Dissolving and mixing device in biological medicine manufacturing process

Abstract

The utility model discloses a dissolving and mixing device in a biological medicine manufacturing process, and relates to the technical field of biological medicine production. The mixing device comprises a mixing device body and a liquid conveying pipe, a dispersing mechanism is arranged at the top of the mixing device body, a feeding mechanism is arranged on one side of the dispersing mechanism, the dispersing mechanism comprises a motor, a transmission shaft is arranged at the output end of the motor, a dispersing disc is arranged at the bottom end of the transmission shaft, and the liquid conveying pipe is arranged in the dispersing disc. A protective shell is arranged below the outer side of the transmission shaft, the feeding mechanism comprises a feeding hopper, and through the feeding mechanism and the feeding hopper, a user is allowed to directly feed powdery biological medicine raw materials, which means that the user does not need to carry out additional pretreatment or processing on the medicine, and the efficiency is improved. Therefore, the mixing effect is improved, the original dissolving step is softened into the equipment, the production cost in the medicine dissolving and mixing process is reduced, and meanwhile, the medicine dissolving and mixing efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of biological medicine production, in particular to a dissolving and mixing device in the biological medicine manufacturing process. Background Art

[0002] The dissolving and mixing device in the manufacturing process of biopharmaceuticals is an important equipment used to ensure the uniform mixing and effective dissolution of biopharmaceuticals. In biopharmaceuticals, the mixing and dissolution of raw materials are key steps in the manufacturing process, which directly affect the quality and effect of the drugs. In order to ensure the consistency and effectiveness of the drugs, the various components in the manufacturing process must be evenly mixed. The dissolving and mixing device can ensure that the different components are fully mixed under appropriate conditions through its specific design and working principle.

[0003] In the process of drug dissolution and mixing by the mixing equipment, in order to ensure that the powdered biological drug can be effectively and quickly mixed inside the mixing device, a common operation method is to perform a preliminary dissolution treatment on the powdered biological drug before stirring and mixing the drug to obtain a high-concentration mixed solution. Subsequently, these high-concentration mixed solutions are injected into the stirring device for uniform stirring treatment. This operation is different from, for example, a multi-stage mixing device for seasoning production with application number: 202320272146.6, and other mixing devices that directly add powders, which is conducive to improving the rapid dissolution of drug powders in the mixing device. However, this traditional mixing method actually divides dissolution and stirring into two independent operation steps. The two steps of dissolution and stirring require a large number of manpower and a relatively cumbersome operation method, which not only increases the production cost of drug dissolution and mixing, but also reduces the efficiency of powdered biological drug dissolution and mixing to a certain extent. Utility Model Content

[0004] Based on this, the purpose of the utility model is to provide a dissolving and mixing device in the process of manufacturing biological drugs to solve the technical problems of traditional forms of drug dissolving and mixing, improve the production cost of drug dissolving and mixing, and reduce the efficiency of dissolving and mixing of powdered biological drugs.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a dissolving and mixing device in the manufacturing process of biological drugs, comprising a mixing device body and an infusion tube, a dispersing mechanism is arranged on the top of the mixing device body, a feeding mechanism is arranged on one side of the dispersing mechanism, the dispersing mechanism comprises a motor, a transmission shaft is arranged at the output end of the motor, a dispersing disk is arranged at the bottom end of the transmission shaft, a protective shell is arranged below the outer side of the transmission shaft, the feeding mechanism comprises a feeding funnel, the feeding funnel is connected with the protective shell through a connecting tube, a spiral blade is arranged on one side of the top of the connecting tube, and a liquid inlet is opened on one side of the connecting tube.

[0006] By adopting the above technical solution, the design and function of the equipment directly support the direct delivery of powdered biological drugs, thereby significantly improving the ease of use of the mixing device. This convenience is not only reflected in the simplification of operating steps, but also in the improvement of the dissolution and mixing efficiency of biological drugs and the convenience of equipment maintenance.

[0007] Furthermore, the protective shell is coaxially arranged with the transmission shaft, and the protective shell is fixedly connected to the inner top surface of the mixing device body.

