Automatic cell sampling device

Abstract

The utility model relates to the technical field of pathological cell smears, in particular to an automatic cell sampling device, which is characterized in that a cell sample and a cell smear device base are respectively placed in respective areas, and a pipetting mechanism is utilized to move back and forth between a cell sample placing area and a cell smear device base placing area to complete centrifugal cell sampling. Automatic sampling is realized through the pipetting mechanism, manual operation is replaced, and the sampling efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of pathological cell smears, and more specifically, to an automated cell sampling device. Background Art

[0002] Smear refers to the process of obtaining samples from cell samples and fixing them on preparation slides during cell preparation.

[0003] General steps for making a traditional centrifugal smear:

[0004] Centrifugation: First, the cells or tissues to be analyzed are separated by centrifugation. This may involve one or more centrifugation steps to obtain the desired cell or tissue pellet.

[0005] Smear preparation: Take a clean slide and apply a layer of cell or tissue suspension on its surface. This can be done by dropping the liquid sample directly onto the slide and then spreading it evenly with another slide, or by using a sample from a centrifuge tube and smearing it directly on the slide.

[0006] Staining: If necessary, the smear can be further stained to enhance the contrast and visualization of cells or tissues. Commonly used stains include Giemsa stain and Wright stain.

[0007] Seal the slide by placing a cover glass on the slide and fix it with glue.

[0008] However, before making the traditional centrifugal smear, the corresponding cell sample to be prepared needs to be sampled, that is, the sealed bottle containing the cell sample is opened, and an appropriate amount of cell sample is placed on a cell smear apparatus equipped with a centrifuge tube. The sampling process requires a lot of human resources, especially when processing large-scale samples. Manual operation is often inefficient, which can easily lead to extended production cycles and increased costs. Utility Model Content

[0009] In view of the above-mentioned deficiencies in the prior art, the purpose of the utility model is to provide an automated cell sampling device, which has the advantages of replacing manual work and improving sampling efficiency.

[0010] The above technical objectives of the utility model are achieved through the following technical solutions: an automated cell sampling device, comprising a frame and a workbench arranged on the frame, wherein the workbench is provided with:

[0011] A cell sample placement area, storing several groups of cell samples;

[0012] A cell smear base placement area, where a plurality of cell smear bases carrying glass slides are placed;

[0013] The liquid transfer mechanism moves back and forth between the cell sample placement area and the cell smear base placement area, and the cell sample is sucked and injected onto the glass slide in the cell smear base placement area to complete the cell sample sampling process.

[0014] Preferably, the workbench is also provided with:

[0015] The centrifuge storage area stores various centrifuges to be used;

[0016] The temporary storage area is provided with a plurality of proportioning test tubes, which are used to prepare a mixed solution of gradient centrifugal solution and cell samples; the mixed solution is mixed and proportioned in the temporary storage area by a pipetting mechanism that moves back and forth between the centrifugal solution storage area and the temporary storage area, thereby completing the sampling process of the mixed solution proportioning.

[0017] Preferably, the pipetting mechanism includes a first slide rail installed on the workbench, a first bracket sliding on the first slide rail, and several groups of pipette guns provided on the first bracket, several groups of the pipette guns are installed on the first bracket through a first lifting module, and several groups of the pipette guns slide on the first slide rail to and fro between the cell sample placement area and the cell smear base placement area to absorb cell samples.

[0018] Preferably, the workbench is also provided with:

[0019] A centrifuge tube placement area, where a number of centrifuge tubes are placed;

[0020] The grabbing mechanism moves back and forth between the cell smear base placement area and the centrifuge tube placement area. After the pipetting mechanism completes the sampling of the cell sample, the centrifuge tube is covered on the cell smear base for rotational assembly to complete the installation process of the cell smear.

[0021] Preferably, the gripping mechanism includes a second slide rail provided on the workbench, a second bracket sliding on the second slide rail, and several groups of rotating jaws provided on the second bracket. The several groups of rotating jaws are installed on the second bracket through a second lifting module. The several groups of rotating jaws slide on the second slide rail and move back and forth between the cell smear base placement area and the centrifuge tube placement area to complete the assembly of the cell smear.

