Cryopreserved liquid temperature control and temperature measurement equipment

By designing the temperature control and temperature measurement equipment of frozen liquid, the instability of frozen liquid storage equipment in pre-cooling and temperature regulation is solved, and the stable temperature control and real-time temperature monitoring of frozen liquid is achieved, ensuring safe storage of cells.

CN222761196UActive Publication Date: 2025-04-15JIANGSU YURUIKANG BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202421454993.5
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-06-25
Publication Date
2025-04-15
Estimated Expiration
2034-06-25

AI Technical Summary

Technical Problem

The existing frozen liquid storage equipment has instability in pre-cooling and temperature regulation, making it difficult to achieve real-time temperature monitoring and adjust the temperature as needed, resulting in frozen liquid being placed in a normal temperature state for a long time, which may lead to damage to the cell state.

Method used

A frozen liquid temperature control and temperature measurement equipment is designed, including a temperature control unit and a temperature measurement unit. The temperature control unit consists of a low-temperature refrigerator, a microcontroller and a touch display screen. The temperature measuring unit realizes temperature monitoring and limit placement of the sample tube through a temperature sensor and a limit rack.

Benefits of technology

It realizes stable temperature control and real-time temperature monitoring of frozen liquid, ensuring that frozen liquid is stored in a low temperature state, avoiding the risk of cells dying due to excessive temperature, and facilitates personnel to regulate the temperature through a touch display screen.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model provides cryopreservation liquid temperature control and temperature measurement equipment, which relates to the field of cryopreservation liquid and comprises a temperature control unit, a temperature measurement unit is arranged in an inner cavity of the temperature control unit, and the temperature control unit comprises a low-temperature refrigerator; according to the cryogenic refrigerator, a sample tube filled with cryopreservation liquid can be limited through the limiting frame, the sample tube can be placed through the cooperation of the placing frame and the placing groove, the temperature of the sample tube can be monitored in real time through the second temperature sensor, the temperature in the cryogenic refrigerator can be monitored through the first temperature sensor, and therefore temperature measuring operation is achieved; temperature data can be analyzed through the microcontroller, the temperature data can be transmitted to the touch display screen to be displayed, meanwhile, the touch display screen is matched with the microcontroller so that personnel can conveniently regulate and control the temperature in the low-temperature refrigerator, temperature control operation is achieved, and the screw rod can rotate to drive the screw sleeve and the placement frame to move; and the placing rack can drive the sample tube to be pushed out, so that personnel can conveniently take and place the sample tube.
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Description

Technical Field

[0001] The utility model belongs to the field of cryopreservation liquid, in particular to a cryopreservation liquid temperature control and temperature measurement device. Background Art

[0002] Cryopreservatives are solutions or liquid media specifically designed to preserve biological specimens such as cells, tissues, serum, etc. They are designed to freeze or refrigerate biological specimens at low temperatures to maintain their activity, stability, and availability for future use or analysis.

[0003] Freshly prepared cryopreservation solution will generate a large amount of heat. Before collecting cells in the cell cryopreservation experiment, the cell cryopreservation solution needs to be pre-cooled in advance to ensure that the temperature of the cell cryopreservation solution is appropriate when the cells are cryopreserved, thereby avoiding cell death due to excessively high temperature. The 4°C pre-cooling temperature of the refrigerator in the prior art is not stable enough, which is not only inconvenient for real-time monitoring of the sample tube temperature, but also difficult to adjust the temperature in the refrigerator according to the situation. When a large number of cells are frozen, the cryopreservation solution is kept at room temperature for a long time, which may cause temperature rise and affect the cell state. In addition, when the sample tubes containing the cryopreservation solution are placed in the refrigerator, they are often directly stuck in the placement hole, and when they are taken out, they need to be taken out by a buckling method, which is inconvenient.

