Eluting device for heparin sodium

Abstract

The utility model relates to the technical field of heparin sodium elution, in particular to a heparin sodium elution device which comprises an elution tank, a rotary drum is rotatably connected to the upper end of the interior of the elution tank, the middle of the rotary drum is of a net structure, one end of the rotary drum extends to the upper portion of the elution tank and is fixedly connected with a drum cover through a plurality of connecting rods, and the other end of the rotary drum is fixedly connected with the drum cover. The upper end in the barrel cover is rotationally connected with a rotating shaft which penetrates through the rotating barrel and extends to the lower end in the elution tank, and the outer wall of the rotating shaft is fixedly connected with a spiral blade matched with the rotating barrel; the rotating shaft is matched with the spiral blade to convey resin and a sodium chloride solution with heparin sodium into the rotating drum from bottom to top, when the resin and the sodium chloride solution with heparin sodium reach the net-shaped structure, the sodium chloride solution with heparin sodium enters the elution tank through the net-shaped structure, and meanwhile, the resin continues to be conveyed through the rotating drum, so that the resin and the sodium chloride solution with heparin sodium enter the elution tank through the net-shaped structure. And the resin is discharged through a gap between the drum cover and the rotary drum, so that the eluted resin is conveniently discharged from the elution tank.

Description

Technical Field

[0001] The utility model relates to the technical field of sodium heparin elution, in particular to a sodium heparin elution device. Background Art

[0002] The elution tank for sodium heparin production is used in the elution process of the sodium heparin production process. The resin adsorbed with the sodium heparin component in the adsorption process of the previous elution process is added to the elution tank, and then the sodium chloride solution is added to the elution tank. The motor of the elution tank drives the stirrer to rotate through the stirring shaft to stir and mix the sodium chloride solution and the resin. The resin is eluted with the sodium chloride solution to obtain an elution solution, so that the eluent contains sodium heparin.

[0003] The patent number of the Chinese patent CN214522857U discloses a sodium heparin elution device, which includes an elution tank, a motor, and a liquid discharge device. The elution tank is provided with a stirrer, and the stirrer is connected to the motor arranged on the upper part of the elution tank through a stirring shaft; the liquid discharge device is arranged at the bottom of the elution tank, and a filter screen is arranged on the liquid discharge device, and the filter screen is installed on the cross section of the liquid discharge pipe of the liquid discharge device, and one end of the liquid discharge pipe is connected to the elution tank, and the other end is connected to the next process. Compared with the prior art, the sodium heparin elution device of the utility model can fully elute the resin and extract the heparin component adsorbed therein. At the same time, the utility model has a simple structure and a reasonable design, which can improve production efficiency and increase economic benefits.

[0004] After elution is completed, the above device separates the heparin-containing solution from the resin through a filter. However, the above device is inconvenient to discharge the separated resin. When discharging, the filter needs to be disassembled and then discharged through a drain pipe, which is inconvenient to use. Utility Model Content

[0005] The utility model aims to provide a sodium heparin eluting device, which has the characteristics of being easy to discharge the eluted resin and being convenient to use.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a sodium heparin elution device, comprising an elution tank, the inner upper end of the elution tank is rotatably connected to a rotating drum, the middle part of the rotating drum is set as a mesh structure, one end of the rotating drum extends to the top of the elution tank and is fixedly connected to a drum cover through a plurality of connecting rods, the inner upper end of the drum cover is rotatably connected to a rotating shaft that passes through the rotating drum and extends to the inner lower end of the elution tank, and the outer wall of the rotating shaft is fixedly connected to a spiral blade matching the rotating drum;

[0007] The inner lower end of the elution tank is fixedly connected with a filter screen, and the other end of the rotating shaft is fixedly connected with a scraper abutting against the filter screen;

[0008] The outer wall of the rotating drum is fixedly connected with a plurality of evenly distributed first stirring blades, and the inner wall of the elution tank is fixedly connected with a plurality of evenly distributed second stirring blades.

