Composite chitosan dressing

Abstract

The utility model provides a composite chitosan dressing, and relates to the technical field of dressing articles. The dressing comprises an air inflation layer and an air inflation layer, the polyurethane film layer is arranged on the air inflation layer and is bonded with the air inflation layer; the chitosan hydrogel film layer is arranged on the polyurethane film layer, and a plurality of through holes are formed in the chitosan hydrogel film layer; and the release layer is bonded with the chitosan hydrogel film layer. The dressing provided by the utility model is simple in structure, and the healing promoting effect of the dressing on a wound surface and the use comfort of a patient are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of dressing supplies, in particular to a composite chitosan dressing. Background Art

[0002] Human skin is mainly composed of epidermis, dermis and subcutaneous tissue. The dermis is mainly composed of collagen secreted by fibroblast precursor cells. The collagen fibers that constitute collagen are neatly arranged to maintain the smoothness, luster, elasticity and toughness of the skin. However, trauma or infection such as burns, scalds, acne, surgery, etc. causes the dermis layer composed of collagen to be defective and the collagen structure to be disordered. The organism in the human body cannot completely repair the dermis and subcutaneous tissues, which are complex in structure. Therefore, when the epidermis is torn and the dermis is injured, the wound can only be repaired by connective tissue. At this time, the collagen fibers that were originally neatly arranged began to shrink, disorder, backlog, and break, and new capillaries and nerve fibers grew into the new connective tissue. In this way, the misaligned arrangement and regeneration of collagen fibers make the healed skin uneven, and the blood circulation of the injured skin becomes unstable, and the pigment of the injured skin will mutate. The surface layer of the skin can be repaired by the division of the basal cells of the epidermis, but this usually causes color changes. It is difficult for the skin to repair its original shape and color, thus forming uneven, color-changing scars.

[0003] Large scars after wound healing will cause physical and psychological trauma to patients, especially some exposed parts such as limbs, neck, etc., which seriously affect patients' daily life. There are many ways to prevent and treat scars, mainly applying scar cream, using medical dressings, wearing elastic clothing, superficial radiotherapy, injection therapy, laser therapy and surgical treatment. However, these methods have their own shortcomings. For example, laser therapy is mainly used to treat scars that have already occurred in the late stage of wound healing. Not only is the treatment cost high, but it is also difficult to achieve perfect results; scar cream has a single efficacy and poor therapeutic effect; medical dressings have a single structure and can only be applied alone. Different dressings need to be replaced, which is time-consuming and cannot meet people's needs; and the existing composite dressings have a complex structure. It is difficult to exert the actual effect of the dressings by simply splicing and assembling dressings with different functions. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a composite chitosan dressing to improve the healing effect of the dressing on the wound surface and the comfort level of the patient in use.

[0005] In order to solve the above technical problems, the solutions provided by the embodiments of the present utility model are as follows:

[0006] A composite chitosan dressing, comprising:

[0007] Inflatable layer;

[0008] A polyurethane film layer disposed on the inflation layer and bonded to the inflation layer;

[0009] A chitosan hydrogel film layer is disposed on the polyurethane film layer, wherein the chitosan hydrogel film layer is provided with a plurality of through holes;

[0010] A release layer bonded to the chitosan hydrogel film layer.

[0011] Optionally, the area of ​​the inflation layer is larger than the area of ​​the polyurethane film layer;

[0012] The area of ​​the polyurethane film layer is greater than that of the chitosan hydrogel film layer.

[0013] Optionally, the inflation layer is made of one of rubber, polyurethane and polyethylene.

[0014] Optionally, the inflation layer comprises:

[0015] An air-filled layer body having a cavity structure;

[0016] A first bonding surface disposed at a first end of the inflation layer body;

[0017] A second bonding surface is disposed at the second end of the inflation layer body and can be bonded to the first bonding surface.

[0018] Optionally, a one-way valve switch communicating with the cavity structure is provided on the inflation layer body.

[0019] Optionally, a plurality of through holes are evenly opened on the chitosan hydrogel film layer.

[0020] Optionally, the apertures of the plurality of through holes are 0.5 mm to 3 mm, and the spacing between the plurality of through holes is 1 mm to 5 mm.

[0021] Optionally, silicone gel is evenly coated on the surface of the polyurethane film layer in contact with the chitosan hydrogel film layer.

[0022] Optionally, the thickness of the polyurethane film layer coated with silicone gel is 0.1 cm-0.5 cm.

