Instilling device for pneumoconiosis mouse

Abstract

The utility model discloses an instillation device for a pneumoconiosis mouse. The instillation device comprises a bottom plate; an operation plate is arranged at the top of the bottom plate; a first support and a second support are arranged on the front side of the bottom plate. The first bracket is rotationally connected with a first bidirectional screw rod; the first two-way screw rod is positioned above the operation plate; the first bidirectional screw rod is in threaded connection with two first sliding blocks; the two first sliding blocks are provided with first pulling ropes used for pulling the lower incisor of the pneumoconiosis experimental mouse. The second bracket is rotationally connected with a second bidirectional screw rod; the second two-way screw rod is positioned in front of the operation plate; the second bidirectional screw rod is in threaded connection with two second sliding blocks; the two second sliding blocks are provided with second pulling ropes used for pulling the upper incisor of the pneumoconiosis experimental mouse. Through cooperation of the first bidirectional lead screw, the first sliding block, the second bidirectional lead screw, the second sliding block, the first traction rope and the second traction rope, the opening size of the oral cavity of the pneumoconiosis experimental mouse can be controlled, and operation is convenient and fast.

Description

Technical Field

[0001] The utility model relates to the technical field of experimental tools, in particular to an instillation device for pneumoconiosis mice. Background Art

[0002] Pneumoconiosis is a general term for a group of occupational lung diseases characterized by diffuse fibrosis of lung tissue caused by long-term inhalation of industrial dust of different pathogenicity and its retention in the lungs during occupational activities. Its main clinical symptoms are four major symptoms mainly in the respiratory system, such as cough, sputum, chest pain, and dyspnea, as well as wheezing, hemoptysis and systemic symptoms. Further development may cause complications / comorbidities, among which tuberculosis and chronic cor pulmonale are the main ones. The pathological change of pneumoconiosis is diffuse fibrosis of lung tissue, which is a serious disease that destroys the structure of lung tissue and damages lung function. In the process of pneumoconiosis research and experiments, it is often necessary to administer drugs to the lungs of experimental mice. Before pulmonary administration, the anesthetized experimental mice need to be intubated, and the drug administration catheter is inserted into the trachea through the glottis of the experimental mouse before administration.

[0003] A Chinese utility model patent with announcement number CN214908608U discloses a tracheal instillation device for mice and rats, comprising an operating table, an upper incisor fixing mechanism, and a lower incisor fixing mechanism, wherein the upper incisor fixing mechanism comprises an upper incisor fixing nail and an upper incisor pulley fixed at the left and right ends of the operating table, an upper incisor fixing wire is connected to the upper incisor fixing nail, and the upper incisor fixing wire is connected to the upper incisor counterweight after passing through the upper incisor pulley; the lower incisor fixing mechanism is located at the lower part of the upper incisor fixing mechanism and comprises a lower incisor fixing nail and a lower incisor pulley arranged at the left and right ends of the operating table, the lower incisor fixing nail is fixedly connected to the operating table, a slideway arranged in the up and down direction is arranged on the operating table, the lower incisor pulley is slidably arranged in the slideway, the lower incisor fixing nail is connected to the lower incisor fixing wire, and the lower incisor fixing wire is connected to the lower incisor counterweight after passing through the lower incisor pulley.

[0004] The above patent uses a counterweight to drive a fixed line to open the mouse's mouth. Although it can adapt to mice of different sizes to a certain extent by configuring and stacking counterweights of different specifications, it still has the problem of inconvenient operation and difficulty in adjusting and controlling the size of the mouth opening.

[0005] Therefore, how to provide an instillation device for pneumoconiosis rats that is easy to operate and can control the size of the oral opening is one of the technical problems that urgently need to be solved in the field. Utility Model Content

[0006] In view of this, the utility model provides an instillation device for pneumoconiosis rats, the purpose of which is to solve the problems existing in the prior art.

