Reagent bearing mechanism and blood coagulation detector
By designing the reagent bearing mechanism of multiple reagent strip groups, the problems of waste of reagents and diversified detection requirements of traditional coagulation detectors are solved, and efficient and reliable coagulation detection is achieved.
Patent Information
- Application Number
- CN202420646255.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-29
- Publication Date
- 2025-04-22
- Estimated Expiration
- 2034-03-29
AI Technical Summary
Traditional coagulation detectors use large-capacity containers to load reagents, resulting in waste of reagents and inability to meet diversified testing needs.
A reagent carrier mechanism is designed, including a carrier rack and at least two different reagent strip sets, each of which has multiple storage tanks for storing different types of single-person reagents and cleaning liquids.
Through this reagent bearing mechanism, the waste of reagents is reduced, diverse detection needs are met, and the pipette needle is cleaned through cleaning liquid, improving the reliability and user experience of detection.
Smart Images
Figure CN222784513U_ABST
Abstract
Description
Technical Field
[0001] The present application relates to the technical field of medical devices, and in particular to a reagent carrying mechanism and a coagulation detector. Background Art
[0002] With the improvement of medical technology, coagulation testing has become a routine analytical method in hospitals. Coagulation testing refers to the method of detecting the coagulation function of a sample through a coagulation tester. During the coagulation test, reagents need to be added to the sample and the sample and reagents need to be fully mixed. Traditional coagulation testers use large-capacity containers such as reagent bottles and test kits to load reagents. Large-capacity containers are only suitable for scenarios with large sample sizes. When the sample size is small, the reagent cannot be fully consumed within the validity period, resulting in reagent waste. Moreover, traditional large-capacity containers can only load a single reagent and cannot meet diversified testing needs. Utility Model Content
[0003] Based on this, it is necessary to provide a reagent carrying mechanism and a coagulation detector that can reduce waste and meet diversified testing needs in order to address the above problems.
[0004] A reagent carrying mechanism, the reagent carrying mechanism comprising:
[0005] a carrier frame; and
[0006] At least two different reagent card strip groups, each of the reagent card strip groups includes at least one reagent card strip, and each of the reagent card strips in each of the reagent card strip groups can be selectively and detachably mounted on the carrier;
[0007] Each of the reagent card strips in each group of the reagent card strip groups has a first storage slot and a second storage slot arranged along its own extension direction, the first storage slot of each of the reagent card strips in each group of the reagent card strip groups is used to store single-person reagents for detection, the first storage slots of the reagent card strips in different reagent card strip groups are used to store different types of single-person reagents, and the second storage slot of at least one of the reagent card strips in at least one group of the reagent card strip groups is used to store cleaning solution.
[0008] In some embodiments, the reagent card strip groups are two groups, and the reagent card strips in one group of the reagent card strip groups are defined as first reagent card strips, and the reagent card strips in the other group of the reagent card strip groups are defined as second reagent card strips;
[0009] The first storage slot of the first reagent card strip is used to store a single-person reagent for at least one of the prothrombin time test, the activated partial thromboplastin time test, the thrombin time test and the fibrinogen test, and the second storage slot of the first reagent card strip is used to store a cleaning solution;
[0010] The first storage slot of the second reagent card strip is used to store a single-person reagent for at least one of the fibrin degradation product detection, D-dimer detection and antithrombin III detection, and the second storage slot of the second reagent card strip is used to store a single-person reagent or cleaning solution for at least one of the fibrin degradation product detection, D-dimer detection and antithrombin III detection.
[0011] In some embodiments, one of the reagent card strips has a plurality of the first reagent card strips, and the first reagent card strip has six first storage slots and two second storage slots arranged in sequence along its extension direction;
[0012] All the first reagent card strips are divided into five types;
[0013] Any one of the first storage slots of the first reagent card strip of the first type and any two of the first storage slots of the first reagent card strip of the second type are used to store single-portion reagents for prothrombin time detection; any three of the first storage slots of the first reagent card strip of the third type are respectively used to store single-portion reagents for prothrombin time detection and two single-portion reagents for activated partial thromboplastin time detection; any five of the first storage slots of the first reagent card strip of the fourth type are respectively used to store single-portion reagents for prothrombin time detection, two single-portion reagents for activated partial thromboplastin time detection, and two single-portion reagents for fibrinogen detection; six of the first storage slots of the first reagent card strip of the fifth type are respectively used to store single-portion reagents for prothrombin time detection, two single-portion reagents for activated partial thromboplastin time detection, two single-portion reagents for fibrinogen detection, and single-portion reagent for thrombin time detection, and at least one of the second storage slots of the first to fifth types of the first reagent card strips is used to store cleaning solution.
[0014] In some embodiments, the first reagent card strips of the first type to the fifth type have the same first storage slot for storing single-serving reagents for prothrombin time detection; the first reagent card strips of the third type to the fifth type have the same first storage slot for storing first single-serving reagents for activated partial thromboplastin time detection; the first reagent card strips of the third type to the fifth type have the same first storage slot for storing second single-serving reagents for activated partial thromboplastin time detection; the first reagent card strips of the fourth type to the fifth type have the same first storage slot for storing first single-serving reagents for fibrinogen detection; the first reagent card strips of the fourth type to the fifth type have the same first storage slot for storing second single-serving reagents for fibrinogen detection, and the first reagent card strips of the first type to the fourth type have the same second storage slot for storing cleaning solution.
[0015] In some embodiments, the first first storage slot of the first reagent card strips of the first to fifth types and the second first storage slot of the first reagent card strips of the second type are both used to store single-serving reagents for prothrombin time detection; the second first storage slot of the first reagent card strips of the third to fifth types are both used to store the first single-serving reagent for activated partial thromboplastin time detection; the third first storage slot of the first reagent card strips of the third to fifth types are both used to store the second single-serving reagent for activated partial thromboplastin time detection; the fourth first storage slot of the first reagent card strip of the fifth type is used to store single-serving reagents for thrombin time detection; the fifth first storage slot of the first reagent card strips of the fourth to fifth types is used to store the first single-serving reagent for fibrinogen detection; the sixth first storage slot of the first reagent card strips of the fourth to fifth types is used to store the second single-serving reagent for fibrinogen detection, and the first second storage slot of the first reagent card strips of the first to fourth types are both used to store cleaning solution.