[0004] In summary, the utility model therefore provides a freezing liquid temperature control and temperature measurement device to solve the above problems. Utility Model Content

[0005] In order to solve the above technical problems, the utility model provides the following technical solutions:

[0006] A freezing liquid temperature control and temperature measurement device comprises a temperature control unit, an inner cavity of the temperature control unit is provided with a temperature measurement unit, the temperature control unit comprises a low-temperature refrigerator, and the top of the low-temperature refrigerator is movably connected to a box cover through a hinge, the front of the low-temperature refrigerator is fixedly connected to a microcontroller, and the front of the microcontroller is provided with a touch display screen, the temperature measurement unit comprises a limit frame, and the number of the limit frames is two, a connecting frame is fixedly connected between the two limit frames, a placing frame is movably connected to the lower end of the surface of the connecting frame, a placing groove is opened on the top of the placing frame, and a second temperature sensor is provided in the inner cavity of the placing groove, a first temperature sensor is provided on the top of the connecting frame, a screw is movably connected to the inner cavity of the connecting frame, and a screw sleeve is threadedly connected to the surface of the screw.

[0007] Furthermore, in the utility model, a through slot is provided on the top of the placement rack, the screw sleeve is fixedly connected to the inner wall of the through slot, a limiting hole is provided on the top of the limiting rack, and the connecting rack is located in the inner cavity of the through slot.

[0008] Furthermore, in the utility model, a turntable is fixedly connected to the top of the screw, the bottom of the screw is movably connected to the bottom of the inner cavity of the low-temperature refrigerator through a bearing, the bottom of the connecting frame is fixedly connected to the bottom of the inner cavity of the low-temperature refrigerator, and a plug is provided on the back of the low-temperature refrigerator, and the plug is connected to an external power supply.

[0009] Furthermore, in the utility model, the front of the low-temperature refrigerator is movably connected to a protective cover via a hinge, the protective cover is made of transparent plastic, and the touch display screen and the microcontroller are both located in the inner cavity of the protective cover and movably connected to the inner cavity of the protective cover.

[0010] Furthermore, in the utility model, a support rod is provided between the box cover and the low-temperature refrigerator, one end of the support rod is movably connected to the box cover through a rotating shaft, a limiting groove is provided on the top of the low-temperature refrigerator, and the other end of the support rod extends to the inner cavity of the limiting groove and is slidably connected to the inner cavity of the limiting groove.

[0011] Furthermore, in the present invention, the output end of the microcontroller is connected to the input end of the low-temperature refrigerator, the touch display screen and the microcontroller are bidirectionally connected, and the output ends of the second temperature sensor and the first temperature sensor are connected to the input end of the microcontroller.

[0012] Beneficial effects: The utility model has the following beneficial effects:

[0013] The utility model can close the low-temperature refrigerator through the box cover, thereby ensuring the sealing property of the low-temperature refrigerator. At the same time, the low-temperature refrigerator can generate low temperature, so that the interior of the low-temperature refrigerator is in a low-temperature state, which is convenient for storing freezing liquid. The sample tube filled with freezing liquid can be limited by the limiting rack, and the placing rack can be used to place the sample tube in cooperation with the placing slot. The temperature of the sample tube can be monitored in real time by the second temperature sensor, and the first temperature sensor can monitor the temperature inside the low-temperature refrigerator, so as to realize the temperature measurement operation. The temperature data can be analyzed by the microcontroller, and the temperature data can be transmitted to the touch display screen for display. At the same time, the touch display screen cooperates with the microcontroller to facilitate personnel to adjust the temperature inside the low-temperature refrigerator and realize the temperature control operation. The rotation of the screw can drive the screw sleeve and the placing rack to move, and then the placing rack can drive the sample tube to be pushed out, thereby facilitating personnel to take and put the sample tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the structure of the utility model;

[0015] Figure 2 This is a schematic diagram of the structure of the low-temperature refrigerator of the utility model in the open state;

[0016] Figure 3 This is a schematic diagram of the connection structure of the placement rack and the connection rack of the utility model;

[0017] Figure 4 This utility model Figure 2 Schematic diagram of the local enlarged structure at point A in the middle.