[0008] By adopting the above technical solution, the protective shell can effectively protect the transmission shaft, dispersion disk and other internal mechanisms from interference or damage by external environmental factors such as dust, moisture, etc., which is of great significance for maintaining the long-term stable operation of the equipment and extending its service life.

[0009] Furthermore, a synchronous wheel is arranged on the outer side of the transmission shaft and the top end of the spiral blade, and a synchronous belt is arranged on the outer side of the synchronous wheel.

[0010] By adopting the above technical solution, the rotation of the drive shaft can be accurately transmitted to the spiral blades through the linkage relationship between the synchronous wheel and the synchronous belt. This synchronous transmission method ensures precise coordination between the two, avoids possible speed differences or transmission errors, and thus improves the overall operating efficiency of the equipment.

[0011] Furthermore, the liquid inlet and the liquid infusion tube are both connected to an external water storage device through a water pump.

[0012] By adopting the above technical solution, the mixing device can automatically extract the required water from the external water storage device through the drive of the water pump without manual addition. This automatic water supply method not only improves work efficiency, but also reduces errors and inconveniences in manual operation. Since the water enters the mixing device through the closed infusion tube and the liquid inlet, this design helps to reduce the entry of external contaminants, which is of great significance for ensuring the purity and safety of drugs.

[0013] Furthermore, the protective shell, connecting pipe and feeding funnel are all made of stainless steel.

[0014] By adopting the above technical solution, stainless steel is a material with excellent corrosion resistance, which is particularly suitable for equipment parts that may come into contact with biological drugs, mixed liquids or water. This corrosion resistance ensures that these parts will not be damaged by chemical corrosion during long-term use, thereby extending the service life of the equipment.

[0015] Furthermore, the dispersion disk has a conical structure, and a plurality of baffles are arranged on the surface of the dispersion disk.

[0016] By adopting the above technical solution, the combination of the conical structure and the baffle helps to enhance the centrifugal force generated when the dispersion disk rotates. This enhanced centrifugal force can more effectively throw the biological drug from the surface of the dispersion disk, further promoting the mixing of the raw material and the solution.

[0017] Furthermore, the plurality of baffles are arranged in an equidistant ring shape along the central axis of the dispersion disk.

[0018] By adopting the above technical solution, the baffles arranged in an equidistant ring ensure the uniform distribution of the raw materials on the dispersion disk. This layout avoids excessive aggregation of the raw materials in a certain area, thereby promoting uniform mixing of the raw materials and the solution. At the same time, it can enhance the centrifugal force of the dispersion disk, and the baffles can more effectively throw the raw materials out from the center of the dispersion disk.

[0019] Furthermore, a magnetic stirring mechanism is provided on one side of the bottom surface of the mixing device body, and a supporting frame is provided below the mixing device body.

[0020] By adopting the above technical solution, the magnetic stirring mechanism stirs the mixed liquid through the action of the magnetic field. This stirring method can ensure that all parts of the mixed liquid are fully mixed, thereby improving the mixing efficiency. Compared with traditional mechanical stirring, magnetic stirring is more uniform and less likely to produce dead corners.

[0021] In summary, the utility model mainly has the following beneficial effects:

[0022] 1. The utility model uses a feeding mechanism and a dispersing mechanism. The device allows users to directly put powdered biological drug raw materials into the feeding funnel through the design of the feeding funnel, which means that users do not need to perform additional pretreatment or processing on the drugs, simplifying the operation process and improving work efficiency. Then the rotation of the spiral blades has a forced feeding effect on the powdered biological drug raw materials in the feeding funnel, and evenly and continuously transports them to the inside of the connecting pipe. Subsequently, the liquid inlet continuously transports external moisture to the inside of the connecting pipe and preliminarily mixes it with the drug raw materials. This design helps to speed up the dissolution efficiency of the drug and prevent the drug from agglomerating during the dissolution process. This not only improves the mixing effect, but also reduces the need for subsequent processing steps, which is conducive to softening the original dissolution step into the interior of the device, which is conducive to reducing the production cost in the drug dissolution and mixing process, and at the same time enhancing the dissolution and mixing efficiency of the drug;

