Sample loading module and particle analyzer

Abstract

The embodiment of the utility model provides a sample loading module which comprises a shell, a high-throughput assembly, a single-tube assembly and a sample loading assembly, and the sample loading assembly comprises a first driving part and a sample loading needle. A plurality of sample tubes can be mounted on the porous plate frame, and the first driving piece can drive the sample loading needle to sequentially correspond to the plurality of sample tubes and perform collection, so that high-throughput sample loading of the particle analyzer is realized. Meanwhile, when a single-tube test needs to be carried out, the sample tube can be mounted through the single-tube assembly, and the sample loading needle can be driven to the single-tube assembly through the first driving part for collection, so that single-tube sample loading of the particle analyzer is realized. The particle analyzer not only can realize two modes of high-throughput single-tube sample loading and high-throughput sample loading at the same time, but also can ensure relative independence of single-tube sample loading and high-throughput sample loading and avoid mutual interference. The utility model also provides a particle analyzer.

Description

Technical Field

[0001] The present application relates to the technical field of biological equipment, and in particular to a sample loading module and a particle analyzer. Background Art

[0002] The particle analyzer is a device that automatically analyzes and sorts cells, and plays an important role in clinical tests such as hematology and tumor diagnosis, immune function, and reticulocyte count. The particle analyzer has a sample loading module that can collect samples from sample tubes.

[0003] The sample loading module has two loading modes: single-tube loading and high-throughput loading. However, the single-tube loading and high-throughput loading modes of the existing particle analyzer are not compatible, that is, the particle analyzer only supports single-tube loading, or the particle analyzer supports high-throughput loading, but the sample tube needs to be placed in the high-throughput area when single-tube loading, and single-tube loading may affect high-throughput loading. The particle analyzer cannot meet the requirement of interspersing single-tube loading without affecting high-throughput loading, and its compatibility is poor and its application range is narrow. Utility Model Content

[0004] The embodiments of the present application provide a sample loading module and a particle analyzer to at least partially improve the above-mentioned technical problems.

[0005] In the first aspect, an embodiment of the present application provides a loading module, including a shell, a high-throughput component, a single-tube component and a loading component. A accommodating cavity is formed in the shell, the high-throughput component is located in the accommodating cavity, the high-throughput component is provided with a porous plate rack, the porous plate rack is used to install multiple sample tubes, the single-tube component is located outside the accommodating cavity and is arranged side by side with the high-throughput component, the single-tube component is used to install the sample tube, the loading component includes a first driving member and a loading needle, the loading needle is used to collect samples in the sample tube, and the first driving member is used to drive the loading needle to selectively collect the sample tube of the single-tube component or the high-throughput component.

[0006] In one embodiment, the sample loading component further includes a second driving member, which is drivingly connected to the sample loading needle and is used to drive the sample loading needle to selectively extend into or out of the sample tube.

[0007] In one embodiment, the loading needle has a limiting end, the second driving member is provided with a limiting groove, the limiting groove extends along the transmission direction of the second driving member, and the limiting end extends into the limiting groove.

[0008] In one embodiment, the multi-well plate rack includes a plurality of rows of mounting hole groups arranged side by side along a first direction, each row of mounting hole groups includes a plurality of mounting holes, and each mounting hole is used to mount a sample tube.

[0009] In one embodiment, the high-throughput component further comprises a third driving member, which is used to drive the multi-well plate rack to move so that the loading needle is selectively arranged corresponding to the plurality of mounting holes in each row of mounting hole groups.

[0010] In one embodiment, when the first driving member drives the loading needle to move to correspond to a row of mounting hole groups, the third driving member is configured to control the movement of the multi-well plate rack so that multiple sample tubes installed in the mounting hole groups correspond to the loading needle in sequence.

[0011] In one embodiment, the single tube assembly is provided with a fixing hole, the fixing hole is connected to the accommodating cavity, the single tube assembly includes an elastic fixing piece, the elastic fixing piece has a clamping space, and the clamping space is arranged corresponding to the fixing hole so that the sample tube can extend into the clamping space through the fixing hole.

[0012] In one embodiment, the shell includes a bottom shell and a top shell, the top shell and the bottom shell form a receiving cavity, and the top shell is rotatably arranged relative to the bottom shell to selectively close or open the receiving cavity.