[0023] Optionally, the release layer includes:

[0024] A first release layer;

[0025] A second release layer is arranged in parallel with the first release layer.

[0026] The above solution of the utility model includes at least the following beneficial effects:

[0027] The dressing provided by the above scheme of the utility model comprises: an air-filled layer; a polyurethane film layer arranged on the air-filled layer and bonded to the air-filled layer; a chitosan hydrogel film layer arranged on the polyurethane film layer, wherein a plurality of through holes are provided on the chitosan hydrogel film layer; and a release layer bonded to the chitosan hydrogel film layer. The dressing provided by the utility model has a simple structure and is easy to use. The air-filled layer applies pressure during the wound healing period to reduce the force of the wound being stretched outward, thereby effectively preventing scar hyperplasia. The polyurethane film layer can inhibit capillary regeneration and reduce collagen deposition during the wound healing period, and the pressure applied by the air-filled layer can prevent scar hyperplasia. The hemostatic, antibacterial and healing-promoting properties of the chitosan hydrogel film layer can accelerate wound healing in the early and middle stages of wound care. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 is a top view of the composite chitosan dressing provided by an embodiment of the utility model;

[0029] Explanation of the accompanying drawings: 11. First release layer; 12. Second release layer; 2. Chitosan hydrogel film layer; 21. Through hole; 3. Polyurethane film layer; 4. Inflatable layer; 40. Inflatable layer body; 41. First bonding surface; 42. Second bonding surface; 43. One-way valve switch. DETAILED DESCRIPTION

[0030] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the accompanying drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments described herein. On the contrary, these embodiments are provided to enable a more thorough understanding of the present invention and to fully convey the scope of the present invention to those skilled in the art.

[0031] Here, firstly, the mechanism of action of the chitosan hydrogel film layer mentioned in the following embodiments of the present invention is described:

[0032] Hemostatic mechanism of chitosan hydrogel film: Chitosan has active amino groups that can aggregate red blood cells and concentrate platelets to achieve hemostatic function without relying on conventional coagulation pathways;

[0033] The antibacterial mechanism of chitosan hydrogel film: active amino groups can combine with negatively charged substances in bacteria, such as milk protein and nucleic acid, affecting the normal physiological functions of cells and causing death, or adsorb on the surface of bacterial cells to form a polymer film, causing changes in their permeability and causing cell death;

[0034] The healing mechanism of chitosan hydrogel film: Chitosan can promote the migration and proliferation of fibroblasts; chitosan activates the activity of major histocompatibility complex, Fc receptor (antibody crystallizable fragment) and mannitol receptor, thereby promoting the release of macrophages; chitosan can promote the synthesis of human epidermal cell DNA; chitosan can promote the activity of prolyl hydroxylase, thereby accelerating the synthesis of collagen;

[0035] like Figure 1 As shown, the embodiment of the utility model provides a composite chitosan dressing, comprising:

[0036] Inflatable layer 4;

[0037] A polyurethane film layer 3 disposed on the inflation layer 4 and bonded to the inflation layer 4;

[0038] A chitosan hydrogel film layer 2 is disposed on the polyurethane film layer 3, and a plurality of through holes 21 are formed on the chitosan hydrogel film layer 2;

[0039] A release layer 1 bonded to the chitosan hydrogel film layer 2.

[0040] In this embodiment, the inflation layer 4, the polyurethane film layer 3, the chitosan hydrogel film layer 2 and the release layer 1 are stacked and bonded in sequence to form an overall structure of a dressing having different functional layers; here, the functional layers can be bonded together by an adhesive; preferably, the adhesive can be α-cyanoacrylic acid;

[0041] One side of the chitosan hydrogel film layer 2 is in contact with the polyurethane film layer 3, and the other side is in contact with the wound surface. In an optional embodiment of the present invention, silicone gel is evenly coated on the side of the polyurethane film layer 3 in contact with the chitosan hydrogel film layer 2. By opening a plurality of through holes 21 on the chitosan hydrogel film layer 2, the silicone gel on the polyurethane film layer 3 can fully contact with the wound surface. After contacting the wound surface, the silicone gel can promote epithelial tissue metabolism, adjust the structure and function of epithelial tissue, inhibit capillary proliferation near the wound surface, inhibit collagen deposition, improve local blood circulation, and promote epithelial repair. On the other hand, a silicone gel film can be formed to prevent infection and reduce water evaporation, which is conducive to softening scars produced during wound healing.

