A high performance liquid chromatography tandem mass spectrometry integrated machine

Abstract

The utility model provides a high-performance liquid chromatography-tandem mass spectrometry integrated machine, which relates to the field of liquid chromatography-tandem mass spectrometry integrated machines, and includes: a machine body and a placement box, the outer wall of the machine body is connected to a positioning shaft, and the outer side of the positioning shaft is rotatably connected to a damping sleeve, the placement box is connected to the outer side of the damping sleeve, and the placement box includes a cooling box body, and a pull-out box is slidably inserted inside the cooling box body, a positioning plate is provided inside the pull-out box, and a guide sleeve is provided at the upper end of the positioning plate, and a clamp is provided inside the positioning plate, and the clamp is provided at the lower side of the guide sleeve. The utility model solves the problems of inconvenience in placing test tubes in the placement box involved in the existing liquid chromatography-tandem mass spectrometry detector, and the use restrictions on the specifications and sizes of the test tubes.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography-tandem mass spectrometry integrated machine, and in particular to a high performance liquid chromatography-tandem mass spectrometry integrated machine. Background Art

[0002] The liquid chromatography-tandem mass spectrometry integrated machine is used for the qualitative and quantitative detection of pesticide residues, veterinary drug residues, illegal additives, trace pollutants and other trace (including trace and ultra-trace) components in food, feed, plant-derived products and their products, food packaging, animal-derived products and their products, water samples and other samples. The instrument type is a tandem quadrupole mass spectrometer, which should meet the requirements of high-throughput quantitative analysis and qualitative functions of liquid chromatography-mass spectrometry. After searching, the prior art (publication number: CN218412396U) records that "a liquid chromatography tandem mass spectrometry detector for detecting the concentration of olanzapine in serum includes a liquid chromatography tandem mass spectrometry detector body, a connecting plate is fixedly connected to the side wall of the liquid chromatography tandem mass spectrometry detector body, a placement box is fixedly connected to the side wall of the connecting plate, a cover plate is hinged on the upper side of the placement box, a refrigerator is provided on the bottom side wall of the placement box, a bracket net is fixedly connected to the inner side wall of the placement box, a support plate is fixedly connected to the inner side wall of the placement box, and a plurality of collection test tubes are connected to the support plate through a plurality of clamping devices. The utility model has a reasonable design and an ingenious conception. By arranging a convenient low-temperature storage device on the side wall of the liquid chromatography tandem mass spectrometry detector body, the liquid chromatography tandem mass spectrometry detector can more conveniently store serum samples when detecting the concentration of olanzapine in serum, and is highly convenient to use."

[0003] Although the liquid chromatography tandem mass spectrometry detector in the prior art has achieved the convenience of storing samples, it still has some shortcomings. When the clamping plate inside the placement box of the existing liquid chromatography tandem mass spectrometry detector is used to clamp the test tube, the test tube lacks a guide device when placing it, and the upper side of the clamping plate is a flat structure, which may require multiple alignment of the center clamping hole position of the holding plate during placement, affecting the operating efficiency and being inconvenient; secondly, when the bottom outer diameter of the test tube is larger than the clamping hole in the middle of the clamping plate, even if the bottom of the test tube is aligned with the clamping hole, the clamping hole cannot be inserted to push the clamping plate outward for activity, so there are certain usage restrictions on the outer diameter size of the test tube. Utility Model Content

[0004] In order to overcome the defects of the prior art, a high performance liquid chromatography tandem mass spectrometry integrated machine is now provided to solve the problems that the placement box involved in the existing liquid chromatography tandem mass spectrometry detector is inconvenient for placing test tubes and there are usage restrictions on the specifications and sizes of the test tubes.

[0005] To achieve the above-mentioned purpose, a high performance liquid chromatography-tandem mass spectrometry integrated machine is provided, comprising: a machine body and a placement box, the outer wall of the machine body is connected to a positioning shaft, and the outer side of the positioning shaft is rotatably connected to a damping sleeve, the placement box is connected to the outer side of the damping sleeve, and the placement box comprises a cooling box body, and a pull-out box is slidably inserted into the cooling box body, a positioning plate is provided inside the pull-out box, and a guide sleeve is provided at the upper end of the positioning plate, and a clamp is provided inside the positioning plate, and the clamp is provided on the lower side of the guide sleeve.

