Multifunctional combined magnetic frame

Abstract

The utility model discloses a multifunctional combined magnetic frame in the technical field of magnetic frames, which comprises a central body and four plastic perforated plates, the four plastic perforated plates comprise an upper perforated plate, a lower perforated plate, a first end perforated plate and a second end perforated plate, a mounting cavity is arranged in the central body, a magnet is mounted in the cavity of the central body in a penetrating manner, and the upper perforated plate, the lower perforated plate, the first end perforated plate and the second end perforated plate are arranged on the central body. A rubber plug is arranged at the tail end of the magnet and extends out of the center body, and the upper hole plate and the lower hole plate are installed on the upper face and the lower face of the center body respectively. The magnetic frame is mainly composed of the magnet, the center body and the four plastic perforated plates, the magnetic force penetrates into the center body in the middle of the perforated plates, the rubber plug is designed at the tail end of the center body and used for fixing the magnet, and when the magnet needs to be pulled out, only the rubber plug needs to be pulled out and the magnet needs to be removed. Therefore, when the samples are uniformly mixed, the magnetic bead suspension with the samples can be uniformly mixed without taking down the centrifugal tubes one by one, and the experiment efficiency is greatly improved.

Description

Technical Field

[0001] The utility model belongs to the technical field related to magnetic frames, and specifically relates to a multifunctional combined magnetic frame. Background Art

[0002] The magnetic bead method for extracting or purifying nucleic acids has been widely used in the field of genomic research in molecular biology. The magnetic bead method for extracting or purifying nucleic acids usually involves adsorbing nucleic acids onto magnetic beads in a high-salt and highly polar solution. After discarding the clear solution, alcohol is used to wash away substances that are not firmly bound to the surface of the magnetic beads, thereby achieving the purpose of extracting or purifying nucleic acids. In the process of extracting or purifying nucleic acids by the magnetic bead method, the washing of the magnetic beads and nucleic acid complexes usually requires the use of external magnetic force to adsorb the magnetic beads. After the magnetic material is fully combined with the sample to be separated, the magnet in the magnetic frame applies an external magnetic field to the solution. Under the action of the external magnetic field, the magnetic material combined with the sample to be separated is enriched from the solution, thereby achieving the purpose of separating the sample.

[0003] The existing magnetic rack is generally composed of a main frame and a magnetic plate, wherein a plurality of perforations are provided on the main frame for installing test tubes, and a magnet is fixedly embedded in the magnetic plate. When the sample needs to be free of the magnetic field, it is often necessary to remove the centrifuge tubes one by one, which is very troublesome and laborious and easy to overturn the sample. Depending on the sample volume, the washing of magnetic beads and nucleic acid conjugates can be carried out in centrifuge tubes of different specifications, but the magnetic racks on the market are usually only suitable for centrifuge tubes of some specifications (mainly for centrifuge tubes of 1.5ml-2ml specifications). When using centrifuge tubes of other specifications, they cannot be adapted due to problems such as being unable to be placed or poor enrichment effects, such as smaller volumes of 0.2ml or larger volumes of 15ml and 50ml. Often, the same laboratory needs to prepare magnetic racks of different specifications, which increases costs and is inconvenient to carry. At the same time, when the number of samples is relatively large, magnetic racks of different specifications with more holes are often matched, which also causes waste of magnetic racks to a certain extent.

[0004] In view of this, the present utility model is proposed. Utility Model Content

[0005] The technical problem to be solved by the utility model is to overcome the deficiencies of the prior art and provide a multifunctional combined magnetic frame. To solve the above technical problems, the basic concept of the technical solution adopted by the utility model is:

[0006] A multifunctional combined magnetic frame comprises a central body and four plastic porous plates, the four plastic porous plates comprise an upper orifice plate, a lower orifice plate, an end orifice plate one and an end orifice plate two, an installation cavity is arranged in the central body, a magnet is installed in the cavity of the central body, a rubber plug is arranged at the end of the magnet and extends outside the central body, the upper orifice plate and the lower orifice plate are respectively installed on the upper and lower surfaces of the central body, the end orifice plate one and the end orifice plate two are respectively installed at the two end positions of the central body, the upper orifice plate, the lower orifice plate, the end orifice plate one and the end orifice plate two are all provided with installation grooves in the middle positions, the mating surfaces of the central body and the plastic porous plates are provided with fixing buckles, and the upper orifice plate, the lower orifice plate, the end orifice plate one and the end orifice plate two are provided with centrifuge tube placement holes of different specifications.