[0016] In some embodiments, different first storage slots in the second reagent card strip are used to store different types of single-person reagents.
[0017] In some embodiments, another group of the reagent card strips has a plurality of the second reagent card strips, and the second reagent card strips have six first storage slots and two second storage slots arranged in sequence along the extension direction thereof;
[0018] All the second reagent card strips are divided into five types;
[0019] The six first storage slots and two second storage slots of the first type of the second reagent card strip are respectively used to store three single-portion reagents for fibrin degradation product detection, two single-portion reagents for D-dimer detection, and three single-portion reagents for antithrombin III detection; any two of the first storage slots of the second reagent card strip of the second type are respectively used to store two single-portion reagents for D-dimer detection; any three of the first storage slots of the third type of the second reagent card strip are respectively used to store three single-portion reagents for fibrin degradation product detection; any five of the first storage slots of the fourth type of the second reagent card strip are respectively used to store three single-portion reagents for fibrin degradation product detection and two single-portion reagents for D-dimer detection; any three of the first storage slots of the fifth type of the second reagent card strip are respectively used to store three single-portion reagents for antithrombin III detection, and at least one of the second storage slots of the first to fifth types of the second reagent card strip is used to store cleaning solution.
[0020] In some embodiments, the first storage slots for storing single-serving reagents for detecting fibrin degradation products of the second reagent card strips of the first type, the third type to the fourth type are unified; the first storage slots for storing single-serving reagents for detecting D-dimer of the second reagent card strips of the first type, the third type and the fourth type are unified, and the second storage slots for storing cleaning fluid of the second reagent card strips of the second type to the fifth type are unified.
[0021] In some embodiments, the first first storage slot of the second reagent card strips of the first type, the third type and the fourth type is used to store the first single-serving reagent for detecting fibrin degradation products; the second first storage slot of the second reagent card strips of the first type, the third type and the fourth type is used to store the second single-serving reagent for detecting fibrin degradation products; the third first storage slot of the second reagent card strips of the first type, the third type and the fourth type is used to store the third single-serving reagent for detecting fibrin degradation products; the fourth first storage slot of the second reagent card strips of the first type, the second type and the fourth type is used to store the first single-serving reagent for detecting D-dimer; the fifth first storage slot of the second reagent card strips of the first type, the second type and the fourth type is used to store the second single-serving reagent for detecting D-dimer; the sixth first storage slot and two second storage slots of the second reagent card strip of the first type are respectively used to store three single-serving reagents for detecting antithrombin III; the first three first storage slots of the second reagent card strips of the fifth type are respectively used to store three single-serving reagents for detecting antithrombin III; the first first storage slot of the second reagent card strips of the second to fifth types is used to store cleaning solution.
[0022] A blood coagulation detector, comprising:
[0023] A reagent carrying mechanism as described in any one of the above embodiments;
[0024] cleaning facilities; and
[0025] A pipetting mechanism having a pipetting needle;
[0026] The pipette needle is used to transfer a single portion of reagent in the first storage tank, and the pipette needle uses a cleaning fluid to clean its own inner wall of the needle tube at the cleaning mechanism before or after each transfer of a single portion of reagent. The cleaning mechanism is used to clean the outer wall of the needle tube of the pipette needle.
[0027] The reagent carrying mechanism and the coagulation detector can provide single-person reagents for testing by storing single-person reagents for testing in the first storage slot, without the need for large-capacity containers, to meet the testing of single-person samples by the coagulation detector, reduce reagent waste, and improve user experience. In addition, the first storage slots of the reagent card strips in different reagent card strip groups are used to store different types of single-person reagents, and the second storage slot of at least one reagent card strip in at least one reagent card strip group is used to store cleaning solution. Therefore, different reagent card strips can be used to perform different tests, and the cleaning solution in the reagent card strip can also be used to clean the pipette needle, which is diverse and can meet diversified testing needs. BRIEF DESCRIPTION OF THE DRAWINGS
[0028] Figure 1 This is a schematic diagram of the structure of a reagent carrying mechanism in one embodiment of the present application.
[0029] Figure 2 It is a schematic diagram of the types of single-dose reagents stored in the first reagent card strip and the second reagent card strip in the reagent carrying mechanism of the present application.
[0030] Figure Number:
[0031] 1. Reagent carrying mechanism;
[0032] 10. Reagent card strip; 11. First reagent card strip; 12. Second reagent card strip; 13. First storage slot; 14. Second storage slot;
[0033] 20. Carrying rack; 21. Reagent card strip carrying position; 22. Sample tube carrying position. DETAILED DESCRIPTION
[0034] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.
[0035] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.
[0036] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.
[0037] In this application, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.
[0038] In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being “above”, “above”, and “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below”, and “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.
[0039] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be a central element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be a central element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method.
[0040] The present application provides a coagulation detector, which is used to perform coagulation detection and obtain detection results, and the detection results are used to provide a basis for judging whether the patient's coagulation function is normal.
[0041] See also Figure 1 The coagulation detector includes a reagent carrying mechanism 1, a sample loading carrying mechanism, a transfer mechanism, a pipetting mechanism, a cleaning mechanism and a detection mechanism. The reagent carrying mechanism 1 is used to store samples, single-portion reagents and cleaning solutions. The transfer mechanism is used to transfer the detection container between the sample loading carrying mechanism and the detection mechanism. The pipetting mechanism has a pipetting needle. The pipetting needle is used to transfer the sample to the detection container located at the sample loading carrying mechanism, and transfer the single-portion reagent to the detection container during the process of transferring the detection container from the sample loading carrying mechanism to the detection mechanism. The cleaning mechanism is used to clean the outer wall of the needle tube of the pipetting needle. When the pipetting needle absorbs the cleaning solution and moves to the cleaning mechanism, it can use the cleaning solution to clean the inner wall of its own needle tube. The detection mechanism is used to detect the detection container after the sample and the single-portion reagent are mixed and reacted to obtain the detection result.
