A gene information analysis simulation device

Abstract

The utility model discloses a gene information analysis simulation device, comprising a gene sequencer, wherein a chip installation slot of the gene sequencer is connected to a mobile chip box through a telescopic control rod, the chip is installed in the mobile chip box, an injection driving part which can be rotated to a vertical or horizontal state is installed on the outer wall of the mobile chip box, a clamping control plate for fixing a liquid transfer gun is fixed in the injection driving part, after the liquid transfer gun is fixed, a library to be tested is discharged into the chip through the extrusion of the injection driving part, two limit levers which are respectively in a horizontal and a vertical state are fixed on the side wall of the mobile chip box to prevent the injection driving part from excessively rotating, and the injection driving part comprises a rotating base with a motor embedded therein and a rotating connecting rod; the gene information analysis simulation device can effectively reduce manpower work, has low labor requirements, can be operated without high proficiency, can accurately control the injection rate, will not cause the problem of bubbles generated by too fast injection, and has high practical value.

Description

Technical Field

[0001] The utility model specifically relates to a gene information analysis simulation device, belonging to the technical field of gene information analysis simulation. Background Art

[0002] Gene information analysis refers to the conversion of gene sequence data into gene annotation information, including gene name, gene type, exons, introns and other information, in order to further understand the function and role of genes. Gene information analysis is an important part of genomic research, and is of great significance for in-depth understanding of the growth and development of organisms and the mechanism of disease occurrence. Its simulation is usually completed by preparing a gene sequencer in conjunction with a computer, placing the library to be tested, that is, the DNA sample, into the gene sequencer for sequencing to obtain gene sequence data, inputting the gene sequence data into the computer, and using gene information analysis software for analysis. The software converts the gene sequence data into gene annotation information, including gene name, gene type, exons, introns and other information.

[0003] However, in the existing gene information analysis simulation device, when the library to be tested is added to the chip, it is usually done manually. The library to be tested needs to be sucked up by a pipette and then injected into the chip through a disposable sample block. The operation is cumbersome and requires high standards from the staff. When injecting the raw materials, the pipette needs to be kept vertical, and the injection rate cannot be too fast, otherwise bubbles may be generated. Therefore, we need a semi-automatic mechanized gene information analysis simulation device to solve the above problems. Utility Model Content

[0004] The purpose of the utility model is to provide a gene information analysis simulation device to address the deficiencies of the prior art, so as to reduce manpower and achieve accurate injection.

[0005] A gene information analysis simulation device comprises a gene sequencer, wherein a chip installation slot of the gene sequencer is connected to a mobile chip box via a telescopic control rod, the chip is installed in the mobile chip box, an injection drive component which can be rotated to a vertical or horizontal state is installed on the outer wall of the mobile chip box, a clamping control plate for fixing a pipette gun is fixed in the injection drive component, and after the pipette gun is fixed, a library to be tested is discharged into the chip through the squeezing of the injection drive component.

[0006] Furthermore, two limit levers in horizontal and vertical states are fixed on the side walls of the movable chip box to prevent the injection drive component from excessive rotation, so that the injection drive component can only rotate and switch between horizontal and vertical states with the motor output shaft as the axis. The structure is more stable and ensures accurate positioning during injection.

[0007] Furthermore, the injection drive component includes a rotating base with a motor embedded therein and a rotating connecting rod, the rotating connecting rod is fixed on the rotating base, and the output shaft of the motor is fixed on the outer wall of the mobile chip box. When turned on, relative rotational motion is generated, which drives the rotating base and the mobile connecting rod to rotate, thereby realizing the overall rotation of the injection drive component and driving the clamping control plate connected thereto to rotate.

[0008] Furthermore, an electric telescopic rod is installed on the top of the rotating connecting rod, and a mounting bracket is fixed on the telescopic end of the electric telescopic rod. The clamping control board is arranged on the mounting bracket, which can drive the height adjustment of the pipette gun under the extension and retraction of the electric telescopic rod. The clamping control board and the pipette gun clamped thereon are raised or lowered by the extension and retraction of the electric telescopic rod, so that the pipette gun is conveniently inserted into the disposable sample adding block.

[0009] Furthermore, the top of the mounting bracket is connected to a pressure-feeding top plate through a lifting control rod, and the pressure-feeding top plate is used to press the pipette to discharge liquid. After the pipette is inserted into the disposable sample block, the lifting control rod contracts, driving the pressure-feeding top plate to press against the pipette, so that the library to be tested in the pipette is discharged. The moving speed of the lifting control rod can be preset to avoid bubbles caused by too fast contraction, and the discharge is stable.