[0007] As a further solution of the utility model: a support platform is provided on the installation surface of the central body at a position outside the fixed buckle, a mounting matching platform is provided on the installation surface of the plastic porous plate, and fixed matching platforms are provided on both sides of the installation groove, which cooperate with the fixed buckle to realize the fixed installation of the plastic porous plate.

[0008] As a further solution of the utility model: the rubber plug is arranged at the mounting groove of the second end hole plate to facilitate the removal of the magnet.

[0009] As a further solution of the utility model: the four corners of the upper orifice plate, the lower orifice plate, the end orifice plate one and the end orifice plate two are all provided with protruding parts and recessed parts. By assembling the protruding parts and the recessed parts of two magnetic frames, multiple magnetic frames can be spliced ​​together.

[0010] As a further solution of the utility model: the protruding parts and the recessed parts on the plastic porous plate are both diagonal structures, and the two diagonal protruding parts are equivalent to two more fixed feet on the plane, which is also convenient for fixing and supporting the magnetic frame during the experiment, avoiding the waste of samples and experimental reagents caused by overturning the magnetic frame.

[0011] As a further solution of the utility model: the specifications of the aperture settings of the centrifuge tube placement holes on the plastic porous plate are 0.2ml, 0.5ml, 1.5ml / 2ml, 15ml and 50ml, which can simultaneously meet the insertion requirements of centrifuge tubes with different apertures.

[0012] The protruding part and the side of the recessed part are provided with connection holes, and the protruding part and the recessed part are matched with each other to form an assembly connection sheet and an assembly screw.

[0013] After adopting the above technical scheme, the utility model has the following beneficial effects compared with the prior art.

[0014] The magnetic frame of the utility model mainly consists of a magnet, a central body and four plastic porous plates. The magnet penetrates into the central body in the middle of the porous plate and a rubber plug is designed at the end to fix the magnet. When the magnet needs to be pulled out, it is only necessary to pull out the rubber plug and remove the magnet. In this way, when mixing the samples, it is possible to operate the magnetic bead suspension with the samples for mixing without removing the centrifuge tubes one by one, which greatly improves the experimental efficiency.

[0015] The plastic porous plate in the magnetic frame of the utility model can be assembled with the central body through the middle groove, so the corresponding porous plate can be installed according to the number of apertures required by oneself. The apertures of the porous plate include 0.2ml, 0.5ml, 1.5ml / 2ml, 15ml and 50ml, which can simultaneously meet the insertion of centrifuge tubes with different apertures. Moreover, through the combination of the porous plates, personalized design of different aperture numbers can be achieved without the need to purchase different magnetic frames, which greatly saves experimental costs.

[0016] The specific implementation of the utility model is further described in detail below with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are part of this application and are used to provide a further understanding of the utility model. The schematic embodiments of the utility model and their descriptions are used to explain the utility model, but do not constitute an improper limitation on the utility model. Obviously, the drawings described below are only some embodiments. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0018] In the figure:

[0019] Figure 1 It is a schematic diagram of the structure of the utility model;

[0020] Figure 2 It is the front view of the utility model;

[0021] Figure 3 It is a cross-sectional view of the installation position of the upper orifice plate of the utility model;

[0022] Figure 4 It is a schematic diagram of the combined state of the utility model.

[0023] In the figure: 1. center body; 2. magnet; 3. rubber plug; 4. upper orifice plate; 5. lower orifice plate; 6. end orifice plate 1; 7. end orifice plate 2; 8. centrifuge tube placement hole; 9. mounting groove; 10. protruding part; 11. recessed part; 12. connecting hole; 13. support platform; 14. fixing buckle; 15. fixing matching platform; 16. installing matching platform; 17. assembling connecting piece; 18. assembling screw.