[0013] In a second aspect, an embodiment of the present application provides a particle analyzer, comprising a loading module, an optical module, a liquid circuit module and an electrical module of the first aspect, wherein the optical module comprises an optical detection device and a detection chamber, the optical detection device is used to obtain information about a sample in the detection chamber, the liquid circuit module comprises a negative pressure source and a pipeline, the pipeline connects the loading module, the negative pressure source and the detection chamber, the negative pressure source is used to provide power for the sample flow, and the electrical module is electrically connected to the loading component, the negative pressure source and the optical detection device.

[0014] In one embodiment, the fluid circuit module has a clearance space for the third driving member to move.

[0015] The sample loading module and particle analyzer provided in the embodiment of the present application can be equipped with a plurality of sample tubes in a multi-hole plate rack, and the first driving member can drive the sample loading needle to correspond to and collect samples in sequence with the plurality of sample tubes, thereby realizing high-throughput sample loading of the particle analyzer. At the same time, when a single-tube test is required, the sample tube can be installed through a single-tube assembly, and the sample loading needle can be driven to the single-tube assembly and collected through the first driving member, thereby realizing single-tube sample loading of the particle analyzer. The particle analyzer can realize both high-throughput single-tube sample loading and high-throughput sample loading at the same time, and can ensure the relative independence of single-tube sample loading and high-throughput sample loading to avoid mutual interference. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the implementation modes of the present application, the drawings required for use in the description of the implementation modes will be briefly introduced below. Obviously, the drawings described below are only some implementation modes of the present application. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0017] Figure 1 A schematic diagram of the structure of a particle analyzer proposed in an embodiment of the present application;

[0018] Figure 2 A schematic diagram of the structure of another particle analyzer proposed in an embodiment of the present application;

[0019] Figure 3 A schematic diagram of the structure of a sample loading module proposed in an embodiment of the present application;

[0020] Figure 4 A schematic diagram of the structure of another sample loading module proposed in an embodiment of the present application.

[0021] Figure numerals: particle analyzer 100, sample loading module 10, shell 11, accommodating chamber 111, top cover 112, high-throughput component 12, porous plate rack 121, third driving member 122, third transmission belt 1221, third driver 1222, single tube component 13, test tube rack 131, elastic fixing member 132, clamping space 1321, fixing hole 133, sample loading component 14, first driving member 141, first transmission belt 1411, first driver 1412, second driving member 142, second transmission belt 1421, second driver 1422, limiting groove 1423, sample loading needle 143, limiting end 1431, optical module 20, optical detection device 21, front light path system 211, rear light path system 212, detection chamber 22, liquid path module 30, negative pressure source 31, pipeline 32, electrical module 40, sample tube 50, opening 51. DETAILED DESCRIPTION

[0022] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the implementation mode of the present application will be clearly and completely described below in conjunction with the drawings in the implementation mode of the present application. Obviously, the described implementation mode is only a part of the implementation mode of the present application, not all the implementation modes. Based on the implementation mode in the present application, all other implementation modes obtained by those skilled in the art without making creative work are within the scope of protection of the present application.

[0023] In this application, unless otherwise clearly specified or limited, the terms "installation", "connection", "fixation" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be internal communication between two elements, or it can be only surface contact, or surface contact connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0024] In addition, the terms "first", "second", etc. are only used to distinguish descriptions and cannot be understood as specific or special structures. The descriptions of the terms "some embodiments", "other embodiments", etc. mean that the specific features, structures, materials or characteristics described in conjunction with the embodiments or examples are included in at least one embodiment or example of the present application. In the present application, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine the different embodiments or examples described in the present application and the features of the different embodiments or examples without contradiction.

[0025] Example

[0026] The present application embodiment provides a particle analyzer 100, see Figure 1 as well as Figure 2 The particle analyzer 100 may include a sample loading module 10, an optical module 20, a liquid circuit module 30 and an electrical module 40. The liquid circuit module 30 connects the sample loading module 10 and the optical module 20, and the electrical module 40 supplies power and / or transmits signals to the sample loading module 10, the optical module 20 and the liquid circuit module 30.

[0027] See also Figure 2 as well as Figure 3 The sample loading module 10 may include a shell 11, a high-throughput component 12, a single-tube component 13 and a sample loading component 14. A accommodating cavity 111 is formed in the shell 11. The high-throughput component 12 can be accommodated in the accommodating cavity 111. The high-throughput component 12 and the single-tube component 13 can be adjacent to or spaced apart. The single-tube component 13 is arranged outside the accommodating cavity 111, and the sample loading component 14 can be inserted into the sample tube 50.

