Bilateral jugular vein self-administration device

Abstract

A double-side jugular vein self-administration device comprises a box type device body, an experiment box body module (200), a medicine containing pipe and a peristaltic pump, and is characterized in that the experiment box body module (200), the medicine containing pipe and the peristaltic pump are arranged in the box type device body, and the medicine containing pipe is connected with the experiment box body module (200) through the peristaltic pump. According to the device, addiction comparison of two kinds of medicine can be conducted on the same rat at the same time, the device is easy and convenient to operate, the overall design is attractive and elegant, the detachable separation cavity is convenient to clean, and development of the next group of experiments is facilitated.

Description

Technical Field

[0001] The invention relates to the field of animal inhalation drug delivery devices, in particular to a bilateral jugular vein self-delivery device. Background Art

[0002] Intravenous self-administration is one of the most widely used animal models in drug addiction research. The most notable feature of the intravenous self-administration model is that experimental animals can obtain drugs through specific autonomous behaviors such as pressing a lever or poking their noses. This model directly illustrates the relationship between the subjective effects of drugs and drug-seeking behavior, simulating the subjective initiative of humans from drug use to addiction to the greatest extent.

[0003] Intravenous auto-administration can be achieved in a variety of animals, including rats, mice, primates, cats, dogs, etc. Rats are commonly used as experimental animals for physiology, pharmacology, and pharmacokinetic studies. At the same time, rats are the most commonly used animals in intravenous auto-administration experiments due to their moderate size and rapid postoperative recovery.

[0004] Currently, the unilateral administration method is used in the rat upper jugular vein self-administration experiment. This method has some disadvantages. Since only one jugular vein can be cannulated, it is impossible to directly compare two drugs or conditions at the same time in the experiment. Therefore, more experimental animals may be needed to complete the comparative study. However, using different experimental animals for comparative studies may lead to data variability due to individual differences, increasing the uncertainty of the experimental results. Summary of the invention

[0005] In order to overcome the existing defects, the present invention proposes a bilateral jugular vein self-administration device.

[0006] A bilateral jugular vein self-administration device comprises a box-type device body, an experimental box module, a drug-containing tube and a peristaltic pump. The experimental box module, the drug-containing tube and the peristaltic pump are arranged in the box-type device body, and the drug-containing tube is connected to the experimental box module through the peristaltic pump.

[0007] The device body includes a shell, a front door is located on the front of the device body, the front door is connected to the shell by a hinge, the door can be opened by a handle on the front door, the circuit control board is arranged in the shell, and the industrial control all-in-one machine is arranged on one side of the shell by a cantilever.

[0008] Among them, the experimental box module includes a box, the box door is located at the front of the box, the box door is connected to the box through a box hinge, and the box door can be opened by a box door handle located on the box door. A catheter bracket is arranged on the top of the box, and the catheter bracket fixes the left catheter and the right catheter and extends to the inside of the box; a left nose touch sensor is arranged on one side of the box, and a right nose touch sensor is arranged on the other side, and the left nose touch sensor and the right nose touch sensor on the other side are connected to the industrial control all-in-one machine; a bottom column is arranged at the bottom of the box.

[0009] Among them, the drug holding tube is divided into a left drug holding tube and a right drug holding tube; the peristaltic pump is divided into a left peristaltic pump and a right peristaltic pump, the left peristaltic pump is connected to the left drug holding tube and connected to the drug inlet end of the left catheter; the right peristaltic pump is connected to the right drug holding tube and connected to the drug inlet end of the right catheter.

[0010] The industrial control integrated machine controls the medicine to enter the rat jugular vein from the left medicine tube and the right medicine tube through the left catheter and the right catheter.

[0011] The present application provides a device for comparing the addictiveness of two drugs on the same rat at the same time. The device is easy to operate, has an elegant overall design, and has a detachable separation chamber for easy cleaning, which facilitates the conduct of the next group of experiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 Schematic diagram of the bilateral jugular vein self-administration device.

[0013] Figure 2 This is a schematic diagram of the experimental box module structure. DETAILED DESCRIPTION

[0014] A bilateral jugular vein self-administration device provided by the present invention is described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0015] Figure 1-2 As shown, a bilateral jugular vein self-administration device includes a box-type device body, an experimental box module 200, a drug-containing tube and a peristaltic pump. It is characterized in that the experimental box module 200, the drug-containing tube and the peristaltic pump are arranged in the box-type device body, and the drug-containing tube is connected to the experimental box module 200 through the peristaltic pump.