[0022] Preferably, a pipette placement area for placing a plurality of pipettes is provided on the workbench, and the pipetting mechanism sleeves the pipettes on the pipette placement area.

[0023] Preferably, the workbench is provided with:

[0024] A cover glass placement area, storing a number of cover glasses;

[0025] The slide moving mechanism is used for sucking the cover glass to cover the cell smear base in the cell smear base placement area, and moving back and forth between the cell smear base placement area and the cover glass placement area.

[0026] Preferably, the sheet moving mechanism includes a third slide rail disposed on the workbench, a third bracket sliding on the third slide rail, and a plurality of groups of suction claws disposed on the third bracket, and the plurality of groups of suction claws are installed on the third bracket through a third lifting module.

[0027] Preferably, the workbench is provided with a filter sleeve placement area for placing a plurality of filter sleeves to be used, and the pipetting mechanism passes through the filter sleeve placement area, the cell sample placement area and the cell smear base placement area in sequence. After the pipetting mechanism puts the filter sleeve on the filter sleeve placement area, the cell sample is sucked through the cell sample placement area to separate the cell clusters in the cell sample, and the cell clusters are adhered to the slide in the cell smear base placement area.

[0028] Preferably, the filter sleeve comprises a connecting tube plugged with the end of the pipetting mechanism and a filter screen arranged at one end of the connecting tube, and the diameter of the connecting tube is smaller than the diameter of the bottle mouth of the cell sample placement area.

[0029] In summary, the utility model has the beneficial effects: the utility model completes centrifugal cell sampling by placing the cell sample and the cell smear base in their respective areas, and uses a pipetting mechanism to move back and forth between the cell sample placement area and the cell smear base placement area, and realizes automated sampling through the pipetting mechanism, replacing manual work and improving sampling efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a schematic diagram of the overall sampling structure of the first embodiment of the utility model;

[0031] Figure 2 It is a structural schematic diagram of the liquid transfer mechanism, the liquid transfer mechanism and the sheet transfer mechanism of the first embodiment of the utility model;

[0032] Figure 3 It is a schematic diagram of the overall sampling structure of the second embodiment of the utility model;

[0033] Figure 4 It is a structural schematic diagram of the centrifuge liquid storage area of ​​the second embodiment of the utility model;

[0034] Figure 5 It is a structural schematic diagram of the filter sleeve of the second embodiment of the utility model.

[0035] Figure numerals: 1, rack; 11, workbench; 12, cell sample placement area; 13, cell smear base placement area; 14, centrifuge storage area; 15, temporary storage area; 16, centrifuge tube placement area; 17, pipette placement area; 18, cover glass placement area; 19, slide placement area; 2, liquid transfer mechanism; 21, first slide rail; 22, first bracket; 23, liquid transfer gun; 24, first lifting module; 3, grabbing mechanism; 31, second slide rail; 32, second bracket; 33, rotating clamp; 34, second lifting module; 4, film transfer mechanism; 41, third slide rail; 42, third bracket; 43, suction claw; 44, third lifting module; 5, filter sleeve placement area; 51, filter sleeve; 52, connecting pipe; 53, filter screen; 6, support seat; 61, rotating shaft; 62, driving member; 63, mounting seat; 64, positioning hole. DETAILED DESCRIPTION

[0036] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0037] It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it can be directly on the other component or indirectly on the other component. When a component is referred to as being "connected to" another component, it can be directly or indirectly connected to the other component.

[0038] It should be understood that the terms "length", "width", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0039] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0040] Example 1: An automated cell sampling device, see Figure 1 and Figure 2, comprising a frame 1 and a workbench 11 arranged on the frame 1, wherein the workbench 11 is provided with:

[0041] The cell sample placement area 12 stores several groups of cell samples;

[0042] The cell smear base placement area 13 is provided with a plurality of cell smear bases for carrying glass slides;

[0043] The liquid transfer mechanism 2 moves back and forth between the cell sample placement area 12 and the cell smear base placement area 13, and the cell sample is sucked and injected onto the glass slide in the cell smear base placement area 13, thereby completing the cell sample sampling process.

