Extraction and purification device compatible with samples of various specifications

Abstract

The utility model discloses an extraction and purification device compatible with various specifications of samples. The extraction and purification device comprises a turntable type workbench, a turntable driving device and a translation sliding extraction and purification device, the translational sliding extraction and purification device comprises a translational sliding device and a first extraction unit. The translation sliding device comprises a sliding guide rail, a sliding frame and a sliding driving device. The first extraction unit comprises a mounting frame, an extraction driving device and a first extraction device. The sliding direction of the translation sliding device is consistent with the tangential direction of the rotating disc, and the tangential direction of the rotating disc in the rotating disc driving device is parallel to the edge of one side of the kit on the rotating disc driving device, so that extraction and detection of the translation sliding extraction and purification device are realized. The extraction and purification device compatible with the samples of various specifications can be adjusted according to the use condition, extraction and purification of a single row of samples are achieved, and extraction, purification and reaction are continuously carried out in a highly automatic mode.

Description

Technical Field

[0001] The utility model belongs to the technical field of extraction equipment, in particular to an extraction and purification device compatible with samples of various specifications. Background Art

[0002] The magnetic bead method for extracting bioactive substances is divided into the magnetic rod method and the suction method. The suction method is performed through an automatic pipetting device. Taking the magnetic bead method nucleic acid extractor as an example, the lysis solution and magnetic bead adsorption can be added through an automatic pipetting device; the solution is removed, the rinse solution is added, the magnetic beads are adsorbed, the rinse solution is removed, and the elution buffer is added. The magnetic rod extraction is a technology developed in recent years. Its principle is to immerse the magnetic separation device in the liquid, and through the action of the magnetic field, the particles that can be attracted by the magnetism in the mixture are concentrated on the surface of the separation device. In one method, the magnetic separation device is a sleeve. By inserting a magnetic rod, the sleeve is magnetic, and the particles that can be attracted by the magnetism in the mixture are attracted to the surface of the sleeve. When the magnetic rod is removed, the sleeve loses its magnetism and the particles attracted by the magnetism are separated from the sleeve.

[0003] In the current rotary disk extraction device, during the extraction process, the rotary disk extraction device transfers the reagent kit to the position of the extraction device through the rotary disk, and the extraction device processes the sample in turn to extract the sample. However, when processing a small amount of extracted samples, the entire device still needs to work, which increases the cost of use. Utility Model Content

[0004] In view of this, the utility model provides an extraction and purification device that is compatible with samples of various specifications and can reduce usage costs to meet industrial needs.

[0005] An extraction and purification device compatible with samples of various specifications includes a turntable, a rotating disk driving device arranged on the turntable and used to drive the reagent kit to be extracted to rotate in a circle, and at least one translation sliding extraction and purification device arranged on the turntable. The translation sliding extraction and purification device includes at least one translation sliding device arranged on one side of the rotating disk, and a first extraction unit arranged on the translation sliding device. The translation sliding device includes a sliding guide rail arranged on the turntable, a sliding frame slidably connected to the sliding guide rail, and a sliding driving device arranged on the turntable and connected to one side of the sliding frame. The first extraction unit includes a mounting frame arranged on the sliding frame, an extraction driving device arranged on the mounting frame, and a first extraction device arranged on the extraction driving device. The sliding direction of the translation sliding device is consistent with the tangent direction of the rotating disk, and the tangent direction of the rotating disk in the rotating disk driving device is parallel to the edge of one side of the reagent kit on the rotating disk driving device, so as to realize the extraction detection of the translation sliding extraction and purification device.

[0006] Furthermore, the extraction and purification device compatible with samples of various specifications also includes at least one extraction and purification device arranged on the turntable workbench.

[0007] Furthermore, the extraction and purification device includes a second mounting frame arranged on the turntable workbench, a second extraction drive device arranged on the second mounting frame, and a second extraction device arranged on the second extraction drive device, the translational sliding extraction and purification device, and the extraction and purification device are arranged around the rotating disk drive device.

[0008] Furthermore, the translational sliding extraction and purification device and the extraction and purification device are respectively provided with magnetic rods and magnetic sleeves of different diameters.

