Serum collecting and buffering device

Abstract

The utility model discloses a serum collecting and buffering device, which belongs to the field of serum storage equipment and comprises a collecting tank and a buffering tank, an infusion port of the collecting tank is communicated with a liquid inlet of the buffering tank, an infusion port is arranged at the bottom end of the collecting tank and close to the buffering tank, and a liquid inlet is arranged at the top end of one side of the buffering tank facing the collecting tank. The liquid conveying opening is communicated with one end of an insertion pipe sequentially through a reducer union, an elbow and a quick connector, the other end of the insertion pipe extends into the buffer tank from the liquid inlet, and a circulation channel is reserved between the insertion pipe and the inner wall of the bottom end of the buffer tank. According to the serum collecting and buffering device, the liquid conveying opening of the collecting groove is connected with the liquid inlet of the buffering tank through the reducer union, the elbow and the quick connector, it is guaranteed that liquid can be smoothly and quickly conveyed into the buffering tank from the collecting groove, resistance in the conveying process is reduced, and conveying efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of serum storage equipment, in particular to a serum collection buffer device. Background Art

[0002] In the process of biopharmaceuticals and cell culture, collection tanks and buffer tanks are often required. The collection tank is used to receive serum or other biological fluids generated from upstream processes (such as separation, purification, etc.), and at the same time acts as a buffer to regulate the pressure in the system and prevent equipment damage or process instability caused by flow fluctuations; the buffer tank is used to temporarily store serum or other biological fluids to ensure continuous supply during the production process, and acts as a buffer to balance the flow differences between upstream and downstream processes and ensure the stability and continuity of the production process.

[0003] The existing collection tanks and buffer tanks are usually arranged separately and connected by pumping, which has the disadvantages of energy waste and large floor space. Summary of the invention

[0004] The utility model aims to provide a serum collection buffer device to solve the above technical problems.

[0005] To achieve the above-mentioned purpose, the utility model provides a serum collection buffer device, comprising a collecting trough and a buffer tank, the infusion port of the collecting trough is connected with the liquid inlet of the buffer tank, the bottom end of the collecting trough and close to the buffer tank is provided with an infusion port, the top end of the buffer tank facing the collecting trough is provided with a liquid inlet, the infusion port is connected with one end of an insertion tube via a reducer, an elbow and a quick connector in sequence, the other end of the insertion tube extends into the interior of the buffer tank from the liquid inlet, and a flow channel is left between the insertion tube and the inner wall of the bottom end of the buffer tank.

[0006] Preferably, the bottom end of the buffer tank is configured as a U-shaped structure, and the bottom end of the insertion tube is configured as a pointed structure having the same slope as that of the U-shaped structure.

[0007] Preferably, a double-layer annular hole is provided at the top of the buffer tank, the double-layer annular hole comprises an inner annular hole and an outer annular hole, wherein the inner annular hole comprises two cleaning and disinfection holes arranged axially symmetrically, and the two cleaning and disinfection holes are both connected to the CIP cleaning device;

[0008] The outer ring hole includes a feed port, a pressure gauge port, a first differential pressure level gauge port, a bursting disc port, a safety valve port, a respirator port, a first spare port, a first split sight glass installation port, a second split sight glass installation port, and a second spare port arranged in a circumferential array;

[0009] A discharge port is arranged at the center position of the bottom end of the buffer tank, and a second differential pressure level gauge port, a thermometer port and a sewage outlet are also arranged at the bottom end of the buffer tank.

[0010] Preferably, the two cleaning and disinfection holes are connected to the pure water pipe and the alkaline water pipe respectively through a three-way pipe, and the pure water pipe and the alkaline water pipe are connected to the CIP cleaning device;

[0011] The sewage outlet is connected to one end of the sewage pipe, and the other end of the sewage pipe is provided with a conductivity meter;

[0012] The conductivity meter is electrically connected to the CIP cleaning device via a PLC controller.