[0042] Among them, single-person reagent refers to the sufficient amount of reagent for a single test of a single sample.
[0043] It is worth mentioning that the pipette needle first moves to the cleaning mechanism before or after adding a sample to the detection container, and before or after adding a single dose of reagent to the detection container, and uses the cleaning mechanism to clean the outer wall of its own needle tube. Afterwards, the pipette needle absorbs the cleaning liquid, and moves to the cleaning mechanism to spit out the cleaning liquid, so as to use the cleaning liquid to clean the inner wall of its own needle tube. For the convenience of explanation, the following embodiments are all explained by taking the example that the pipette needle moves to the cleaning mechanism to clean the inner and outer walls of its own needle tube after adding a sample to the detection container and adding a single dose of reagent.
[0044] Please refer again Figure 1 , and also see Figure 2The reagent carrying mechanism 1 includes a carrier 20 and at least two different reagent card strip groups, each reagent card strip group includes at least one reagent card strip 10, and each reagent card strip 10 in each reagent card strip group can be selectively and detachably installed on the carrier 20. Each reagent card strip 10 in each reagent card strip group has a first storage slot 13 and a second storage slot 14 arranged along its own extension direction. The first storage slot 13 of each reagent card strip 10 in each reagent card strip group is used to store a single-portion reagent for detection, the first storage slot 13 of the reagent card strip 10 in different reagent card strip groups is used to store different types of single-portion reagents, and the second storage slot 14 of at least one reagent card strip 10 in at least one reagent card strip group is used to store a cleaning solution. Among them, the transfer needle is used to transfer the single-portion reagent in the first storage slot 13, and the transfer needle uses the cleaning solution to clean the inner wall of its needle tube at the cleaning mechanism before or after each transfer of the single-portion reagent.
[0045] In the same time period, each reagent card group has at most one reagent card 10 installed on the carrier 20. In addition, in order to ensure that the pipette needle can be cleaned, in the same time period, there must be at least one reagent card 10 with cleaning solution stored on the carrier 20.
[0046] Specifically, the carrier 20 and the reagent card strip 10 extend in the same direction (the extension direction is as shown in FIG. Figure 1 The carrier 20 is provided with a reagent card strip bearing position 21 and a sample tube bearing position 22, which are arranged in sequence along the extension direction of the carrier 20. The reagent card strip bearing position 21 is used to bear the reagent card strip 10, and the sample tube bearing position 22 is used to bear the sample tube, in which the sample tube stores the sample. Optionally, the reagent card strip bearing position 21 and the sample tube bearing position 22 can both be groove structure positions, hole structure positions or other structure positions, so that the reagent card strip bearing position 21 can fix the reagent card strip 10, and the sample tube bearing position 22 can fix the sample tube.
[0047] The reagent card strip bearing positions 21 include at least two, and all the reagent card strip bearing positions 21 are arranged in sequence along the extension direction of the bearing frame 20. Exemplarily, the number of reagent card strip bearing positions 21 is equal to that of the reagent card strip group and corresponds one to one, and the reagent card strips 10 of the reagent card strip group are detachably mounted on the corresponding reagent card strip bearing positions 21. Exemplarily, the number of reagent card strip bearing positions 21 is equal to that of the reagent card strip group, and the reagent card strips 10 of the reagent card strip group are detachably mounted on any reagent card strip bearing position 21. For the convenience of description, the following embodiments are all described by taking the one-to-one correspondence between the reagent card strip bearing positions 21 and the reagent card strip group as an example.
[0048] Different types of reagents are used for different tests. The same test may use one or more types of reagents, depending on the test requirements. Taking PT (Prothrombin time) test and APTT (Activated Partial Thromboplastin Time) test as examples, there is one reagent for PT test and two reagents for APTT test. Different test containers are used for different tests. For example, when the same sample needs to be tested for PT and APTT at the same time, the sample is allocated to two different test containers, and the reagents for PT and APTT are added to two different test containers respectively.
[0049] The same reagent card strip group may include one or more reagent card strips 10. The types of single-person reagents stored in different reagent card strips 10 in the same reagent card strip group may be at least partially the same or completely different, and the types of single-person reagents stored in different reagent card strips 10 in different reagent card strip groups may be completely different.
[0050] According to the detection requirements, each reagent card strip 10 in each reagent card strip group can be selectively and detachably installed on the carrier 20. Specifically, taking the reagent card strip group as two groups, where the reagent card strips 10 in one reagent card strip group are all used to store single-person reagents for PT detection, and the reagent card strips 10 in the other reagent card strip group are all used to store single-person reagents for APTT detection, when PT detection is required, only one reagent card strip 10 containing a single-person reagent for PT detection is placed in the corresponding reagent card strip carrying position 21, and when APTT detection is required, only one reagent card strip 10 containing a single-person reagent for APTT detection is placed in the corresponding reagent card strip carrying position 21, and when PT detection and APTT detection are required at the same time, the reagent card strips 10 containing single-person reagents for PT detection and APTT detection need to be placed on the respective corresponding reagent card strip carrying positions 21.
[0051] The first storage slot 13 of each reagent card strip 10 in each reagent card strip group is used to store a single-portion reagent for detection. Different first storage slots 13 of the same reagent card strip 10 can store the same or different types of single-portion reagents.
[0052] The surface of the reagent card strip 10 is provided with a sealing film, which is used to seal the notches of the first storage tank 13 and the second storage tank 14 to prevent leakage or mutual contamination of the single-portion reagent and cleaning solution, and is convenient for storage and transportation. When the reagent card strip 10 needs to be used for detection, the sealing film can be torn open or pierced with a reagent needle.
