Knee joint microneedle patch not easy to fall off

Abstract

The utility model relates to the technical field of medical supplies, in particular to a knee joint microneedle patch not prone to falling off, which comprises a heating layer, a sealing breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles. The adhesive layer, the patch base layer and the sealed breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing breathable layer; the microneedle is of a big-end-up structure, the upper end of the microneedle is arranged on the patch base layer, and the tip of the microneedle penetrates through the adhesive layer to be exposed; the microneedle is made of memory alloy, and the temperature of a high-temperature phase of the memory alloy is 40-43 DEG C; the low-temperature phase temperature of the memory alloy is below 40 DEG C; the structure of the microneedle in a high-temperature phase is linear, and the structure of the microneedle in a low-temperature phase is hook-shaped; according to the utility model, the detachable heating layer is used, so that the linear type can be kept in a high-temperature phase, and after the microneedle is inserted into the skin and even the joint, the heating layer is detached, so that the microneedle is changed into a hook type in a low-temperature phase at the body temperature of about 37 DEG C to be hooked in a human body, and further, the microneedle is not easy to separate.

Description

Technical Field

[0001] The utility model relates to the technical field of medical supplies, in particular to a micro-needle patch for a knee joint which is not easy to fall off. Background Art

[0002] Rheumatoid arthritis is an autoimmune disease that involves a series of complex factors such as environmental triggers, genotype and immune system, which is usually characterized by synovitis, cartilage erosion and structural joint damage. As an incurable and irreversible disease, current clinical treatment focuses on alleviating local inflammation and overall disease progression.

[0003] Existing drug administration methods for treating rheumatoid arthritis include administering therapeutic drugs or biological agents orally, by injection, needle-free scalp patch or smear, but there are many problems with oral administration and injection. For example, the disadvantages of oral administration include: poor selectivity of the drug, which can easily cause patients to have varying degrees of gastrointestinal reactions and renal toxicity and side effects, and there is a first-pass elimination effect through liver metabolism, which will reduce the efficacy of the drug. Injection generally includes intravenous injection and intra-articular injection. Intravenous injection is effective through the systemic circulation. Although the drug has high bioavailability, it may act on multiple target organs or target cells due to poor selectivity, which may cause adverse reactions and poor patient tolerance. Although intra-articular injection can directly inject the drug into the lesion site, intra-articular injection is a multi-site injection, which is complicated to operate and poor patient tolerance. At the same time, it requires special personnel to operate, is expensive, and is difficult for general patients to accept. In the needle-free scalp patch or smear administration method, the drug needs to pass through a thick stratum corneum to reach the human body, which greatly reduces the drug's delivery efficiency, resulting in unsatisfactory treatment effects.

[0004] Therefore, the prior art uses a microneedle patch for treating rheumatoid arthritis. However, when the microneedle patch is applied to the knee joint, the microneedle patch is easy to fall off due to the large range of motion of the knee joint, which is very inconvenient. Utility Model Content

[0005] In order to overcome the defects of the prior art mentioned above, the technical problem to be solved by the utility model is to provide a knee joint microneedle patch which is not easy to fall off.

[0006] In order to solve the above technical problems, the technical solution adopted by the utility model is:

[0007] A microneedle patch for a knee joint that is not easy to fall off, comprising a heating layer, a sealing and breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles;

[0008] The adhesive layer, the patch base layer, and the sealing and breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing and breathable layer;

[0009] The microneedle is a structure with a large top and a pointed bottom, with the top end arranged on the patch base layer and the tip passing through the adhesive layer and exposed;

[0010] The material of the microneedle is a memory alloy, the high temperature phase temperature of the memory alloy is 40°C-43°C; the low temperature phase temperature of the memory alloy is below 40°C; the structure of the microneedle in the high temperature phase is a straight line type, and the structure in the low temperature phase is a hook type.

[0011] Preferably, the memory alloy is one of nickel-titanium memory alloy, copper-zinc memory alloy, copper-aluminum-nickel memory alloy or nickel-titanium-copper memory alloy.

[0012] Preferably, the adhesive layer and the patch base layer are provided with air holes.

[0013] Preferably, the sealing and breathable layer is composed of a double layer of non-woven fabric.

[0014] Preferably, a through hole is provided in the microneedle, and a terminal end of the through hole extends to the side wall of the microneedle and communicates with the outside.

[0015] Preferably, a medical solution is provided in the through hole.

