Magnetic frame with adjustable magnetic force

Abstract

A supporting main body comprises a bottom plate and a supporting column arranged on the bottom plate, a frame body is arranged on the supporting column and is provided with at least one positioning hole used for vertically positioning a PCR (Polymerase Chain Reaction) tube, a conductive coil is wound on at least the lower part of the supporting column, and two ends of the conductive coil are electrically connected with an external power supply. The conductive coil is electrified to generate a magnetic field for magnetic adsorption, so that the preparation steps of the magnetic frame can be simplified, different magnetic forces can be generated by setting different currents of the conductive coil, and the adjustability of the magnetic force of the magnetic frame is realized; the adsorption effect of magnetic microspheres in different numbers of PCR tubes can be met, the adsorption effect can be guaranteed, and the adsorption efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of a magnetic frame for separating magnetic microspheres, in particular to a magnetic frame with adjustable magnetic force. Background Art

[0002] After the preparation, experiment, washing or adsorption of magnetic microspheres, the magnetic microspheres can be fixed by adsorbing them to the wall of PCR tubes by magnetic attraction so as to separate them from the working solution for extraction. For many small-scale experiments, PCR tubes are often used as carriers for magnetic microspheres and working solution. Therefore, the magnetic attraction of the magnetic stand can be used to complete the adsorption of magnetic microspheres in the PCR tubes.

[0003] In the prior art, there is a magnetic frame for magnetic bead separation with application number 202321623958.7, which discloses that a magnetic attraction component is arranged in the middle cavity of a column to form a magnetic frame. However, it is necessary to arrange the middle cavity on the column, which makes the preparation steps of the magnetic frame more complicated. In addition, the magnetic attraction component arranged in the middle cavity is a magnet, and its magnetic attraction effect is certain. When there are many objects to be acted on or the position of the PCR tube is far away from the position of the column, the magnetic frame with a fixed magnetic attraction force does not have a better adsorption effect, resulting in weak or unstable adsorption of the magnetic microspheres, affecting the separation effect of the magnetic microspheres. Utility Model Content

[0004] The utility model aims to provide a magnetic frame with adjustable magnetic force. The magnetic field generated by energizing the conductive coil can not only simplify the preparation steps of the magnetic frame, but also generate magnetic forces of different magnitudes by setting the current of the conductive coil to different magnitudes, thereby achieving adjustable magnetic force of the magnetic frame, satisfying the adsorption of magnetic microspheres in different numbers of PCR tubes, ensuring the adsorption effect, and improving the adsorption efficiency.

[0005] In order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a magnetic frame with adjustable magnetic force, comprising:

[0006] A supporting body, comprising a bottom plate and a supporting column arranged on the bottom plate,

[0007] A frame is arranged on the support column and is provided with at least one positioning hole for vertically positioning the PCR tube.

[0008] The conductive coil is wound around at least the lower portion of the support column, and both ends of the coil are electrically connected to an external power source.

[0009] As a further optimization, the support column includes a lower column and an upper column coaxially arranged on the upper end of the lower column, and a limiting step for supporting the frame is formed on the upper end surface of the lower column and located on the peripheral side of the upper column. The frame is provided with a through hole passing through its main body, and the through hole is sleeved on the upper column; the positioning hole is formed on the side of the through hole.

[0010] As a further optimization, the conductive coil is wound around the lower part of the lower column.

[0011] As a further optimization, there are two positioning holes, which are symmetrically arranged on both sides of the through hole, and the central axis is coplanar with the central axis of the support column, so that the space can be fully and reasonably utilized while ensuring the balance of the magnetic frame.

[0012] As a further optimization, the number of the racks is two, and the two racks are stacked and abut against the limiting step.

[0013] As a further optimization, the two frames are arranged perpendicular to each other.

[0014] As a further optimization, a vertical slot is provided on the upper column, and a limit plate is provided on the side wall of the through hole. The limit plate is embedded in the vertical slide groove, which can ensure that the frame is accurately positioned on the support column and prevent the frame from rotating relative to the support column.

[0015] As a further optimization, a pair of limit plates are symmetrically provided in the through hole, and four vertical slots are symmetrically provided on the upper column.

[0016] As a further optimization, the upper end of the support column is provided with a guide section to facilitate the positioning hole sleeve on the support column.