[0053] In the present application, by storing a single-person reagent for detection in the first storage slot 13, it is possible to provide a single-person reagent for detection without using a large-capacity container, so as to meet the detection of a single person sample by the coagulation detector, reduce reagent waste, and improve the user experience. In addition, the first storage slot 13 of the reagent card strips 10 in different reagent card strip groups is used to store different types of single-person reagents, and the second storage slot 14 of at least one reagent card strip 10 in at least one reagent card strip group is used to store cleaning solution. Therefore, different reagent card strips 10 can be used to perform different tests, and the cleaning solution in the reagent card strip 10 can also be used to clean the pipetting needle, which has diversity and can meet diversified detection needs.
[0054] In some embodiments of the present application, the storage capacity of the second storage slot 14 in the same reagent card strip 10 is greater than the storage capacity of the first storage slot 13 .
[0055] As an example, the second storage tank 14 and the first storage tank 13 may have the same depth, but the cross-sectional area of the second storage tank 14 is larger than the cross-sectional area of the first storage tank 13, so that the storage volume of the second storage tank 14 is larger than the storage volume of the first storage tank 13. As an example, the depth of the second storage tank 14 may be larger than the depth of the first storage tank 13, but the cross-sectional area of the second storage tank 14 is equal to the cross-sectional area of the first storage tank 13, so that the storage volume of the second storage tank 14 is larger than the storage volume of the first storage tank 13.
[0056] During the operation of the coagulation detector, the pipette needle needs to clean its own inner wall of the needle tube with cleaning fluid after each sample or reagent addition. The more items are tested, the more types of single-person reagents need to be used, the more times the pipette needle needs to be cleaned, and therefore the total amount of cleaning fluid required is also greater.
[0057] By setting the storage volume of the second storage tank 14 to be larger than the storage volume of the first storage tank 13, more cleaning liquid can be stored by utilizing the larger volume of the second storage tank 14, so as to facilitate multiple cleaning of the pipetting needle and improve the reliability of detection.
[0058] In some embodiments of the present application, there are two reagent card strip groups, and the reagent card strips 10 of one reagent card strip group are defined as first reagent card strips 11, and the reagent card strips 10 of the other reagent card strip group are defined as second reagent card strips 12;
[0059] The first storage slot 13 of the first reagent card strip 11 is used to store a single-person reagent for at least one of the PT test, the ATPP test, the TT (Thrombin Time) test, and the FIB (Fibrinogen) test, and the second storage slot 14 of the first reagent card strip 11 is used to store a cleaning solution;
[0060] The first storage slot 13 of the second reagent card strip 12 is used to store single-person reagents for at least one of the FDP (Fibrinogen Degradation Products) test, DD (D-Dimer) test and AT-III (Antithrombin-III) test, and the second storage slot 14 of the second reagent card strip 12 is used to store single-person reagents or cleaning solutions for at least one of the FDP test, DD test and AT-III test.
[0061] by Figure 1 For example, two reagent card strip bearing positions 21 set in the extension direction of the bearing frame 20 are defined as the first reagent card strip bearing position and the second reagent card strip bearing position, respectively, and the two reagent card strip groups are the first reagent card strip group and the second reagent card strip group, and all the reagent card strips 10 in the first reagent card strip group are called first reagent card strips 11, and all the reagent card strips 10 in the second reagent card strip group are called second reagent card strips 12. The first reagent card strip 11 is placed in the first reagent card strip bearing position, and the second reagent card strip 12 is placed in the second reagent card strip bearing position.
[0062] Please also read Figure 2 , the first reagent card strip 11 cooperates with the second reagent card strip 12, so that the coagulation tester can perform multiple tests. For example, taking the first storage slot 13 of the first reagent card strip 11 storing single-person reagents for PT detection and ATPP detection, and the second reagent card strip 12 storing single-person reagents for FDP detection and DD detection as an example, when the first reagent card strip 11 is located at the first reagent card strip carrying position, the first reagent card strip 11 can be used for PT detection and ATPP detection of a single person sample, and when the second reagent card strip 12 is located at the second reagent card strip carrying position, the second reagent card strip 12 can be used for FDP detection and DD detection of a single person sample. The first reagent card strip 11 cooperates with the second reagent card strip 12 to be used for PT detection, ATPP detection, FDP detection and DD detection of a single person sample.
[0063] The second storage slot 14 of the second reagent card strip 12 can be used to store a single reagent or a cleaning solution. When the second storage slot 14 of the second reagent card strip 12 is used to store a single reagent, the second reagent card strip 12 must be used in conjunction with the first reagent card strip 11 storing the cleaning solution, so that the pipette needle can be cleaned with the cleaning solution in the first reagent card strip 11. When the cleaning solution is stored in the second reagent card strip 12, the second reagent card strip 12 can be used alone.
[0064] Through the above design, the single-person reagents stored in the first reagent card strip 11 and the second reagent card strip 12 are diversified, and the two can be used independently or in combination to perform multiple tests on single-person samples, meeting diversified testing needs.
[0065] Further, in some embodiments of the present application, one of the reagent card strips has a plurality of first reagent card strips 11, and the first reagent card strips 11 have six first storage slots 13 and two second storage slots 14 sequentially arranged along the extension direction thereof;
[0066] All first reagent card strips 11 are divided into five types; any one first storage slot 13 of the first reagent card strip 11 of the first type and any two first storage slots 13 of the first reagent card strip 11 of the second type are used to store single-person reagents for PT detection; any three first storage slots 13 of the first reagent card strip 11 of the third type are used to store single-person reagents for PT detection and two single-person reagents for ATPP detection (in Figure 2 In the embodiment, the first single-serving reagent for ATPP detection is referred to as ATPP-1, and the second single-serving reagent for ATPP detection is referred to as ATPP-2); any five first storage slots 13 of the fourth type of first reagent card strip 11 are used to store a single-serving reagent for PT detection, two single-serving reagents for ATPP detection, and two single-serving reagents for FIB detection (in Figure 2 The first single-serving reagent for FIB detection is referred to as FIB-1, and the second single-serving reagent for FIB detection is referred to as FIB-2); the six first storage slots 13 of the fifth type of first reagent card strip 11 are respectively used to store a single-serving reagent for PT detection, two single-serving reagents for ATPP detection, two single-serving reagents for FIB detection, and a single-serving reagent for TT detection, and at least one second storage slot 14 of the first to fifth types of first reagent card strips 11 is used to store a cleaning solution.
