Chromatographic column structure

Abstract

The utility model relates to the technical field of liquid chromatography, in particular to a chromatographic column structure which comprises a column body, a sieve plate stud and a column joint, a fixed sieve plate is arranged on the end face of one end of the sieve plate stud, and a first external thread is arranged on the outer side face of the end, provided with the fixed sieve plate, of the sieve plate stud; a first internal thread matched with the first external thread is arranged at one end of the column body; the sieve plate stud is in threaded connection with the interior of the column body; a second external thread is arranged on the outer side of the column body, a second internal thread matched with the second external thread is arranged on the inner side of one end of the column connector, and a sample inlet is formed in the end face of the other end of the column connector. The sieve plate stud is designed, so that the fixed sieve plate can be fixed in the column body in a threaded connection mode, one end of the sieve plate stud is left outside the column body, and the fixed sieve plate can be taken out by screwing the end; the fixed sieve plate is in threaded connection with the inner wall of the chromatographic column without gaps, so that all samples can be filtered by the fixed sieve plate.

Description

Technical Field

[0001] The present application relates to the technical field of liquid chromatography, and in particular to a chromatographic column structure. Background Art

[0002] The chromatographic column is composed of a chromatographic column tube, an end joint, a sealing ring and a filter screen, etc. The screen is generally set at both ends of the chromatographic column tube to block and fix the filler in the chromatographic column. At the same time, the screen can also filter mechanical impurities in the mobile phase sample to protect the chromatographic column.

[0003] In the prior art, the sieve plate of the chromatographic column is generally a sheet structure, and the assembly method is to place the sieve plate on the limiting step in the chromatographic column, and then install other components to block the sieve plate in the chromatographic column to achieve the fixation of the sieve plate. When the sieve plate needs to be removed, due to the small diameter of the chromatographic column, it is generally necessary to use tweezers or other tools to clamp the sieve plate out, which is very inconvenient. Utility Model Content

[0004] The main purpose of the present application is to provide a chromatographic column structure, aiming to solve the problem of inconvenient loading and unloading of existing chromatographic column sieve plates.

[0005] The present application provides a chromatography column structure, comprising a column body, a sieve plate stud and a column joint;

[0006] The sieve plate stud is a hollow cylinder, a fixed sieve plate is arranged on one end surface of the sieve plate stud, and a first external thread is arranged on the outer side surface of one end of the sieve plate stud where the fixed sieve plate is arranged;

[0007] One end of the column is provided with a first internal thread matching the first external thread; the sieve plate stud is threadedly connected in the column;

[0008] The outer side of the column is provided with a second external thread, the inner side of one end of the column joint is provided with a second internal thread matching the second external thread, and the column joint is threadedly connected to the outer side of the column; the other end face of the column joint is provided with an injection port.

[0009] Optionally, a sealing ring is provided on the end surface of the sieve plate stud away from the fixed sieve plate, and a sealing groove matching the sealing ring is provided on the inner side of the end surface of the column joint.

[0010] Optionally, the first external thread and the first internal thread are tapered threads.

[0011] Optionally, a boss is provided at one end of the sieve plate stud outside the column, and the diameter of the boss is the same as the diameter of the column.

[0012] Optionally, an outer surface of one end of the sieve plate stud outside the column body is engraved with an anti-slip texture.

[0013] Optionally, a sample injection guide tube is provided in the column joint, one end of the sample injection guide tube is connected to the sample injection port, and the other end of the sample injection guide tube is in contact with the fixed sieve plate.

[0014] Optionally, a movable sieve plate is overlapped on the fixed sieve plate.

[0015] Optionally, the fixed screen plate is provided with a positioning groove; and the movable screen plate is provided with a positioning column matching the positioning groove.

[0016] Optionally, a dust cover for sealing the injection port is provided on the column joint.

[0017] Optionally, the dust cover is arranged on one side of the injection port through a damping shaft.

[0018] Compared with the prior art, the beneficial effects achieved by this application are:

[0019] The present application designs a sieve plate stud, so that the fixed sieve plate can be fixed in the column body by threaded connection, and one end of the sieve plate stud remains outside the column body, and the fixed sieve plate can be taken out by screwing the end; and the fixed sieve plate is connected to the inner wall of the chromatographic column by threads, without gaps, to ensure that all samples can be filtered through the fixed sieve plate. The chromatographic column of the present application has a simple structure and few parts, and does not need to use small-volume components such as springs, buckles or balls, thereby avoiding easy damage caused by complex mechanical structure and many parts. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without paying any creative work.

[0021] Figure 1 This is a schematic cross-sectional view of a chromatographic column structure in one embodiment of the present application;

[0022] Figure 2 This is a schematic diagram of the sealing ring and sealing groove structure in one embodiment of the present application;

[0023] Figure 3 This is a schematic diagram of a fixed sieve plate in one embodiment of the present application;

[0024] Figure 4 This is a schematic diagram of a movable sieve plate in one embodiment of the present application;

[0025] Figure 5 This is a schematic diagram of the dust cover structure in one embodiment of the present application.