[0007] In order to solve the above technical problems, the utility model adopts the following technical solutions:

[0008] A drip device for pneumoconiosis mice comprises: a base plate; an operating panel is provided on the top of the base plate; a first bracket and a second bracket are provided on the front side of the base plate; a first bidirectional screw is rotatably connected to the first bracket; the first bidirectional screw is located above the operating panel; two first sliding blocks are threadedly connected to the first bidirectional screw; a first traction rope for pulling the lower incisors of pneumoconiosis experimental mice is provided on the two first sliding blocks; one end of the first bidirectional screw extends to the outside of the first bracket and is provided with a first handle; a second bidirectional screw is rotatably connected to the second bracket; the second bidirectional screw is located in front of the operating panel; two second sliding blocks are threadedly connected to the second bidirectional screw; two second sliding blocks are provided with a second traction rope for pulling the upper incisors of pneumoconiosis experimental mice; one end of the second bidirectional screw extends to the outside of the second bracket and is provided with a second handle.

[0009] Preferably, a first threaded hole is formed on the first handle; a first fastening bolt is threadedly connected to the first threaded hole; a second threaded hole is formed on the second handle; a second fastening bolt is threadedly connected to the second threaded hole.

[0010] Preferably, a rotating shaft is provided in the middle of the bottom of the operating panel; the rotating shaft is rotatably connected to the bottom plate; fixed blocks are provided on the left and right sides of the operating panel; a through first pin hole is provided on the fixed block; a second pin hole is provided on the bottom plate; the first pin holes are the same in number as the second pin holes and are arranged one-to-one; pin shafts are inserted into the first pin holes and the second pin holes.

[0011] Preferably, a vertical plate is provided on the rear side of the operating panel; a baffle is provided on the front side of the vertical plate; a threaded rod is rotatably connected to the baffle plate on the side close to the vertical plate; the threaded rod is threadedly connected to the vertical plate; a third handle is provided on the end of the threaded rod away from the baffle plate; a through hole is opened on the baffle plate for the tail of a pneumoconiosis experimental mouse to pass through.

[0012] Preferably, a third limiting sliding block is provided at the bottom of the baffle; a third limiting sliding groove matched with the third limiting sliding block is provided on the operating panel; and the third limiting sliding block is slidably connected in the third limiting sliding groove.

[0013] Preferably, a fixing belt is provided on one side of the top of the operating panel; a limiting plate corresponding to the fixing belt is provided on the other side of the top of the operating panel; a through slot for the fixing belt to pass through is provided on the limiting plate; and a hook surface and a fur surface which cooperate with each other are provided on the upper surface of the fixing belt.

[0014] Preferably, an LED lighting lamp is provided on the front side of the base plate.

[0015] Preferably, a base is provided under the bottom plate; the rear side of the bottom plate is rotatably connected to the rear side of the base; telescopic rods are hinged on both the left and right sides of the base; the other end of the telescopic rod is hinged on the bottom plate; and a third fastening bolt for fastening the telescopic rod is provided on the telescopic rod.

[0016] Preferably, both left and right sides of the top of the base are provided with receiving grooves; one end of the telescopic rod is hinged to the front side of the corresponding receiving groove.

[0017] Preferably, both the first traction rope and the second traction rope are provided with tooth sleeves; and tooth grooves are provided on the tooth sleeves.

[0018] Compared with the prior art, the utility model has achieved the following technical effects: the utility model drives two first sliding blocks to move toward or away from each other through the first bidirectional lead screw, and drives two second sliding blocks to move toward or away from each other through the second bidirectional lead screw, thereby driving the first traction rope and the second traction rope to pull the lower incisors and the upper incisors of the pneumoconiosis experimental mouse, thereby opening the mouth of the pneumoconiosis experimental mouse to an appropriate size, and the entire device has a simple structure, is easy to operate, and can control the size of the mouth opening. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic structural diagram of an instillation device for pneumoconiosis rats according to the utility model;

[0020] Figure 2 for Figure 1 A partial enlarged view of part A;

[0021] Figure 3 It is a schematic diagram of the structure of the first bracket and the second bracket;

[0022] Figure 4 is a schematic diagram of the structure of the base;