[0067] There may be one or more first reagent card strips 11 of each type, and the specific number can be set according to requirements.
[0068] Taking the six first storage slots 13 arranged along the extension direction of the first reagent card strip 11 as an example, namely the first first storage slot 13, the second first storage slot 13... and the sixth first storage slot 13, when any first storage slot 13 in the first type of first reagent card strip 11 is used to store a single-person reagent for PT detection, for example, the first first storage slot 13 of the first type of first reagent card strip 11 is used to store the reagent for PT detection, or the second first storage slot 13 of the first type of first reagent card strip 11 is used to store the reagent for PT detection, and so on.
[0069] Any two first storage slots 13 of the second type first reagent card strip 11 store single-person reagents for PT detection. Therefore, the second type first reagent card strip 11 can be used for PT detection of double-person samples.
[0070] By setting a plurality of types of first reagent card strips 11, different types of first reagent card strips 11 can be used for various project detection independently or in combination with the second reagent card strip 12, which is conducive to meeting diversified detection needs. In addition, at least one second storage slot 14 of the first to fifth types of first reagent card strips 11 is used to store cleaning liquid, and each first reagent card strip 11 is used independently or in combination with the second reagent card strip 12, which is conducive to the full cleaning of the pipette needle.
[0071] Further, in some embodiments of the present application, the first storage slots 13 for storing single-serving reagents for PT detection of the first reagent card strips 11 of the first to fifth types are unified; the first storage slots 13 for storing the first single-serving reagents for ATPP detection of the first reagent card strips 11 of the third to fifth types are unified; the first storage slots 13 for storing the second single-serving reagents for ATPP detection of the first reagent card strips 11 of the third to fifth types are unified; the first storage slots 13 for storing the first single-serving reagents for FIB detection of the first reagent card strips 11 of the fourth to fifth types are unified; the first storage slots 13 for storing the second single-serving reagents for FIB detection of the first reagent card strips 11 of the fourth to fifth types are unified, and the second storage slots 14 for storing the cleaning solution of the first reagent card strips 11 of the first to fourth types are unified.
[0072] Here, unified means the same location. For example, the first storage slots 13 for storing single-serving reagents for PT detection in the first reagent card strips 11 of the first to fifth types are unified, which means that the first storage slots 13 for storing single-serving reagents for PT detection in the first reagent card strips 11 of the first to fifth types are the first storage slots 13 at the same location.
[0073] Specific as Figure 2As shown, the first first storage slot 13 of the first reagent card strips 11 of the first to fifth types and the second first storage slot 13 of the first reagent card strips 11 of the second type are all used to store single-serving reagents for PT detection; the second first storage slot 13 of the first reagent card strips 11 of the third to fifth types are all used to store the first single-serving reagent for ATPP detection; the third first storage slot 13 of the first reagent card strips 11 of the third to fifth types are all used to store the second single-serving reagent for ATPP detection; the fourth first storage slot 13 of the first reagent card strips 11 of the fifth type is used to store the single-serving reagent for TT detection; the fifth first storage slot 13 of the first reagent card strips 11 of the fourth to fifth types is used to store the first single-serving reagent for FIB detection, the sixth first storage slot 13 of the first reagent card strips 11 of the fourth to fifth types is used to store the second single-serving reagent for FIB detection, and the first second storage slot 14 of the first reagent card strips 11 of the first to fourth types are all used to store cleaning solution. The first second storage slot 14 of some first reagent card strips 11 of the fifth type is used to store cleaning solution, and the first and second second storage slots 14 of the remaining first reagent card strips 11 of the fifth type are both used to store cleaning solution.
[0074] For example, Figure 2As shown, the storage conditions of the six first storage slots 13 and the two second storage slots 14 of the first reagent card strip 11 of the first type are: single-portion reagent for PT detection, empty, empty, empty, empty, empty, cleaning solution, empty. The storage conditions of the six first storage slots 13 and the two second storage slots 14 of the second type of first reagent card strip 11 are: single-portion reagent for PT detection, single-portion reagent for PT detection, empty, empty, empty, empty, cleaning solution, empty. The storage conditions of the six first storage slots 13 and the two second storage slots 14 of the third type of first reagent card strip 11 are: single-portion reagent for PT detection, first single-portion reagent for APTT detection, second single-portion reagent for APTT detection, empty, empty, empty, cleaning solution, empty. The storage conditions of the six first storage slots 13 and the two second storage slots 14 of the first reagent card strip 11 of the fourth type are: single-serving reagent for PT detection, the first single-serving reagent for APTT detection, the second single-serving reagent for APTT detection, empty, the first single-serving reagent for FIB detection, the second single-serving reagent for FIB detection, cleaning solution, empty. The storage conditions of the six first storage slots 13 and the two second storage slots 14 of the first reagent card strip 11 of the fifth type are: single-serving reagent for PT detection, the first single-serving reagent for APTT detection, the second single-serving reagent for APTT detection, single-serving reagent for TT detection, the first single-serving reagent for FIB detection, the second single-serving reagent for FIB detection, cleaning solution, empty. Alternatively, the storage conditions of the six first storage slots 13 and the two second storage slots 14 of the fifth type of first reagent card strip 11 are as follows: single-person reagent for PT detection, the first single-person reagent for APTT detection, the second single-person reagent for APTT detection, a single-person reagent for TT detection, the first single-person reagent for FIB detection, the second single-person reagent for FIB detection, cleaning solution, and cleaning solution.