[0009] Furthermore, the extraction and purification device compatible with samples of various specifications also includes at least one reagent box lifting device arranged on the turntable workbench.

[0010] Furthermore, the extraction and purification device compatible with samples of various specifications also includes at least one magnetic head replacement device arranged on the workbench.

[0011] Furthermore, each of the reagent box lifting devices corresponds to the translational sliding extraction and purification device or any one of the extraction and purification devices.

[0012] Compared with the prior art, the extraction and purification device compatible with samples of various specifications provided by the utility model realizes the extraction of samples in a single reagent box on the rotating disk driving device through the translation sliding extraction and purification device. The translation sliding device in the translation sliding extraction and purification device drives the first extraction unit to extract, and the sliding driving device in the translation sliding device drives the sliding frame to slide along the sliding guide rail. The first extraction unit is arranged on the sliding frame, so that the translation sliding device can drive the first extraction unit to move horizontally, and the first extraction driving device in the first extraction unit drives the first extraction device to lift and extract. The first extraction device can be provided with magnetic rods and magnetic sleeves of required specifications according to the extraction requirements, and the first extraction device can be equipped with multiple rows or single rows of magnetic rods and magnetic sleeves for driving. When the first extraction driving device drives the translation sliding extraction and purification device to extract, the magnetic rods and magnetic sleeves in the first extraction device extract the sample slots in the reagent box in sequence. The extraction and purification device compatible with samples of various specifications can be adjusted according to the usage conditions to realize the extraction and purification of single-row samples, and realize highly automated continuous extraction, purification and reaction. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the structure of an extraction and purification device provided by the utility model that is compatible with samples of various specifications. DETAILED DESCRIPTION

[0014] The following is a further detailed description of the specific embodiments of the present invention. It should be understood that the description of the embodiments of the present invention herein is not intended to limit the protection scope of the present invention.

[0015] like Figure 1 As shown, it is a schematic diagram of the structure of the extraction and purification device compatible with samples of various specifications provided by the utility model. The extraction and purification device compatible with samples of various specifications includes a turntable 1, a rotating disk driving device 10 arranged on the turntable 1 and used to drive the reagent kit to be extracted (not shown) to rotate in a circle, at least one translational sliding extraction and purification device 20 arranged on the turntable 1, at least one extraction and purification device 30 arranged on the turntable 1, at least one reagent kit lifting device 40 arranged on the turntable 1, and at least one magnetic head replacement device arranged on the workbench 1 (not shown). The extraction and purification device compatible with samples of various specifications also includes some other functional modules, such as assembly components, electrical connection components, etc., which should be technologies known to those skilled in the art and will not be described in detail one by one here.

[0016] The turntable workbench 1 is used to support the rotating disk driving device 10, the translational sliding extraction and purification device 20, the extraction and purification device 30, and the reagent box lifting device 40. The turntable workbench 1 is a prior art and will not be described in detail here.

[0017] The rotating disk drive device 10 can drive the reagent box (not shown) to rotate. The rotating disk drive device 10 can rotate and transmit the reagent box to the translational sliding extraction and purification device 20 and the extraction position of the extraction and purification device 30. The rotating disk drive device 10 is a prior art and will not be described in detail here.

[0018] The translational sliding extraction and purification device 20 includes a translational sliding device 21 disposed on the turntable workbench 1 and a first extraction unit 22 disposed on the translational sliding device 21 .

[0019] The translation sliding device 21 includes a sliding rail 211 disposed on the turntable workbench 1, a sliding frame 212 slidably connected to the sliding rail 211, and a sliding driving device 213 disposed on the turntable workbench 1 and connected to one side of the sliding frame 212. The sliding rail 211 is used to guide the sliding frame 212, and the sliding driving device 213 drives the sliding frame 212 to slide along the sliding rail 211. The first extraction unit 22 is disposed on the sliding frame 212, so that the translation sliding device 21 can drive the first extraction unit 22 to move horizontally. The sliding direction of the translational sliding device 21 is consistent with the tangential direction of the rotating disk (not shown) in the rotating disk driving device 10, and the tangential direction of the rotating disk (not shown) in the rotating disk driving device 10 is parallel to the edge of one side of the reagent box (not shown) on the rotating disk driving device 10, so that the translational sliding device 21 can drive the first extraction unit 22 to move onto the reagent box to realize the extraction detection of the translational sliding extraction and purification device 20.