[0009] In order to drive the cylinder cover and the rotating shaft to rotate, as a preferred heparin sodium elution device of the utility model, the upper end surface of the elution tank is fixedly connected to a driving box located above the cylinder cover, the upper end surface of the cylinder cover is fixedly connected to a connecting cylinder, and the other end of the connecting cylinder extends to the interior of the driving box and is fixedly connected to a first bevel gear;

[0010] The inner upper end of the driving box is rotatably connected to the second bevel gear, and one end of the rotating shaft passes through the connecting tube and the first bevel gear and is fixedly connected to the second bevel gear.

[0011] In order to collect the resin after elution, as a preferred heparin sodium elution device of the utility model, the upper end surface of the elution tank is fixedly connected to a receiving trough which is sleeved on the outer wall of the rotating drum and flush with the rotating drum, and the outer wall of the receiving trough is connected to a discharge trough.

[0012] In order to drive the first bevel gear and the second bevel gear to rotate in opposite directions, as a preferred heparin sodium elution device of the utility model, a motor is installed on the right side wall of the drive box, and the output end of the motor extends to the interior of the drive box and is fixedly connected to a third bevel gear that is meshed with the first bevel gear and the second bevel gear.

[0013] In order to facilitate the discharge of the sodium chloride solution containing sodium heparin from the elution tank, as a preferred sodium heparin elution device of the utility model, the lower end surface of the elution tank is connected to a drain pipe, and a valve is installed on the outer wall of the drain pipe.

[0014] In order to facilitate the addition of the resin to be eluted and the sodium chloride solution into the elution tank, as a preferred elution device of sodium heparin of the utility model, the upper end surface of the elution tank is connected to a feed pipe located on one side of the receiving trough.

[0015] In order to prevent the first stirring blade and the second stirring blade from colliding with each other, as a preferred heparin sodium elution device of the utility model, the first stirring blade and the second stirring blade are staggered.

[0016] Compared with the prior art, the beneficial effects of the utility model are as follows:

[0017] The motor cooperates with the third bevel gear to drive the first bevel gear and the second bevel gear to rotate, and the first bevel gear and the second bevel gear drive the cylinder cover and the rotating shaft to rotate. The rotating shaft cooperates with the spiral blade to transport the resin and the sodium chloride solution with sodium heparin from bottom to top into the rotating cylinder. When the resin and the sodium chloride solution with sodium heparin reach the mesh structure, the sodium chloride solution with sodium heparin enters the elution tank through the mesh structure. At the same time, the resin continues to be transported through the rotating cylinder, so that the resin enters the receiving trough through the gap between the cylinder cover and the rotating cylinder, and then is discharged through the discharge trough, so that the eluted resin is conveniently discharged from the elution tank, and then the valve is opened again to discharge the sodium chloride solution with sodium heparin after the reaction through the discharge pipe, thereby completing the elution of sodium heparin. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 This is a front cross-sectional structural schematic diagram of the utility model;

[0020] Figure 3 This is a schematic diagram of the cross-sectional structure of the utility model from top view;

[0021] Figure 4 For this utility model Figure 2 The enlarged structural diagram of part a in the middle;

[0022] In the figure: 1, elution tank; 2, rotating drum; 3, drum cover; 4, rotating shaft; 5, spiral blade; 6, filter screen; 7, scraper; 8, first stirring blade; 9, second stirring blade; 10, driving box; 11, connecting cylinder; 12, first bevel gear; 13, second bevel gear; 14, receiving trough; 15, discharge trough; 16, motor; 17, third bevel gear; 18, discharge pipe; 19, valve; 20, feed pipe. DETAILED DESCRIPTION