[0044] In this embodiment, the cell sample and the cell smear base are placed in their respective areas, and the pipetting mechanism 2 is used to move back and forth between the cell sample placement area 12 and the cell smear base placement area 13 to complete centrifugal cell sampling. The pipetting mechanism 2 realizes automated sampling, replaces manual work, and improves sampling efficiency.

[0045] Specifically, the pipetting mechanism 2 includes a first slide rail 21 installed on the workbench 11, a first bracket 22 sliding on the first slide rail 21, and a plurality of groups of pipette guns 23 provided on the first bracket 22. The plurality of groups of pipette guns 23 are installed on the first bracket 22 through a first lifting module 24. The plurality of groups of pipette guns 23 slide on the first slide rail 21 and move back and forth between the cell sample placement area 12 and the cell smear base placement area 13 to absorb cell samples.

[0046] The pipetting mechanism 2 needs to move back and forth between the cell sample placement area 12 and the cell smear base placement area 13 to complete the sampling process of the cell sample. For this purpose, it needs to move linearly along the direction of the first slide rail 21, supported by the first bracket 22, and use the first lifting module 24 to install several groups of the pipetting guns 23 on the first bracket 22, so that the pipetting guns 23 can approach or move away from the workbench 11, and complete the axial movement of the X-axis and Y-axis in turn, so as to achieve the operation process of taking and discharging liquid by the pipetting gun 23.

[0047] Specifically, the workbench 11 is also provided with:

[0048] A centrifuge tube placement area 16 is provided with a plurality of centrifuge tubes;

[0049] The grabbing mechanism 3 moves back and forth between the cell smear base placement area 13 and the centrifuge tube placement area 16. After the pipetting mechanism 2 completes the sampling of the cell sample, the centrifuge tube is covered on the cell smear base for rotational assembly to complete the installation process of the cell smear.

[0050] Before the pipetting mechanism 2 completes the transfer of the cell sample, it is necessary to first cover the centrifuge tube on the slide of the cell smear base, and use the grabbing mechanism 3 to move back and forth between the cell smear base placement area 13 and the centrifuge tube placement area 16 to complete the installation process of the cell smear and the production process of the centrifugal smear.

[0051] Specifically, the grasping mechanism 3 includes a second slide rail 31 provided on the workbench 11, a second bracket 32 ​​sliding on the second slide rail 31, and a plurality of groups of rotating jaws 33 provided on the second bracket 32. The plurality of groups of rotating jaws 33 are installed on the second bracket 32 ​​through a second lifting module 34. The plurality of groups of rotating jaws 33 slide on the second slide rail 31 and move back and forth between the cell smear base placement area 13 and the centrifuge tube placement area 16 to complete the assembly of the cell smear.

[0052] In this embodiment, in order to realize the automated production of cell smears, after the cell sample sampling process is completed on the cell smear base, the centrifuge tube needs to be further covered on the cell smear base for assembly. The specific operation includes: grabbing the centrifuge tube by a plurality of groups of suction claws 43, completing the movement of the left and right X-axis based on the sliding of the second slide rail 31, using the second bracket 32 ​​as support, and realizing the upper and lower Y-axis movement of the suction claw 43 by the second lifting module 34, and then rotating the clamping claw 33 to slide on the second slide rail 31 to go back and forth between the cell smear base placement area 13 and the centrifuge tube placement area 16 to complete the assembly of the cell smear.

[0053] In addition, the gripping mechanism 3 is also used to perform the opening operation. Since the cell sample needs to be preserved by sealing the bottle cap in the early stage, when taking the cell sample, the bottle cap of the sealed bottle needs to be opened in advance. For this purpose, the bottle cap is clamped by the rotating clamp 33, and the sealed bottle is limited by the fixture. The bottle cap of the sealed bottle is opened by coordinating the movement of the rotating clamp 33 and the second lifting module 34. In this way, auxiliary bottle opening is performed in the cell sample placement area 12 to achieve the purpose of automated production.

[0054] Specifically, a pipette placement area 17 for placing a plurality of pipettes is provided on the workbench 11 , and the pipetting mechanism 2 is provided with pipettes on the pipette placement area 17 .

