram of the cross-sectional plan structure of the utility model.

[0022] In the figure: 1. blending tank; 101. feed port; 102. discharge port; 103. support foot; 2. stirring and mixing mechanism; 201. stirring motor; 202. mixing rod; 203. blade; 204. spiral stirring blade; 3. grinding and feeding mechanism; 301. fixing seat; 302. feeding motor; 303. spiral feeding blade; 4. mixing funnel; 5. through hole. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-4 The utility model provides the following technical solutions: an aseptic blending device for fenofibrate capsules, comprising a blending tank body 1 and a stirring and mixing mechanism 2 installed on the blending tank body 1, a mixing funnel 4 is provided inside the blending tank body 1, the stirring and mixing mechanism 2 extends into the mixing funnel 4 along the center of the mixing funnel 4, and the staggered blades 203 on the stirring and mixing mechanism 2 are just located between the upper and lower cavities of the mixing funnel 4; a grinding and feeding mechanism 3 extending into the blending tank body 1 is provided outside the blending tank body 1, and the feeding direction of the grinding and feeding mechanism 3 is the position of the blades 203.

[0025] The stirring and mixing mechanism 2 and the grinding and feeding mechanism 3 are both electrically connected to an external power source through a control switch.

[0026] Preferably, the blending tank body 1 comprises: a feed port 101, a discharge port 102 and a support leg 103, wherein the feed port 101 and the discharge port 102 are respectively arranged at the upper and lower ends of the blending tank body 1, and the support leg 103 is obliquely connected to the bottom of the blending tank body 1.

[0027] During specific use, the feed port 101 and the discharge port 102 are respectively used for the entry of initial raw materials and the discharge of raw materials after uniform grinding and mixing; secondly, the feed port 101 and the discharge port 102 can be connected to other corresponding pipelines through connectors such as clamps, bolts, etc. to form a sealed passage to achieve aseptic linear production of fenofibrate capsules.

[0028] Preferably: the stirring and mixing mechanism 2 includes: a stirring motor 201, a mixing rod 202, a blade 203 and a spiral stirring blade 204, the stirring motor 201 is installed on the top of the blending tank body 1, the stirring motor 201 passes through the top of the blending tank body 1 and is fixedly connected to the mixing rod 202 through a coupling, and the outer wall of the mixing rod 202 is sequentially provided with a blade 203 and a spiral stirring blade 204 from top to bottom.

[0029] During specific use, when the stirring motor 201 is controlled to run, the stirring motor 201 will drive the mixing rod 202, the blade 203 and the spiral stirring blade 204 to rotate, so that the blade 203 can grind and cut the filled raw materials in the upper cavity of the mixing funnel 4. After being cut into a suitable fineness, the raw materials will fall into the lower cavity of the mixing funnel 4 for uniform stirring.

[0030] Preferably, the spiral stirring blade 204 stirs spirally downward, and the surface of the lower cavity of the mixing funnel 4 is provided with through holes 5 arranged at equal intervals.

[0031] During specific use, the spiral stirring blade 204 spirally stirs downward to form a downward pressure in the lower cavity of the mixing funnel 4. Through this downward pressure, the raw materials are evenly mixed and stirred and then discharged from the through hole 5. Those that do not meet the fineness requirements continue to be tumbled, cut and stirred in a mixing cycle until they meet the fineness requirements and are discharged from the through hole 5.

[0032] Preferably, the blades 203 are arranged in at least two layers in an annular manner, and the two layers of blades 203 are staggered, and the cutting radius of the blades 203 is equal to the opening radius between the upper and lower cavities of the mixing funnel 4.

[0033] During specific use, the multi-layer staggered arrangement of the blades 203 can effectively improve the grinding and cutting fineness and grinding and cutting efficiency of the raw materials; the blades 203 are more preferably arranged in three layers, one layer is located in the upper cavity of the mixing funnel 4, one layer is located between the upper and lower cavities of the mixing funnel 4, and the last layer is located in the lower cavity of the mixing funnel 4. In this way, the raw materials can be ground and cut no matter where they are, and the grinding and cutting fineness and grinding and cutting efficiency will be further improved.