[0024] It should be noted that these drawings and textual descriptions are not intended to limit the conceptual scope of the present invention in any way, but rather to illustrate the concept of the present invention for those skilled in the art by referring to specific embodiments. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the embodiments of the utility model clearer, the technical solutions in the embodiments will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. The following embodiments are used to illustrate the utility model but are not used to limit the scope of the utility model.

[0026] like Figures 1 to 4 As shown, a multifunctional combined magnetic frame includes a central body 1 and four plastic porous plates, the four plastic porous plates include an upper orifice plate 4, a lower orifice plate 5, an end orifice plate 1 6 and an end orifice plate 2 7, an installation cavity is arranged in the central body 1, a magnet 2 is installed in the cavity of the central body 1, a rubber plug 3 is arranged at the end of the magnet 2 and extends outside the central body 1, the upper orifice plate 4 and the lower orifice plate 5 are respectively installed on the upper and lower surfaces of the central body 1, the end orifice plate 1 6 and the end orifice plate 2 7 are respectively installed at the two end positions of the central body 1, the upper orifice plate 4, the lower orifice plate 5, the end orifice plate 1 6 and the end orifice plate 2 7 are respectively provided with an installation groove 9 in the middle position, a fixing buckle 14 is arranged on the matching surface of the central body 1 and the plastic porous plate, and the upper orifice plate 4, the lower orifice plate 5, the end orifice plate 1 6 and the end orifice plate 2 7 are provided with centrifuge tube placement holes 8 of different specifications.

[0027] Among them, a support platform 13 is arranged on the installation surface of the central body 1 at the outside of the fixed buckle 14, an installation matching platform 16 is arranged on the installation surface of the plastic porous plate, and fixed matching platforms 15 are arranged on both sides of the installation groove 9, which cooperate with the fixed buckle 14 to realize the fixed installation of the plastic porous plate.

[0028] The rubber plug 3 is arranged at the mounting groove 9 of the end hole plate 7 to facilitate the extraction of the magnet 2.

[0029] The four corners of the upper orifice plate 4, the lower orifice plate 5, the end orifice plate 1 6 and the end orifice plate 2 7 are all provided with protruding parts 10 and recessed parts 11. By assembling the protruding parts 10 and recessed parts 11 of two magnetic frames, multiple magnetic frames can be spliced.

[0030] The protruding parts 10 and the recessed parts 11 on the plastic porous plate are both diagonal structures. The two diagonal protruding parts are equivalent to two more fixed feet on the plane, which also facilitates the fixed support of the magnetic frame during the experiment and avoids the waste of samples and experimental reagents caused by overturning the magnetic frame.

[0031] The specifications of the aperture settings of the centrifuge tube placement holes 8 on the plastic porous plate include 0.2ml, 0.5ml, 1.5ml / 2ml, 15ml and 50ml, which can simultaneously meet the requirements of inserting centrifuge tubes with different apertures.

[0032] The protruding part 10 and the side of the recessed part 11 are provided with connecting holes 12 , and the protruding part 10 and the recessed part 11 are matched with each other to form an assembling connecting piece 17 and an assembling screw 18 .

[0033] The working principle of the utility model is as follows: the magnetic frame mainly consists of a magnet 2, a central body 1 and four plastic porous plates, the four plastic porous plates are respectively an upper orifice plate 4, a lower orifice plate 5, an end orifice plate 1 6 and an end orifice plate 2 7, which are respectively snap-fitted and installed on different planes of the central body 1, the magnet 2 is inserted into the central body 1 in the middle of the porous plate, and a rubber plug 3 is designed at the end for fixing the magnet 2, the rubber plug 3 extends to the mounting groove 9 of the end orifice plate 2 7, when the magnet 2 needs to be pulled out, it is only necessary to pull out the rubber plug 3 and remove the magnet 2, so that when the sample is mixed, it is possible to operate the magnetic bead suspension with the sample for mixing without removing the centrifuge tubes one by one, which greatly improves the experimental efficiency;

[0034] The plastic porous plate can be assembled with the central body 1 through the middle mounting groove 9, the fixing buckle 14, and the fixing matching card platform 15, so the corresponding plastic porous plate can be installed according to the number of apertures required by oneself. The apertures of the plastic porous plate include 0.2ml, 0.5ml, 1.5ml / 2ml, 15ml and 50ml, which can simultaneously meet the insertion of centrifuge tubes with different apertures. Moreover, through the combination of the porous plates, personalized design of different aperture numbers can be achieved without the need to purchase different magnetic frames, which greatly saves the experimental cost. The design of setting the porous in the relative direction can also use the opposite porous as the fixing hole of the centrifuge tube, which plays a role in fixing the centrifuge tube during experimental operation.