[0006] Furthermore, a rectangular slot is provided on the front inner side of the cooling box, and a refrigerator is installed on the inner bottom of the rectangular slot.

[0007] Furthermore, a sealing cover is provided on the front side of the pull-out box, and a supporting mesh plate is provided on the bottom of the pull-out box, and the supporting mesh plate is located on the lower side of the positioning plate.

[0008] Furthermore, a clamping groove is provided inside the positioning plate, movable grooves are provided on both side walls of the clamping groove, a guide rod is provided on the inner wall of the movable groove, and a spring is sleeved on the outer side of the guide rod.

[0009] Furthermore, the clamping member is slidably connected in the movable groove, and the clamping member includes two outer arc plates on the front and rear sides, and the inner arc plates are connected between the outer arc plates.

[0010] Furthermore, a guide hole is formed at the outer end of the outer arc plate, and a guide rod is slidably connected in the guide hole, and the upper and lower ends of the outer arc plate are connected to limit blocks.

[0011] Furthermore, the outer diameter of the outer arc plate is larger than that of the inner arc plate, and a step is provided between the outer edges of the outer arc plate and the inner arc plate, and the outer arc surface of the outer arc plate is installed with an outer ball, and the arc surface of the inner arc plate is installed with an inner ball.

[0012] The beneficial effects of the utility model are:

[0013] 1. When in use, pull the pull-out box out of the cooling box, then align the bottom of the test tube with the guide sleeve of the conical structure and insert it downward. The guide sleeve of the conical structure facilitates the positioning and insertion of the test tube. When the test tube enters the clamping groove, the bottom of the test tube contacts the inner arc plate or the outer arc plate included in the clamping piece. When it contacts the outer arc plate, due to the step relationship between the outer arc plate and the inner arc plate, and through the rolling of the outer ball, the test tube continues to slide toward the inner arc plate, and then contacts the inner ball on the surface of the inner arc plate. When the test tube continues to move downward, the clamping pieces on both sides can be pushed to move in the movable groove, thereby squeezing the spring, so that under the rebound action of the spring, the clamping effect of the test tube is achieved, thereby achieving the effect of easy placement. At the same time, the upper side of the clamping piece is in an open state, and the surface is set to an arc structure, so that it can adapt to the placement of test tubes of different specifications and sizes, thereby improving the practicality of the device.

[0014] 2. By using the positioning shaft and the damping sleeve, it is convenient to set up multiple groups of placement boxes distributed up and down in the vertical direction outside the positioning shaft, so as to realize the classified placement of different samples. At the same time, through the rotation connection between the damping sleeve and the positioning shaft, any placement box can be rotated to an appropriate position, so as to achieve the effect of facilitating the use and movement of the placement box, shorten the transfer distance of the test tube from the placement box to the machine body, and make it more convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a front view structural schematic diagram of an embodiment of the utility model.

[0016] Figure 2 It is a schematic diagram of the three-dimensional structure of the placement box according to an embodiment of the utility model.

[0017] Figure 3 The utility model is a schematic diagram of the cross-sectional structure of the pull-out box of the embodiment.

[0018] Figure 4 For the utility model embodiment Figure 3 Schematic diagram of the structure at point A in the middle.

[0019] Figure 5 It is a schematic diagram of the three-dimensional structure of the clamping member according to an embodiment of the utility model.

[0020] In the figure: 1, machine body; 11, positioning shaft; 12, damping bushing; 2, placement box; 21, cooling box; 22, pull-out box; 23, positioning plate; 231, movable groove; 232, spring; 233, guide rod; 24, supporting mesh plate; 25, guide sleeve; 26, clamping piece; 261, outer arc plate; 262, limit block; 263, outer ball; 264, inner arc plate; 265, inner ball; 27, clamping groove. DETAILED DESCRIPTION

[0021] Reference Figures 1 to 5 As shown, the utility model provides a high performance liquid chromatography-tandem mass spectrometry integrated machine, comprising: a machine body 1 and a placement box 2, the outer wall of the machine body 1 is connected with a positioning shaft 11, and the outer side of the positioning shaft 11 is rotatably connected with a damping sleeve 12, the placement box 2 is connected to the outer side of the damping sleeve 12, and the placement box 2 comprises a cooling box body 21, and a pull-out box 22 is slidably inserted inside the cooling box body 21, a positioning plate 23 is provided inside the pull-out box 22, and a guide sleeve 25 is provided at the upper end of the positioning plate 23, and a clamping member 26 is provided inside the positioning plate 23, and the clamping member 26 is provided on the lower side of the guide sleeve 25.