[0016] Preferably, the outer peripheral surface of the microneedle is coated with a drug body.

[0017] Preferably, it also includes a protective film, the protective film is provided with a needle groove matching with the microneedle, and the protective film is attached to the lower surface of the adhesive layer.

[0018] The beneficial effects of the utility model are as follows: by using a detachable heating layer, the microneedles can be heated to 40°C-43°C during use, so that the microneedles remain straight in the high temperature phase; after the microneedles are inserted into the skin or even the joints, the heating layer is removed, so that the microneedles become hook-shaped in the low temperature phase at about 37°C under body temperature and are hooked into the human body, making them less likely to come off; the sealing and breathable layer can be used to achieve breathability, and the heating layer can be removed at the same time to avoid affecting breathability. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 The figure shows a schematic diagram of the structure of a microneedle patch for knee joints that is not easy to fall off under high temperature according to a specific embodiment of the utility model;

[0020] Figure 2 The figure shows a schematic diagram of the structure of a microneedle patch for knee joints that is not easy to fall off in a specific embodiment of the utility model in a low temperature phase when in use;

[0021] Explanation of the numbers: 1. Heating layer; 2. Sealing and breathable layer; 3. Patch base layer; 4. Adhesive layer; 5. Microneedle; 6. Through hole; 7. Protective film. DETAILED DESCRIPTION

[0022] In order to explain the technical content, achieved objectives and effects of the present invention in detail, the following is an explanation in conjunction with the implementation modes and the accompanying drawings.

[0023] Please refer to Figure 1 to Figure 2 As shown, the utility model is a microneedle patch for knee joint that is not easy to fall off, comprising a heating layer, a sealing and breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles;

[0024] The adhesive layer, the patch base layer, and the sealing and breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing and breathable layer;

[0025] The microneedle is a structure with a large top and a pointed bottom, with the top end arranged on the patch base layer and the tip passing through the adhesive layer and exposed;

[0026] The material of the microneedle is a memory alloy, the high temperature phase temperature of the memory alloy is 40°C-43°C; the low temperature phase temperature of the memory alloy is below 40°C; the structure of the microneedle in the high temperature phase is a straight line type, and the structure in the low temperature phase is a hook type.

[0027] From the above description, it can be seen that by using a detachable heating layer, the microneedles can be heated to 40℃-43℃ during use, so that the microneedles remain straight at high temperature. After the microneedles are inserted into the skin or even the joints, the heating layer is removed, so that the microneedles become hook-shaped at low temperature at about 37℃ under body temperature and are hooked into the human body, making them less likely to detach. The sealing and breathable layer can be used to achieve breathability, and the heating layer can be removed at the same time to avoid affecting breathability.

[0028] Furthermore, the memory alloy is one of nickel-titanium memory alloy, copper-zinc memory alloy, copper-aluminum-nickel memory alloy or nickel-titanium-copper memory alloy.

[0029] From the above description, it can be seen that by adopting the memory alloy of the existing technology, the difficulty of research and development is reduced and rapid market promotion is facilitated.

[0030] Furthermore, the adhesive layer and the patch base layer are provided with ventilation holes.

[0031] From the above description, it can be seen that the air vents can be used to quickly exhaust air and avoid the feeling of stuffiness.

[0032] Furthermore, the sealing and breathable layer is composed of a double layer of non-woven fabric.

[0033] Furthermore, a through hole is provided in the microneedle, and the end of the through hole extends to the side wall of the microneedle and communicates with the outside.

[0034] From the above description, it can be known that liquid medicine or powder medicine can be placed inside the through hole to facilitate drug application.

[0035] Furthermore, a medical solution is arranged in the through hole.

[0036] It can be seen from the above description that by setting the liquid medicine, different liquid medicines can be configured according to needs, and the liquid medicines can be immersed or sucked into the through holes through the capillary effect.

[0037] Furthermore, the outer surface of the microneedle is coated with a drug.

[0038] From the above description, it can be known that the drug can be directly administered by contact through the drug body to meet the needs of drugs with different release rates.

[0039] Furthermore, it also includes a protective film, which is provided with a needle groove that cooperates with the microneedle, and the protective film is attached to the lower surface of the adhesive layer.

[0040] From the above description, it can be seen that the protective film can be torn off during use and then attached to the skin to prevent the adhesive layer from failing.

