Induced pluripotent stem cell freezing storage device

Abstract

The utility model discloses an induced pluripotent stem cell freezing storage device which comprises a freezing storage box, fixing plates are installed at the two ends in the freezing storage box, telescopic sliding plates are installed on the inner sides of the fixing plates, limiting rings are arranged in the telescopic sliding plates and the fixing plates, and a plurality of telescopic springs are connected between the telescopic sliding plates. Nut blocks are connected to the two sides of the limiting base correspondingly, conveying lead screws are installed in the nut blocks, and a driving motor is connected to one end of each conveying lead screw. A silica gel sponge block is arranged in the packaging cover, and a lower pressing plate is connected to the lower portion of the silica gel sponge block. Compared with an existing device, the induced pluripotent stem cell freezing storage device has the advantages that the nut block and the limiting base can be conveyed in the vertical direction through the rotating conveying lead screw, so that a test tube can be driven to move upwards, the test tube can be conveniently moved out of the box body, the limiting ring and the outer wall of the test tube are both made of smooth materials, and the test tube can be conveniently moved upwards and taken out.

Description

Technical Field

[0001] The utility model relates to the technical field of storage devices, in particular to a freezing storage device for induced pluripotent stem cells. Background Art

[0002] Induced pluripotent stem cells refer to terminally differentiated somatic cells that are reprogrammed into pluripotent stem cells by introducing specific transcription factors. When induced pluripotent stem cells are transported and transferred, they need to be frozen and stored, which requires the use of an induced pluripotent stem cell freezing storage device.

[0003] The Chinese patent with the authorization publication number CN220557280U discloses a frozen storage device for stem cell transportation, which relates to the field of greenhouse technology, including a refrigerator, a screw rod is installed upright inside the refrigerator, and a nut block is sleeved on the outside of the screw rod, a sleeve is installed on the outside of the nut block, and a bearing ring is sleeved on the outer wall of the sleeve, and a placement plate is arranged equidistantly outside the screw rod, and a circular opening is opened in the middle of the placement plate, and the inner wall of the circular opening is in contact with the outer wall of the outer ring of the bearing ring. In the utility model, the sleeve, the placement plate, the nut block and the arc plate are provided, so that the internal nut block can be easily operated to move up and down on the screw rod, thereby adjusting the spacing between each group of placement plates according to the length of the stem cell storage tube, and then the spring and the arc plate are cooperated to provide a placement position for different thick stem cell storage tubes, which has high practicality.

[0004] Although the above-mentioned stem cell freezing storage device provides a placement position for stem cell storage tubes of different thicknesses through the cooperation of springs and arc plates, during the storage process, in order to maintain the stability of the placement, the reagent tubes are usually fixed directly in the box, which makes it inconvenient to take out the reagent bottles later. For this reason, we propose an induced pluripotent stem cell freezing storage device. Utility Model Content

[0005] The purpose of the utility model is to provide an induced pluripotent stem cell freezing storage device to solve the problem raised in the above background technology that during the storage process, usually in order to maintain the stability of placement, the reagent tube will be directly fixed in the box, and it is inconvenient to take out the reagent bottle later.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solution: an induced pluripotent stem cell cryopreservation device, comprising:

[0007] A refrigerated storage box, wherein both ends of the refrigerated storage box are equipped with fixed plates, and a telescopic slide plate is installed inside the fixed plate, and the inside of the telescopic slide plate and the fixed plate are both provided with a limit ring, and a plurality of telescopic springs are connected between the telescopic slide plates;

[0008] A limiting base is installed at the bottom of the refrigerated storage box, both sides of the limiting base are connected with nut blocks, and a transmission screw rod is installed inside the nut block, and one end of the transmission screw rod is connected to a driving motor;

[0009] The packaging cover is installed above the freezing storage box, a silicone sponge block is arranged inside the packaging cover, and a lower pressing plate is connected below the silicone sponge block.

[0010] Preferably, the telescopic slide plate and the fixed plate are symmetrical to each other, and an elastic telescopic structure is formed between the telescopic slide plates via a telescopic spring.

[0011] Preferably, the limiting rings are equidistantly distributed, and the telescopic slide plate and the limiting base are parallel to each other.

