Production device of scyllo-inositol

Abstract

The utility model discloses a scyllo-inositol production device, and relates to the technical field of scyllo-inositol production, an inlet of a conversion tank is respectively communicated with a myo-inositol solution tank, a boric acid tank, a crude enzyme liquid tank and a sodium hydroxide tank, the conversion liquid tank is communicated with a first filter, the first filter is communicated with a conversion filter cake tank, an outlet of the conversion filter cake tank is communicated with a dissolving tank, and the dissolving tank is communicated with a second filter. An inlet of the dissolving tank is communicated with a dilute phosphoric acid tank through a pipeline; an outlet of the dissolving tank is communicated with a crystallizing tank through a pipeline. The whole process is easy to operate, the conversion rate of the scyllo-inositol reaches 90% or above, few byproducts are produced in the conversion process, scyllo sugar does not need to be degraded, and in addition, ethanol serves as a poor solvent of the scyllo-inositol, so that the crystallized scyllo-inositol is high in yield and good in crystal form.

Description

Technical Field

[0001] The utility model relates to the technical field of scyllo-inositol production, in particular to a scyllo-inositol production device. Background Art

[0002] Scyllo-inositol (SI) is a diastereomer of myo-inositol (MI) and exists in plants, animals and some bacteria, but its content in nature is much lower than that of myo-inositol.

[0003] In the traditional synthesis method, scyllo-inositol is mainly prepared by complex chemical synthesis using myo-inositol as raw material. However, this method requires the protection and deprotection of hydroxyl groups, and the steps are cumbersome, which is not conducive to large-scale production. In recent years, with the development of bioengineering technology, the biological preparation of scyllo-inositol has become a new development trend, but the conversion rate of scyllo-inositol is only about 35%, the raw material utilization rate is low, and the subsequent extraction still needs to consider how to separate scyllo-inositol, which makes it difficult to achieve industrial production. Summary of the invention

[0004] The technical problem to be solved by the utility model is: in view of the deficiencies in the prior art, a production device of scyllo-inositol is provided, which has high conversion rate of scyllo-inositol, simple separation and is suitable for industrial production.

[0005] In order to solve the above technical problems, the technical solution of the utility model is:

[0006] A scyllo-inositol production device comprises a conversion tank, wherein the inlet of the conversion tank is connected to a myo-inositol solution tank, a boric acid tank, a crude enzyme liquid tank and a sodium hydroxide tank through pipelines, the conversion liquid tank is connected to a first filter through a pipeline, the solid phase outlet of the first filter is connected to a conversion filter cake tank, the outlet of the conversion filter cake tank is connected to a dissolution tank, and the inlet of the dissolution tank is connected to a dilute phosphoric acid tank through a pipeline;

[0007] The outlet of the dissolving tank is connected to a crystallizing tank through a pipeline, the inlet of the crystallizing tank is connected to a first ethanol tank through a pipeline, the outlet of the crystallizing tank is connected to a second filter, and the solid phase outlet of the second filter is connected to a crude product tank.

[0008] As an improved technical solution, the first filter is a plate and frame filter press or a centrifuge.

[0009] As an improved technical solution, the outlet of the crude product tank is connected to a dryer, and the outlet of the dryer is connected to a finished product tank.

[0010] As an improved technical solution, the outlet of the crude product tank is connected to a flushing tank, the inlet of the flushing tank is connected to a second ethanol tank through a pipeline, the outlet of the flushing tank is connected to a third filter, the solid phase outlet of the third filter is connected to an intermediate tank, and the outlet of the intermediate tank is connected to the dryer.

[0011] As an improved technical solution, the liquid phase outlet of the third filter is connected to a temporary storage tank.

[0012] As an improved technical solution, the outlet of the dissolution tank is connected to the decolorization tank through a pipeline, the inlet of the decolorization tank is connected to an activated carbon tank, the outlet of the decolorization tank is connected to a fourth filter, and the liquid phase outlet of the fourth filter is connected to the crystallization tank.

[0013] As a preferred technical solution, the inlet of the decolorization tank is connected to a diatomaceous earth tank.

[0014] As a preferred technical solution, the liquid phase outlet of the fourth filter is connected to a concentration tank, and the outlet of the concentration tank is connected to the crystallization tank.

[0015] Due to the adoption of the above technical solution, the beneficial effects of the utility model are:

[0016] The utility model provides a scyllo-inositol production device, comprising a conversion tank, the inlet of which is connected to a myo-inositol solution tank, a boric acid tank, a crude enzyme liquid tank and a sodium hydroxide tank respectively through pipelines, the conversion liquid tank is connected to a first filter through a pipeline, the solid phase outlet of the first filter is connected to a conversion filter cake tank, the outlet of the conversion filter cake tank is connected to a dissolution tank, the inlet of the dissolution tank is connected to a dilute phosphoric acid tank through a pipeline; the outlet of the dissolution tank is connected to a crystallization tank through a pipeline, the inlet of the crystallization tank is connected to a first ethanol tank through a pipeline, the outlet of the crystallization tank is connected to a second filter, and the solid phase outlet of the second filter is connected to a crude product tank. The mixed crude enzyme liquid of inositol dehydrogenase and scyllo-inositol dehydrogenase converts myo-inositol, myo-inositol is converted to scyllo-inositol, and then to scyllo-inositol, and the boric acid scyllo-inositol composite salt precipitation is obtained by pre-adding boric acid to react with the generated scyllo-inositol, breaking the conversion balance, making the conversion reaction continuously forward, and greatly improving the conversion rate of scyllo-inositol. After the conversion is completed, the scyllo-inositol borate complex salt precipitate is added with dilute phosphoric acid to dissolve, and the scyllo-inositol borate complex salt precipitate is decomposed into a mixed solution of boric acid and scyllo-inositol, and finally scyllo-inositol is precipitated by cooling and crystallization to obtain a crude scyllo-inositol product. The whole process is simple to operate, the conversion rate of scyllo-inositol reaches more than 90%, the by-products in the conversion process are few, and there is no need to degrade scyllo-inositol. In addition, ethanol is a poor solvent for scyllo-inositol, so that the yield of scyllo-inositol after crystallization is high and the crystal form is good.

[0017] The first filter of the utility model is a plate-frame filter press or a centrifuge, and has a good filtering effect.

[0018] The outlet of the crude product tank is connected to a dryer, and the outlet of the dryer is connected to a finished product tank. By drying the crude scyllo-inositol, the water content of the finished product is further reduced, thereby improving the quality of the product.

[0019] The outlet of the crude product tank is connected to a flushing tank, the inlet of the flushing tank is connected to a second ethanol tank through a pipeline, the outlet of the flushing tank is connected to a third filter, the solid phase outlet of the third filter is connected to an intermediate tank, and the outlet of the intermediate tank is connected to the dryer. The crude scyllo-inositol product is flushed with ethanol to further remove impurities in the product and improve the quality of the product.

[0020] The liquid phase outlet of the third filter is connected to a temporary storage tank, and the temporary storage tank contains a mixed liquid of ethanol and boric acid, which can be reused for conversion and crystallization after separation, avoiding waste and saving costs.

[0021] The outlet of the dissolving tank is connected to the decolorizing tank through a pipeline, the inlet of the decolorizing tank is connected to an activated carbon tank, the outlet of the decolorizing tank is connected to the fourth filter, and the liquid phase outlet of the fourth filter is connected to the crystallization tank. By decolorizing the mixed solution of scyllo-inositol and boric acid with activated carbon, the chromaticity of the product is improved.

[0022] The inlet of the decolorization tank is connected to a diatomaceous earth tank, and the diatomaceous earth can remove enzyme protein and impurities in the mixed liquid, thereby further improving the purity of the product.

[0023] The liquid phase outlet of the fourth filter is connected to a concentration tank, and the outlet of the concentration tank is connected to the crystallization tank. By pre-concentrating the material, the solid content of the material is increased from 10% w / w to 20-30% w / w, shortening the time required for crystallization. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0025] Figure 1 It is a schematic diagram of the structure of an embodiment of the utility model;

[0026] Among them: 1. conversion tank; 2. myo-inositol solution tank; 3. boric acid tank; 4. crude enzyme liquid tank; 5. sodium hydroxide tank; 6. first filter; 7. conversion filter cake tank; 8. dissolution tank; 9. dilute phosphoric acid tank; 10. crystallization tank; 11. first ethanol tank; 12. second filter; 13. crude product tank; 14. dryer; 15. finished product tank; 16. flushing tank; 17. second ethanol tank; 18. third filter; 19. intermediate tank; 20. temporary storage tank; 21. decolorization tank; 22. activated carbon tank; 23. fourth filter; 24. diatomaceous earth tank; 25. concentration tank. DETAILED DESCRIPTION

[0027] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0028] like Figure 1 As shown, a production device of scyllo-inositol comprises a conversion tank 1, the inlet of the conversion tank 1 is connected to a myo-inositol solution tank 2, a boric acid tank 3, a crude enzyme liquid tank 4 and a sodium hydroxide tank 5 through pipelines, the conversion liquid tank is connected to a first filter 6 through a pipeline, the solid phase outlet of the first filter 6 is connected to a conversion filter cake tank 7, the outlet of the conversion filter cake tank 7 is connected to a dissolution tank 8, the inlet of the dissolution tank 8 is connected to a dilute phosphoric acid tank 9 through a pipeline; the outlet of the dissolution tank 8 is connected to a crystallization tank 10 through a pipeline, the inlet of the crystallization tank 10 is connected to a first ethanol tank 11 through a pipeline, the outlet of the crystallization tank 10 is connected to a second filter 12, and the solid phase outlet of the second filter 12 is connected to a crude product tank 13. The mixed crude enzyme solution of inositol dehydrogenase and scyllo-inositol dehydrogenase converts myo-inositol, and myo-inositol is converted into scyllo-inositol, and then into scyllo-inositol. Boric acid is added in advance to react with the generated scyllo-inositol to obtain a boric acid scyllo-inositol complex salt precipitate, which breaks the conversion balance, makes the conversion reaction proceed continuously in the positive direction, and greatly improves the conversion rate of scyllo-inositol. After the conversion is completed, the scyllo-inositol complex salt precipitate obtained is added with dilute phosphoric acid to dissolve, and the boric acid scyllo-inositol complex salt precipitate is decomposed into a mixed solution of boric acid and scyllo-inositol, and finally, scyllo-inositol is precipitated by cooling and crystallization to obtain a crude scyllo-inositol. The whole process is simple to operate, the conversion rate of scyllo-inositol reaches more than 90%, there are few by-products in the conversion process, and scyllo-inositol does not need to be degraded. In addition, ethanol is used as a poor solvent for scyllo-inositol, so that the scyllo-inositol yield after crystallization is high and the crystal form is good.