[0075] By setting different types of first reagent card strips 11 to store the same type of single-portion reagent in the first storage slot 13 in a unified manner, and the first and second storage slots 14 of different types of first reagent card strips 11 are both used to store cleaning solution, during the reagent or cleaning solution filling process, different types of first reagent card strips 11 can be uniformly filled with the same type of single-portion reagent or cleaning solution, thereby reducing the frequency of repeated flushing of the filling pipeline and improving the filling efficiency.
[0076] In some embodiments of the present application, different first storage slots 13 in the second reagent card strip 12 are used to store different types of single-serving reagents.
[0077] The second reagent card strip 12 of this storage method can store a variety of single-person reagents, thereby ultimately achieving diversified project testing.
[0078] In some embodiments of the present application, another reagent card strip group has a plurality of second reagent card strips 12, and the second reagent card strips 12 have six first storage slots 13 and two second storage slots 14 arranged in sequence along the extension direction thereof;
[0079] All second reagent card strips 12 are divided into five types; the six first storage slots 13 and two second storage slots 14 of the first type of second reagent card strip 12 are respectively used to store three single-person reagents for FDP detection (in Figure 2 The first single-dose reagent for FDP detection is referred to as FDP-1, the second single-dose reagent for FDP detection is referred to as FDP-2, and the third single-dose reagent for FDP detection is referred to as FDP-3). Figure 2 The first single-dose reagent for DD detection is referred to as DD-1, the second single-dose reagent for DD detection is referred to as DD-2), and the three single-dose reagents for AT-III detection (in Figure 2 In the embodiment, the first single-serving reagent for AT-III detection is referred to as AT-III-1, the second single-serving reagent for AT-III detection is referred to as AT-III-2, and the third single-serving reagent for AT-III detection is referred to as AT-III-3); any two first storage slots 13 of the second reagent card strip 12 of the second type are respectively used to store two single-serving reagents for DD detection; any three first storage slots 13 of the second reagent card strip 12 of the third type are respectively used to store three single-serving reagents for FDP detection; any five first storage slots 13 of the second reagent card strip 12 of the fourth type are respectively used to store three single-serving reagents for FDP detection and two single-serving reagents for DD detection; any three first storage slots 13 of the second reagent card strip 12 of the fifth type are respectively used to store three single-serving reagents for AT-III detection, and at least one second storage slot 14 of the second reagent card strips 12 of the first to fifth types is used to store cleaning solution.
[0080] There may be one or more second reagent card strips 12 of each type, and the specific number may be set according to requirements.
[0081] Taking the six first storage slots 13 arranged along the extension direction of the second reagent card strip 12 as an example, namely the first storage slot 13, the second first storage slot 13... and the sixth first storage slot 13, any three first storage slots 13 of the fifth type of second reagent card strip 12 are respectively used to store three single-portion reagents for AT-III detection. For example, the first first storage slot 13 of the fifth type of second reagent card strip 12 stores the first single-portion reagent for AT-III detection, the second first storage slot 13 of the fifth type of second reagent card strip 12 stores the second single-portion reagent for AT-III detection, and the third first storage slot 13 of the fifth type of second reagent card strip 12 stores the third single-portion reagent for AT-III detection, or the third first storage slot 13 of the fifth type of second reagent card strip 12 stores the first single-portion reagent for AT-III detection, the fourth first storage slot 13 of the fifth type of second reagent card strip 12 stores the second single-portion reagent for AT-III detection, and the third first storage slot 13 of the fifth type of second reagent card strip 12 stores the fifth single-portion reagent for AT-III detection. The first storage slots 13 of the first to fifth types of second reagent card strips 12 and the second storage slots 14 of the first type of second reagent card strips 12 are used to store single-dose reagents, and the second storage slots 14 of the second to fifth types of second reagent card strips 12 are used to store cleaning solutions.
[0082] It is worth mentioning that, since the first type of second reagent card strip 12 does not contain cleaning fluid, the second type of second reagent card strip 12 should be used in conjunction with the first reagent card strip 11 containing cleaning fluid.
[0083] By providing multiple types of second reagent card strips 12 , different types of second reagent card strips 12 can be used for various project tests independently or in combination with the first reagent card strips 11 , which is helpful to meet diversified test requirements.
[0084] Furthermore, in some embodiments of the present application, the first storage slots 13 for storing single-portion reagents for FDP detection of the second reagent card strips 12 of the first type, the third type, and the fourth type are unified; the first storage slots 13 for storing single-portion reagents for DD detection of the second reagent card strips 12 of the first type, the third type, and the fourth type are unified, and the second storage slots 14 for storing cleaning solution of the second reagent card strips 12 of the second type to the fifth type are unified.
[0085] For example, Figure 2As shown, the first first storage slot 13 of the second reagent card strips 12 of the first type, the third type and the fourth type is used to store the first single-person reagent for FDP detection; the second first storage slot 13 of the second reagent card strips 12 of the first type, the third type and the fourth type is used to store the second single-person reagent for FDP detection; the third first storage slot 13 of the second reagent card strips 12 of the first type, the third type and the fourth type is used to store the third single-person reagent for FDP detection; the fourth first storage slot 13 of the second reagent card strips 12 of the first type, the second type and the fourth type is used to store the third single-person reagent for FDP detection; The first single-serving reagent for DD detection is used; the fifth first storage slot 13 of the second reagent card strips 12 of the first type, the second type and the fourth type is used to store the second single-serving reagent for DD detection; the sixth first storage slot 13 and the two second storage slots 14 of the first type of second reagent card strips 12 are respectively used to store three single-serving reagents for AT-III detection; the first three first storage slots 13 of the second reagent card strips 12 of the fifth type are respectively used to store three single-serving reagents for AT-III detection; the first first storage slot 13 of the second reagent card strips 12 of the second to fifth types is used to store cleaning solution.