[0042] The unperforated portion of the chitosan hydrogel film layer 2 is directly in contact with the wound surface, and the water-locking function of the chitosan hydrogel film layer 2 can provide a moist healing environment for the wound surface, thereby accelerating wound healing. During the wound healing stage, the inflatable layer 4 can apply appropriate pressure to the wound surface. Through physical compression therapy, in conjunction with the action mechanism of the polyurethane film layer 3 and the chitosan hydrogel film layer 2, scar hyperplasia can be prevented, while the healing effect of the dressing can be improved.

[0043] The main components of the chitosan hydrogel film layer described in the embodiment of the utility model include chitosan and glycerol. During the specific preparation, chitosan can be first dissolved and precipitated in an alkaline environment to obtain a chitosan flocculated precipitate, and the chitosan flocculated precipitate is further dispersed in water within a preset pH range to obtain a chitosan hydrogel, and the chitosan hydrogel is further mixed with glycerol to obtain a chitosan hydrogel film.

[0044] In an optional embodiment of the utility model, the thickness of the polyurethane film layer 3 coated with silicone gel is 0.1cm-0.5cm; the thickness of the chitosan hydrogel film layer 2 is 0.03cm-0.1cm; by setting the polyurethane film layer and chitosan hydrogel film layer of appropriate thickness, the comfort of use is further improved.

[0045] In an optional embodiment of the utility model, a plurality of through holes 21 are evenly opened on the chitosan hydrogel film layer 2 to ensure that the silicone gel on the polyurethane film layer 3 can be in uniform contact with the wound surface with the evenly distributed through holes 21 to achieve its healing effect;

[0046] Furthermore, the aperture of the plurality of through holes 21 is 0.5 mm-3 mm, and the hole spacing of the plurality of through holes 21 is 1 mm-5 mm; by providing through holes with appropriate aperture and hole spacing, it is beneficial for the silicone gel on the polyurethane film layer 3 to contact with the wound, further giving full play to the effect of the silicone gel in promoting wound healing and preventing scar hyperplasia, thereby improving the use effect of the dressing.

[0047] In an optional embodiment of the present invention, the area of ​​the inflation layer 4 is larger than the area of ​​the polyurethane film layer 3; the area of ​​the polyurethane film layer 3 is larger than the area of ​​the chitosan hydrogel film layer 2, so as to ensure that each layer in the entire dressing is in full contact with the wound surface, fully utilize the healing mechanism of each layer structure, and ensure the healing effect of the wound surface; here, there is no specific restriction on the size of the inflation layer, the polyurethane film layer 3 and the chitosan hydrogel film layer 2, and appropriate functional layers of different sizes can be selected according to actual needs, as long as the area of ​​the inflation layer 4 is larger than the area of ​​the polyurethane film layer 3; the area of ​​the polyurethane film layer 3 is larger than the area of ​​the chitosan hydrogel film layer 2.

[0048] In an optional embodiment of the present utility model, the inflatable layer is described, and the inflatable layer 4 includes: an inflatable layer body 40 having a cavity structure;

[0049] A first bonding surface 41 disposed at a first end of the inflation layer body 40;

[0050] A second bonding surface 42 is disposed at the second end of the inflation layer body 40 and can be bonded to and matched with the first bonding surface 41 .

[0051] In this embodiment, the inflatable layer body 40 has a double-layered hollow structure; in an achievable example of the present invention, the inflatable layer 4 is made of one of rubber, polyurethane, and polyethylene. By introducing an appropriate amount of gas into the inflatable layer body 40 with a double-layered and hollow structure, the pressure in the entire inflatable layer 4 is changed, and then appropriate pressure is provided to the wound surface, forming a physical compression therapy for wound healing. In the early stage of wound healing, the polyurethane film layer 3 and the chitosan hydrogel film layer 2 can be ensured to be in full contact with the wound surface, thereby achieving the functions of preventing scar hyperplasia and wound healing; in the late stage of wound healing and while consuming part of the raw materials, pressure is applied through the inflatable layer 4 to further promote the polyurethane film layer 3 and the chitosan hydrogel film layer 2 to fit the wound surface, thereby ensuring the healing effect;

[0052] The first adhesive surface 41 and the second adhesive surface 42 are respectively fixedly connected to the two ends of the inflation layer body 40. Preferably, the first adhesive surface 41 can be set as a Velcro fleece surface, and the second adhesive surface 42 can be set as a Velcro hook surface. When the dressing is used, the first adhesive surface 41 and the second adhesive surface 42 cooperate with each other to fix the dressing on the outside of the wound surface.