[0022] In this embodiment, the body 1 and the placement box 2 constitute the main structure of the high performance liquid chromatography tandem mass spectrometry integrated machine involved in this application.

[0023] Specifically, the placement box 2 is provided with three groups of upper and lower layers on the outer side of the positioning shaft 11, so as to facilitate the placement of test tubes loaded with different samples.

[0024] Specifically, the guide sleeve 25 is configured as a tapered tube structure that is wide at the bottom and narrow at the bottom, and the outer diameter of the bottom of the tapered tube is the same as the clamping groove 27 described below.

[0025] like Figure 2 , Figure 3 and Figure 4 As shown, a rectangular slot is provided on the inner front side of the cooling box body 21, and a refrigerator is installed on the inner bottom of the rectangular slot, a sealing cover is provided on the front side of the pull-out box 22, and a supporting mesh plate 24 is provided on the bottom of the pull-out box 22, and the supporting mesh plate 24 is located on the lower side of the positioning plate 23, a clamping groove 27 is provided on the inner side of the positioning plate 23, and movable grooves 231 are provided on the groove walls on both sides of the clamping groove 27, and a guide rod 233 is provided on the inner groove wall of the movable groove 231, and a spring 232 is sleeved on the outer side of the guide rod 233.

[0026] Specifically, the length and width of the sealing cover at the front end of the pull-out box 22 are greater than the overall length and width of the pull-out box 22, and a circle of sealing gasket is provided near the edge of the inner side to achieve a sealing effect on the interior when the pull-out box 22 is closed. At the same time, magnets with opposite polarities that attract each other are provided at the inner end of the pull-out box 22 and the bottom of the rectangular slot of the cooling box 21, so that the pull-out box 22 remains stable when closed.

[0027] Specifically, the outer notch of the movable groove 231 is provided with a limiting port smaller than the inner diameter of the movable groove 231 , so that the clamping member 26 is stably clamped in the movable groove 231 in the initial state.

[0028] like Figure 4 and Figure 5As shown, the clamping member 26 is slidably connected in the movable groove 231, and the clamping member 26 includes two outer arc plates 261 on the front and rear sides, and an inner arc plate 264 is connected between the outer arc plates 261, a guide hole is opened at the outer end of the outer arc plate 261, and the guide rod 233 is slidably connected in the guide hole, and the upper and lower ends of the outer arc plate 261 are connected to the limiting block 262, the outer diameter of the outer arc plate 261 is larger than the inner arc plate 264, and a step is provided between the outer edges of the outer arc plate 261 and the inner arc plate 264, and the arc surface of the outer arc plate 261 is installed with an outer ball 263, and the arc surface of the inner arc plate 264 is installed with an inner ball 265.

[0029] Specifically, the step provided between the outer arc plate 261 and the inner arc plate 264 enables the outer arc plate 261 to limit the position of the test tube when the inner arc plate 264 clamps the test tube.

[0030] As a preferred embodiment, by setting a limit block 262, the limit block 262 contacts the limit port on the outside of the movable groove 231 to limit the movement of the clamping member 26; by setting a guide rod 233 and a guide hole, the linear sliding of the clamping member 26 is facilitated, and the spring 232 enables the clamping member 26 to have an elastic supporting effect.

[0031] As a preferred embodiment, by providing the outer ball 263 and the inner ball 265, the test tube is brought into rolling contact with the arc plate when being taken or placed, thereby reducing the friction of taking or placing the test tube and increasing the convenience of taking or placing.