[0018] In the figure:

[0019] 1. Temperature control unit; 11. Low temperature refrigerator; 111. Limiting groove; 112. Protective cover; 12. Box cover; 121. Support rod; 13. Microcontroller; 14. Touch screen; 2. Temperature measuring unit; 21. Limiting frame; 211. Limiting hole; 22. First temperature sensor; 23. Placement frame; 24. Placement groove; 25. Second temperature sensor; 26. Through groove; 27. Connecting frame; 28. Screw; 281. Turntable; 29. ​​Screw sleeve. DETAILED DESCRIPTION

[0020] In order to better understand the technical content of the utility model, specific embodiments are cited and described as follows in conjunction with the accompanying drawings. In this disclosure, various aspects of the utility model are described with reference to the accompanying drawings, and many illustrative embodiments are shown in the accompanying drawings. The embodiments of the present disclosure are not necessarily defined to include all aspects of the utility model. It should be understood that the various concepts and embodiments introduced above, as well as those described in more detail below, can be implemented in any of many ways, because the concepts and embodiments disclosed in the utility model are not limited to any implementation method. In addition, some aspects disclosed in the utility model can be used alone, or used in any appropriate combination with other aspects disclosed in the utility model.

[0021] Example 1

[0022] like Figure 1-4 As shown, it is the first embodiment of the utility model, which provides a freezing liquid temperature control and temperature measurement device, including a temperature control unit 1, the inner cavity of the temperature control unit 1 is provided with a temperature measurement unit 2, the temperature control unit 1 includes a low-temperature refrigerator 11, and the top of the low-temperature refrigerator 11 is movably connected to a box cover 12 through a hinge, the front of the low-temperature refrigerator 11 is fixedly connected to a microcontroller 13, and the front of the microcontroller 13 is provided with a touch display screen 14, the temperature measurement unit 2 includes a limit frame 21, and the number of the limit frames 21 is two, a connecting frame 27 is fixedly connected between the two limit frames 21, the lower end of the surface of the connecting frame 27 is movably connected to a placement frame 23, the top of the placement frame 23 is provided with a placement groove 24, and the inner cavity of the placement groove 24 is provided with a second temperature sensor 25, the top of the connecting frame 27 is provided with a first temperature sensor 22, the inner cavity of the connecting frame 27 is movably connected to a screw 28, and the surface of the screw 28 is threadedly connected to a screw sleeve 29.

[0023] like Figure 1-4As shown, the low-temperature refrigerator 11 can be closed by the box cover 12, thereby ensuring the sealing of the low-temperature refrigerator 11. At the same time, the low-temperature refrigerator 11 can generate a low temperature, so that the interior of the low-temperature refrigerator 11 is in a low-temperature state, which is convenient for storing the freezing liquid. The sample tube containing the freezing liquid can be limited by the limiting frame 21, and the placement frame 23 cooperates with the placement groove 24 to limit the placement of the sample tube. The temperature of the sample tube can be monitored in real time by the second temperature sensor 25, and the first temperature sensor 22 can monitor the temperature inside the low-temperature refrigerator 11, so as to realize the temperature measurement operation, and the monitored temperature data will be automatically transmitted to the microcontroller 13, and the microcontroller 13 can be used to The temperature data is analyzed and transmitted to the touch screen 14 for display, which is convenient for personnel to view. When the temperature data does not fall within the preset value, the personnel can input the required temperature through the touch screen 14, and the touch screen 14 will transmit a signal to the microcontroller 13. The microcontroller 13 will transmit a signal to the low-temperature refrigerator 11, so that the low-temperature refrigerator 11 gradually generates a low temperature until the required temperature is reached, thereby realizing temperature regulation and completing the temperature control operation. When the sample tube needs to be taken out, the screw sleeve 29 and the placement rack 23 can be driven to move by rotating the screw rod 28, and then the placement rack 23 can drive the sample tube to be pushed out, which is convenient for personnel to take and put the sample tube.

[0024] Example 2

[0025] Reference Figure 1-3 , which is the second embodiment of the utility model, and this embodiment is based on the previous embodiment.

[0026] In this embodiment, a through groove 26 is provided at the top of the placement rack 23, the screw sleeve 29 is fixedly connected to the inner wall of the through groove 26, a limiting hole 211 is provided at the top of the limiting rack 21, and the connecting rack 27 is located in the inner cavity of the through groove 26. The sizes of the placement grooves 24 and 211 are suitable for 50ml sample tubes and 15ml sample tubes. 8 50ml sample tubes and 10 15ml sample tubes can be placed at one time, and numbers can be set for easy distinction.