[0023] In order to make the purpose, technical solution and advantages of the utility model clearer, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the utility model and are not used to limit the utility model. In the description of the utility model, it should be understood that the orientation or position relationship indicated by the terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc. is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the utility model. In addition, in the description of the utility model, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0024] See also Figures 1 to 4 A sodium heparin elution device comprises an elution tank 1, the upper end of the inner part of the elution tank 1 is rotatably connected with a rotating drum 2, the middle part of the rotating drum 2 is set as a mesh structure, one end of the rotating drum 2 extends to the top of the elution tank 1 and is fixedly connected with a drum cover 3 through a plurality of connecting rods, the upper end of the inner part of the drum cover 3 is rotatably connected with a rotating shaft 4 that passes through the rotating drum 2 and extends to the lower end of the inner part of the elution tank 1, and the outer wall of the rotating shaft 4 is fixedly connected with a spiral leaf 5 that matches the rotating drum 2;

[0025] A filter screen 6 is fixedly connected to the lower end of the elution tank 1, and a scraper 7 abutting against the filter screen 6 is fixedly connected to the other end of the rotating shaft 4;

[0026] The outer wall of the rotating drum 2 is fixedly connected with a plurality of evenly distributed first stirring blades 8 , and the inner wall of the elution tank 1 is fixedly connected with a plurality of evenly distributed second stirring blades 9 .

[0027] In this embodiment: when in use, the resin to be eluted and the sodium chloride solution are first added into the elution tank 1 through the feed pipe 20, so that the liquid level is located at the mesh structure, and at the same time, the mass ratio of the resin to the sodium chloride is 1:3;

[0028] Then, the drum cover 3 cooperates with a plurality of connecting rods to drive the drum 2 to rotate, and the drum 2 drives the plurality of first stirring blades 8 to rotate. The resin and the sodium chloride are stirred by the cooperation between the plurality of first stirring blades 8 and the plurality of second stirring blades 9. At the same time, the rotating shaft 4 drives the spiral blades 5 to rotate in the opposite direction, and the sodium chloride solution entering the drum 2 through the mesh structure is transported from top to bottom, so that the sodium chloride solution in the elution tank 1 circulates, thereby accelerating the mixing efficiency between the resin and the sodium chloride solution.

[0029] After a long period of stirring, the valve 19 is opened, and the sodium chloride solution with heparin after the reaction is discharged through the drain pipe 18, and the resin is filtered through the filter screen 6. At the same time, the rotating shaft 4 drives the scraper 7 to rotate, and the scraper 7 can scrape the resin on the filter screen 6 to prevent the filter screen 6 from being blocked. After the sodium chloride solution with sodium heparin after the reaction is drained, the valve 19 is closed, and then half of the previous amount of sodium chloride solution is added to the elution tank 1 again. Then, the above steps are repeated. Through multiple elutions, the resin can be fully eluted and the sodium heparin component adsorbed therein can be extracted;

[0030] After the last elution is completed, the cylinder cover 3 and the rotating shaft 4 rotate in opposite directions, and the rotating shaft 4 cooperates with the spiral blade 5 to transport the resin and the sodium chloride solution with sodium heparin from bottom to top into the rotating cylinder 2. When the resin and the sodium chloride solution with sodium heparin reach the mesh structure, the sodium chloride solution with sodium heparin enters the elution tank 1 through the mesh structure. At the same time, the resin continues to be transported through the rotating cylinder 2, so that the resin enters the receiving trough 14 through the gap between the cylinder cover 3 and the rotating cylinder 2, and then is discharged through the discharge trough 15, so that the eluted resin is conveniently discharged from the elution tank 1, and then the valve 19 is opened again to discharge the sodium chloride solution with sodium heparin after the reaction through the discharge pipe 18, thereby completing the elution of sodium heparin.

[0031] As a technical optimization solution of the utility model, the upper end surface of the elution tank 1 is fixedly connected to a driving box 10 located above the cylinder cover 3, and the upper end surface of the cylinder cover 3 is fixedly connected to a connecting cylinder 11, and the other end of the connecting cylinder 11 extends to the interior of the driving box 10 and is fixedly connected to a first bevel gear 12;

[0032] The second bevel gear 13 is rotatably connected to the upper end of the driving box 10 , and one end of the rotating shaft 4 passes through the connecting tube 11 and the first bevel gear 12 and is fixedly connected to the second bevel gear 13 .

