A preparation device for tedizolid phosphate lyophilized powder for injection

Abstract

The utility model discloses a preparation device for lyophilized powder of tedizolid phosphate for injection, which belongs to the technical field of pharmaceutical production equipment. The preparation device comprises: a box, the inner wall of the box is provided with a partition, and the inner cavity of the box is divided into a feed cavity and a freezing cavity by the partition; a connecting pipe is provided at the center of the partition, and a screen is provided at the upper end of the connecting pipe; an arc-shaped silica gel plate is also provided in the feed cavity, and a guide plate is also provided in the freezing cavity. The preparation device of tedizolid phosphate lyophilized powder for injection provided by the utility model, the tedizolid phosphate raw material drug enters the feed cavity, the tedizolid phosphate raw material drug is screened by the screen, and then the residence time of the tedizolid phosphate raw material drug on the surface of the guide plate is increased by the setting of the guide plate, so as to facilitate the rapid freezing and cooling of the tedizolid phosphate raw material drug, ensure sufficient freezing, reduce the freezing and cooling time, and improve the efficiency of freezing and cooling.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical production equipment, in particular to a preparation device for tedizolid phosphate lyophilized powder for injection. Background Art

[0002] Tedizolid phosphate, chemically named [(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxooxazolidin-5-yl]methyl dihydrogen phosphate, is a new type of oxazolidinone antibiotic. Tedizolid phosphate is a prodrug that can be rapidly converted into biologically active tedizolid by phosphatases in the body. Tedizolid binds to the 50S subunit of bacterial ribosomes and inhibits protein synthesis, thereby exerting its antibacterial effect. Its mechanism of action is different from other non-oxazolidinone antibiotics, so it is unlikely to develop cross-resistance with other types of antibacterial drugs.

[0003] Tedizolid phosphate for injection is supplied as a sterile lyophilized powder for injection in 200 mg single-dose vials. Each 200 mg vial must be reconstituted with sterile water for injection and then diluted only with 0.9% Sodium Chloride Injection, USP.

[0004] The commonly used synthesis route of tedizolid phosphate is the synthesis route of bromo-2-cyanopyridine. The obtained raw material has poor fluidity and agglomeration. When directly freeze-dried to prepare tedizolid phosphate lyophilized powder, it is easy to be insufficient and the effect is poor. Utility Model Content

[0005] The utility model aims to provide a preparation device for lyophilized powder of tedizolid phosphate for injection, so as to solve the problem that the lyophilization effect of the existing lyophilized powder of tedizolid phosphate for injection is poor due to the poor flow properties of the raw material drug during the preparation process.

[0006] The technical solution of the utility model to solve the above technical problems is as follows:

[0007] The utility model provides a preparation device of tedizolid phosphate lyophilized powder for injection, the preparation device comprising: a box body, the inner wall of the box body is provided with a partition, and the inner cavity of the box body is divided into a feeding cavity and a freezing cavity by the partition;

[0008] A feed inlet is provided above the box body, and the feed inlet is communicated with the feed cavity;

[0009] The partition is arranged along the circumference of the inner wall of the box body, a connecting pipe is arranged at the center of the partition, and a screen is arranged at the upper end of the connecting pipe;

[0010] The feed chamber is also provided with an arc-shaped silica gel plate; the arc-shaped silica gel plate is arranged along the circumference of the inner wall of the box body, and the arc-shaped silica gel plate is arranged on the upper end surface of the partition;

[0011] A guide plate is also arranged in the freezing chamber, and the guide plate is arranged on the lower end surface of the partition.

[0012] Furthermore, in the preparation device of the tedizolid phosphate lyophilized powder for injection, the preparation device also includes a vacuum pump, and the vacuum pump is connected to the freezing chamber through a vacuum tube.