[0012] Preferably, the packaging cover forms an elastic structure through the silicone sponge block and the lower pressing plate, and the lower pressing plate and the limiting base are parallel to each other.

[0013] Preferably, the packaging cover is further provided with:

[0014] A positioning block is connected to two sides below the packaging cover, and a fixing knob is installed inside the positioning block.

[0015] Preferably, a rotating structure is formed between the driving motor and the transmission screw rod, and the transmission screw rod passes through the interior of the nut block, and the nut block is fixedly connected to the limiting base.

[0016] Compared with the prior art, the utility model provides an induced pluripotent stem cell cryopreservation device, which has the following beneficial effects:

[0017] The utility model can drive the transmission screw to rotate through the driving motor, and the rotating transmission screw can transmit the nut block and the limiting base in the vertical direction, so as to drive the test tube to move upward, which is convenient for moving the test tube up and out of the box. The limiting ring and the outer wall of the test tube are made of smooth materials, which can facilitate the upward movement and removal of the test tube, avoiding the problem that during storage, the reagent tube is usually directly fixed in the box to maintain the stability of placement, and it is inconvenient to take out the reagent bottle later. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 It is a schematic diagram of the internal structure of the utility model;

[0020] Figure 3 It is a schematic diagram of the external structure of the utility model;

[0021] Figure 4 For this utility model Figure 2 Schematic diagram of the enlarged structure at point A in the middle.

[0022] In the figure: 1. Refrigerated storage box; 2. Fixed plate; 3. Telescopic slide plate; 4. Limiting ring; 5. Telescopic spring; 6. Limiting base; 7. Nut block; 8. Transmission screw rod; 9. Driving motor; 10. Packaging cover; 11. Lower pressure plate; 12. Silicone sponge block; 13. Positioning block; 14. Fixing knob. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] See also Figure 1-3 A freezing storage device for induced pluripotent stem cells comprises: a freezing storage box 1, wherein both ends of the freezing storage box 1 are provided with fixed plates 2, and a telescopic slide plate 3 is provided on the inner side of the fixed plate 2, and a limit ring 4 is provided inside the telescopic slide plate 3 and the fixed plate 2, and a plurality of telescopic springs 5 ​​are connected between the telescopic slide plates 3; the telescopic slide plate 3 and the fixed plate 2 are symmetrical with each other, and an elastic telescopic structure is formed between the telescopic slide plates 3 through the telescopic springs 5; the telescopic springs 5 ​​can facilitate the relative movement between the telescopic slide plates 3, so that a mutual force can be generated between the telescopic slide plate 3 and the fixed plate 2, and reagent tubes of different sizes can be positioned; a positioning block 13, which is connected under the packaging cover 10 On both sides of the square, a fixing knob 14 is installed inside the positioning block 13; the positioning block 13 and the fixing knob 14 can facilitate the relative fixation of the packaging cover 10 and the refrigerated storage box 1; the packaging cover 10 is installed above the refrigerated storage box 1, and a silicone sponge block 12 is arranged inside the packaging cover 10, and a lower pressure plate 11 is connected to the lower part of the silicone sponge block 12; the packaging cover 10 forms an elastic structure through the silicone sponge block 12 and the lower pressure plate 11, and the lower pressure plate 11 and the limiting base 6 are parallel to each other; the silicone sponge block 12 and the lower pressure plate 11 can generate elastic force between the packaging cover 10 and the test tube, which is convenient for the lower pressure plate 11 to position the test tube, thereby improving the stability of the test tube placement.

[0025] See also Figure 1 , 24. A freezing storage device for induced pluripotent stem cells, comprising: a limiting base 6, which is installed at the bottom of a freezing storage box 1, with limiting rings 4 equidistantly distributed, and the telescopic slide 3 and the limiting base 6 are parallel to each other; the limiting rings 4 symmetrically disposed can clamp and position the wall of the reagent tube, and the bottom of the reagent tube can be limited by the limiting base 6; nut blocks 7 are connected to both sides of the limiting base 6, and a transmission screw 8 is installed inside the nut block 7, and one end of the transmission screw 8 is connected to a driving motor 9; a rotating structure is formed between the driving motor 9 and the transmission screw 8, and the transmission screw 8 runs through the inside of the nut block 7, and the nut block 7 is fixedly connected to the limiting base 6; the driving motor 9 can drive the transmission screw 8 to rotate, and the rotating transmission screw 8 can vertically transmit the nut block 7 and the limiting base 6, thereby driving the test tube to move upward, so as to facilitate the test tube to be moved up to the outside of the box, and the limiting ring 4 and the outer wall of the test tube are made of smooth material, which can facilitate the upward removal of the test tube.