[0016] The device body includes a shell 104, a front door 102 located on the front of the device body, the front door 102 is connected to the shell 104 through a hinge 103, and the box door can be opened by a handle 101 located on the front door 102, a circuit control board 105 is arranged in the shell 104, and an industrial control all-in-one machine 106 is arranged on one side of the shell 104 through a cantilever 107.

[0017] The experimental box module 200 includes a box 207, a box door 202 is located at the front of the box 207, the box door 202 is connected to the box 207 through a box hinge 203, and the box door can be opened by a box door handle 201 located on the box door 202. A catheter bracket 205 is arranged on the top of the box 207, and the catheter bracket 205 fixes the left catheter 204 and the right catheter 206 and extends to the inside of the box 207; a left nose touch sensor 208 is arranged on one side of the box 207, and a right nose touch sensor 209 is arranged on the other side. The left nose touch sensor 208 and the right nose touch sensor 209 on the other side are connected to the industrial control integrated machine 106; a bottom column 210 is arranged at the bottom of the box 207.

[0018] The drug holding tube is divided into a left drug holding tube 111 and a right drug holding tube 110; the peristaltic pump is divided into a left peristaltic pump 113 and a right peristaltic pump 112, the left peristaltic pump 113 is connected to the left drug holding tube 111 and connected to the drug inlet end of the left catheter 204; the right peristaltic pump 112 is connected to the right drug holding tube 110 and connected to the drug inlet end of the right catheter 206.

[0019] The industrial control integrated machine 106 controls the drug to enter the rat jugular vein from the left drug tube 111 and the right drug tube 110 through the left catheter 204 and the right catheter 206 .

[0020] In actual work,

[0021] Step 1: Place the rat in a self-administration box and connect the dosing tube to the carapace;

[0022] Step 2: Set up the self-medication program in the industrial control integrated computer. Touch the left and right nose contacts to receive the corresponding medicine.

[0023] Step 3: Add rats to the corresponding cages;

[0024] Step 4: Add medicine to the left and right medicine tubes;

[0025] Step 5: Click Run;

[0026] Step 6: At the end of the experiment, separate the rat from the drug administration tube, empty the drug in the drug tube, and put the rat back into the cage.

[0027] Finally, it should be noted that the above embodiments are only used to describe the technical solution of the present invention rather than to limit the technical method. The present invention can be extended to other modifications, changes, applications and embodiments in application, and therefore all such modifications, changes, applications and embodiments are considered to be within the scope of the present invention.

Claims

1. A bilateral jugular vein self-administration device, comprising a box-type device body, an experimental box module (200), a drug-containing tube and a peristaltic pump, characterized in that: The experimental box module (200), the medicine-containing tube and the peristaltic pump are arranged in a box-type device body, and the medicine-containing tube is connected to the experimental box module (200) via the peristaltic pump.

2. The bilateral jugular vein self-administration device according to claim 1, characterized in that: The device body comprises a shell (104), a front door (102) located at the front of the device body, the front door (102) being connected to the shell (104) via a hinge (103), the door being openable via a handle (101) located on the front door (102), a circuit control board (105) being arranged in the shell (104), and an industrial control integrated machine (106) being arranged on one side of the shell (104) via a cantilever (107).

3. The bilateral jugular vein self-administration device according to claim 1, characterized in that: The experimental box module (200) comprises a box (207), a box door (202) located at the front of the box (207), the box door (202) being connected to the box (207) via a box hinge (203), and the box door can be opened via a box door handle (201) located on the box door (202); a catheter bracket (205) is arranged on the top of the box (207), the catheter bracket (205) fixes a left catheter (204) and a right catheter (206) and extends to the inside of the box (207); a left nose touch sensor (208) is arranged on one side of the box (207), and a right nose touch sensor (209) is arranged on the other side, the left nose touch sensor (208) and the right nose touch sensor (209) are connected to the industrial control integrated machine (106); and a bottom column (210) is arranged at the bottom of the box (207).

4. The bilateral jugular vein self-administration device according to claim 1 or 3, characterized in that: The drug-containing tube is divided into a left drug-containing tube (111) and a right drug-containing tube (110); the peristaltic pump is divided into a left peristaltic pump (113) and a right peristaltic pump (112); the left peristaltic pump (113) is connected to the left drug-containing tube (111) and communicated with the drug-inlet end of the left catheter (204); the right peristaltic pump (112) is connected to the right drug-containing tube (110) and communicated with the drug-inlet end of the right catheter (206).

5. The bilateral jugular vein self-administration device according to claim 4, characterized in that: The industrial control integrated machine (106) controls the medicine to enter the jugular vein of the rat from the left medicine tube (111) and the right medicine tube (110) through the left catheter (204) and the right catheter (206).

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