[0013] Preferably, the two cleaning and disinfection holes and the feed port are connected to the SIP sterilization device via a steam inlet pipe, and a thermometer is also provided at one end of the drain pipe provided with a conductivity meter, and the thermometer is electrically connected to the SIP sterilization device via a PLC controller.

[0014] Therefore, the utility model adopts the above-mentioned serum collection buffer device, which has the following beneficial effects:

[0015] 1. Efficient transmission: Design of the infusion port and the liquid inlet: The infusion port of the collection tank and the liquid inlet of the buffer tank are connected through reducers, elbows and quick connectors to ensure that the liquid can be smoothly and quickly transferred from the collection tank to the inside of the buffer tank, reducing the resistance during the transmission process and improving the transmission efficiency;

[0016] 2. Prevent foam: The insertion tube is inserted into the buffer tank, and the bottom end of the buffer tank is set to a U-shaped structure. The bottom end of the insertion tube is also designed to be a pointed structure with the same slope as the U-shaped structure, which helps to prevent the formation of foam in the traditional high-distance serum injection;

[0017] 3. Multi-purpose interface: Double-layer ring hole design: The top of the buffer tank is equipped with a double-layer ring hole, including multiple functional interfaces, such as cleaning and disinfection holes, feed ports, pressure gauge ports, liquid level gauge ports, safety valve ports, etc., so that the buffer tank can be easily operated in a variety of ways, such as cleaning, disinfection, monitoring of pressure and liquid level, etc.;

[0018] 4. Automated cleaning and disinfection: The cleaning and disinfection holes are connected to the pure water pipe and the alkaline water pipe respectively through a three-way pipe. The independent design of the pure water pipe and the alkaline water pipe avoids the decline of cleaning and disinfection effect caused by pipeline contamination;

[0019] 5. Safe and reliable: The buffer tank is equipped with a safety valve and a bursting disc port. These safety devices can automatically open when the pressure exceeds the set value to release excess pressure and ensure the safe operation of the system;

[0020] 6. Accurate monitoring: Liquid level gauge and thermometer: Multiple liquid level gauges and thermometers are installed in the buffer tank to monitor the liquid level and temperature in the tank in real time to ensure that the liquid is stored and transported under appropriate conditions;

[0021] 7. Environmental protection design: The cleaning effect can be monitored by a conductivity meter to ensure that the cleaning effect of the CIP cleaning device (cleaning in place) meets the standards;

[0022] 8. Sterilization function: The feed port and cleaning and disinfection hole are connected to the SIP (Sterilization InPlace) sterilization device through the steam inlet pipe, which can realize automatic sterilization operation to ensure the sterility of the liquid in the tank;

[0023] 9. No dead corners in cleaning: Two cleaning ports are set at the top of the buffer tank to avoid dead corners in cleaning;

[0024] 10. Multifunctional interface: There are multiple spare ports on the top of the buffer tank, which can be used to add other functional equipment according to actual needs to improve the flexibility and scalability of the system.

[0025] In summary, the serum collection buffer device adopted in the utility model realizes many advantages such as efficient transmission, foam prevention, multi-purpose interface, automatic cleaning and disinfection, safety and reliability, precise monitoring, environmentally friendly design, sterilization function, easy maintenance and multi-functional interface through optimized design, and is suitable for various high-demand biopharmaceutical and medical fields.

[0026] The technical solution of the utility model is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a side view of a serum collection buffer device of the utility model;

[0028] Figure 2 The utility model is a top view of a buffer tank of a serum collection buffer device.

[0029] Attached photos

[0030] 1. Collecting tank; 2. Reducer; 3. Elbow; 4. Quick connector; 5. Insert tube; 6. Discharge port; 7. Buffer tank; 8. Spray head; 9. Cleaning and disinfection tube; 10. Cleaning and disinfection hole; 11. Feed port; 12. Pressure gauge port; 13. First differential pressure level gauge port; 14. Bursting disc port; 15. Safety valve port; 16. Respirator port; 17. First spare port; 18. Second split sight glass installation port; 19. Second spare port. DETAILED DESCRIPTION

[0031] In the description of the present utility model, it should be noted that the terms "upper", "lower", "inside", "outside", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the utility model product is usually placed when in use, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as a limitation on the present utility model. In the description of the present utility model, it should also be noted that, unless otherwise clearly specified and limited, the terms "set", "install", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific circumstances.