[0033] In this embodiment, the first bevel gear 12 rotates, and the first bevel gear 12 cooperates with the connecting tube 11 to drive the tube cover 3 to rotate. At the same time, the second bevel gear 13 rotates in the opposite direction, and the second bevel gear 13 drives the rotating shaft 4 to rotate.

[0034] As a technical optimization solution of the utility model, the upper end surface of the elution tank 1 is fixedly connected with a material receiving groove 14 which is sleeved on the outer wall of the rotating drum 2 and flush with the rotating drum 2, and the outer wall of the material receiving groove 14 is connected with a material discharge groove 15.

[0035] In this embodiment, the receiving tank 14 can collect the eluted resin, and the discharging tank 15 can discharge the collected resin in a centralized manner.

[0036] As a technical optimization solution of the utility model, a motor 16 is installed on the right side wall of the drive box 10. The output end of the motor 16 extends into the interior of the drive box 10 and is fixedly connected to a third bevel gear 17 that meshes with the first bevel gear 12 and the second bevel gear 13.

[0037] In this embodiment, the motor 16 is started, the motor 16 drives the third bevel gear 17 to rotate, and the third bevel gear 17 drives the first bevel gear 12 and the second bevel gear 13 to rotate in opposite directions.

[0038] As a technical optimization solution of the utility model, the lower end surface of the elution tank 1 is connected with a drain pipe 18 , and a valve 19 is installed on the outer wall of the drain pipe 18 .

[0039] In this embodiment, the drain pipe 18 is convenient for discharging the sodium chloride solution containing sodium heparin from the elution tank 1 .

[0040] As a technical optimization solution of the utility model, the upper end surface of the elution tank 1 is connected to a feed pipe 20 located on one side of the material receiving trough 14 .

[0041] In this embodiment, the feed pipe 20 is convenient for adding the resin to be eluted and the sodium chloride solution into the elution tank 1.

[0042] As a technical optimization solution of the present invention, the first stirring blades 8 and the second stirring blades 9 are staggered.

[0043] In this embodiment, the first stirring blades 8 and the second stirring blades 9 are staggered to prevent the first stirring blades 8 and the second stirring blades 9 from colliding with each other.

[0044] Working principle: When in use, first add the resin to be eluted and the sodium chloride solution into the elution tank 1 through the feed pipe 20, so that the liquid level is located at the mesh structure, and at the same time, the mass ratio of the resin to the sodium chloride is 1:3;

[0045] Then, the motor 16 is started, and the motor 16 drives the third bevel gear 17 to rotate, and the third bevel gear 17 drives the first bevel gear 12 and the second bevel gear 13 to rotate in opposite directions, and the first bevel gear 12 cooperates with the connecting cylinder 11 to drive the cylinder cover 3 to rotate, and the cylinder cover 3 cooperates with multiple connecting rods to drive the rotating cylinder 2 to rotate, and the rotating cylinder 2 drives the multiple first stirring blades 8 to rotate, and the resin and the sodium chloride are stirred through the mutual cooperation between the multiple first stirring blades 8 and the multiple second stirring blades 9. At the same time, the second bevel gear 13 drives the rotating shaft 4 to rotate, and the rotating shaft 4 drives the spiral blades 5 to rotate in the opposite direction, and the sodium chloride solution entering the rotating cylinder 2 through the mesh structure is transported from top to bottom, so that the sodium chloride solution in the elution tank 1 is circulated, thereby accelerating the mixing efficiency between the resin and the sodium chloride solution;

[0046] After a long period of stirring, the valve 19 is opened, and the sodium chloride solution with heparin after the reaction is discharged through the drain pipe 18, and the resin is filtered through the filter screen 6. At the same time, the rotating shaft 4 drives the scraper 7 to rotate, and the scraper 7 can scrape the resin on the filter screen 6 to prevent the filter screen 6 from being blocked. After the sodium chloride solution with sodium heparin after the reaction is drained, the valve 19 is closed, and then half of the previous amount of sodium chloride solution is added to the elution tank 1 again. Then, the above steps are repeated. Through multiple elutions, the resin can be fully eluted and the sodium heparin component adsorbed therein can be extracted;