[0028] It is understandable that the high-throughput component 12 and the single-tube component 13 can also be used to install sample bottles, centrifuge tubes, etc. This embodiment is not limited thereto, and corresponding settings can be made according to specific implementation requirements.

[0029] In one embodiment, please refer to Figure 2 as well as Figure 3The shell 11 can be a metal shell, such as stainless steel, aluminum alloy, etc. The metal shell has sufficient structural strength to protect the internal components. The high-throughput component 12, the single-tube component 13 and the sample loading component 14 can be fixed in the shell 11. Specifically, the shell 11 may include a top cover 112, and the top cover 112 can selectively open or close the accommodating chamber 111. The top cover 112 can open at least part of the accommodating chamber 111, and the operator can install and disassemble the sample tube 50 and maintain the sample loading component 14. And during the working process or when it is stationary, the top cover 112 can completely close the accommodating chamber 111 to prevent external interference with the operation of the particle analyzer 100. The high-throughput component 12 and the components inside it are protected by the shell 11 to prevent external interference with the working operation, which has a certain protective effect.

[0030] See also Figure 3 The sample loading assembly 14 may include a first driving member 141 and a sample loading needle 143. The sample loading needle 143 is used to collect samples in the sample tube 50. The first driving member 141 is used to drive the sample loading needle 143 to selectively collect the sample tube 50 of the single tube assembly 13 or the sample tube 50 of the high-throughput assembly 12. Specifically, the first driving member 141 is used to drive the sample loading needle 143 to move in a first direction (such as Figure 3 L1 of the high-throughput assembly 12), the first direction and the second direction intersect. Further, the single tube assembly 13 and the high-throughput assembly 12 can be arranged side by side along the first direction, and the first driving member 141 can drive the sample loading needle 143 to selectively correspond to the single tube assembly 13 or the high-throughput assembly 12. Alternatively, the multiple sample tubes 50 of the high-throughput assembly 12 are distributed along the first direction, and then the first driving member 141 drives the sample loading needle 143 to move along the first direction and sequentially correspond to the sample tubes 50. The sample collection of the single tube assembly 13 and the high-throughput assembly 12 is realized by the first driving member 141, which improves the use flexibility of the sample loading assembly 14 and improves its scope of application.

[0031] The sample loading assembly 14 may further include a second driving member 142, the second driving member 142 is connected to the sample loading needle 143, and the second driving member 142 is used to drive the sample loading needle 143 to selectively extend into or out of the sample tube 50. Further, the sample loading needle 143 may be arranged along the second direction (such as Figure 3 The sample tube 50 has an opening 51, and the opening 51 is arranged toward the second direction. The second driving member 142 is used to drive the loading needle 143 to move along the second direction to selectively move into or out of the sample tube 50. The length of the loading needle 143 is greater than or equal to the depth of the sample tube 50, so that the loading needle 143 can collect all the samples of the sample tube 50 to avoid wasting samples.

[0032] For more details, please also refer to Figure 3 as well as Figure 4The first driving member 141 may include a first transmission belt 1411 and a first driver 1412. The second driving member 142 is mounted on the first transmission belt 1411, and the first transmission belt 1411 is distributed along the first direction. The first driver 1412 rotates forward or reversely to drive the second driving member 142 to move along the first direction or the reverse direction through the first transmission belt 1411, thereby realizing that the first driving member 141 drives the sample loading needle 143 to selectively correspond to the single tube assembly 13 or the high-throughput assembly 12. The second driving member 142 may include a second transmission belt 1421 and a second driver 1422. The sample loading needle 143 is mounted on the second transmission belt 1421, and the second transmission belt 1421 is distributed along the second direction. The second driver 1422 rotates forward or reversely to drive the sample loading needle 143 to move along the first direction or the reverse direction through the second transmission belt 1421, thereby realizing that the second driving member 142 drives the sample loading needle 143 to move along the second direction to selectively move into or out of the sample tube 50.