[0013] Furthermore, in the preparation device of the lyophilized powder of tedizolid phosphate for injection, the preparation device also includes a heat dissipation pipe and a refrigerator, a plurality of the heat dissipation pipes are arranged circumferentially along the inner wall of the freezing chamber, and adjacent heat dissipation pipes are connected; the refrigerator is connected to the heat dissipation pipe through a refrigeration pipe.

[0014] Furthermore, in the preparation device of the tedizolid phosphate lyophilized powder for injection, the preparation device also includes a temperature detector and a pressure detector, and both the pressure detector and the temperature detector are connected to the freezing chamber.

[0015] Furthermore, in the preparation device of the tedizolid phosphate lyophilized powder for injection, the preparation device also includes a mounting frame, and the box is arranged on the mounting frame.

[0016] Furthermore, in the device for preparing lyophilized powder of tedizolid phosphate for injection, a stirring motor is provided in the feeding chamber, and a stirring blade is connected to the output end of the stirring motor.

[0017] Furthermore, in the device for preparing the lyophilized powder of tedizolid phosphate for injection, a flexible scraper is connected to the end of the stirring blade.

[0018] Furthermore, in the device for preparing the lyophilized powder of tedizolid phosphate for injection, the guide plate is an annular structure, and the diameter of the guide plate decreases from top to bottom, and the lower end of the guide plate has a notch.

[0019] Furthermore, in the device for preparing lyophilized powder of tedizolid phosphate for injection, a storage box is provided at the bottom end of the box.

[0020] Furthermore, in the device for preparing the lyophilized powder of tedizolid phosphate for injection, solenoid valves are provided on the vacuum tube and the refrigeration tube.

[0021] The utility model has the following beneficial effects:

[0022] The utility model provides a preparation device for lyophilized tedizolid phosphate for injection. The tedizolid phosphate raw material medicine enters a feed cavity, is screened by a screen, and then the residence time of the tedizolid phosphate raw material medicine on the surface of the guide plate is increased by setting a guide plate, so that the tedizolid phosphate raw material medicine is quickly frozen and cooled, sufficient freezing is ensured, the freezing and cooling time is reduced, and the freezing and cooling efficiency is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The drawings described herein are used to provide a further understanding of the embodiments of the present utility model, constitute a part of this application, and do not constitute a limitation of the embodiments of the present utility model. In the drawings:

[0024] Figure 1 It is a structural explosion diagram of the preparation device of the tedizolid phosphate lyophilized powder for injection of the utility model;

[0025] Figure 2 It is a schematic diagram of the inner structure of the shell of the preparation device of tedizolid phosphate lyophilized powder for injection of the utility model;

[0026] Figure 3 It is a stereoscopic diagram of the shell of the device for preparing lyophilized powder of tedizolid phosphate for injection of the utility model;

[0027] Figure 4 The utility model is a schematic diagram of the inner structure of the cover plate of the preparation device of tedizolid phosphate lyophilized powder for injection.

[0028] Marks and corresponding parts names in the attached drawings:

[0029] In the figure: 100-box, 110-partition, 111-connecting pipe, 112-screen, 120-feeding chamber, 121-feeding port, 122-arc-shaped silicone plate, 123-stirring motor, 124-stirring blade, 125-scraper, 130-freezing chamber, 131-guide plate, 132-heat dissipation pipe, 140-vacuum pump, 141-vacuum tube, 142-solenoid valve, 150-refrigeration machine, 151-refrigeration tube, 161-temperature detector, 162-pressure detector, 170-mounting frame. DETAILED DESCRIPTION

[0030] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Generally, the components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0031] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Example

[0033] Please refer to Figure 1-4 The preparation device of the lyophilized powder of tedizolid phosphate for injection provided in the embodiment of the utility model comprises: a box 100, the inner wall of the box 100 is provided with a partition 110, and the inner cavity of the box 100 is divided into a feeding cavity 120 and a freezing cavity 130 by the partition 110;