[0055] When the pipette 23 sucks the cell sample, it does not suck the cell sample directly through the pipette 23, but through the pipette set on the pipette 23, which directly contacts the cell sample. Different cell samples can be replaced by different pipettes to avoid mutual infection between different cell samples, thereby realizing the reuse of the pipette.

[0056] Specifically, the workbench 11 is provided with:

[0057] A cover glass placement area 18 is used to store a plurality of cover glasses;

[0058] The slide moving mechanism 4 is used to absorb the cover glass and cover the cell smear base in the cell smear base placement area 13, and move back and forth between the cell smear base placement area 13 and the cover glass placement area 18.

[0059] The cover process of the slide is completed by the slide moving mechanism 4.

[0060] Specifically, the sheet moving mechanism 4 includes a third slide rail 41 arranged on the workbench 11, a third bracket 42 sliding on the third slide rail 41, and a plurality of groups of suction claws 43 arranged on the third bracket 42. The plurality of groups of suction claws 43 are installed on the third bracket 42 through a third lifting module 44.

[0061] The sheet moving mechanism 4 is supported by a third bracket 42, and provides movement in the left and right moving direction of the X axis through the third slide rail 41. Based on this, a plurality of groups of suction claws 43 are supported by the third lifting module 44 to complete the movement in the up and down moving direction of the Y axis, thereby realizing the gripping of the slide or cover glass by the suction claws 43.

[0062] The glass slide is grabbed before the cell smear apparatus is assembled. At this time, only the cell smear apparatus base is placed on the cell smear apparatus base placement area 13. The glass slide is grabbed by the suction claw 43 to lay a foundation for the cell smear apparatus assembly.

[0063] The cover glass is grabbed after the cell smear is centrifuged. At this time, the grabbing mechanism 3 is required to remove the centrifuge tube from the cell smear base, and then the suction claw 43 of the slide moving mechanism 4 is used to grab the slide, and the slide is covered on the cover glass on the cell smear base to complete the sealing operation.

[0064] In order to strengthen the adhesion between the cover glass and the slide, a glue dripping module is provided on the gripping mechanism 3 in this embodiment. The glue dripping module moves with the gripping mechanism 3 and includes a plurality of glue dripping tubes, a syringe for storing glue, and a driving member 62 for pushing the syringe.

[0065] Before the cover glass is covered on the slide glass, the syringe is squeezed by the driving member 62 so that the glue in the syringe flows out through the glue dropper onto the slide glass, and the glue is used to consolidate the adhesion between the cover glass and the slide glass.

[0066] In this embodiment, the centrifuge tube placement area 16, the cell sample placement area 12, and the injection tube placement area are cross-arranged. In addition, the first slide rail 21, the second slide rail 31, and the third slide rail 41 are the same slide rail, which is used to save equipment space.

[0067] In this embodiment, the cell sample placement area 12, the centrifuge tube placement area 16 and the pipette placement area 17 are all arranged side by side and mixed together, and are not separated independently, so as to save the floor space of each placement area.

[0068] Example 2: An automated cell sampling device, see Figures 3 to 5 The difference between this embodiment and the first embodiment is that: the workbench 11 is also provided with:

[0069] The centrifuge storage area 14 stores various centrifuges to be used;

[0070] The temporary storage area 15 is provided with a plurality of proportioning test tubes, which are used to prepare a mixed solution of the gradient centrifugal solution and the cell sample; the liquid transfer mechanism 2 moves back and forth between the centrifugal solution storage area 14 and the temporary storage area 15, and the mixed solution is mixed and proportioned in the temporary storage area 15, completing the sampling process of the mixed solution proportioning.

[0071] The temporary storage area 15 includes a support seat 6 disposed on the workbench 11, a rotating shaft 61 penetrating the support seat 6, and a driving member 62 installed on the support seat 6 to drive the rotating shaft 61 to rotate. A mounting seat 63 is installed on the rotating shaft 61, and a plurality of positioning holes 64 are opened on the mounting seat 63. A plugged matching test tube is installed in each positioning hole 64.