[0027] The top of the screw 28 is fixedly connected to a turntable 281, the bottom of the screw 28 is movably connected to the bottom of the inner cavity of the low-temperature refrigerator 11 through a bearing, the bottom of the connecting frame 27 is fixedly connected to the bottom of the inner cavity of the low-temperature refrigerator 11, and a plug is provided on the back of the low-temperature refrigerator 11, and the plug is connected to an external power supply.

[0028] The front of the low-temperature refrigerator 11 is movably connected to a protective cover 112 via a hinge. The protective cover 112 is made of transparent plastic. The touch display screen 14 and the microcontroller 13 are both located in the inner cavity of the protective cover 112 and movably connected to the inner cavity of the protective cover 112.

[0029] like Figure 1-3As shown, the placement rack 23 can be limited by the through groove 26, and then when the screw sleeve 29 drives the placement rack 23 to move, since the connecting rack 27 is located inside the through groove 26, the placement rack 23 will move along the surface of the connecting rack 27 to prevent the placement rack 23 from rotating during movement. The sample tubes of 50ml and 15ml sizes can be limited and placed through the limiting holes 211 and the placement grooves 24. The screw 28 can be driven to rotate by the turntable 281 to improve ease of use. The plug is connected to an external power supply to power the low-temperature refrigerator 11, and the protective cover 112 can protect the microcontroller 13 and the touch display screen 14.

[0030] Example 3

[0031] Reference Figure 2 and 4 , which is the third embodiment of the utility model, and this embodiment is based on the previous two embodiments.

[0032] In this embodiment, a support rod 121 is arranged between the box cover 12 and the low-temperature refrigerator 11, one end of the support rod 121 is movably connected to the box cover 12 through a rotating shaft, a limiting groove 111 is opened on the top of the low-temperature refrigerator 11, and the other end of the support rod 121 extends to the inner cavity of the limiting groove 111 and is slidably connected to the inner cavity of the limiting groove 111.

[0033] The output end of the microcontroller 13 is connected to the input end of the low-temperature refrigerator 11, the touch display screen 14 and the microcontroller 13 are bidirectionally connected, the output ends of the second temperature sensor 25 and the first temperature sensor 22 are connected to the input end of the microcontroller 13, and the touch display screen 14 can adjust the target temperature, display the actual temperature and storage time.

[0034] like Figure 2 and 4 As shown, by pulling the box cover 12, the box cover 12 moves to one side around the axis of the rotating shaft, and the box cover 12 drives the support rod 121 to slide along the inner cavity of the limiting groove 111, so that the box cover 12 can gradually open the low-temperature refrigerator 11. During the opening process, the support rod 121 supports the box cover 12 to ensure the stability of the box cover 12. The box cover 12 is connected to the low-temperature refrigerator 11 through the microcontroller 13, so as to facilitate the control of the operation of the low-temperature refrigerator 11.

[0035] When in use, first, the box cover 12 can close the low-temperature refrigerator 11, thereby ensuring the sealing of the low-temperature refrigerator 11. At the same time, the low-temperature refrigerator 11 can generate a low temperature, so that the interior of the low-temperature refrigerator 11 is in a low-temperature state, which is convenient for storing the freezing liquid. The sample tube containing the freezing liquid can be limited by the limiting frame 21, and the placement frame 23 cooperates with the placement slot 24 to limit the placement of the sample tube. The temperature of the sample tube can be monitored in real time by the second temperature sensor 25, and the first temperature sensor 22 can monitor the temperature inside the low-temperature refrigerator 11, so as to realize the temperature measurement operation, and the monitored temperature data can be automatically transmitted to the microcontroller 13, and the temperature data can be analyzed by the microcontroller 13, and the temperature data can be transmitted to the microcontroller 13 at the same time. The touch screen 14 is displayed for easy viewing by personnel. When the temperature data does not fall within the preset value, the personnel can input the required temperature through the touch screen 14. The touch screen 14 will transmit a signal to the microcontroller 13. The microcontroller 13 will transmit a signal to the low-temperature refrigerator 11, so that the low-temperature refrigerator 11 gradually generates a low temperature until the required temperature is reached, thereby realizing temperature regulation and completing the temperature control operation. When the sample tube needs to be taken out, the turntable 281 is rotated, and the turntable 281 drives the screw 28 to rotate. The screw 28 can drive the screw sleeve 29 to move upward while rotating. The screw sleeve 29 drives the placement rack 23 and the sample tube to move upward, and then the sample tube will be gradually pushed upward, so as to facilitate personnel to take the sample tube.