[0086] When the reagent is in use, the first type of first reagent card strip 11 is used for PT detection of single person samples, the second type of first reagent card strip 11 is used for PT detection of double person samples, the third type of first reagent card strip 11 is used for PT detection and APTT detection of single person samples, the fourth type of first reagent card strip 11 is used for PT detection, APTT detection and FIB detection of single person samples, and the fifth type of first reagent card strip 11 in which the first second storage tank 14 stores cleaning solution is used for PT detection, APTT detection, TT detection and FIB detection of single person samples, commonly known as the four coagulation tests.
[0087] The first and second second storage tanks 14 both store the fifth type of first reagent card strip 11 of the cleaning solution and the first type of second reagent card strip 12 for use in PT detection, APTT detection, TT detection, FIB detection, FDP detection, DD detection and AT-III detection of single human samples, commonly known as the seven coagulation tests. The first second storage tank 14 stores the fifth type of first reagent card strip 11 of the cleaning solution and the second type of second reagent card strip 12 for use in PT detection, APTT detection, TT detection, FIB detection and DD detection of single human samples, commonly known as the five coagulation tests.
[0088] The second reagent card strip 12 of the second type is used for DD detection of a single sample, the second reagent card strip 12 of the third type is used for FDP detection of a single sample, and the second reagent card strip 12 of the fourth type is used for FDP detection and DD detection of a single sample, commonly known as fibrinolysis two-step detection. The first reagent card strip 11 of the fourth type is used in conjunction with the second reagent card strip 12 of the second type for PT detection, APTT detection, FIB detection and DD detection of a single sample. The second reagent card strip 12 of the fifth type is used for AT-III detection of a single sample, commonly known as anticoagulant ability detection.
[0089] By setting different types of second reagent card strips 12 to store the same type of single-portion reagent, the first storage slots 13 are as unified as possible, and the first second storage slots 14 of different types of second reagent card strips 12 are used to store cleaning liquid as much as possible. Therefore, during the reagent or cleaning liquid filling process, different types of second reagent card strips 12 can be uniformly filled with the same type of single-portion reagent or cleaning liquid, reducing the frequency of repeated flushing of the filling pipeline and improving the filling efficiency.
[0090] The reagent carrying mechanism 1 and the coagulation detector can provide single-portion reagents for testing by storing single-portion reagents for testing in the first storage slot 13, without using a large-capacity container, so as to meet the testing of single-person samples by the coagulation detector, reduce reagent waste, and improve user experience. In addition, the first storage slot 13 of the reagent card strips 10 in different reagent card strip groups is used to store different types of single-portion reagents, and the second storage slot 14 of at least one reagent card strip 10 in at least one reagent card strip group is used to store cleaning solution. Therefore, different reagent card strips 10 can be used to perform different tests, and the cleaning solution in the reagent card strip 10 can also be used to clean the pipetting needle, which has diversity and can meet diversified testing needs.
[0091] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
[0092] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.
Claims
1. A reagent carrying mechanism, characterized in that: The reagent carrying mechanism comprises: a carrier frame (20); and At least two different reagent card strip groups, each of the reagent card strip groups comprising at least one reagent card strip (10), and each of the reagent card strips (10) in each of the reagent card strip groups can be selectively and detachably mounted on the carrier (20); Each of the reagent card strips (10) in each group of the reagent card strip groups has a first storage slot (13) and a second storage slot (14) arranged along its own extension direction; the first storage slot (13) of each of the reagent card strips (10) in each group of the reagent card strip groups is used to store a single-portion reagent for detection; the first storage slots (13) of the reagent card strips (10) in different groups of the reagent card strips are used to store different types of single-portion reagents; and the second storage slot (14) of at least one of the reagent card strips (10) in at least one group of the reagent card strip groups is used to store a cleaning solution.
2. The reagent carrying mechanism according to claim 1, characterized in that: There are two groups of reagent card strips, wherein the reagent card strips (10) in one group of the reagent card strips are defined as first reagent card strips (11), and the reagent card strips (10) in the other group of the reagent card strips are defined as second reagent card strips (12); The first storage slot (13) of the first reagent card strip (11) is used to store a single-person reagent for at least one of the prothrombin time test, the activated partial thromboplastin time test, the thrombin time test and the fibrinogen test, and the second storage slot (14) of the first reagent card strip (11) is used to store a cleaning solution; The first storage slot (13) of the second reagent card strip (12) is used to store a single-person reagent for at least one of the fibrin degradation product detection, D-dimer detection and antithrombin III detection, and the second storage slot (14) of the second reagent card strip (12) is used to store a single-person reagent or cleaning solution for at least one of the fibrin degradation product detection, D-dimer detection and antithrombin III detection.
3. The reagent carrying mechanism according to claim 2, characterized in that: One of the reagent card strip groups comprises a plurality of first reagent card strips (11), wherein the first reagent card strip (11) comprises six first storage slots (13) and two second storage slots (14) arranged in sequence along its extension direction; All the first reagent card strips (11) are divided into five types; Any one of the first storage slots (13) of the first reagent card strip (11) of the first type and any two of the first storage slots (13) of the first reagent card strip (11) of the second type are used to store a single-portion reagent for prothrombin time detection; any three of the first storage slots (13) of the first reagent card strip (11) of the third type are respectively used to store a single-portion reagent for prothrombin time detection and two single-portion reagents for activated partial thromboplastin time detection; any five of the first storage slots (13) of the first reagent card strip (11) of the fourth type are respectively used to store a single-portion reagent for prothrombin time detection and two single-portion reagents for activated partial thromboplastin time detection. Single-serve reagent for prothrombin time detection, two single-serve reagents for activated partial thromboplastin time detection, and two single-serve reagents for fibrinogen detection; the six first storage slots (13) of the fifth type of the first reagent card strip (11) are respectively used to store a single-serve reagent for prothrombin time detection, two single-serve reagents for activated partial thromboplastin time detection, two single-serve reagents for fibrinogen detection, and a single-serve reagent for thrombin time detection; at least one of the second storage slots (14) of the first to fifth types of the first reagent card strips (11) is used to store cleaning solution.