[0033] It is understandable that the first driving member 141 and the second driving member 142 may also adopt other transmission modes, including but not limited to pneumatic transmission, hydraulic transmission, chain transmission, gear transmission, etc., which are not limited in this embodiment. Taking the pneumatic transmission adopted by the second driving member 142 as an example, the second driving member 142 includes a cylinder and a slide rail, the slide rail is distributed along the second direction, the sample loading needle 143 is installed on the slide rail, the cylinder is connected to the sample loading needle 143, and the cylinder is controlled to push the sample loading needle 143 to move along the second direction.

[0034] In one embodiment, to avoid wasting samples, the end of the sample loading needle 143 is moved to the bottom of the sample tube 50. However, excessive movement of the sample loading needle 143 may damage the sample tube 50, resulting in sample leakage. Figure 3 In this embodiment, the sample loading needle 143 has a limiting end 1431, and the limiting end 1431 can move with the sample loading needle 143 relative to the second driving member 142. The second driving member 142 is provided with a limiting groove 1423, and the limiting groove 1423 extends along the transmission direction of the second driving member 142, that is, the direction in which the second driving member 142 drives the sample loading needle 143 to move. Further, the limiting groove 1423 can extend along the second direction, and the limiting end 1431 extends into the limiting groove 1423. When the sample loading needle 143 moves along the second direction under the drive of the second driving member 142, when the limiting end 1431 moves to the two ends of the limiting groove 1423, the limiting groove 1423 can limit the movement of the limiting end 1431, and then the movement of the sample loading needle 143 will also be limited, so that the sample loading needle 143 will not have excessive movement, thereby ensuring that the sample tube 50 is not damaged and the moving distance is appropriate. The length of the limiting groove 1423 can be selected and designed according to the relative position relationship between the sample loading needle 143 and the sample tube 50 and the size parameters of the two, and this embodiment does not limit this.

[0035] It is understandable that sensors may also be provided on the first driving member 141 , the second driving member 142 and the loading needle 143 . The sensors may be limit switches or infrared distance sensors, etc., to ensure the position accuracy of the loading needle 143 and improve the collection effect of the loading component 14 .

[0036] See also Figure 3 , the high-throughput component 12 is provided with a porous plate rack 121, and the porous plate rack 121 is used to install multiple sample tubes 50. Specifically, when large-scale testing is required, the porous plate rack 121 can hold multiple sample tubes 50 of the same batch, and the first driving member 141 can drive the loading needle 143 to move around the porous plate rack 121, and the second driving member 142 drives the loading needle 143 to move in or out of the sample tube 50. Specifically, the porous plate rack 121 may include multiple rows of mounting hole groups arranged side by side. In one embodiment, the multiple rows of mounting hole groups may be arranged side by side along a first direction. For example, the number of mounting hole groups may be 1, 2, 3, etc., and each row of mounting hole groups includes multiple mounting holes. Further, the multiple mounting holes of the mounting hole group may be arranged along a third direction (such as Figure 3 Each mounting hole is used to mount a sample tube 50, that is, each sample tube 50 can be inserted into a corresponding mounting hole to achieve fixation of the sample tube 50.

[0037] In one embodiment, see Figure 4 The high-throughput assembly 12 also includes a third driving member 122, which drives the porous plate rack 121 to move, so that the sample loading needle 143 is selectively arranged corresponding to the multiple mounting holes in each row of mounting hole groups. Further, the third driving member 122 can drive the porous plate rack 121 to move along a third direction, and the third direction intersects with both the first direction and the second direction. More specifically, the third driving member 122 can include a third transmission belt 1221 and a third driver 1222, the porous plate rack 121 is installed on the third transmission belt 1221, and the third transmission belt 1221 is distributed along the third direction, and the third driver 1222 is forward or reversely operated, so as to drive the porous plate rack 121 to move along the third direction or its reverse direction through the third transmission belt 1221, thereby realizing the effect of the third driving member 122 driving the porous plate rack 121 to move along the third direction so that multiple sample tubes 50 can be arranged corresponding to the sample loading needle 143.

[0038] See also Figure 3When the first driving member 141 drives the sample loading needle 143 to move to correspond to a row of mounting hole groups, the third driving member 122 is configured to control the movement of the multi-well plate rack 121 so that the multiple sample tubes 50 installed in the mounting hole groups correspond to the sample loading needle 143 in sequence. The first driving member 141 and the third driving member 122 cooperate with each other to make the multiple sample tubes 50 of the multi-well plate rack 121 correspond to the sample loading needle 143. When the sample tube 50 corresponds to the sample loading needle 143, the second driving member 142 drives the sample loading needle 143 to be inserted into the sample tube 50 for collection and after the collection is completed, the sample loading needle 143 is driven to move out of the sample tube 50, so that the sample loading needle 143 can absorb the samples in the multiple sample tubes 50 of the multi-well plate rack 121, so as to achieve high-throughput detection.