[0053] Preferably, a one-way valve switch 43 connected to the cavity structure is provided on the inflation layer body 40, so that an appropriate amount of gas can be introduced into the inflation layer body 40 through the one-way valve switch 43 to provide pressure to cooperate with the polyurethane film layer 3 and the chitosan hydrogel film layer 2 to promote wound healing.

[0054] In an optional embodiment of the present invention, the release layer is described. The release layer includes: a first release layer 11 ; and a second release layer 12 arranged in parallel with the first release layer 11 .

[0055] In this embodiment, the first release layer 11 and the second release layer 12 cooperate with each other and are peelably bonded to the chitosan hydrogel film layer 2. When the dressing is not used, the first release layer 11 and the second release layer 12 cooperate with each other and are bonded to the chitosan hydrogel film layer 2 to avoid failure of the active layer of the dressing (the polyurethane film layer 3 and the chitosan hydrogel film layer 2); preferably, the first release layer 11 and the second release layer 12 can both be silicone paper leaf guards.

[0056] The composite chitosan dressing provided by the utility model is first used to clean and disinfect the wound surface, then select a dressing product of suitable size, tear off the release layer, and stick the functional layer of the dressing (the chitosan hydrogel film layer 2 is directly attached to the wound surface, the inflation layer 4 is on the outside, and the polyurethane film layer 3 is arranged between the chitosan hydrogel film layer 2 and the inflation layer 4, and is attached to the wound surface through the through hole 21 on the chitosan hydrogel film layer 2) to the wound surface, and the first adhesive surface 41 and the second adhesive surface 42 cooperate with each other to fix the wound surface. The dressing is fixed; the pressure of the dressing is adjusted by the one-way valve switch 43 to give the appropriate pressure to the wound; in the process of wound healing, the polyurethane film layer 3 can inhibit capillary regeneration and reduce collagen deposition during the wound healing period, and the inflation layer 4 can give pressure during the wound healing period to reduce the force of the wound being stretched outward, and at the same time, the purpose of preventing scar hyperplasia can be achieved by cooperating with the polyurethane film layer 3; the hemostatic, antibacterial and healing-promoting properties of the chitosan hydrogel film layer 2 can accelerate wound healing in the early and middle stages of wound care.

[0057] The above is a preferred embodiment of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A composite chitosan dressing, characterized in that: include: Inflatable layer (4); A polyurethane film layer (3) disposed on the inflation layer (4) and bonded to the inflation layer (4); A chitosan hydrogel film layer (2) disposed on the polyurethane film layer (3), wherein the chitosan hydrogel film layer (2) is provided with a plurality of through holes (21); A release layer (1) bonded to the chitosan hydrogel film layer (2).

2. The composite chitosan dressing according to claim 1, characterized in that: The area of ​​the inflation layer (4) is larger than the area of ​​the polyurethane film layer (3); The area of ​​the polyurethane film layer (3) is greater than the area of ​​the chitosan hydrogel film layer (2).

3. The composite chitosan dressing according to claim 1, characterized in that: The material of the inflation layer (4) is one of rubber, polyurethane and polyethylene.

4. The composite chitosan dressing according to claim 1 or 3, characterized in that: The inflation layer (4) comprises: An air-filled layer body (40) having a cavity structure; A first bonding surface (41) provided at a first end of the inflation layer body (40); A second bonding surface (42) is disposed at the second end of the inflation layer body (40) and is bondable to the first bonding surface (41).

5. The composite chitosan dressing according to claim 4, characterized in that: The inflation layer body (40) is provided with a one-way valve switch (43) communicating with the cavity structure.

6. The composite chitosan dressing according to claim 1, characterized in that: The plurality of through holes (21) are evenly arranged on the chitosan hydrogel film layer (2).

7. The composite chitosan dressing according to claim 1 or 6, characterized in that: The hole diameters of the plurality of through holes (21) are 0.5 mm to 3 mm, and the hole spacings of the plurality of through holes (21) are 1 mm to 5 mm.

8. The composite chitosan dressing according to claim 1, characterized in that: The surface of the polyurethane film layer (3) in contact with the chitosan hydrogel film layer (2) is evenly coated with silicone gel.

9. The composite chitosan dressing according to claim 8, characterized in that: The thickness of the polyurethane film layer (3) coated with silicone gel is 0.1 cm-0.5 cm.

10. The composite chitosan dressing according to claim 1, characterized in that: The release layer comprises: A first release layer (11); A second release layer (12) is arranged in parallel with the first release layer (11).

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