[0026] Working principle: When using the induced pluripotent stem cell freezing storage device, firstly, place the test tube containing cells inside the limiting ring 4, and facilitate the relative movement between the telescopic slide plate 3 through the telescopic spring 5, so that a mutual force can be generated between the telescopic slide plate 3 and the fixed plate 2, and the reagent tube wall can be clamped and positioned through the mutually symmetrical limiting rings 4, and the bottom of the reagent tube can be limited by the limiting base 6; secondly, cover the packaging cover 10, and facilitate the relative fixation of the packaging cover 10 and the freezing storage box 1 through the positioning block 13 and the fixing knob 14; then, the elastic force is generated between the packaging cover 10 and the test tube through the silicone sponge block 12 and the lower pressing plate 11, so as to facilitate the lower The pressure plate 11 positions the test tube, thereby improving the stability of the test tube placement; finally, during the storage process, the freezing storage box 1 is a prior art, and has a freezing structure inside, which can freeze and store cells through the freezing storage box 1. When it needs to be taken out later, the packaging cover 10 is removed, and the drive motor 9 is started. The drive motor 9 drives the transmission screw 8 to rotate. The rotating transmission screw 8 can transmit the nut block 7 and the limiting base 6 in the vertical direction, thereby driving the test tube to move upward, making it easy to move the test tube out of the box. At the same time, the limiting ring 4 and the outer wall of the test tube are made of smooth materials, which can facilitate the upward movement and removal of the test tube. This is the working principle of the induced pluripotent stem cell freezing storage device.

[0027] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A freezing storage device for induced pluripotent stem cells, characterized in that: include: A refrigerated storage box (1), wherein both ends of the refrigerated storage box (1) are provided with fixed plates (2), and a telescopic slide plate (3) is provided inside the fixed plate (2), and a limit ring (4) is provided inside the telescopic slide plate (3) and the fixed plate (2), and a plurality of telescopic springs (5) are connected between the telescopic slide plates (3); A limiting base (6) is installed at the bottom of the refrigerated storage box (1), and nut blocks (7) are connected to both sides of the limiting base (6), and a transmission screw rod (8) is installed inside the nut block (7), and one end of the transmission screw rod (8) is connected to a driving motor (9); A packaging cover (10) is installed above the freezing storage box (1), a silicone sponge block (12) is arranged inside the packaging cover (10), and a lower pressing plate (11) is connected below the silicone sponge block (12).

2. The induced pluripotent stem cell cryopreservation device according to claim 1, characterized in that: The telescopic slide plate (3) and the fixed plate (2) are symmetrical to each other, and an elastic telescopic structure is formed between the telescopic slide plates (3) via a telescopic spring (5).

3. The induced pluripotent stem cell cryopreservation device according to claim 1, characterized in that: The limiting rings (4) are equidistantly distributed, and the telescopic slide plate (3) and the limiting base (6) are parallel to each other.

4. The induced pluripotent stem cell cryopreservation device according to claim 1, characterized in that: The packaging cover (10) forms an elastic structure between the silicone sponge block (12) and the lower pressing plate (11), and the lower pressing plate (11) and the limiting base (6) are parallel to each other.

5. The induced pluripotent stem cell cryopreservation device according to claim 1, characterized in that: The packaging cover (10) is also provided with: A positioning block (13) is connected to two sides below the packaging cover (10), and a fixing knob (14) is installed inside the positioning block (13).

6. The induced pluripotent stem cell cryopreservation device according to claim 1, characterized in that: A rotating structure is formed between the driving motor (9) and the transmission screw rod (8), and the transmission screw rod (8) penetrates the interior of the nut block (7), and the nut block (7) is fixedly connected to the limiting base (6).

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