[0072] When gradient medium preparation and cell sample addition are performed, the driving member 62 drives the rotating shaft 61 to rotate, thereby driving the mounting seat 63 to rotate and be tilted;

[0073] When the gradient medium and the cell sample are transferred, the driving member 62 drives the rotating shaft 61 to rotate, thereby driving the mounting seat 63 to rotate and be placed vertically.

[0074] The driving member 62 is used to drive the mounting seat 63 to swing as a whole. When the gradient medium is prepared and the cell sample is added, that is, when the pipetting mechanism 2 is used to add liquid, the driving member 62 drives the rotating shaft 61 to rotate, and drives the mounting seat 63 to rotate and tilt, so that the matching test tube is set tilted. During the liquid addition process, the gradient liquid and the cell sample can slowly flow into the matching test tube along the side wall to complete the preparation of the gradient medium. The driving member 62 is a cylinder equipped with a crank structure, and the crank structure converts the linear movement of the cylinder into the rotational motion of the rotating shaft 61, and the crank structure is connected to the rotating shaft 61.

[0075] Based on the setting of the first embodiment, the matching test tubes and the centrifugal fluid are placed in their respective areas, and the pipetting mechanism 2 is used to move back and forth between the centrifugal fluid storage area 14, the cell sample placement area 12 and the temporary storage area 15 to complete the gradient centrifugation cell sampling. The multifunctional selective operation can complete the gradient centrifugation cell sampling process or the one-time centrifugation cell sampling process, realize automated sampling and improve the cell sampling efficiency, while enhancing the advantages of multifunctional selection application.

[0076] Specifically, the workbench 11 is provided with a filter sleeve 51 placement area 5 for placing a plurality of filter sleeves 51 to be used, and the pipetting mechanism 2 passes through the filter sleeve 51 placement area 5, the cell sample placement area 12 and the cell smear base placement area 13 in sequence. After the pipetting mechanism 2 puts the filter sleeve 51 on the filter sleeve 51 placement area 5, the cell sample placement area 12 is used to absorb the cell sample to separate the cell clusters in the cell sample, and the cell clusters are adhered to the slide in the cell smear base placement area 13.

[0077] In addition to completing the centrifugal smear operation or the gradient centrifugal smear operation, the present embodiment can also realize a fast and convenient pattern smear operation, that is, the pattern smear is completed by directly extracting the cell clusters in the cell sample, then coating the cell clusters on the glass slide, and finally covering the glass slide with a cover glass to complete the preparation of the pattern smear.

[0078] The specific operation is that the pipetting mechanism 2 first puts the filter sleeve 51 on the filter sleeve 51 placement area 5, and then moves it to the cell sample placement area 12, and absorbs the cell sample through the pipetting mechanism 2. During the absorption process, the cell clusters in the cell sample are separated, and then the cell clusters are moved to the cell smear base placement area 13 by the pipetting mechanism 2, and the cell clusters are adhered to the slide of the cell smear base to complete the smear process.

[0079] This embodiment provides sampling methods for three types of cell smears:

[0080] 1. During the primary centrifugation process: after the centrifugation of the cell smear device is completed, the centrifuge tube is first removed by the grabbing mechanism 3, and then the cover glass is grabbed by the suction claw 43, and the cover glass located in the cover glass placement area 18 is moved to the slide glass in the cell smear device base placement area 13 for capping;

[0081] 2. During the gradient centrifugation process: the liquid to be tested after gradient centrifugation will be directly transferred back and forth between the temporary storage area 15 and the cell smear base placement area 13 by the pipetting mechanism 2. At this time, only the liquid to be tested is left in the proportioning test tube. The pipetting mechanism 2 absorbs the liquid to be tested and transfers it to the slide in the cell smear base placement area 13. Then, the suction claw 43 is used to grab the cover glass, and the cover glass located in the cover glass placement area 18 is moved to the slide in the cell smear base placement area 13 for capping.

[0082] 3. Pattern preparation: After the pipetting mechanism 2 filters the cell sample through the filter sleeve 51, the filter 53 is adhered to the slide glass in the cell smear base placement area 13, and then the cover glass is grabbed by the suction claw 43, and the cover glass located in the cover glass placement area 18 is moved to the slide glass in the cell smear base placement area 13 for sealing. The rest of this embodiment is the same as the first embodiment, and the features not explained in this embodiment are all explained in the first embodiment, and will not be repeated here.