[0032] The following is a detailed description of the embodiments of the present invention in conjunction with the accompanying drawings.

[0033] like Figure 1 and Figure 2 As shown, a serum collection buffer device comprises a collection tank 1 and a buffer tank 7, wherein the infusion port of the collection tank 1 is connected with the liquid inlet of the buffer tank 7, the bottom end of the collection tank 1 and a position close to the buffer tank 7 is provided with an infusion port, the top end of the buffer tank 7 facing the collection tank 1 is provided with a liquid inlet, the infusion port is connected with one end of the insertion tube 5 through the reducer 2, the elbow 3 and the quick connector 4 in sequence, the other end of the insertion tube 5 extends into the interior of the buffer tank 7 from the liquid inlet, and a flow channel is left between the insertion tube 5 and the inner wall of the bottom end of the buffer tank 7. The bottom end of the buffer tank 7 is set to a U-shaped structure, and the bottom end of the insertion tube 5 is set to a pointed mouth structure with the same slope as the U-shaped structure.

[0034] The collecting tank 1 in this embodiment is fixed to the top end of the support frame, and the bottom end of the support frame is provided with universal wheels for moving the position of the collecting tank 1.

[0035] A double-layer annular hole is provided at the top of the buffer tank 7, and the double-layer annular hole includes an inner annular hole and an outer annular hole, wherein the inner annular hole includes two cleaning and disinfection holes 10 arranged axially symmetrically, and the two cleaning and disinfection holes 10 are connected to the CIP cleaning device; the outer annular hole includes a feed port 11, a pressure gauge port 12, a first differential pressure level gauge port 13, a bursting disc port 14, a safety valve port 15, a respirator port 16, a first spare port 17, a first split sight glass installation port, a second split sight glass installation port 18 and a second spare port 19 arranged in a circular array; a discharge port 6 is provided at the center position of the bottom end of the buffer tank 7, and the bottom end of the buffer tank 7 is also provided with a second differential pressure level gauge port, a thermometer port and a sewage outlet.

[0036] The two cleaning and disinfection holes 10 are connected to the pure water pipe and the alkaline water pipe respectively through a tee pipe, and the pure water pipe and the alkaline water pipe are both connected to the CIP cleaning device; the sewage outlet is connected to one end of the sewage pipe, and a conductivity meter is provided at the other end of the sewage pipe; the conductivity meter is electrically connected to the CIP cleaning device through a PLC controller, so that the conductivity meter can reflect the changes in the ion concentration in the water, thereby indirectly reflecting the cleanliness of the water quality.

[0037] The interior of the buffer tank 7 of the present embodiment is connected to two cleaning and disinfection holes 10 via two cleaning and disinfection pipes 9 respectively. A spray head 8 is provided at the bottom end of the cleaning and disinfection pipe 9 to expand the spraying area.

[0038] The two cleaning and disinfection holes 10 and the feed port 11 are both connected to the SIP sterilization device through the steam inlet pipe, that is, the feed port 11 and the cleaning and disinfection hole 10 are connected to the SIP sterilization device through different steam pipes, so that the feed channel can be intermittently sterilized by the SIP sterilization device. The end of the sewage pipe provided with the conductivity meter is also provided with a thermometer, and the thermometer is electrically connected to the SIP sterilization device through the PLC controller. It should be noted that the above-mentioned electronic components are mature products on the market. This embodiment only needs to purchase them and connect them according to the instructions, and no improvement is made to them, so their circuit connection structure and principle will not be repeated here.