[0041] Embodiment 1

[0042] A microneedle patch for a knee joint that is not easy to fall off, comprising a heating layer, a sealing and breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles; the heating layer can be heated by iron powder oxidation and heat release, or can be heated by electric heating;

[0043] The adhesive layer, the patch base layer, and the sealing and breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing and breathable layer;

[0044] The microneedle is a structure with a large top and a pointed bottom, with the top end arranged on the patch base layer and the tip passing through the adhesive layer and exposed;

[0045] The material of the microneedle is a memory alloy, the high temperature phase temperature of the memory alloy is 40°C-43°C; the low temperature phase temperature of the memory alloy is below 40°C; the structure of the microneedle in the high temperature phase is a straight line type, and the structure in the low temperature phase is a hook type.

[0046] The memory alloy is one of nickel-titanium memory alloy, copper-zinc memory alloy, copper-aluminum-nickel memory alloy or nickel-titanium-copper memory alloy.

[0047] The adhesive layer and the patch base layer are provided with ventilation holes.

[0048] The sealing and breathable layer is composed of a double layer of non-woven fabric.

[0049] A through hole is arranged in the microneedle, and the end of the through hole extends to the side wall of the microneedle and is connected with the outside.

[0050] A medicinal solution is arranged in the through hole.

[0051] It also includes a protective film, which is provided with a needle groove that matches the microneedle, and the protective film is attached to the lower surface of the adhesive layer.

[0052] Embodiment 2

[0053] A microneedle patch for a knee joint that is not easy to fall off, comprising a heating layer, a sealing and breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles;

[0054] The adhesive layer, the patch base layer, and the sealing and breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing and breathable layer;

[0055] The microneedle is a structure with a large top and a pointed bottom, with the top end arranged on the patch base layer and the tip passing through the adhesive layer and exposed;

[0056] The material of the microneedle is a memory alloy, the high temperature phase temperature of the memory alloy is 40°C-43°C; the low temperature phase temperature of the memory alloy is below 40°C; the structure of the microneedle in the high temperature phase is a straight line type, and the structure in the low temperature phase is a hook type.

[0057] The memory alloy is one of nickel-titanium memory alloy, copper-zinc memory alloy, copper-aluminum-nickel memory alloy or nickel-titanium-copper memory alloy.

[0058] The adhesive layer and the patch base layer are provided with ventilation holes.

[0059] The sealing and breathable layer is composed of a double layer of non-woven fabric.

[0060] The outer surface of the microneedle is coated with a drug body.

[0061] It also includes a protective film, which is provided with a needle groove that matches the microneedle, and the protective film is attached to the lower surface of the adhesive layer.

[0062] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent transformations made using the contents of the specification and drawings of the present invention, or directly or indirectly applied in the relevant technical field, are also included in the patent protection scope of the present invention.

Claims

1. A microneedle patch for knee joint that is not easy to fall off, characterized in that: It includes a heating layer, a sealing and breathable layer, a patch base layer, an adhesive layer and a plurality of microneedles; The adhesive layer, the patch base layer, and the sealing and breathable layer are arranged from bottom to top; the heating layer is detachably connected to the sealing and breathable layer; The microneedle is a structure with a large top and a pointed bottom, with the top end arranged on the patch base layer and the tip passing through the adhesive layer and exposed; The material of the microneedle is a memory alloy, the high temperature phase temperature of the memory alloy is 40°C-43°C; the low temperature phase temperature of the memory alloy is below 40°C; the structure of the microneedle in the high temperature phase is a straight line type, and the structure in the low temperature phase is a hook type.

2. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: The memory alloy is one of nickel-titanium memory alloy, copper-zinc memory alloy, copper-aluminum-nickel memory alloy or nickel-titanium-copper memory alloy.

3. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: The adhesive layer and the patch base layer are provided with ventilation holes.

4. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: The sealing and breathable layer is composed of a double layer of non-woven fabric.

5. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: A through hole is arranged in the microneedle, and the end of the through hole extends to the side wall of the microneedle and is connected with the outside.

6. The non-detachable knee joint microneedle patch according to claim 5, characterized in that: A medicinal solution is arranged in the through hole.

7. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: The outer surface of the microneedle is coated with a drug body.

8. The non-detachable knee joint microneedle patch according to claim 1, characterized in that: It also includes a protective film, which is provided with a needle groove that matches the microneedle, and the protective film is attached to the lower surface of the adhesive layer.

Images