[0029] The first filter 6 is a plate-and-frame filter press or a centrifuge, which has a good filtering effect.

[0030] The outlet of the crude product tank 13 is connected to a dryer 14, and the outlet of the dryer 14 is connected to a finished product tank 15. By drying the crude scyllo-inositol, the water content of the finished product is further reduced, thereby improving the quality of the product.

[0031] The outlet of the crude product tank 13 is connected to a flushing tank 16, the inlet of the flushing tank 16 is connected to a second ethanol tank 17 through a pipeline, the outlet of the flushing tank 16 is connected to a third filter 18, the solid phase outlet of the third filter 18 is connected to an intermediate tank 19, and the outlet of the intermediate tank 19 is connected to the dryer 14. Flushing the crude scyllo-inositol with ethanol further removes impurities in the product, thereby improving the quality of the product.

[0032] The liquid phase outlet of the third filter 18 is connected to a temporary storage tank 20. The temporary storage tank 20 contains a mixed liquid of ethanol and boric acid, which can be reused for conversion and crystallization after separation, thereby avoiding waste and saving costs.

[0033] The outlet of the dissolving tank 8 is connected to the decolorizing tank 21 through a pipeline, the inlet of the decolorizing tank 21 is connected to the activated carbon tank 22, the outlet of the decolorizing tank 21 is connected to the fourth filter 23, and the liquid phase outlet of the fourth filter 23 is connected to the crystallization tank 10. By decolorizing the mixed solution of scyllo-inositol and boric acid with activated carbon, the chromaticity of the product is improved.

[0034] The inlet of the decolorization tank 21 is connected to a diatomaceous earth tank 24. The diatomaceous earth can remove enzyme proteins and impurities in the mixed solution, thereby further improving the purity of the product.

[0035] The liquid phase outlet of the fourth filter 23 is connected to a concentration tank 25, and the outlet of the concentration tank 25 is connected to the crystallization tank 10. By concentrating the material in advance, the solid content of the material is increased from 10% w / w to 20-30% w / w, shortening the time required for crystallization.

[0036] It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the claims attached to this application.

Claims

1. A production device for scyllo-inositol, characterized in that: It comprises a conversion tank, the inlet of which is connected to a myo-inositol solution tank, a boric acid tank, a crude enzyme liquid tank and a sodium hydroxide tank through pipelines, the conversion tank is connected to a first filter through a pipeline, the solid phase outlet of the first filter is connected to a conversion filter cake tank, the outlet of the conversion filter cake tank is connected to a dissolution tank, and the inlet of the dissolution tank is connected to a dilute phosphoric acid tank through a pipeline; The outlet of the dissolving tank is connected to a crystallizing tank via a pipeline, the inlet of the crystallizing tank is connected to a first ethanol tank via a pipeline, the outlet of the crystallizing tank is connected to a second filter, and the solid phase outlet of the second filter is connected to a crude product tank.

2. A scyllo-inositol production device as claimed in claim 1, characterized in that: The first filter is a plate and frame filter press or a centrifuge.

3. A scyllo-inositol production device as claimed in claim 1, characterized in that: The outlet of the crude product tank is connected to a dryer, and the outlet of the dryer is connected to a finished product tank.

4. A scyllo-inositol production device as claimed in claim 3, characterized in that: The outlet of the crude product tank is connected to a flushing tank, the inlet of the flushing tank is connected to a second ethanol tank through a pipeline, the outlet of the flushing tank is connected to a third filter, the solid phase outlet of the third filter is connected to an intermediate tank, and the outlet of the intermediate tank is connected to the dryer.

5. A scyllo-inositol production device as claimed in claim 4, characterized in that: The liquid phase outlet of the third filter is connected to a temporary storage tank.

6. The production device of scyllo-inositol according to claim 1, characterized in that: The outlet of the dissolving tank is connected to the decolorizing tank through a pipeline, the inlet of the decolorizing tank is connected to an activated carbon tank, the outlet of the decolorizing tank is connected to a fourth filter, and the liquid phase outlet of the fourth filter is connected to the crystallization tank.

7. A scyllo-inositol production device as claimed in claim 6, characterized in that: The inlet of the decolorizing tank is connected with a diatomaceous earth tank.

8. A scyllo-inositol production device as claimed in claim 6, characterized in that: The liquid phase outlet of the fourth filter is connected to a concentration tank, and the outlet of the concentration tank is connected to the crystallization tank.

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