[0039] Method of use: The serum produced by the upstream process enters the collection tank 1, and after being buffered by the collection tank 1, it flows into the bottom of the buffer tank 7 along the reducer 2, the elbow 3 and the insertion tube 5 in sequence until all are discharged. After a period of use, it is cleaned, disinfected and sterilized in sequence. The cleaning and disinfection steps are as follows: first, empty the serum in the buffer tank 7, then open the pure water pipe of the CIP cleaning device, spray pure water into the buffer tank 7 through the two cleaning and disinfection holes 10 and the spray head 8, pre-clean with the help of pure water, and use the sewage pipe to discharge the cleaning sewage; then close the pure water pipe, open the alkaline water pipe, spray 2% NaOH solution into the buffer tank 7 through the two cleaning and disinfection holes 10 and the spray head 8 for alkaline washing, and use the circulation pump to extract the washed NaOH solution to the alkaline liquid storage tank of the CIP cleaning device; finally, open the pure water pipe again, close the alkaline water pipe for flushing, and use the conductivity meter to check whether the set cleaning effect is achieved after the flushing. If not, continue to wash with pure water until the set cleaning effect is achieved.

[0040] The sterilization steps are as follows: open the SIP sterilization device and introduce steam into the buffer tank 7 through the two cleaning and disinfection holes 10 and the spray head 8 to perform SIP sterilization on the buffer tank 7. At the same time, introduce steam into the buffer tank 7 through the feed port 11 at regular intervals to perform SIP sterilization on the feed pipeline until the temperature collected by the temperature sensor reaches the set temperature, start timing, and close the SIP sterilization device until the set time is reached.

[0041] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model rather than to limit it. Although the utility model has been described in detail with reference to the preferred embodiments, ordinary technicians in this field should understand that they can still modify or replace the technical solution of the utility model with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the utility model.

Claims

1. A serum collection buffer device, comprising a collection tank and a buffer tank, wherein the infusion port of the collection tank is connected to the liquid inlet of the buffer tank, characterized in that: An infusion port is provided at the bottom of the collecting tank and close to the buffer tank, and a liquid inlet is provided at the top of the buffer tank on the side facing the collecting tank. The infusion port is connected to one end of the insertion tube via a reducer, an elbow and a quick connector in sequence, and the other end of the insertion tube extends into the interior of the buffer tank through the liquid inlet, and a flow channel is left between the insertion tube and the inner wall of the bottom end of the buffer tank.

2. A serum collection buffer device according to claim 1, characterized in that: The bottom end of the buffer tank is arranged in a U-shaped structure, and the bottom end of the insertion tube is arranged in a pointed mouth structure with the same slope as that of the U-shaped structure.

3. A serum collection buffer device according to claim 1, characterized in that: A double-layer annular hole is provided at the top of the buffer tank, and the double-layer annular hole includes an inner annular hole and an outer annular hole, wherein the inner annular hole includes two cleaning and disinfection holes arranged axially symmetrically, and the two cleaning and disinfection holes are both connected to the CIP cleaning device; The outer ring hole includes a feed port, a pressure gauge port, a first differential pressure level gauge port, a bursting disc port, a safety valve port, a respirator port, a first spare port, a first split sight glass installation port, a second split sight glass installation port, and a second spare port arranged in a circumferential array; A discharge port is arranged at the center position of the bottom end of the buffer tank, and a second differential pressure level gauge port, a thermometer port and a sewage outlet are also arranged at the bottom end of the buffer tank.

4. A serum collection buffer device according to claim 3, characterized in that: The two cleaning and disinfection holes are connected to the pure water pipe and the alkaline water pipe respectively through the three-way pipe, and the pure water pipe and the alkaline water pipe are connected to the CIP cleaning device; The sewage outlet is connected to one end of the sewage pipe, and the other end of the sewage pipe is provided with a conductivity meter; The conductivity meter is electrically connected to the CIP cleaning device via a PLC controller.

5. A serum collection buffer device according to claim 4, characterized in that: The two cleaning and disinfection holes and the feed port are connected to the SIP sterilization device through the steam inlet pipe. A thermometer is also provided at one end of the sewage pipe where the conductivity meter is provided. The thermometer is electrically connected to the SIP sterilization device through the PLC controller.

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