[0039] In another embodiment, the high-throughput component 12 may also be provided with an in-line test tube component, a disc test tube component, etc. The high-throughput component 12 may be selected and designed according to specific implementation requirements and sample types, etc., and this embodiment is not limiting.

[0040] Please continue reading Figure 3 The single tube assembly 13 is used to install the sample tube 50. The single tube assembly 13 includes a test tube rack 131, and the sample tube 50 can be installed on the test tube rack 131. More specifically, the single tube assembly 13 is provided with a fixing hole 133, and the fixing hole 133 connects the accommodating chamber 111 and the external environment. The aperture of the fixing hole 133 can be greater than or equal to the outer diameter of the sample tube 50, so that the sample tube 50 can be inserted into the fixing hole 133. In one embodiment, the axis of the fixing hole 133 is arranged along a first direction. Furthermore, the fixing hole 133 can be opened in a vertical downward direction, so that the sample tube 50 can be vertically inserted into the fixing hole 133, thereby avoiding the sample tube 50 from tilting or inverting, etc., and protecting the safety of the sample.

[0041] The single tube assembly 13 may include an elastic fixing member 132, which is installed on the test tube rack 131. The elastic fixing member 132 has a clamping space 1321. The size of the clamping space 1321 is smaller than the outer contour size of the sample tube 50, and the clamping space 1321 is arranged corresponding to the fixing hole 133, so that the sample tube 50 can extend into the clamping space 1321 through the fixing hole 133. When the sample tube 50 is inserted into the elastic fixing member 132, the elastic fixing member 132 is squeezed and deformed, and the end of the sample tube 50 has an annular protrusion. When the protrusion passes through the elastic fixing member 132, the elastic fixing member 132 shrinks to achieve a limiting effect on the sample tube 50. For example, the elastic fixing member 132 can be made of materials such as silicone. Compared with hard materials, the elastic fixing member 132 can prevent scratches on the sample tube 50 and avoid sample leakage. In addition, the elastic fixing member 132 is more convenient for the installation of the sample tube 50 and reduces the assembly accuracy requirements. The elastic fixing member 132 can realize a detachable connection between the test tube rack 131 and the sample tube 50. For example, during the high-throughput detection process, when a single-tube detection is urgently required, the sample tube 50 can be fixed in the elastic fixing member 132. The high-throughput test is suspended and the single-tube detection is performed. When the single-tube detection is completed, the high-throughput test can be continued. The single-tube test can be completed without replacing the sample tube 50 in the porous rack plate and opening the shell 11. In addition, the single-tube assembly 13 and the high-throughput assembly 12 are relatively independent, and the single-tube test will not affect the subsequent high-throughput test.

[0042] It is understandable that the test tube rack 131 can also be used to place a cleaning tube, and the cleaning tube contains a cleaning agent. During high-throughput detection, the particle analyzer 100 can perform multi-batch sample detection. When loading samples from different batches, the loading needle 143 can be inserted into the cleaning tube to clean the inside of the particle analyzer 100 to avoid interference between different samples and ensure the accuracy of sample detection. In addition, cleaning work can also be performed between high-throughput detection and single-tube detection to avoid mutual influence between the two.

[0043] In one embodiment, high-throughput detection requires a certain amount of time, and emergency workers may not be able to monitor the particle analyzer 100 for a long time. However, cleaning work needs to be performed at the end of the particle analyzer 100 to ensure the subsequent normal use of the particle analyzer 100. In this embodiment, the cleaning tube can be placed on the test tube rack 131, and the first driving member 141 is configured to drive the sample loading needle 143 to a relative position of the test tube rack 131 after driving the sample loading needle 143 to be set correspondingly to each sample tube 50 on the high-throughput component 12. The second driving member 142 is configured to drive the sample loading needle 143 to absorb the cleaning agent when the sample loading needle 143 is driven to be set relative to the test tube rack 131, and automatically complete the cleaning of the inside of the particle analyzer 100.