[0017] As a further optimization, a plurality of positioning grooves are provided on the bottom plate, which can be used to locate the bottom end of the PCR tube to ensure the accurate position of the PCR tube.

[0018] Compared with the prior art, the utility model has the following beneficial effects:

[0019] 1. The magnetic field generated by the conductive coil after being energized is used to magnetically adsorb the magnetic microspheres, which can not only simplify the preparation steps of the magnetic frame, but also generate different magnetic forces by setting different currents of the conductive coil, thereby achieving adjustable magnetic force of the magnetic frame;

[0020] 2. The frame can be installed on the support column by a relatively simple set-up based on the adjustable (enlarged) magnetic force, which is convenient for increasing the number of positioning holes (frames) for positioning PCR tubes and ensuring a relatively stable position. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a structural diagram of the utility model.

[0022] Figure 2 It is an exploded view of the utility model.

[0023] Figure 3 This is a structural diagram of another embodiment of the support body of the utility model.

[0024] Figure 4 It is a structural diagram of another embodiment of the frame of the utility model. DETAILED DESCRIPTION

[0025] The following are specific embodiments of the present invention and the accompanying drawings to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

[0026] like Figures 1 to 2 As shown, a magnetic frame with adjustable magnetic force includes a supporting body, a frame body 30 and a conductive coil 40. The supporting body includes a base plate 10 and a supporting column 20 arranged on the base plate 10. The frame body 30 is arranged on the supporting column 20 and is provided with a pair of positioning holes 301 for vertically positioning the PCR tube 100. The conductive coil 40 is wound around the lower part of the supporting column 20 and is located below the frame body 30. Both ends of the conductive coil 40 are electrically connected to an external power supply.

[0027] In the present invention, the PCR tube 100 is passed through the positioning hole 301 and its lower end is abutted against the bottom plate 10, and the external power supply is turned on to energize the wire coil 40. The wound conductive coil forms a magnetic field that can have a magnetic attraction effect, especially at its upper and lower ends. The magnetic force generated by the conductive coil 40 can adsorb the magnetic microspheres in the PCR tube 100 to the bottom wall and side wall of the PCR tube for fixation, and the liquid in the PCR tube 100 can be easily pumped away to achieve the detachment of the magnetic microspheres.

[0028] The utility model replaces the conventional method of opening a central cavity in the support column and filling it with a magnet by using the magnetic field generated by the conductive coil 40 after being energized. On the one hand, it can simplify the preparation steps of the magnetic frame. On the other hand, when the current passing through the conductive coil is set to different sizes, magnetic forces of different sizes can be generated, thereby achieving adjustable magnetic force of the magnetic frame to meet different usage conditions.

[0029] Preferably, the support column 20 is a cylindrical structure, which is convenient for the conductive coil 40 to be wound thereon; in addition, the support column 20 is an iron column, and when the conductive coil 40 is energized, its material can enhance the magnetic field generated by the conductive coil 40.

[0030] The overall installation structure of the magnetic frame can be set as follows: the support column 20 includes a lower column 21 and an upper column 22 coaxially arranged on the upper end of the lower column 21, and the two are an integrated structure. A limiting step 211 for supporting the frame body 30 is formed on the upper end surface of the lower column 21 and located on the surrounding side of the upper column 22. The frame body 30 is provided with a through hole 302 that penetrates its main body. The through hole 302 is sleeved on the upper column 22 so that the lower end of the frame body 30 abuts against the limiting step 221. The positioning hole 301 is formed on the side of the through hole 302. This can facilitate the installation and replacement of the frame body 30. For example, the frame body 30 with a positioning hole 301 of a non-aperture diameter can be easily replaced.

[0031] The conductive coil 40 is wound around the lower part of the lower column 21, and the magnetic field it generates is mainly concentrated on the lower part of the support column 20, so the magnetic force can be more concentrated on the lower part of the PCR tube 100, making it convenient to fix the magnetic microspheres on the lower part of the PCR tube 100 for subsequent operations.

[0032] Preferably, the two positioning holes 301 are symmetrically arranged on both sides of the through hole 302, and the central axis of the positioning holes 301 is coplanar with the central axis of the support column 20, so that the PCR tube 100 can be closer to the support column 20 and maintain balance relative to both sides of the support column. A pair of PCR tubes 100 can be placed through the two positioning holes 301 to improve the magnetic attraction efficiency.