[0034] Preferably: the grinding and feeding mechanism 3 includes: a fixed seat 301, a feeding motor 302 and a spiral feeding blade 303, the fixed seat 301 is fixedly connected to the outside of the blending tank 1, the feeding motor 302 is installed at the top of the fixed seat 301, and one end of the spiral feeding blade 303 is rotatably set inside the fixed seat 301 and fixedly connected to the output end of the feeding motor 302.

[0035] During specific use, when the feeding motor 302 is controlled to run, the feeding motor 302 will drive the spiral feeding blade 303 to rotate, and then the filled raw materials will be continuously pushed to the blade 203 position by the spiral feeding blade 303 for grinding and cutting, thereby improving the grinding efficiency of the raw materials.

[0036] Working principle: Taking the production of non-Nobel capsules as an example, first start the stirring and mixing mechanism 2 and the grinding and feeding mechanism 3. After the non-Nobel capsule raw materials are filled into the feed port 101, the raw materials are continuously pushed to the multi-layer blades 203 arranged on the stirring and mixing mechanism 2 through the grinding and feeding mechanism 3, so that the blades 203 quickly cut the raw materials into finer powder and fall into the lower cavity of the mixing funnel 4. After falling into the lower cavity of the mixing funnel 4, the spiral stirring blades 204 will continuously mix and stir the fallen raw materials evenly. Through the continuous falling of the raw materials, downward pressure will be formed in the lower cavity of the mixing funnel 4, and the raw materials will accumulate and roll. The mixture that meets the fineness requirements will be discharged from the through hole 5, and the mixture that does not meet the fineness requirements will continue to roll, grind, cut, mix and finally be discharged in the lower cavity of the mixing funnel 4.

[0037] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. An aseptic blending device for fenofibrate capsules, comprising a blending tank (1) and a stirring and mixing mechanism (2) installed on the blending tank (1), characterized in that: A mixing funnel (4) is provided inside the blending tank (1), the stirring and mixing mechanism (2) extends into the mixing funnel (4) along the center of the mixing funnel (4), and the staggered blades (203) on the stirring and mixing mechanism (2) are located exactly between the upper and lower cavities of the mixing funnel (4); The outside of the blending tank body (1) is provided with a grinding and feeding mechanism (3) extending into the inside of the blending tank body (1), and the feeding direction of the grinding and feeding mechanism (3) is the position where the blade (203) is located.

2. The aseptic blending device for fenofibrate capsules according to claim 1, characterized in that: The blending tank body (1) comprises: a feed inlet (101), a discharge port (102) and a support foot (103); the feed inlet (101) and the discharge port (102) are respectively arranged at the upper and lower ends of the blending tank body (1); and the support foot (103) is obliquely connected to the bottom of the blending tank body (1).

3. The aseptic blending device for fenofibrate capsules according to claim 1, characterized in that: The stirring and mixing mechanism (2) comprises: a stirring motor (201), a mixing rod (202), a blade (203) and a spiral stirring blade (204); the stirring motor (201) is installed on the top of the blending tank (1); the stirring motor (201) passes through the top of the blending tank (1) and is fixedly connected to the mixing rod (202); the outer wall of the mixing rod (202) is provided with a blade (203) and a spiral stirring blade (204) in sequence from top to bottom.

4. The aseptic blending device for fenofibrate capsules according to claim 3, characterized in that: The spiral stirring blade (204) stirs in a spiral downward manner.

5. The aseptic blending device for fenofibrate capsules according to claim 3, characterized in that: The blades (203) are arranged in at least two layers in an annular pattern, and the blades (203) are distributed in a staggered manner, and the cutting radius of the blades (203) is equal to the opening radius between the upper and lower cavities of the mixing funnel (4).

6. The aseptic blending device for fenofibrate capsules according to claim 1, characterized in that: The grinding and feeding mechanism (3) comprises: a fixed seat (301), a feeding motor (302) and a spiral feeding blade (303), wherein the fixed seat (301) is fixedly connected to the outside of the blending tank (1), the feeding motor (302) is installed on the top of the fixed seat (301), and one end of the spiral feeding blade (303) is rotatably arranged inside the fixed seat (301) and is fixedly connected to the output end of the feeding motor (302).

7. The aseptic blending device for fenofibrate capsules according to claim 1, characterized in that: The surface of the lower cavity of the mixing funnel (4) is provided with through holes (5) arranged at equal intervals.

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