[0044] See also Figure 2 The optical module 20 includes an optical detection device 21 and a detection chamber 22. The optical detection device 21 is used to obtain information about the sample in the detection chamber 22. The optical module 20 may include an optical detection device 21 and a detection chamber 22. The optical detection device 21 and the detection chamber 22 may be arranged with a gap. The detection chamber 22 may be connected to the sample loading module 10 through the liquid path module 30 so that the sample can flow through the detection chamber 22. The optical detection device 21 is used to obtain information about the sample in the detection chamber 22, and transmit the sample information to the electronic device through wired transmission or wireless transmission. Among them, the electronic device includes but is not limited to computers, mobile devices, display screens, etc.

[0045] Specifically, the optical detection device 21 may include a front optical path system 211 and a rear optical path system 212, etc., and the detection chamber 22 may be arranged between the front optical path system 211 and the rear optical path system 212. The front optical path system 211 may include one or more laser generators, etc., and the front optical path system 211 may control the detection light such as laser to be emitted into the detection chamber 22. Under the pressure of the gas, the sample enters the sheath liquid, and the sheath liquid may be pre-stored in the liquid path module 30 or transmitted from the outside. Among them, the sheath liquid may be a balanced electrolyte solution without a fluorescent background, and the sheath liquid includes but is not limited to sodium chloride, potassium chloride, disodium ethylenediaminetetraacetic acid and antibacterial agents. The detection chamber 22 has a nozzle. When the pressure difference between the sheath liquid pressure and the sample pressure reaches a certain level, the cells in the sample are arranged in a single row and ejected from the nozzle under the constraint of the sheath liquid, and the nozzle can form a stable liquid flow. In addition, the liquid flow passes through the detection light focusing area of ​​the detection chamber 22, and the cells stained with specific fluorescent dyes are excited by the laser to produce fluorescence of a specific wavelength. The rear optical path system 212 may include an optical collection device, and the rear optical path system 212 can collect the fluorescence information. In addition, the rear optical path system 212 also includes optical components, including but not limited to lenses, apertures, filters, etc. The fluorescence information can be adjusted by the optical components for subsequent more accurate calculation and analysis.

[0046] Please continue reading Figure 1 , the liquid circuit module 30 may include a negative pressure source 31 and a pipeline 32, the pipeline 32 connects the sample loading module 14, the negative pressure source 31 and the detection chamber 22, and the negative pressure source 31 is used to provide power for the sample to flow. The negative pressure source 31 can be a ceramic pump or a negative pressure tank or a plunger pump or a pressure pump or a combination thereof. When the sample loading needle 143 is inserted into the sample tube 50, the negative pressure source 31 starts to work and generates negative pressure, so that the sample loading needle 143 draws the sample into the detection chamber 22, and the sample can be detected by the optical module 20.

[0047] In one embodiment, the liquid circuit module 30 is connected to the sample loading module 10, and the liquid circuit module 30 and the sample loading module 10 are arranged adjacent to each other. This configuration can shorten the distance between the sample loading module 10 and the liquid cooling module, so as to reduce the length of the exposed pipeline 32 and improve the integration of the particle analyzer 100. Furthermore, the liquid circuit module 30 has a clearance space for the third driving member 122 to move, and the third driving member 122 can move into the clearance space during the process of driving the porous plate rack 121, thereby reducing the volume of the particle analyzer 100 and further improving the integration.

[0048] See also Figure 1 , the electrical module 40 is electrically connected to the sample loading component 14, the negative pressure source 31 and the optical detection device 21. The electrical module 40 can supply power to the sample loading component 14, the negative pressure source 31 and the optical detection device 21, and the electrical module 40 can convert AC power such as the mains into DC power for subsequent use. In addition, the electrical module 40 can also adjust the current parameters so that it can meet the use requirements. Specifically, the electrical module 40 may include but is not limited to a transformer, a rectifier circuit, a filter circuit, a voltage stabilizing circuit and a protection circuit, etc. The transformer can be used to convert the input AC power into a suitable voltage. The rectifier circuit can convert AC power into DC power. The filter circuit can filter out clutter and interference in the DC power to make the current more stable. The voltage stabilizing circuit can maintain the stability of the output voltage to prevent damage to the particle analyzer 100 due to voltage fluctuations. The protection circuit can automatically cut off the power supply when the voltage of the particle analyzer 100 is too high, too low or the current is too large to protect it from damage. Furthermore, the optical detection device 21 can transmit the sample information to the electrical module 40, and then transmit it to the electronic device through the electrical module 40, so that the power supply and information transmission can be integrated.