[0020] The first extraction unit 22 includes a first mounting frame 221 disposed on the sliding frame 212 , a first extraction driving device 222 disposed on the first mounting frame 221 , and a first extraction device 223 disposed on the first extraction driving device 222 .

[0021] The first mounting frame 221 is used to support the first extraction drive device 222. The first extraction drive device 222 drives the first extraction device 223 to rise and fall and extract. The first extraction device 223 can be provided with magnetic bars and magnetic sleeves of required specifications according to the extraction requirements. The first extraction device 223 can be equipped with multiple rows or a single row of magnetic bars and magnetic sleeves for driving. The first extraction drive device 222 and the first extraction device 223 are both existing technologies and will not be described in detail here.

[0022] Each of the extraction and purification devices 30 includes a second mounting frame 31 disposed on the turntable workbench 1, a second extraction drive device 32 disposed on the second mounting frame 31, and a second extraction device 33 disposed on the second extraction drive device 32. The second mounting frame 31 is used to support the second extraction drive device 32, and the second extraction drive device 32 drives the second extraction device 33 to rise and fall and extract. The second extraction drive device 32 and the second extraction device 33 are both existing technologies and will not be described in detail herein.

[0023] The translational sliding extraction and purification device 20 and the extraction and purification device 30 are arranged along the edge of the rotating disk driving device 10. The user can open any one of the translational sliding extraction and purification device 20 or the extraction and purification device 30 for extraction according to needs.

[0024] Each reagent box lifting device 40 includes a lifting drive device 41 disposed on the turntable workbench 1, and a resisting plate 42 disposed on the lifting drive device 41 and used to resist the reagent box. Each reagent box lifting device 40 corresponds to any one of the translational sliding extraction and purification device 20 or the extraction and purification device 30, and the lifting drive device 41 drives the resisting plate 42 to rise and fall, and the resisting plate 42 can drive the reagent box (not shown) on the rotating disk drive device 10 to move to the extraction position of the translational sliding extraction and purification device 20 or the extraction and purification device 30, so as to facilitate the extraction of the translational sliding extraction and purification device 20 or the extraction and purification device 30.

[0025] When the translational sliding extraction and purification device 20 is performing extraction, and the translational sliding extraction and purification device 20 is provided with a single row of magnetic rods and magnetic sleeves, different reagents are placed in each sample slot, and the magnetic rods and magnetic sleeves in the translational sliding extraction and purification device 223 are inserted into the sample slots in the test kit for extraction in sequence, thereby realizing the extraction of a single test kit.

[0026] When the extraction and purification device 30 performs extraction, the rotating disk driving device 10 sequentially transfers the test kit containing different reagents to one side of the extraction and purification device 30, and the extraction and purification device 30 sequentially extracts and processes the samples in the test kit.

[0027] In addition, at least one magnetic head replacement device (not shown) is provided on the workbench 1, and the magnetic head replacement device is used to place magnetic rods. The translational sliding extraction and purification device 20 and the extraction and purification device 30 can both replace the magnetic rods through the magnetic head replacement device. In this embodiment, the translational sliding extraction and purification device 20 and the extraction and purification device 30 can be provided with magnetic rods and magnetic sleeves of different diameters, so that the translational sliding extraction and purification device 20 and the extraction and purification device 30 are suitable for extraction substances of different specifications, and the magnetic rods and magnetic sleeves on the translational sliding extraction and purification device 20 and the extraction and purification device 30 are used independently to avoid affecting the mutual interference of the extracts. And the magnetic head replacement device generally refers to a component used in an automated extraction system, which is used to replace magnetic rods, which are magnetic particles used to bind and purify nucleic acids. The magnetic head replacement device is a prior art and will not be described in detail here.