[0033] Furthermore, there are two racks 30, and the two racks 30 are stacked and abutted against the limiting step 211, that is, one rack 30 is first set to abut against the limiting step 211, and then another rack 30 is set to abut against the rack 30 located below, so that the magnetic rack has four positioning holes 301, and four PCR tubes 100 can be placed at the same time; and because the energized coil 40 can adjust the current size to generate a larger magnetic force, the adsorption effect of the magnetic microspheres in the four PCR tubes can be guaranteed. In addition, due to the size of the spatial position, it is preferred to set two racks 30 with four positioning holes 301, and the two racks 30 are preferably arranged perpendicular to each other.

[0034] Combination Figures 3 to 4 As shown, in another embodiment of the utility model, a vertical slot 221 is provided on the upper column 22, and the vertical slot 221 extends to the limiting step 211. A limiting plate 31 is provided on the side wall of the through hole 302, and the limiting plate 31 is embedded in the vertical slide groove 221. The cooperation between the limiting plate 31 and the vertical slide groove 221 can prevent the frame 30 from rotating relative to the support column 20, thereby ensuring installation stability and use stability. Based on the setting of four positioning holes 301 of two frames 30, a pair of limiting plates 31 can be symmetrically provided in the through hole 302 of each frame 30, and four vertical slots 211 can be symmetrically provided on the upper column 22 for cooperation.

[0035] The upper end of the support column 20 (ie, the upper column 22 ) is provided with a guide cut surface 222 to facilitate the through hole 302 on the frame 30 to be smoothly mounted on the upper column 22 ; similarly, a guide cut surface can also be formed on the lower end surface of the limiting plate 31 .

[0036] The bottom plate 10 is provided with a plurality of positioning grooves 11 for inserting the lower end of the PCR tube 100 to ensure that the PCR tube 100 is in a vertical state. Furthermore, an elastic member can be provided in the positioning hole 301 to ensure the clamping of the PCR tube to prevent it from shaking (such as shaking caused by inaccurate placement or impact of the magnetic microspheres on the inner wall of the PCR tube when they are magnetically adsorbed). The elastic member can be an elastic gasket or a spring, etc., and abuts against and clamps the PCR tube with the connecting plate provided thereon, so that the aperture of the positioning hole 301 can be set slightly larger.

[0037] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A magnetic frame with adjustable magnetic force, characterized in that: include: A supporting body, comprising a bottom plate and a supporting column arranged on the bottom plate, A frame is arranged on the support column and is provided with at least one positioning hole for vertically positioning the PCR tube. The conductive coil is wound around at least the lower portion of the support column, and both ends of the coil are electrically connected to an external power source.

2. The magnetic frame with adjustable magnetic force according to claim 1, characterized in that: The support column includes a lower column and an upper column coaxially arranged on the upper end of the lower column, and a limiting step for supporting the frame is formed on the upper end surface of the lower column and located on the circumferential side of the upper column. The frame is provided with a through hole penetrating its body, and the through hole is sleeved on the upper column; the positioning hole is formed on the side of the through hole.

3. The magnetic frame with adjustable magnetic force according to claim 2, characterized in that: The conductive coil is wound around the lower portion of the lower column.

4. The magnetic frame with adjustable magnetic force according to claim 2, characterized in that: There are two positioning holes, and the two positioning holes are symmetrically arranged on both sides of the through hole, and the central axis is coplanar with the central axis of the support column.

5. The magnetic frame with adjustable magnetic force according to any one of claims 2 to 4, characterized in that: The number of the racks is two, and the two racks are stacked and abut against the limiting step.

6. The magnetic frame with adjustable magnetic force according to claim 5, characterized in that: The two frames are arranged perpendicularly to each other.

7. The magnetic frame with adjustable magnetic force according to claim 2 or 6, characterized in that: A vertical slot is provided on the upper column, a limiting plate is provided on the side wall of the through hole, and the limiting plate is embedded in the vertical slot.

8. The magnetic frame with adjustable magnetic force according to claim 7, characterized in that: A pair of limiting plates are symmetrically arranged in the through hole, and four vertical slots are symmetrically arranged on the upper column.

9. The magnetic frame with adjustable magnetic force according to claim 1, characterized in that: The upper end of the support column is provided with a guiding section.

10. The magnetic frame with adjustable magnetic force according to claim 1, characterized in that: A plurality of positioning grooves are arranged on the bottom plate.

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