[0023] Figure 5 It is a structural schematic diagram of the gear sleeve;

[0024] In the figure: 1, bottom plate; 2, operation panel; 3, first bracket; 4, second bracket; 5, first bidirectional screw rod; 6, first sliding block; 7, first traction rope; 8, first handle; 9, second bidirectional screw rod; 10, second sliding block; 11, second traction rope; 12, second handle; 13, first fastening bolt; 14, second fastening bolt; 15, rotating shaft; 16, fixing block; 17, pin shaft; 18, vertical plate; 19, baffle plate; 20, threaded rod; 21, third Handle; 22. Through hole; 23. Third limit slider; 24. Third limit slot; 25. Fixing belt; 26. Limit plate; 27. LED lighting; 28. Operating lever; 29. ​​Base; 30. Telescopic rod; 31. Third fastening bolt; 32. Receiving groove; 33. Tooth sleeve; 34. Tooth groove; 35. First pin hole; 36. Second pin hole; 37. First limit slider; 38. First limit slot; 39. Second limit slider; 40. Second limit slot. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] Example

[0027] Reference Figure 1-5As shown, the utility model discloses an instillation device for pneumoconiosis mice, comprising: a bottom plate 1; an operation panel 2 is arranged on the top of the bottom plate 1; a first bracket 3 and a second bracket 4 are arranged on the front side of the bottom plate 1; a first bidirectional screw rod 5 is rotatably connected to the first bracket 3; the first bidirectional screw rod 5 is located above the operation panel 2; two first sliding blocks 6 are threadedly connected to the first bidirectional screw rod 5; the two first sliding blocks 6 are provided with a first traction rope 7 for traction of the lower incisors of the pneumoconiosis experimental mice; the two ends of the first traction rope 7 are respectively fixedly connected to the two first sliding blocks 6; one end of the first bidirectional screw rod 5 extends to the first The bracket 3 is provided with a first handle 8 on the outside; the second bracket 4 is rotatably connected with a second bidirectional screw rod 9; the second bidirectional screw rod 9 is located in front of the operating panel 2; two second sliding blocks 10 are threadedly connected to the second bidirectional screw rod 9; the two second sliding blocks 10 are provided with a second traction rope 11 for traction of the upper incisors of the pneumoconiosis experimental mouse; the two ends of the second traction rope 11 are respectively fixedly connected to the two second sliding blocks 10; one end of the second bidirectional screw rod 9 extends to the outside of the second bracket 4 and is provided with a second handle 12; when in use, first place the anesthetized pneumoconiosis experimental mouse on the operating panel 2 and The pneumoconiosis experimental mouse is placed in a supine position, and then the lower incisors of the pneumoconiosis experimental mouse are hooked with the first traction rope 7, and the upper incisors of the pneumoconiosis experimental mouse are hooked with the second traction rope 11, and then the first handle 8 is rotated, and the first handle 8 drives the first bidirectional screw rod 5 to rotate, and the first bidirectional screw rod 5 drives the two first sliding blocks 6 to move in opposite directions, and the two first sliding blocks 6 pull the first traction rope 7 at the same time, and the first traction rope 7 pulls the lower incisors of the pneumoconiosis experimental mouse, and the second handle 12 is rotated, and the second handle 12 drives the second bidirectional screw rod 9 to rotate, and the second bidirectional screw rod 9 drives the two second sliding blocks 1 0 move in opposite directions, the two second sliding blocks 10 simultaneously pull the second traction rope 11, and the second traction rope 11 pulls the upper incisors of the pneumoconiosis experimental mouse until the mouth of the pneumoconiosis experimental mouse is opened to a suitable size, and then the first grip 8 and the second grip 12 are stopped from rotating, thereby opening the mouth of the pneumoconiosis experimental mouse to a suitable size, then the tongue of the pneumoconiosis experimental mouse is pulled out, and the tracheal cannula rod is inserted into the trachea of ​​the pneumoconiosis experimental mouse, and finally, an injection device such as a syringe is used to drip liquid into the trachea of ​​the pneumoconiosis experimental mouse through the tracheal cannula. The entire device has a simple structure and is easy to operate, and can control the opening size of the mouth.