[0047] After the last elution is completed, the motor 16 drives the third bevel gear 17 to rotate in the opposite direction, and the first bevel gear 12 and the second bevel gear 13 drive the cylinder cover 3 and the rotating shaft 4 to rotate in the opposite direction. The rotating shaft 4 cooperates with the spiral blade 5 to transport the resin and the sodium chloride solution with sodium heparin from bottom to top into the rotating cylinder 2. When the resin and the sodium chloride solution with sodium heparin reach the mesh structure, the sodium chloride solution with sodium heparin enters the elution tank 1 through the mesh structure. At the same time, the resin continues to be transported through the rotating cylinder 2, so that the resin enters the receiving trough 14 through the gap between the cylinder cover 3 and the rotating cylinder 2, and then is discharged through the discharge trough 15, so that the eluted resin is conveniently discharged from the elution tank 1, and then the valve 19 is opened again to discharge the sodium chloride solution with sodium heparin after the reaction through the discharge pipe 18, thereby completing the elution of sodium heparin.

[0048] The above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A sodium heparin elution device, comprising an elution tank (1), characterized in that: The upper end of the interior of the elution tank (1) is rotatably connected to a rotating drum (2), the middle portion of the rotating drum (2) is arranged as a mesh structure, one end of the rotating drum (2) extends to the top of the elution tank (1) and is fixedly connected to a drum cover (3) via a plurality of connecting rods, the upper end of the interior of the drum cover (3) is rotatably connected to a rotating shaft (4) that passes through the rotating drum (2) and extends to the lower end of the interior of the elution tank (1), and the outer wall of the rotating shaft (4) is fixedly connected to a spiral blade (5) that matches the rotating drum (2); A filter screen (6) is fixedly connected to the lower end of the elution tank (1), and a scraper (7) abutting against the filter screen (6) is fixedly connected to the other end of the rotating shaft (4); The outer wall of the rotating drum (2) is fixedly connected to a plurality of evenly distributed first stirring blades (8), and the inner wall of the elution tank (1) is fixedly connected to a plurality of evenly distributed second stirring blades (9).

2. A heparin sodium elution device according to claim 1, characterized in that: The upper end surface of the elution tank (1) is fixedly connected to a driving box (10) located above the cylinder cover (3); the upper end surface of the cylinder cover (3) is fixedly connected to a connecting cylinder (11); the other end of the connecting cylinder (11) extends into the interior of the driving box (10) and is fixedly connected to a first bevel gear (12); The upper end of the interior of the driving box (10) is rotatably connected to a second bevel gear (13), and one end of the rotating shaft (4) passes through the connecting tube (11) and the first bevel gear (12) and is fixedly connected to the second bevel gear (13).

3. A heparin sodium elution device according to claim 1, characterized in that: The upper end surface of the elution tank (1) is fixedly connected to a material receiving groove (14) which is sleeved on the outer wall of the rotating drum (2) and flush with the rotating drum (2), and the outer wall of the material receiving groove (14) is connected to a material discharging groove (15).

4. A heparin sodium elution device according to claim 2, characterized in that: A motor (16) is installed on the right side wall of the drive box (10); an output end of the motor (16) extends into the interior of the drive box (10) and is fixedly connected to a third bevel gear (17) meshing with the first bevel gear (12) and the second bevel gear (13).

5. The heparin sodium elution device according to claim 1, characterized in that: The lower end surface of the elution tank (1) is connected to a liquid discharge pipe (18), and a valve (19) is installed on the outer wall of the liquid discharge pipe (18).

6. A heparin sodium elution device according to claim 1, characterized in that: The upper end surface of the elution tank (1) is connected to a feed pipe (20) located on one side of the material receiving trough (14).

7. A heparin sodium elution device according to claim 1, characterized in that: The first stirring blades (8) and the second stirring blades (9) are arranged in a staggered manner.

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