[0036] The standard parts used in this application document can all be purchased from the market and can be customized according to the description in the specification and drawings. The specific connection methods of each part adopt conventional means such as mature bolts, rivets, welding, etc. in the prior art. The machinery, parts and equipment all adopt conventional models in the prior art. The control method is automatic control through a controller. The control circuit of the controller can be implemented through simple programming by technicians in this field, which is common knowledge in the field. This application is mainly used to protect mechanical devices, so this application no longer explains the control method and circuit connection in detail.

[0037] Although the present invention has been disclosed as above with preferred embodiments, it is not intended to limit the present invention. A person with ordinary knowledge in the technical field to which the present invention belongs may make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention shall be determined by the definition of the claims.

Claims

1. A freezing liquid temperature control and temperature measurement device, comprising a temperature control unit (1), characterized in that: The inner cavity of the temperature control unit (1) is provided with a temperature measuring unit (2), the temperature control unit (1) comprises a low-temperature refrigerator (11), and the top of the low-temperature refrigerator (11) is movably connected to a box cover (12) via a hinge, the front of the low-temperature refrigerator (11) is fixedly connected to a microcontroller (13), and the front of the microcontroller (13) is provided with a touch screen (14), the temperature measuring unit (2) comprises a limit frame (21), and the number of the limit frames (21) is two, and the two limit frames (21) are connected to each other. 1), a connecting frame (27) is fixedly connected between the connecting frame (27), a placing frame (23) is movably connected to the lower end of the surface of the connecting frame (27), a placing groove (24) is provided on the top of the placing frame (23), and a second temperature sensor (25) is arranged in the inner cavity of the placing groove (24), a first temperature sensor (22) is arranged on the top of the connecting frame (27), a screw rod (28) is movably connected to the inner cavity of the connecting frame (27), and a screw sleeve (29) is threadedly connected to the surface of the screw rod (28).

2. The freezing liquid temperature control and temperature measurement device according to claim 1, characterized in that: A through slot (26) is provided on the top of the placement frame (23), the screw sleeve (29) is fixedly connected to the inner wall of the through slot (26), a limiting hole (211) is provided on the top of the limiting frame (21), and the connecting frame (27) is located in the inner cavity of the through slot (26).

3. The freezing liquid temperature control and temperature measurement device according to claim 1, characterized in that: The top of the screw rod (28) is fixedly connected to a turntable (281), the bottom of the screw rod (28) is movably connected to the bottom of the inner cavity of the low-temperature refrigerator (11) via a bearing, the bottom of the connecting frame (27) is fixedly connected to the bottom of the inner cavity of the low-temperature refrigerator (11), and a plug is provided on the back of the low-temperature refrigerator (11), and the plug is connected to an external power supply.

4. The freezing liquid temperature control and temperature measurement device according to claim 1, characterized in that: The front of the low-temperature refrigerator (11) is movably connected to a protective cover (112) via a hinge, and the protective cover (112) is made of transparent plastic. The touch display screen (14) and the microcontroller (13) are both located in the inner cavity of the protective cover (112) and are movably connected to the inner cavity of the protective cover (112).

5. The freezing liquid temperature control and temperature measurement device according to claim 1, characterized in that: A support rod (121) is provided between the box cover (12) and the low-temperature refrigerator (11); one end of the support rod (121) is movably connected to the box cover (12) via a rotating shaft; a limiting groove (111) is provided on the top of the low-temperature refrigerator (11); the other end of the support rod (121) extends to the inner cavity of the limiting groove (111) and is slidably connected to the inner cavity of the limiting groove (111).

6. The freezing liquid temperature control and temperature measurement device according to claim 1, characterized in that: The output end of the microcontroller (13) is connected to the input end of the low-temperature refrigerator (11), the touch display screen (14) and the microcontroller (13) are bidirectionally connected, and the output ends of the second temperature sensor (25) and the first temperature sensor (22) are connected to the input end of the microcontroller (13).