[0028] Compared with the prior art, the extraction and purification device compatible with samples of various specifications provided by the utility model realizes the extraction of samples in a single reagent box on the rotating disk drive device 10 by using the translational sliding extraction and purification device 20. The translational sliding device 21 in the translational sliding extraction and purification device 20 drives the first extraction unit 22 to extract, and the sliding drive device 213 in the translational sliding device 21 drives the sliding frame 212 to slide along the sliding guide rail 211. The first extraction unit 22 is arranged on the sliding frame 212, so that the translational sliding device 21 can drive the first extraction unit 22 to move horizontally, and the first extraction drive device 222 in the first extraction unit 22 drives the first extraction device 223 to rise and fall and extract. The first extraction device 223 can be provided with magnetic rods and magnetic sleeves of required specifications according to the extraction requirements, and the first extraction device 223 can be equipped with multiple rows or single rows of magnetic rods and magnetic sleeves for driving. When the first extraction drive device 222 drives the translational sliding extraction and purification device 20 to extract, the magnetic rods and magnetic sleeves in the first extraction device 223 extract the sample slots in the reagent box in sequence. The extraction and purification device, which is compatible with samples of various specifications, can be adjusted according to usage conditions to achieve extraction and purification of single-row samples, and realize highly automated and continuous extraction, purification and reaction.

[0029] The above are only preferred embodiments of the present invention and are not intended to limit the protection scope of the present invention. Any modification, equivalent substitution or improvement within the spirit of the present invention are included in the scope of the claims of the present invention.

Claims

1. An extraction and purification device compatible with samples of various specifications, comprising a turntable workbench, characterized in that: The extraction and purification device compatible with samples of various specifications includes a rotating disk driving device arranged on the turntable workbench of the workbench and used to drive the reagent kit to be extracted to rotate in a circle, at least one translational sliding extraction and purification device arranged on the turntable workbench of the workbench, the translational sliding extraction and purification device includes at least one translational sliding device arranged on one side of the rotating disk, and a first extraction unit arranged on the translational sliding device, the translational sliding device includes a sliding guide rail arranged on the turntable workbench of the workbench, a sliding frame slidably connected to the sliding guide rail, and a sliding driving device arranged on the turntable of the workbench and connected to one side of the sliding frame, the first extraction unit includes a mounting frame arranged on the sliding frame, an extraction driving device arranged on the mounting frame, and a first extraction device arranged on the extraction driving device, the sliding direction of the translational sliding device is consistent with the tangential direction of the rotating disk, and the tangential direction of the rotating disk in the rotating disk driving device is parallel to the edge of one side of the reagent kit on the rotating disk driving device, so as to realize the extraction detection of the translational sliding extraction and purification device.

2. The extraction and purification device compatible with samples of various specifications as claimed in claim 1, characterized in that: The extraction and purification device compatible with samples of various specifications also includes at least one extraction and purification device arranged on the turntable workbench.

3. The extraction and purification device compatible with samples of various specifications as claimed in claim 2, characterized in that: The extraction and purification device includes a second mounting frame arranged on the turntable workbench, a second extraction drive device arranged on the second mounting frame, and a second extraction device arranged on the second extraction drive device. The translational sliding extraction and purification device and the extraction and purification device are arranged around the rotating disk drive device.

4. The extraction and purification device compatible with samples of various specifications as claimed in claim 2, characterized in that: The translational sliding extraction and purification device and the extraction and purification device are respectively provided with magnetic rods and magnetic sleeves with different diameters.

5. The extraction and purification device compatible with samples of various specifications as claimed in claim 1, characterized in that: The extraction and purification device compatible with samples of various specifications also includes at least one reagent box lifting device arranged on the turntable workbench.

6. The extraction and purification device compatible with samples of various specifications as claimed in claim 1, characterized in that: The extraction and purification device compatible with samples of various specifications also includes at least one magnetic head replacement device arranged on the workbench.

7. The extraction and purification device compatible with samples of various specifications as claimed in claim 5, characterized in that: Each reagent box lifting device corresponds to the translational sliding extraction and purification device or any one of the extraction and purification devices.

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