[0010] Furthermore, a semi-open arc-shaped slot for the pipette to be inserted is provided in the clamping control board, and the clamping control board is made of a plastic material with low elasticity, so that the pipette can be effectively inserted into the semi-open arc-shaped slot for simple fixation.

[0011] Furthermore, an inflatable bag is provided on the inner side wall of the semi-open arc-shaped slot.

[0012] Furthermore, a micro air pump is fixed on the clamping control board, and the discharge port of the micro air pump is connected to each air bag through a pipe built into the clamping control board. After the pipette gun is inserted into the semi-open arc-shaped slot, the micro air pump is turned on to inflate the air bag, so that the air bag expands to further fix the pipette gun stuck in the semi-open arc-shaped slot, thereby ensuring that the pipette gun is stably stuck in the clamping control board for injection.

[0013] Beneficial effects:

[0014] The utility model realizes the addition of the gene library to be tested through semi-automatic mechanization, which reduces the manpower work on the one hand, has low labor requirements and does not require high proficiency, and on the other hand, the mechanized injection can accurately control the injection rate, and the problem of bubbles generated by excessively fast injection will not occur, and has high practical value. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0016] Figure 2It is a structural schematic diagram of the mobile chip box and its connecting parts in the utility model;

[0017] Figure 3 This is a schematic diagram of the structure of the material injection driving member of the utility model in the unfolded state;

[0018] Figure 4 This is a schematic diagram of the structure of the injection driving member in the utility model;

[0019] Figure 5 It is a structural schematic diagram of the clamping control panel in the utility model.

[0020] In the figure: 1. Gene sequencer; 101. Chip installation slot; 2. Telescopic control rod; 3. Mobile chip box; 301. Limit stop rod; 4. Chip; 5. Injection drive; 501. Rotating base; 502. Rotating connecting rod; 503. Electric telescopic rod; 504. Mounting bracket; 505. Lifting control rod; 506. Pressing top plate; 6. Clamping control board; 601. Semi-open arc slot; 602. Inflatable bag; 603. Inflatable pump. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] See also Figure 1-5 As shown, a gene information analysis simulation device includes a gene sequencer 1, a chip 4 installation slot 101 of the gene sequencer 1 is connected to a mobile chip box 3 through a telescopic control rod 2, the chip 4 is installed in the mobile chip box 3, and an injection driving member 5 that can be rotated to a vertical or horizontal state is installed on the outer wall of the mobile chip box 3. A clamping control plate 6 for fixing a pipette gun is fixed in the injection driving member 5. After the pipette gun is fixed, the library to be tested is discharged into the chip 4 through the squeezing of the injection driving member 5.

[0023] In the utility model, the gene sequencer 1 is connected to a computer. After the library to be tested is injected into the chip 4, the simulation software in the computer can perform data simulation. When in use, the injection driving part 5 is first turned to a vertical state and then raised appropriately to reserve enough space for the insertion of the pipette gun. The disposable sample adding block is placed above the chip 4 and aligned with the injection port of the chip 4. The library to be tested is then sucked by the pipette gun, and the pipette gun is then inserted into the clamping control board 6 for fixation. The injection driving part 5 then controls the pipette gun to move downward and insert it into the disposable sample adding block in a vertical state. The injection driving part 5 then presses the pipette gun downward so that the library to be tested in the pipette gun is discharged into the disposable sample adding block for loading. The addition of the gene library to be tested is achieved through semi-automatic mechanization. Compared with traditional manual operation, on the one hand, it reduces manpower work, has lower labor requirements, and does not require very high proficiency. On the other hand, mechanized injection can accurately control the injection rate, and there will be no problem of bubbles generated by excessive injection, which has high practical value.

[0024] As a technical optimization solution of the utility model, two limit levers in horizontal and vertical states are fixed on the side walls of the mobile chip box 3 to prevent the injection drive component 5 from excessive rotation, so that the injection drive component 5 can only rotate and switch between horizontal and vertical states with the motor output shaft as the axis, and the structure is more stable, ensuring accurate positioning during injection.

[0025] As a technical optimization solution of the utility model, the injection driving component 5 includes a rotating base 501 with a motor embedded therein and a rotating connecting rod 502. The rotating connecting rod 502 is fixed on the rotating base 501, and the output shaft of the motor is fixed on the outer wall of the mobile chip box 3. When turned on, a relative rotational motion is generated, which drives the rotating base 501 and the mobile connecting rod to rotate, thereby realizing the overall rotation of the injection driving component 5, and driving the clamping control board 6 connected thereto to rotate. When in use, it is turned to a vertical state to facilitate the insertion of the pipette gun and subsequent injection. When not in use, it is turned to a horizontal state to reduce the space occupied, which has little impact on the overall structure of the existing gene sequencer 1.