[0023] 2. The utility model ensures uniform distribution of raw materials on the dispersion disk by setting baffles that are equidistantly arranged in an annular manner. This layout avoids excessive aggregation of raw materials in a certain area, thereby promoting uniform mixing of raw materials and solution. The combination of the dispersion disk and the baffles with a conical structure helps to enhance the centrifugal force generated when the dispersion disk rotates. This enhanced centrifugal force can more effectively throw the raw materials off the surface of the dispersion disk, further promoting the mixing of the raw materials and the solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is a three-dimensional structural schematic diagram of the utility model;

[0025] Figure 2 It is a cross-sectional structural schematic diagram of the utility model;

[0026] Figure 3 For this utility model Figure 2 The enlarged structural diagram at A in the middle;

[0027] Figure 4 It is a structural schematic diagram of the dispersion disk of the utility model.

[0028] In the figure: 1. mixing device body; 2. support frame; 3. magnetic stirring mechanism; 4. dispersion mechanism; 401. motor; 402. transmission shaft; 403. dispersion disk; 404. protective shell; 405. baffle; 5. feeding mechanism; 501. feeding funnel; 502. connecting pipe; 503. spiral blade; 601. synchronous wheel; 602. synchronous belt; 7. liquid inlet; 8. infusion tube. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. The embodiments described below with reference to the drawings are exemplary and are only used to explain the utility model, and cannot be understood as limiting the utility model.

[0030] The following describes an embodiment of the utility model based on its overall structure. Embodiment 1:

[0031] A dissolving and mixing device in a biological drug manufacturing process, such as Figure 1-Figure 4As shown, it includes a mixing device body 1 and an infusion tube 8, a dispersing mechanism 4 is arranged on the top of the mixing device body 1, and a feeding mechanism 5 is arranged on one side of the dispersing mechanism 4, the dispersing mechanism 4 includes a motor 401, a transmission shaft 402 is arranged at the output end of the motor 401, a dispersing disk 403 is arranged at the bottom end of the transmission shaft 402, and a protective shell 404 is arranged below the outer side of the transmission shaft 402, and the feeding mechanism 5 includes a feeding funnel 501, and the feeding funnel 501 is connected to the protective shell 404 through a connecting tube 502, a spiral blade 503 is arranged on one side of the top of the connecting tube 502, and a liquid inlet 7 is opened on one side of the connecting tube 502. The design and function of the device directly support the direct delivery of powdered biological drugs, thereby significantly improving the convenience of use of the mixing device. This convenience is not only reflected in the simplification of the operating steps, but also in the improvement of the dissolution and mixing efficiency of biological drugs and the convenience of equipment maintenance, allowing users to directly put in powdered biological drug raw materials, which means that users do not need to perform additional pretreatment or processing on the drugs, simplifying the operating process and improving work efficiency.

[0032] See also Figure 1 , Figure 2 The protective shell 404 is coaxially arranged with the transmission shaft 402, and the protective shell 404 is fixedly connected to the inner top surface of the mixing device body 1. The protective shell 404 can effectively protect the transmission shaft 402, the dispersion disk 403 and other internal mechanisms from interference or damage by external environmental factors such as dust, moisture, etc., which is of great significance for maintaining the long-term stable operation and extending the service life of the equipment. At the same time, the use of the protective shell 404 is conducive to preventing the biological drug from splashing when the dispersion disk 403 applies centrifugal force to the drug, thereby enhancing the guiding effect on the drug.