[0032] When in use, the pull-out box is pulled out of the cooling box, and then the bottom of the test tube is aligned with the guide sleeve of the conical structure and inserted downward. The guide sleeve of the conical structure facilitates the positioning and insertion of the test tube. When the test tube enters the clamping groove, the bottom of the test tube contacts the inner arc plate or the outer arc plate included in the clamping piece. When it contacts the outer arc plate, due to the step relationship between the outer arc plate and the inner arc plate, and through the rolling of the outer ball, the test tube continues to slide toward the inner arc plate, and then rolls and contacts with the inner ball on the surface of the inner arc plate. When the test tube continues to move downward, the clamping pieces on both sides can be pushed to move in the movable groove, thereby squeezing the spring, so that under the rebound action of the spring, the clamping effect of the test tube is achieved, thereby achieving the effect of easy placement. At the same time, the upper side of the clamping piece is in an open state, and the surface is set to an arc structure, so that it can adapt to the placement of test tubes of different specifications and sizes, thereby improving the practicability of the device.

[0033] The high performance liquid chromatography-tandem mass spectrometry integrated machine of the utility model can effectively solve the problems of inconvenience in placing test tubes in the placement box involved in the existing liquid chromatography-tandem mass spectrometry detector, as well as the use restrictions on the specifications and sizes of the test tubes. It further improves the convenience of taking and placing test tubes on the basis of the existing high performance liquid chromatography-tandem mass spectrometry integrated machine technology, is suitable for test tubes of different specifications and sizes, and has the effect of position movement and classified placement.

Claims

1. A high performance liquid chromatography tandem mass spectrometry integrated machine, comprising: A machine body (1) and a storage box (2), characterized in that: the outer wall of the machine body (1) is connected to a positioning shaft (11), and the outer side of the positioning shaft (11) is rotatably connected to a damping sleeve (12), the storage box (2) is connected to the outer side of the damping sleeve (12), and the storage box (2) includes a cooling box (21), and a pull-out box (22) is slidably inserted inside the cooling box (21), a positioning plate (23) is provided inside the pull-out box (22), and a guide sleeve (25) is provided at the upper end of the positioning plate (23), and a clamping member (26) is provided inside the positioning plate (23), and the clamping member (26) is provided on the lower side of the guide sleeve (25).

2. The high performance liquid chromatography tandem mass spectrometry integrated device according to claim 1, characterized in that: A rectangular slot is provided on the front inner side of the cooling box (21), and a refrigerator is installed on the inner bottom of the rectangular slot.

3. The high performance liquid chromatography tandem mass spectrometry integrated machine according to claim 1, characterized in that: A sealing cover is provided on the front side of the drawer box (22), and a supporting mesh plate (24) is provided on the bottom of the drawer box (22), and the supporting mesh plate (24) is located on the lower side of the positioning plate (23).

4. The high performance liquid chromatography tandem mass spectrometry integrated machine according to claim 1, characterized in that: The positioning plate (23) is provided with a clamping groove (27) inside, and movable grooves (231) are provided on the groove walls on both sides of the clamping groove (27), and a guide rod (233) is provided on the inner groove wall of the movable groove (231), and a spring (232) is sleeved on the outer side of the guide rod (233).

5. The high performance liquid chromatography tandem mass spectrometry integrated machine according to claim 1, characterized in that: The clamping member (26) is slidably connected in the movable groove (231), and the clamping member (26) comprises two outer arc plates (261) at the front and rear sides, and an inner arc plate (264) is connected between the outer arc plates (261).

6. The high performance liquid chromatography tandem mass spectrometry integrated machine according to claim 5, characterized in that: A guide hole is formed at the outer end of the outer arc-shaped plate (261), and the guide rod (233) is slidably connected in the guide hole, and the upper and lower ends of the outer arc-shaped plate (261) are connected to the limit block (262).

7. The high performance liquid chromatography tandem mass spectrometry integrated machine according to claim 5, characterized in that: The outer diameter of the outer arc plate (261) is greater than that of the inner arc plate (264), and a step is provided between the outer edges of the outer arc plate (261) and the inner arc plate (264), and an outer ball (263) is installed on the arc surface of the outer arc plate (261), while an inner ball (265) is installed on the arc surface of the inner arc plate (264).

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