[0049] The sample loading module 10 and the particle analyzer 100 provided in the embodiment of the present application, the porous plate rack 121 can be installed with multiple sample tubes 50, and the first driving member 141 can drive the sample loading needle 143 to correspond to the multiple sample tubes 50 in sequence and collect, so as to realize the high-throughput sample loading of the particle analyzer 100. At the same time, when a single-tube test is required, the sample tube 50 can be installed through the single-tube assembly 13, and the sample loading needle 143 can be driven to the single-tube assembly 13 and collect through the first driving member 141, so as to realize the single-tube sample loading of the particle analyzer 100. The particle analyzer 100 can realize both high-throughput single-tube sample loading and high-throughput sample loading at the same time, and can ensure the relative independence of single-tube sample loading and high-throughput sample loading to avoid mutual interference.

[0050] The above implementation modes are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned implementation modes, a person skilled in the art should understand that the technical solutions described in the aforementioned implementation modes can still be modified, or some of the technical features can be replaced by equivalents. These modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various implementation modes of the present application, and should all be included in the protection scope of the present application.

Claims

1. A sample loading module, characterized in that: include: A housing, wherein a receiving cavity is formed in the housing; A high-throughput component, the high-throughput component is located in the containing cavity, the high-throughput component is provided with a multi-hole plate rack, and the multi-hole plate rack is used to install a plurality of sample tubes; A single tube assembly, the single tube assembly is located outside the accommodating cavity and arranged side by side with the high-throughput assembly, and the single tube assembly is used to install a sample tube; as well as The sample loading component comprises a first driving member and a sample loading needle, wherein the sample loading needle is used to collect samples in the sample tube, and the first driving member is used to drive the sample loading needle to selectively collect the sample tube of the single tube component or the high-throughput component.

2. The sample loading module according to claim 1, characterized in that: The sample loading component also includes a second driving member, which is drivingly connected to the sample loading needle and is used to drive the sample loading needle to selectively extend into or extend out of the sample tube.

3. The sample loading module according to claim 2, characterized in that: The loading needle has a limiting end, the second driving member is provided with a limiting groove, the limiting groove extends along the transmission direction of the second driving member, and the limiting end extends into the limiting groove.

4. The sample loading module according to claim 2, characterized in that: The multi-hole plate rack comprises a plurality of rows of mounting hole groups arranged side by side along a first direction, each row of the mounting hole groups comprises a plurality of mounting holes, and each of the mounting holes is used to mount one of the sample tubes.

5. The sample loading module according to claim 4, characterized in that: The high-throughput component further comprises a third driving member, and the third driving member is used to drive the multi-hole plate rack to move so that the loading needle is selectively arranged corresponding to a plurality of the mounting holes in each row of the mounting hole group.

6. The sample loading module according to claim 5, characterized in that: When the first driving member drives the loading needle to move to correspond to a row of the mounting hole groups, the third driving member is configured to control the movement of the multi-well plate rack so that the multiple sample tubes installed in the mounting hole groups correspond to the loading needle in sequence.

7. The sample loading module according to any one of claims 1 to 6, characterized in that: The single tube assembly is provided with a fixing hole, the fixing hole is connected to the accommodating cavity, the single tube assembly includes an elastic fixing piece, the elastic fixing piece has a clamping space, and the clamping space is arranged corresponding to the fixing hole so that the sample tube can extend into the clamping space through the fixing hole.

8. The sample loading module according to claim 1, characterized in that: The shell comprises a bottom shell and a top shell, wherein the top shell and the bottom shell enclose the accommodating cavity, and the top shell is rotatably arranged relative to the bottom shell to selectively close or open the accommodating cavity.

9. A particle analyzer, characterized in that: include: The sample loading module according to any one of claims 1 to 8; An optical module, the optical module comprising an optical detection device and a detection chamber, the optical detection device being used to obtain information of a sample in the detection chamber; A liquid circuit module, the liquid circuit module comprising a negative pressure source and a pipeline, the pipeline connecting the sample loading module, the negative pressure source and the detection chamber, the negative pressure source being used to provide power for the sample to flow; as well as An electrical module is electrically connected to the sample loading component, the negative pressure source and the optical detection device.

10. The particle analyzer according to claim 9, characterized in that The fluid path module has a clearance space for the third driving member to move.

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