[0033] See also Figure 1 , Figure 2 , Figure 3 A synchronous wheel 601 is provided on the outer side of the transmission shaft 402 and the top of the spiral blade 503, and a synchronous belt 602 is provided on the outer side of the synchronous wheel 601. Through the linkage relationship between the synchronous wheel 601 and the synchronous belt 602, the rotation of the transmission shaft 402 can be accurately transmitted to the spiral blade 503. This synchronous transmission method ensures precise coordination between the two, avoids possible speed differences or transmission errors, thereby improving the overall operating efficiency of the equipment, and can ensure that the power generated by the motor 401 is effectively transmitted to the transmission shaft 402 and the spiral blade 503, reducing energy loss and improving the operating efficiency of the equipment.

[0034] See also Figure 1 , Figure 2 , Figure 3The liquid inlet 7 and the infusion tube 8 are both connected to the external water storage device through a water pump. Driven by the water pump, the mixing device can automatically extract the required water from the external water storage device without manual addition. This automatic water supply method not only improves work efficiency, but also reduces errors and inconveniences in manual operation. Since the water enters the mixing device through the closed infusion tube 8 and the liquid inlet 7, this design helps to reduce the entry of external pollutants, which is of great significance for ensuring the purity and safety of the medicine. The continuous operation of the water pump can ensure that the mixing device always has sufficient water supply when needed, which is particularly important for scenarios requiring continuous production, and can avoid production interruptions or efficiency reductions due to lack of water.

[0035] See also Figure 2 , Figure 3 The protective shell 404, the connecting tube 502, and the feed funnel 501 are all made of stainless steel. Stainless steel is a material with excellent corrosion resistance, and is particularly suitable for equipment parts that may come into contact with biological drugs, mixed liquids or water. This corrosion resistance ensures that these parts will not be damaged by chemical corrosion during long-term use, thereby extending the service life of the equipment. At the same time, the protective shell 404, the connecting tube 502, and the feed funnel 501 made of this material can resist mechanical stress and external impact, ensuring the stability and safety of the equipment. Embodiment 2:

[0036] See also Figure 2 , Figure 4 The dispersion disk 403 has a conical structure, and a plurality of baffles 405 are arranged on the surface of the dispersion disk 403. The combination of the conical structure and the baffles 405 helps to enhance the centrifugal force generated when the dispersion disk 403 rotates. The enhanced centrifugal force can more effectively throw the raw materials from the surface of the dispersion disk 403, further promoting the mixing of the raw materials and the solution. The presence of the baffles 405 helps to break up the lumps that may be formed in the raw materials during the mixing process. When the lumped raw materials hit the baffles 405, they will be broken up and more evenly dispersed in the solution, thereby improving the uniformity and consistency of the mixing.

[0037] See also Figure 2 , Figure 4, multiple baffles 405 are arranged in an equidistant ring along the central axis of the dispersion disk 403. The equidistant ring-shaped baffles 405 ensure the uniform distribution of the raw materials on the dispersion disk 403. This layout avoids excessive aggregation of the raw materials in a certain area, thereby promoting the uniform mixing of the raw materials and the solution, and at the same time can enhance the centrifugal force of the dispersion disk 403. The baffles 405 can more effectively throw the raw materials outward from the center of the dispersion disk 403. This throwing action helps to mix the raw materials and the solution faster, making the distribution of the raw materials on the dispersion disk 403 more uniform, and the raw materials are more evenly thrown to the edge of the dispersion disk, so as to be more fully contacted and mixed with the solution.

[0038] See also Figure 1 , Figure 2 A magnetic stirring mechanism 3 is arranged on one side of the bottom surface of the mixing device body 1, and a support frame 2 is arranged below the mixing device body 1. The magnetic stirring mechanism 3 stirs the mixed liquid through the action of a magnetic field. This stirring method can ensure that all parts in the mixed liquid are fully mixed, thereby improving the mixing efficiency. Compared with traditional mechanical stirring, magnetic stirring is more uniform and less likely to produce dead corners. Since the magnetic stirring mechanism 3 stirs through the action of a magnetic field, there is no need to introduce mechanical parts into the mixed liquid, thereby reducing the risk of contamination caused by wear or corrosion of mechanical parts, which is particularly important for mixing processes requiring high purity.