[0026] Explanation of symbols: 1-column, 101-first internal thread, 102-second external thread, 2-sieve plate stud, 201-first external thread, 202-sealing ring, 3-column joint, 301-injection port, 302-second internal thread, 303-sealing groove, 4-fixed sieve plate, 401-positioning groove, 5-movable sieve plate, 501-positioning column, 6-dust cover, 601-damping shaft.

[0027] The realization of the purpose, functional features and advantages of this application will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0029] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0030] In the present invention, unless otherwise clearly specified and limited, the terms "connection", "fixation", etc. should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] In addition, if there are descriptions involving "first", "second", etc. in the embodiments of the utility model, the descriptions of "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the meaning of "and / or" appearing in the full text includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or a scheme that satisfies both A and B. In addition, the technical solutions between the various embodiments can be combined with each other, but it must be based on the ability of ordinary technicians in this field to implement. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the utility model.

[0032] In the prior art, the sieve plate of the chromatographic column is generally a sheet structure, and the assembly method is to place the sieve plate on the limiting step in the chromatographic column, and then install other components to block the sieve plate in the chromatographic column to achieve the fixation of the sieve plate. When the sieve plate needs to be taken out, because the diameter of the chromatographic column is very small, it is generally necessary to use tweezers or other tools to clamp the sieve plate out, which is very inconvenient. In addition, in some prior arts, after the sieve plate is assembled, the sealing between the sieve plate and the inner wall of the chromatographic column is not good, which may cause part of the sample to pass between the sieve plate and the inner wall of the chromatographic column without being filtered by the sieve plate, so that impurities enter the chromatographic column packing.

[0033] In order to solve the above technical problems, the present application provides a chromatographic column structure, see Figure 1 , comprising a column 1, a screen plate stud 2 and a column joint 3;

[0034] The sieve plate stud 2 is a hollow cylinder, and a fixed sieve plate 4 is arranged on one end surface of the sieve plate stud 2. A first external thread 201 is arranged on the outer side surface of one end of the sieve plate stud 2 where the fixed sieve plate 4 is arranged.

[0035] One end of the column 1 is provided with a first internal thread 101 matching the first external thread 201; one end of the sieve plate stud 2 is threadedly connected to the inner side of the column 1, and the other end remains outside the column 1;

[0036] The outer side of the column 1 is provided with a second external thread 102, the inner side of one end of the column joint 3 is provided with a second internal thread 302 matching the second external thread 102, and the column joint 3 is threadedly connected to the outer side of the column 1; the other end face of the column joint 3 is provided with an injection port 301.

[0037] The present application designs a sieve plate stud 2, so that the fixed sieve plate 4 can be fixed in the column 1 by threaded connection, and one end of the sieve plate stud 2 remains outside the column 1, and the fixed sieve plate 4 can be taken out by screwing the end, which is easy to operate; and the fixed sieve plate 4 is connected to the inner wall of the chromatographic column by threads, without gaps, ensuring that all samples can be filtered through the fixed sieve plate 4. Some existing chromatographic column designs use components such as springs, buckles or balls, which are complicated to install and operate, and the complex mechanical structure is more prone to failure, while the chromatographic column of the present application has a simple structure, does not use small-volume parts, and is not easy to damage.

[0038] As an optional implementation of the present application, see Figure 2 In order to ensure the sealing of the chromatographic column, a sealing ring 202 is provided on the end face of the sieve plate stud 2 away from the fixed sieve plate 4, and a sealing groove 303 matching the sealing ring 202 is provided on the inner side of the end face of the column joint 3. By providing the sealing ring 202 and the sealing groove 303, the sieve plate stud 2 and the column joint 3 can be sealed after installation to prevent the sample from overflowing from the sieve plate stud 2.

[0039] As an optional embodiment of the present application, the first external screw and the first internal thread 101 are tapered threads. The first external screw and the first internal thread 101 are used to connect the screen plate stud 2 and the column 1, and have high requirements for sealing. Therefore, tapered threads are used, and they can be sealed by directly tightening without any filler. There are two main reasons why tapered threads have sealing properties: 1. Due to the taper, this thread has a "self-tightening effect" when it cooperates with the same tapered thread or cylindrical thread; 2. Its special tooth shape design has the characteristic of "complete fit".

[0040] As an optional implementation of the present application, see Figure 2 , a boss is provided at one end of the sieve plate stud 2 outside the column 1, and the diameter of the boss is the same as the diameter of the column 1. When the boss is not provided, the too small diameter of the sieve plate stud 2 will make it difficult for the staff to operate when screwing. The boss is provided to increase the diameter of one end of the sieve plate stud 2, which is more convenient when screwing. In addition, the boss also has a limiting function. If the first external screw and the first internal thread 101 are pipe threads, in order to prevent the sieve plate stud 2 from being screwed in too deeply, the boss is required for limiting.

[0041] As an optional embodiment of the present application, the outer surface of one end of the screen plate stud 2 outside the column 1 is engraved with an anti-skid texture. The screen plate stud 2 is generally made of metal material, and due to its small diameter, it is easy to slip when twisting if the surface is completely smooth. Therefore, the anti-skid texture is provided to increase the friction of twisting, so that the screen plate stud 2 can be quickly removed.