[0083] The above embodiments are merely explanations of the present invention and are not limitations of the present invention. After reading this specification, those skilled in the art may make modifications to the embodiments without any creative contribution as needed. However, as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. An automated cell sampling device, characterized in that: It comprises a frame and a workbench arranged on the frame, and the workbench is provided with: A cell sample placement area, storing several groups of cell samples; A cell smear base placement area, where a plurality of cell smear bases carrying glass slides are placed; The liquid transfer mechanism moves back and forth between the cell sample placement area and the cell smear base placement area, and the cell sample is sucked and injected onto the glass slide in the cell smear base placement area to complete the cell sample sampling process.

2. The automated cell sampling device according to claim 1, characterized in that: The workbench is also provided with: The centrifuge storage area stores various centrifuges to be used; The temporary storage area is provided with a plurality of proportioning test tubes, which are used to prepare a mixed solution of gradient centrifugal solution and cell samples; the mixed solution is mixed and proportioned in the temporary storage area by a pipetting mechanism that moves back and forth between the centrifugal solution storage area and the temporary storage area, thereby completing the sampling process of the mixed solution proportioning.

3. The automated cell sampling device according to claim 1, characterized in that: The pipetting mechanism includes a first slide rail installed on the workbench, a first bracket sliding on the first slide rail, and several groups of pipette guns arranged on the first bracket. Several groups of the pipette guns are installed on the first bracket through a first lifting module. Several groups of the pipette guns slide on the first slide rail and travel back and forth between the cell sample placement area and the cell smear base placement area to absorb cell samples.

4. The automated cell sampling device according to claim 1, characterized in that: The workbench is also provided with: A centrifuge tube placement area, where a number of centrifuge tubes are placed; The grabbing mechanism moves back and forth between the cell smear base placement area and the centrifuge tube placement area. After the pipetting mechanism completes the sampling of the cell sample, the centrifuge tube is covered on the cell smear base for rotational assembly to complete the installation process of the cell smear.

5. The automated cell sampling device according to claim 4, characterized in that: The gripping mechanism includes a second slide rail arranged on the workbench, a second bracket sliding on the second slide rail, and a plurality of groups of rotating jaws arranged on the second bracket. The plurality of groups of rotating jaws are installed on the second bracket through a second lifting module. The plurality of groups of rotating jaws slide on the second slide rail to and fro between the cell smear base placement area and the centrifuge tube placement area to complete the assembly of the cell smear.

6. The automated cell sampling device according to claim 1, characterized in that: The workbench is provided with a pipette placement area for placing a plurality of pipettes, and the pipetting mechanism sleeves the pipettes on the pipette placement area.

7. The automated cell sampling device according to claim 1, characterized in that: The workbench is provided with: A cover glass placement area, storing a number of cover glasses; The slide moving mechanism is used for sucking the cover glass to cover the cell smear base in the cell smear base placement area, and moving back and forth between the cell smear base placement area and the cover glass placement area.

8. An automated cell sampling device according to claim 7, characterized in that: The sheet moving mechanism comprises a third slide rail arranged on the workbench, a third bracket sliding on the third slide rail, and a plurality of groups of suction claws arranged on the third bracket, wherein the plurality of groups of suction claws are installed on the third bracket through a third lifting module.

9. The automated cell sampling device according to claim 1, characterized in that: The workbench is provided with a filter sleeve placement area for placing a plurality of filter sleeves to be used, and the pipetting mechanism passes through the filter sleeve placement area, the cell sample placement area and the cell smear base placement area in sequence. After the pipetting mechanism puts the filter sleeve on the filter sleeve placement area, the cell sample is sucked through the cell sample placement area to separate the cell clusters in the cell sample, and the cell clusters are adhered to the slide in the cell smear base placement area.

10. An automated cell sampling device according to claim 9, characterized in that: The filter sleeve comprises a connecting tube plugged with the end of the pipetting mechanism and a filter screen arranged at one end of the connecting tube. The diameter of the connecting tube is smaller than the diameter of the bottle mouth of the cell sample placement area.

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