[0039] The implementation principle of the utility model is as follows: first, a proper mixed liquid is infused into the interior of the mixing device body 1 through the infusion tube 8, then, the powdered biological drug raw material is placed in the interior of the feeding funnel 501, and then, the motor 401 and the magnetic stirring mechanism 3 are started, and the motor 401 is used to drive the transmission shaft 402 to rotate, and the transmission shaft 402 drives the dispersion plate 403 to rotate through direct conduction, and at the same time, the transmission shaft 402 drives the spiral blade 503 to rotate through the linkage relationship between the synchronous wheel 601 and the synchronous belt 602, and the rotation of the spiral blade 503 is conducive to the forced feeding effect of the powdered biological drug raw material in the feeding funnel 501, and the powdered biological drug raw material is evenly and continuously transported to the connecting tube 502. Inside, at the same time, the liquid inlet 7 continuously transports external moisture to the inside of the connecting tube 502, and preliminarily mixes this part of moisture with the medicine transported into the connecting tube 502, which is beneficial to accelerate the dissolution efficiency of the medicine and prevent the medicine from agglomerating. After that, the preliminarily dissolved medicine is drained through the connecting tube 502 to transport this part of the medicine to the inside of the protective shell 404 until it falls on the surface of the dispersion disk 403, and then, the rotation of the dispersion disk 403 is used to centrifuge the medicine and evenly scatter the medicine in the solution inside the mixing device body 1, which is beneficial to improve the dissolution efficiency of powdered biological medicines. This equipment is beneficial to directly put powdered biological medicines into the mixing device, thereby improving the convenience of use.

[0040] Parts not involved in the present invention are the same as the prior art or can be implemented by using the prior art, and will not be described in detail here.

[0041] Although an embodiment of the utility model has been shown and described, this specific embodiment is only an explanation of the utility model and is not a limitation of the utility model. The specific features, structures, materials or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. After reading this specification, those skilled in the art may make modifications, substitutions and variations to the embodiments without creative contribution as needed without departing from the principles and purpose of the utility model. However, as long as they are within the scope of the claims of the utility model, they are protected by patent law.

Claims

1. A dissolving and mixing device in a biopharmaceutical manufacturing process, characterized in that: The invention comprises a mixing device body (1) and a liquid infusion tube (8), wherein a dispersion mechanism (4) is arranged on the top of the mixing device body (1), and a feeding mechanism (5) is arranged on one side of the dispersion mechanism (4), wherein the dispersion mechanism (4) comprises a motor (401), a transmission shaft (402) is arranged on the output end of the motor (401), a dispersion disk (403) is arranged on the bottom end of the transmission shaft (402), and a protective shell (404) is arranged below the outer side of the transmission shaft (402), and the feeding mechanism (5) comprises a feeding funnel (501), wherein the feeding funnel (501) is connected to the protective shell (404) via a connecting tube (502), a spiral blade (503) is arranged on one side of the top of the connecting tube (502), and a liquid inlet (7) is opened on one side of the connecting tube (502).

2. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: The protective shell (404) is coaxially arranged with the transmission shaft (402), and the protective shell (404) is fixedly connected to the inner top surface of the mixing device body (1).

3. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: The outer side of the transmission shaft (402) and the top end of the spiral blade (503) are both provided with a synchronous wheel (601), and the outer side of the synchronous wheel (601) is provided with a synchronous belt (602).

4. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: The liquid inlet (7) and the liquid infusion tube (8) are both connected to an external water storage device via a water pump.

5. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: The protective shell (404), the connecting pipe (502), and the feeding funnel (501) are all made of stainless steel.

6. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: The dispersion disk (403) has a conical structure, and a plurality of baffles (405) are provided on the surface of the dispersion disk (403).

7. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 6, characterized in that: The plurality of baffles (405) are arranged in an equidistant annular pattern along the central axis of the dispersion disk (403).

8. The dissolving and mixing device in the process of manufacturing biological medicines according to claim 1, characterized in that: A magnetic stirring mechanism (3) is provided on one side of the bottom surface of the mixing device body (1), and a support frame (2) is provided below the mixing device body (1).

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