[0042] As an optional implementation of the present application, see Figure 2The column joint 3 is provided with a sample injection guide tube, one end of which is connected to the sample injection port 301, and the other end of which is in contact with the fixed sieve plate 4. The guide tube is used to guide the sample to flow directly from the sample injection port 301 to the filter plate, so as to avoid the sample from contacting the inner wall of the sieve plate stud 2 as much as possible, and reduce the adhesion and residue of the sample on the inner wall of the sieve plate stud 2.

[0043] As an optional embodiment of the present application, a movable sieve plate 5 is overlapped on the fixed sieve plate 4. The sieve plate studs 2 of the present application have a certain length, and there is space above the fixed sieve plate 4, so multiple layers of sieve plates can be overlapped and installed according to needs. For example, when it is necessary to filter impurities of very small size, if the fixed sieve plate 4 cannot meet the filtering requirements, a movable sieve plate 5 with a smaller aperture that meets the requirements can be overlapped on the fixed sieve plate 4 to ensure the filtering effect.

[0044] As an optional implementation of the present application, see Figure 3-4 The fixed sieve plate 4 is provided with a positioning groove 401; the movable sieve plate 5 is provided with a positioning column 501 matching the positioning groove 401. When the movable sieve plate 5 is installed, its positioning column 501 is embedded in the positioning groove 401 of the fixed sieve plate 4, so as to realize the limiting of the movable sieve plate 5.

[0045] As an optional embodiment of the present application, the column connector 3 is provided with a dust cover 6 for sealing the injection port 301. When the chromatographic column is not in use, the dust cover 6 can be used to seal the injection port 301 to prevent dust from entering and contaminating the interior of the chromatographic column.

[0046] As an optional implementation of the present application, see Figure 5 , the dust cover 6 is arranged on one side of the injection port 301 through a damping shaft 601. In some prior arts, the injection port 301 is blocked by a separate sealing plug, but this sealing plug is very small in size, difficult to store after removal, and easy to lose; therefore, the present application fixes the dust cover 6 to the upper surface of the column joint 3, and the dust cover 6 and the column joint 3 are integrated and will not be lost. The dust cover 6 can be rotated on the surface of the column joint 3 through the damping shaft 601, so that the injection port 301 can be freely switched between the blocked and open states. The damping shaft 601 can generate friction through the extrusion between the gaskets. A certain amount of force is required to rotate the dust cover 6. When it is turned to the required position, the friction of the shaft can keep the dust cover 6 in this position.

[0047] Those skilled in the art will appreciate that the embodiments described herein are intended to help readers understand the principles of the present invention, and should be understood that the protection scope of the present invention is not limited to such specific statements and embodiments. Those skilled in the art can make various other specific variations and combinations based on the technical inspirations disclosed in the present invention without departing from the essence of the present invention, and these variations and combinations are still within the protection scope of the present invention.

Claims

1. A chromatographic column structure, characterized in that: Includes column, screen studs and column joints; The sieve plate stud is a hollow cylinder, a fixed sieve plate is arranged on one end surface of the sieve plate stud, and a first external thread is arranged on the outer side surface of one end of the sieve plate stud where the fixed sieve plate is arranged; One end of the column is provided with a first internal thread matching the first external thread; the sieve plate stud is threadedly connected to the inner side of the column; The outer side of the column is provided with a second external thread, the inner side of one end of the column joint is provided with a second internal thread matching the second external thread, and the column joint is threadedly connected to the outer side of the column; the other end face of the column joint is provided with an injection port.

2. A chromatographic column structure according to claim 1, characterized in that: A sealing ring is provided on the end surface of one end of the sieve plate stud away from the fixed sieve plate, and a sealing groove matching the sealing ring is provided on the inner side of the end surface of the column joint.

3. A chromatographic column structure according to claim 1, characterized in that: The first external thread and the first internal thread are tapered threads.

4. A chromatographic column structure according to claim 1, characterized in that: A boss is provided at one end of the sieve plate stud outside the column, and the diameter of the boss is the same as the diameter of the column.

5. A chromatographic column structure according to claim 1, characterized in that: The outer surface of one end of the sieve plate stud outside the column is engraved with anti-slip texture.

6. A chromatographic column structure according to claim 1, characterized in that: The column joint is provided with a sample injection guide tube, one end of which is connected to the sample injection port, and the other end of which is in contact with the fixed sieve plate.

7. A chromatographic column structure according to claim 1, characterized in that: A movable sieve plate is overlapped on the fixed sieve plate.

8. A chromatographic column structure according to claim 7, characterized in that: The fixed screen plate is provided with a positioning groove; the movable screen plate is provided with a positioning column matching the positioning groove.

9. A chromatographic column structure according to claim 1, characterized in that: The column joint is provided with a dust cover for sealing the injection port.

10. A chromatographic column structure according to claim 9, characterized in that: The dust cover is arranged on one side of the injection port via a damping shaft.

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