4. The reagent carrying mechanism according to claim 3, characterized in that: The first reagent card strips (11) of the first type to the fifth type have a unified first storage slot (13) for storing a single-serving reagent for prothrombin time detection; the first reagent card strips (11) of the third type to the fifth type have a unified first storage slot (13) for storing a first single-serving reagent for activated partial thromboplastin time detection; the first reagent card strips (11) of the third type to the fifth type have a unified first storage slot (13) for storing a second single-serving reagent for activated partial thromboplastin time detection; the first reagent card strips (11) of the fourth type to the fifth type have a unified first storage slot (13) for storing a first single-serving reagent for fibrinogen detection; the first reagent card strips (11) of the fourth type to the fifth type have a unified first storage slot (13) for storing a second single-serving reagent for fibrinogen detection; and the first reagent card strips (11) of the first type to the fourth type have a unified second storage slot (14) for storing a cleaning solution.
5. The reagent carrying mechanism according to claim 4, characterized in that: The first first storage slot (13) of the first reagent card strip (11) of the first type to the fifth type and the second first storage slot (13) of the first reagent card strip (11) of the second type are both used to store a single-person reagent for PT detection; the second first storage slot (13) of the first reagent card strip (11) of the third type to the fifth type are both used to store a first single-person reagent for activated partial thromboplastin time detection; the third first storage slot (13) of the first reagent card strip (11) of the third type to the fifth type are both used to store a second single-person reagent for activated partial thromboplastin time detection. The fourth first storage slot (13) of the fifth type of the first reagent card strip (11) is used for storing a single-person reagent for thrombin time detection; the fifth first storage slot (13) of the first reagent card strip (11) of the fourth to fifth types is used for storing a first single-person reagent for fibrinogen detection; the sixth first storage slot (13) of the first reagent card strip (11) of the fourth to fifth types is used for storing a second single-person reagent for fibrinogen detection, and the first second storage slot (14) of the first to fourth types of the first reagent card strip (11) is used for storing a cleaning solution.
6. The reagent carrying mechanism according to any one of claims 2 to 5, characterized in that: Different first storage slots (13) in the second reagent card strip (12) are used to store different types of single-person reagents.
7. The reagent carrying mechanism according to claim 6, characterized in that: Another group of the reagent card strips comprises a plurality of the second reagent card strips (12), wherein the second reagent card strips (12) have six first storage slots (13) and two second storage slots (14) arranged in sequence along the extension direction thereof; All the second reagent card strips (12) are divided into five types; The six first storage slots (13) and two second storage slots (14) of the first type of the second reagent card strip (12) are respectively used to store three single-portion reagents for fibrin degradation product detection, two single-portion reagents for D-dimer detection, and three single-portion reagents for antithrombin III detection; any two of the first storage slots (13) of the second type of the second reagent card strip (12) are respectively used to store two single-portion reagents for D-dimer detection; any three of the first storage slots (13) of the third type of the second reagent card strip (12) are respectively used to store Three single-serving reagents for detecting fibrin degradation products; any five of the first storage slots (13) of the fourth type of the second reagent card strip (12) are respectively used to store three single-serving reagents for detecting fibrin degradation products and two single-serving reagents for detecting D-dimer; any three of the first storage slots (13) of the fifth type of the second reagent card strip (12) are respectively used to store three single-serving reagents for detecting antithrombin III, and at least one of the second storage slots (14) of the first to fifth types of the second reagent card strip (12) is used to store cleaning solution.
8. The reagent carrying mechanism according to claim 7, characterized in that: The first storage slot (13) for storing a single-portion reagent for detecting fibrin degradation products of the second reagent card strips (12) of the first type, the third type to the fourth type is unified; the first storage slot (13) for storing a single-portion reagent for detecting D-dimer of the second reagent card strips (12) of the first type, the third type and the fourth type is unified; the second storage slot (14) for storing a cleaning solution of the second reagent card strips (12) of the second type to the fifth type is unified.
9. The reagent carrying mechanism according to claim 8, characterized in that: The first first storage slot (13) of the second reagent card strip (12) of the first type, the third type and the fourth type is used for storing the first single-serving reagent for detecting fibrin degradation products; the second first storage slot (13) of the second reagent card strip (12) of the first type, the third type and the fourth type is used for storing the second single-serving reagent for detecting fibrin degradation products; the third first storage slot (13) of the second reagent card strip (12) of the first type, the third type and the fourth type is used for storing the third single-serving reagent for detecting fibrin degradation products; the fourth first storage slot (13) of the second reagent card strip (12) of the first type, the second type and the fourth type is used for storing D - A first single-serve reagent for D-dimer detection; the fifth first storage slot (13) of the second reagent card strip (12) of the first type, the second type and the fourth type is used to store the second single-serve reagent for D-dimer detection; the sixth first storage slot (13) and two second storage slots (14) of the second reagent card strip (12) of the first type are respectively used to store three single-serve reagents for antithrombin III detection; the first three first storage slots (13) of the second reagent card strip (12) of the fifth type are respectively used to store three single-serve reagents for antithrombin III detection; the first first storage slot (13) of the second reagent card strip (12) of the second to fifth types is used to store cleaning solution.
10. A blood coagulation detector, characterized in that: The blood coagulation detector comprises: A reagent carrying mechanism as described in any one of claims 1 to 9 above; cleaning facilities; and A pipetting mechanism having a pipetting needle; The pipette needle is used to transfer a single-amount reagent in the first storage tank (13), and the pipette needle uses a cleaning fluid to clean the inner wall of its own needle tube at the cleaning mechanism before or after each transfer of the single-amount reagent, and the cleaning mechanism is used to clean the outer wall of the needle tube of the pipette needle.