[0035] Protruding parts 10 and recessed parts 11 are designed at the four corners of the plastic porous plate. By assembling the protruding and recessed parts of the two magnetic frames, multiple magnetic frames can be spliced ​​together, which greatly releases the flexibility of the magnetic frame's ability to process samples and greatly improves the throughput of sample processing. At the same time, the two diagonal protruding parts are equivalent to two more fixed feet on the plane, which is also convenient for fixing and supporting the magnetic frame during the experiment, avoiding the waste of samples and experimental reagents caused by overturning the magnetic frame.

[0036] The above is only a preferred embodiment of the utility model, and does not limit the utility model in any form. Although the utility model has been disclosed as a preferred embodiment as above, it is not used to limit the utility model. Any technician familiar with this patent can make some changes or modify the technical content suggested above into an equivalent embodiment with equivalent changes without departing from the scope of the technical solution of the utility model. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the utility model without departing from the content of the technical solution of the utility model still falls within the scope of the solution of the utility model.

Claims

1. A multifunctional combined magnetic frame, comprising a central body (1) and four plastic porous plates, characterized in that: The four plastic porous plates include an upper porous plate (4), a lower porous plate (5), an end porous plate 1 (6) and an end porous plate 2 (7); a mounting cavity is provided in the central body (1); a magnet (2) is installed in the cavity of the central body (1); a rubber plug (3) is provided at the end of the magnet (2) and extends outside the central body (1); the upper porous plate (4) and the lower porous plate (5) are respectively installed on the upper and lower surfaces of the central body (1); the end porous plate 1 (6) and the end porous plate 2 are respectively installed on the upper and lower surfaces of the central body (1); (7) are respectively installed at the two end positions of the central body (1), and the middle positions of the upper orifice plate (4), the lower orifice plate (5), the end orifice plate one (6) and the end orifice plate two (7) are all provided with installation grooves (9), and the mating surfaces of the central body (1) and the plastic porous plate are provided with fixing buckles (14), and the upper orifice plate (4), the lower orifice plate (5), the end orifice plate one (6) and the end orifice plate two (7) are provided with centrifuge tube placement holes (8) of different specifications.

2. A multifunctional combined magnetic frame according to claim 1, characterized in that: A support platform (13) is provided on the mounting surface of the central body (1) at a position outside the fixing buckle (14), a mounting matching platform (16) is provided on the mounting surface of the plastic porous plate, and fixing matching clamping platforms (15) are provided on both sides of the mounting groove (9).

3. A multifunctional combined magnetic frame according to claim 2, characterized in that: The rubber plug (3) is arranged at the mounting groove (9) of the second end orifice plate (7).

4. A multifunctional combined magnetic frame according to claim 3, characterized in that: The upper orifice plate (4), the lower orifice plate (5), the end orifice plate one (6) and the end orifice plate two (7) are all provided with protruding parts (10) and recessed parts (11) at the four corners.

5. A multifunctional combined magnetic frame according to claim 4, characterized in that: The protruding parts (10) and the recessed parts (11) on the plastic porous plate are both diagonal structures.

6. A multifunctional combined magnetic frame according to claim 5, characterized in that: The specifications of the aperture setting of the centrifuge tube placement hole (8) on the plastic porous plate include 0.2ml, 0.5ml, 1.5ml / 2ml, 15ml and 50ml.

7. A multifunctional combined magnetic frame according to claim 6, characterized in that: The protruding part (10) and the side of the recessed part (11) are provided with connection holes (12), and the protruding part (10) and the recessed part (11) are matched to be provided with assembly connection pieces (17) and assembly screws (18).

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