[0026] As a technical optimization solution of the utility model, an electric telescopic rod 503 is installed on the top of the rotating connecting rod 502, and a mounting bracket 504 is fixed on the telescopic end of the electric telescopic rod 503. The clamping control board 6 is arranged on the mounting bracket 504, and can drive the height adjustment of the pipette gun under the extension and retraction of the electric telescopic rod 503. The clamping control board 6 and the pipette gun clamped therein are raised or lowered by the extension and retraction of the electric telescopic rod 503, which facilitates the insertion of the pipette gun into the disposable sample adding block.

[0027] As a technical optimization solution of the utility model, the top of the mounting bracket 504 is connected to a pressure-feeding top plate 506 through a lifting control rod 505, and the pressure-feeding top plate 506 is used to press the pipette to discharge liquid. After the pipette is inserted into the disposable sample block, the lifting control rod 505 contracts, driving the pressure-feeding top plate 506 to press against the pipette, so that the library to be tested in the pipette is discharged. The moving speed of the lifting control rod 505 can be preset to avoid bubbles caused by too fast contraction and ensure stable discharge.

[0028] As a technical optimization solution of the utility model, a semi-open arc-shaped slot 601 for the pipette to be inserted is provided in the clamping control board 6. The clamping control board 6 is made of a plastic material with low elasticity, so that the pipette can be effectively inserted into the semi-open arc-shaped slot 601 for simple fixation.

[0029] As a technical optimization solution of the present invention, an inflatable bag 602 is provided on the inner side wall of the semi-open arc-shaped slot 601 .

[0030] As a technical optimization scheme of the utility model, a micro air pump 603 is fixed on the clamping control board 6, and the discharge port of the micro air pump 603 is connected with each air bag 602 through a pipe built into the clamping control board 6. After the pipette gun is inserted into the semi-open arc-shaped slot 601, the micro air pump 603 is turned on to inflate the air bag 602, so that the air bag 602 expands to further fix the pipette gun stuck in the semi-open arc-shaped slot 601, thereby ensuring that the pipette gun is stably stuck in the clamping control board 6 for injection.

[0031] It is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be regarded as exemplary and non-restrictive from any point of view, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention. Any reference numeral in a claim should not be regarded as limiting the claim to which it relates.

[0032] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A gene information analysis simulation device, comprising a gene sequencer (1), wherein a chip (4) of the gene sequencer (1) is connected to a mobile chip box (3) via a telescopic control rod (2), and the chip (4) is installed in the mobile chip box (3), characterized in that: An injection drive member (5) that can be rotated to a vertical or horizontal state is installed on the outer wall of the mobile chip box (3), and a clamping control board (6) for fixing a liquid transfer gun is fixed inside the injection drive member (5). After the liquid transfer gun is fixed, the library to be tested is discharged into the chip (4) through the squeezing of the injection drive member (5).

2. The gene information analysis simulation device according to claim 1, characterized in that: Two limit levers in a horizontal and vertical state are fixed on the side wall of the movable chip box (3) to prevent the injection driving member (5) from excessive rotation.

3. The gene information analysis simulation device according to claim 1, characterized in that: The injection driving member (5) comprises a rotating base (501) with a motor embedded therein and a rotating connecting rod (502), wherein the rotating connecting rod (502) is fixed on the rotating base (501), and the output shaft of the motor is fixed on the outer wall of the movable chip box (3), and generates relative rotational motion when turned on, driving the rotating base (501) and the movable connecting rod to rotate.

4. The gene information analysis simulation device according to claim 3, characterized in that: An electric telescopic rod (503) is installed on the top of the rotating connecting rod (502), and a mounting bracket (504) is fixed on the telescopic end of the electric telescopic rod (503). The clamping control board (6) is arranged on the mounting bracket (504) and can drive the height adjustment of the pipette gun under the extension and retraction of the electric telescopic rod (503).

5. The gene information analysis simulation device according to claim 4, characterized in that: The top of the mounting bracket (504) is connected to a pressure-feeding top plate (506) via a lifting control rod (505), and the pressure-feeding top plate (506) is used to press the liquid transfer gun to discharge liquid.

6. The gene information analysis simulation device according to claim 5, characterized in that: A semi-open arc-shaped slot (601) for inserting a liquid transfer gun is provided in the clamping control plate (6).

7. The gene information analysis simulation device according to claim 6, characterized in that: An inflatable bag (602) is provided on the inner side wall of the semi-open arc-shaped slot (601).

8. The gene information analysis simulation device according to claim 7, characterized in that: A micro air pump (603) is fixed on the clamping control board (6), and the discharge port of the micro air pump (603) is connected to each air bag (602) through a pipeline built into the clamping control board (6).

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