[0028] The above technical solution drives the two first sliding blocks to move toward or away from each other through the first bidirectional lead screw, and drives the two second sliding blocks to move toward or away from each other through the second bidirectional lead screw, thereby driving the first traction rope and the second traction rope to pull the lower incisors and upper incisors of the pneumoconiosis experimental mouse, thereby opening the mouth of the pneumoconiosis experimental mouse to an appropriate size. The entire device has a simple structure, is easy to operate, and can control the size of the mouth opening.

[0029] In this embodiment, a first threaded hole is provided on the first handle 8; a first fastening bolt 13 is threadedly connected to the first threaded hole; a second threaded hole is provided on the second handle 12; a second fastening bolt 14 is threadedly connected to the second threaded hole; during use, when the first handle 8 is rotated to a suitable position, the first fastening bolt 13 is rotated until the first fastening bolt 13 abuts against the first bracket 3, thereby fixing the first handle 8; when the second handle 12 is rotated to a suitable position, the second fastening bolt 14 is rotated until the second fastening bolt 14 abuts against the second bracket 4, thereby fixing the second handle 12.

[0030] In this embodiment, a rotating shaft 15 is provided at the middle position of the bottom of the operating panel 2; the rotating shaft 15 is rotatably connected to the bottom plate 1; fixed blocks 16 are provided on the left and right sides of the operating panel 2; a through first pin hole 35 is opened on the fixed block 16; a second pin hole 36 is provided on the bottom plate 1; the first pin holes 35 and the second pin holes 36 are the same in number and are arranged one by one; pin shafts 17 are inserted into the first pin holes 35 and the second pin holes 36; after completing tracheal instillation, the pin shaft 17 is pulled out from the first pin hole 35 and the second pin hole 36, and the operating panel 2 is held and rotated and swung left and right, thereby driving the pneumoconiosis experimental mouse to rotate and swing left and right, and then the liquid in the two lungs of the pneumoconiosis experimental mouse can be evenly distributed.

[0031] In this embodiment, a base 29 is provided under the base plate 1; the rear side of the base plate 1 is rotatably connected to the rear side of the base 29; telescopic rods 30 are hinged on both sides of the base 29; the other end of the telescopic rod 30 is hinged to the bottom of the base plate 1; a third fastening bolt 31 for fastening the telescopic rod 30 is provided on the telescopic rod 30; when in use, the base plate 1 is pushed to rotate around the side hinged with the base 29, and when the base plate 1 is rotated to a suitable angle, the telescopic rod 30 is fixed by the third fastening bolt 31, so that the base plate 1 is fixed at the current position, thereby realizing the angle adjustment between the base plate and the base.

[0032] In this embodiment, both left and right sides of the top of the base 29 are provided with receiving grooves 32; one end of the telescopic rod 30 is hinged to the front side of the corresponding receiving groove 32; by providing the receiving groove 32, the telescopic rod can be stored in the receiving groove.

[0033] In this embodiment, the telescopic rod 30 includes a sleeve and a sliding rod; one end of the sleeve is hinged to the front side of the base 29; one end of the sliding rod is hinged to the bottom of the base plate 1; the sliding rod is slidably connected in the sleeve; the third fastening bolt 31 is threadedly connected to the sleeve near one end of the sliding rod.

[0034] In this embodiment, a vertical plate 18 is provided on the rear side of the operating panel 2; a baffle 19 is provided on the front side of the vertical plate 18; a threaded rod 20 is rotatably connected to the baffle 19 on the side close to the vertical plate 18; the threaded rod 20 is threadedly connected to the vertical plate 18; a third handle 21 is provided on the end of the threaded rod 20 away from the baffle 19; a through hole 22 is provided on the baffle 19 for the tail of the pneumoconiosis experimental mouse to pass through; by providing the baffle 19, a supporting effect can be played on the pneumoconiosis experimental mouse, thereby reducing the harm of the device to the pneumoconiosis experimental mouse; when in use, the third handle 21 is rotated, and the third handle 21 drives the threaded rod 20 to rotate while moving the threaded rod 20 back and forth, and the threaded rod 20 drives the baffle 19 to move back and forth, so that the position of the baffle 19 can be adjusted, thereby meeting the supporting requirements of pneumoconiosis experimental mice of different sizes.