[0034] A feed inlet 121 is provided above the box body 100, and the feed inlet 121 is communicated with the feed cavity 120;

[0035] The partition 110 is arranged along the inner wall circumferentially of the box body 100, a connecting pipe 111 is arranged at the center of the partition 110, and a screen 112 is arranged at the upper end of the connecting pipe 111;

[0036] The feed cavity 120 is also provided with an arc-shaped silicone plate 122; the arc-shaped silicone plate 122 is arranged along the inner wall circumference of the box body 100, and the arc-shaped silicone plate 122 is arranged on the upper end surface of the partition 110;

[0037] A guide plate 131 is further provided in the freezing chamber 130 , and the guide plate 131 is provided on the lower end surface of the partition 110 .

[0038] The utility model provides a preparation device for lyophilized powder of tedizolid phosphate for injection. The tedizolid phosphate raw material medicine enters into a feed chamber 120, and is screened by a screen 112. Then, by setting a guide plate 131, the residence time of the tedizolid phosphate raw material medicine on the upper surface of the guide plate 131 is increased, so that the tedizolid phosphate raw material medicine is quickly frozen and cooled, and sufficient freezing is ensured, and the freezing and cooling time is reduced, thereby improving the freezing and cooling efficiency.

[0039] In some feasible embodiments, the preparation device further includes a vacuum pump 140, and the vacuum pump 140 is connected to the freezing chamber 130 through a vacuum pipe 141. The vacuum pump 140 evacuates the freezing chamber 130 to maintain a vacuum environment.

[0040] In some feasible embodiments, the preparation device further includes a heat dissipation pipe 132 and a refrigerator 150. A plurality of heat dissipation pipes 132 are arranged circumferentially along the inner wall of the freezing chamber 130, and adjacent heat dissipation pipes 132 are connected. The refrigerator 150 is connected to the heat dissipation pipe 132 through a cooling pipe 151. The heat dissipation pipe 132 is arranged between the inner wall of the box body 100 and the lower surface of the guide plate 131, and the freezing chamber 130 is cooled by the refrigerant through the heat dissipation pipe 132.

[0041] In some feasible embodiments, the preparation device further includes a temperature detector 161 and a pressure detector 162 , and both the pressure detector 162 and the temperature detector 161 are connected to the freezing chamber 130 .

[0042] During the preparation of tedizolid phosphate freeze-dried powder, the temperature is maintained between -40°C and -50°C, and the pressure is maintained between 1-10mP. The pressure detector 162 and the temperature detector 161 detect the working temperature and working pressure of the freezing chamber 130 to ensure that the freezing requirements are met.

[0043] In some feasible embodiments, the preparation device further includes a mounting frame 170, and the box body 100 is disposed on the mounting frame 170. The mounting frame 170 is used to provide support for the box body 100 and provide stability for the box body 100.

[0044] In some feasible embodiments, a stirring motor 123 is further provided in the feed chamber 120, and a stirring blade 124 is connected to the output end of the stirring motor 123. The stirring motor 123 and the stirring blade 124 are arranged in the feed chamber 120, and the tedizolid phosphate API is stirred in the feed chamber 120 to prevent the tedizolid phosphate API from precipitating, and the sieve 112 is more easily used for screening.

[0045] In some feasible embodiments, a flexible scraper 125 is connected to the end of the stirring blade 124. The flexible scraper 125 facilitates scraping off the tedizolid phosphate API on the inner wall of the box 100 during the stirring process to avoid adhesion to the inner wall of the box 100.

[0046] In some feasible embodiments, the guide plate 131 is an annular structure, and the diameter of the guide plate 131 decreases from top to bottom, and a notch is provided at the lower end of the guide plate 131. The guide plate 131 forms a space for freezing the tedizolid phosphate raw material, and the frozen lyophilized powder is discharged from the lower end of the guide plate 131.