[0035] In this embodiment, the baffle 19 is an arc-shaped structure.

[0036] In this embodiment, a third limit slider 23 is provided at the bottom of the baffle 19; a third limit slot 24 adapted to the third limit slider 23 is provided on the operating panel 2; the third limit slider 23 is slidably connected in the third limit slot 24; by providing the third limit slider and the third limit slot, the smoothness of the movement process of the baffle 19 can be improved.

[0037] In this embodiment, an operating rod 28 is provided on the top of the vertical plate 18; when in use, by holding the operating rod 28, the operating plate 2 can be more conveniently rotated left and right.

[0038] In this embodiment, a fixing belt 25 is provided on one side of the top of the operating panel 2; a limiting plate 26 corresponding to the fixing belt 25 is provided on the other side of the top of the operating panel 2; a through slot for the fixing belt 25 to pass through is opened on the limiting plate 26; the upper surface of the fixing belt 25 is provided with a hook surface and a fur surface that cooperate with each other to form a Velcro structure; when in use, after the fixing belt 25 passes through the through slot on the limiting plate 26, the hook surface and the fur surface on the upper surface of the fixing belt 25 are bonded together, so that the pneumoconiosis experimental mouse can be fixed on the operating panel 2, and at the same time, the Velcro structure formed by the hook surface and the fur surface can meet the use of pneumoconiosis experimental mice of different sizes.

[0039] In this embodiment, an LED lighting lamp 27 is provided on the front side of the base plate 1 for convenient lighting.

[0040] In this embodiment, a tooth sleeve 33 is provided at the middle position of the first traction rope 7 and the middle position of the second traction rope 11; a tooth groove 34 is provided on the tooth sleeve 33; when in use, the upper incisors and lower incisors of the pneumoconiosis experimental mouse can be inserted into the tooth groove 34 on the corresponding tooth sleeve 33 to reduce the damage to the pneumoconiosis experimental mouse.

[0041] In this embodiment, the first bracket 3 includes a horizontal plate and two first vertical plates; the two first vertical plates are fixedly connected to the left and right sides of the bottom plate respectively; the horizontal plate is fixedly connected between the two first vertical plates; the two ends of the first bidirectional screw rod 5 are rotatably connected to the two first vertical plates respectively.

[0042] In this embodiment, a first limit slider 37 is provided on the top of each first sliding block 6; a first limit slot 38 adapted to the first limit slider 37 is provided on the bottom of the cross plate; the first limit slider 37 is slidably connected in the first limit slot 38; by setting the first limit slider and the first limit slot, the smoothness of the movement process of the first sliding block can be improved.

[0043] In this embodiment, the second bracket includes two second vertical plates; the two second vertical plates are fixedly connected to the left and right sides of the bottom plate respectively; and the two ends of the second bidirectional screw rod 9 are rotatably connected to the two second vertical plates respectively.

[0044] In this embodiment, a second limiting slider 39 is provided at the bottom of each second sliding block 10; a second limiting groove 40 adapted to the second limiting slider 39 is provided at the top of the base plate 1; the second limiting slider 39 is slidably connected in the second limiting groove 40; by setting the second limiting slider and the second limiting groove, the smoothness of the movement process of the second sliding block can be improved.

[0045] In some other embodiments, the LED lighting lamp 27 is connected to the base plate 1 through an adjustable curved pipe, so that the position of the lighting lamp 27 can be adjusted conveniently.

[0046] The above description is only a preferred embodiment of the present invention and does not limit the technical scope of the present invention. Therefore, any minor modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. An instillation device for pneumoconiosis rats, characterized in that: include: A bottom plate (1); an operating panel (2) is provided on the top of the bottom plate (1); a first bracket (3) and a second bracket (4) are provided on the front side of the bottom plate (1); a first bidirectional screw rod (5) is rotatably connected to the first bracket (3); the first bidirectional screw rod (5) is located above the operating panel (2); two first sliding blocks (6) are threadedly connected to the first bidirectional screw rod (5); the two first sliding blocks (6) are provided with a first traction rope (7) for traction of the lower incisors of the pneumoconiosis experimental mice; one end of the first bidirectional screw rod (5) The first bracket (3) is provided with a first handle (8); the second bracket (4) is rotatably connected to a second bidirectional screw rod (9); the second bidirectional screw rod (9) is located in front of the operating panel (2); the second bidirectional screw rod (9) is threadedly connected to two second sliding blocks (10); the two second sliding blocks (10) are provided with a second traction rope (11) for traction of the upper incisors of pneumoconiosis experimental mice; one end of the second bidirectional screw rod (9) extends to the outside of the second bracket (4) and is provided with a second handle (12).

2. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: The first handle (8) is provided with a first threaded hole; a first fastening bolt (13) is threadedly connected to the first threaded hole; the second handle (12) is provided with a second threaded hole; a second fastening bolt (14) is threadedly connected to the second threaded hole.

3. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: A rotating shaft (15) is provided at the middle position of the bottom of the operating panel (2); the rotating shaft (15) is rotatably connected to the bottom plate (1); fixed blocks (16) are provided on the left and right sides of the operating panel (2); a through first pin hole (35) is provided on the fixed block (16); a second pin hole (36) is provided on the bottom plate (1); the first pin holes (35) and the second pin holes (36) are the same in number and are arranged in a one-to-one correspondence; pin shafts (17) are inserted into the first pin holes (35) and the second pin holes (36).

4. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: A vertical plate (18) is provided at the rear side of the operation panel (2); a baffle (19) is provided at the front side of the vertical plate (18); a threaded rod (20) is rotatably connected to the baffle (19) on the side close to the vertical plate (18); the threaded rod (20) is threadedly connected to the vertical plate (18); a third handle (21) is provided at the end of the threaded rod (20) away from the baffle (19); and a through hole (22) is provided on the baffle (19) for the tail of a pneumoconiosis experimental mouse to pass through.

5. The instillation device for pneumoconiosis rats according to claim 4, characterized in that: A third limiting slide block (23) is provided at the bottom of the baffle (19); a third limiting slide groove (24) adapted to the third limiting slide block (23) is provided on the operating panel (2); and the third limiting slide block (23) is slidably connected in the third limiting slide groove (24).

6. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: A fixing belt (25) is provided on one side of the top of the operating panel (2); a limiting plate (26) corresponding to the fixing belt (25) is provided on the other side of the top of the operating panel (2); a through slot for the fixing belt (25) to pass through is provided on the limiting plate (26); and a hook surface and a fur surface which cooperate with each other are provided on the upper surface of the fixing belt (25).

7. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: An LED lighting lamp (27) is provided on the front side of the base plate (1).

8. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: A base (29) is provided below the bottom plate (1); the rear side of the bottom plate (1) is rotatably connected to the rear side of the base (29); telescopic rods (30) are hingedly connected to the left and right sides of the base (29); the other end of the telescopic rod (30) is hingedly connected to the bottom plate (1); and a third fastening bolt (31) for fastening the telescopic rod (30) is provided on the telescopic rod (30).

9. The instillation device for pneumoconiosis rats according to claim 8, characterized in that: The top of the base (29) is provided with receiving grooves (32) on both left and right sides; one end of the telescopic rod (30) is hinged to the front side of the corresponding receiving groove (32).

10. The instillation device for pneumoconiosis rats according to claim 1, characterized in that: The first traction rope (7) and the second traction rope (11) are both provided with a tooth sleeve (33); the tooth sleeve (33) is provided with a tooth groove (34).

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