[0047] In some feasible embodiments, a storage box is provided at the bottom of the box body 100. The freeze-dried powder discharged from the guide plate 131 directly enters the storage box, which is convenient for collection and further processing.

[0048] In some feasible ways, the vacuum tube 141 and the refrigeration tube 151 are provided with a solenoid valve 142. The vacuum tube 141 and the refrigeration tube 151 are provided with a solenoid valve 142, and the solenoid valve 142 is used to realize intelligent control, so as to conveniently maintain the set pressure and temperature.

[0049] The above specific implementation methods further illustrate the purpose, technical solutions and beneficial effects of the utility model in detail. It should be understood that the above are only specific implementation methods of the utility model and are not used to limit the protection scope of the utility model. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the utility model should be included in the protection scope of the utility model.

Claims

1. A preparation device for tedizolid phosphate lyophilized powder for injection, characterized in that: The preparation device comprises: a box (100), the inner wall of the box (100) is provided with a partition (110), and the inner cavity of the box (100) is divided into a feeding cavity (120) and a freezing cavity (130) by the partition (110); A feed inlet (121) is provided above the box body (100), and the feed inlet (121) is communicated with the feed cavity (120); The partition (110) is arranged along the circumference of the inner wall of the box body (100), a connecting pipe (111) is arranged at the center of the partition (110), and a screen (112) is arranged at the upper end of the connecting pipe (111); An arc-shaped silica gel plate (122) is also arranged in the feed cavity (120); the arc-shaped silica gel plate (122) is arranged along the circumference of the inner wall of the box body (100), and the arc-shaped silica gel plate (122) is arranged on the upper end surface of the partition plate (110); A guide plate (131) is also provided in the freezing chamber (130), and the guide plate (131) is provided on the lower end surface of the partition plate (110).

2. The preparation device of tedizolid phosphate lyophilized powder for injection according to claim 1, characterized in that: The preparation device further comprises a vacuum pump (140), and the vacuum pump (140) is connected to the freezing chamber (130) via a vacuum tube (141).

3. The preparation device of tedizolid phosphate lyophilized powder for injection according to claim 2, characterized in that: The preparation device also includes a heat dissipation pipe (132) and a refrigerator (150), wherein a plurality of the heat dissipation pipes (132) are circumferentially arranged along the inner wall of the freezing chamber (130), and adjacent heat dissipation pipes (132) are connected; and the refrigerator (150) is connected to the heat dissipation pipe (132) via a refrigeration pipe (151).

4. The preparation device of tedizolid phosphate lyophilized powder for injection according to claim 1, characterized in that: The preparation device further comprises a temperature detector (161) and a pressure detector (162), and both the pressure detector (162) and the temperature detector (161) are connected to the freezing chamber (130).

5. The preparation device of tedizolid phosphate lyophilized powder for injection according to claim 1, characterized in that: The preparation device further comprises a mounting frame (170), and the box body (100) is arranged on the mounting frame (170).

6. The device for preparing lyophilized powder of tedizolid phosphate for injection according to claim 1, characterized in that: A stirring motor (123) is also provided in the feed chamber (120), and a stirring blade (124) is connected to the output end of the stirring motor (123).

7. The device for preparing lyophilized powder of tedizolid phosphate for injection according to claim 6, characterized in that: The end of the stirring blade (124) is connected to a flexible scraper (125).

8. The preparation device of tedizolid phosphate lyophilized powder for injection according to claim 1, characterized in that: The guide plate (131) is an annular structure, and the diameter of the guide plate (131) decreases from top to bottom, and the lower end of the guide plate (131) has a notch.

9. The device for preparing lyophilized powder of tedizolid phosphate for injection according to claim 1, characterized in that: A storage box is provided at the bottom end of the box body (100).

10. The device for preparing lyophilized powder of tedizolid phosphate for injection according to claim 3, characterized in that: The vacuum tube (141) and the refrigeration tube (151) are provided with electromagnetic valves (142).

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