Compression positioning pin and gene sequencing chip platform

Abstract

The utility model provides a pressing positioning pin and a gene sequencing chip platform. The pressing positioning pin comprises a pin body, a pressing block and a driving guide device, wherein the pressing block and the driving guide device are arranged in an inner cavity of the pin body; the side wall of the pin body is provided with an extending opening communicated with the inner cavity. The pressing block is in driving connection with the driving guide device, and at least part of the pressing block is located in the extending opening; the driving guide device is connected to the pressing block and used for driving the pressing block to move outwards and upwards in the extending opening and driving the pressing block to move inwards and downwards in the extending opening. According to the compression positioning pin and the gene sequencing chip platform provided by the invention, the positioning accuracy of the gene sequencing chip can be effectively improved, and the accuracy and reliability of gene sequencing can be improved.

Description

Technical Field

[0001] The present application relates to the technical field of gene sequencing platform auxiliary devices, and in particular to a clamping positioning pin and a gene sequencing chip platform. Background Art

[0002] The principle of the second-generation gene sequencer (NGS) is to add a sample to a gene sequencing chip, perform biochemical reactions (excision, synthesis, temperature rise and fall, etc.), take pictures, convert the fluorescent signal into an electrical signal, and then read it.

[0003] The chip reagent loading, temperature rise and fall and other operations need to be performed on the matching chip platform. At present, most of the chips of the second-generation sequencer are placed manually on the chip platform. Based on the sequencing principle of the second-generation gene sequencer, the chip needs to be accurately positioned (with an error of no more than 0.05mm) before being fixed. The current chip positioning solution is to manually press the glass or silicon wafer of the chip upward and to the left against the pins to ensure accurate positioning, and then turn on the vacuum adsorption function on the chip platform to adsorb and fix the chip on the platform.

[0004] The above-mentioned chip positioning scheme requires manual placement of the chip. Due to the many uncertainties in manual operation, the operation accuracy cannot be effectively controlled. If the chip is not placed accurately, it is very easy to cause subsequent reagent loading failure or leakage, resulting in sequencing failure; it may also cause inaccurate position of subsequent photos, resulting in a reduction in data volume. There are often human operation errors when manually placing the chip. For example, if the pins are not close when the chip is placed, or if the chip becomes loose during adsorption after placement, it will cause deviations in the chip position. For example, when there is debris on the lower surface of the chip or the surface of the platform, or in high altitude areas, the adsorption force will be significantly weakened, and loose adsorption or no adsorption will directly lead to sequencing failure.

[0005] The positioning pins in the current existing technology are hard positioning methods and cannot be adaptively adjusted. When placed manually, they are prone to crooked or tilted placement. When there is a deviation in the chip size processing, it may also cause wear on the glass chip, resulting in adverse effects on the accuracy of subsequent gene sequencing. Utility Model Content

[0006] Based on this, the present application provides a clamping positioning pin and a gene sequencing chip platform to improve the problems in the prior art such as the artificial chip placement deviation caused by the inability of the pins to adaptively adjust, and the inability to take into account the chips of different specifications formed due to size processing deviations, thereby improving the accuracy of gene sequencing.

[0007] To achieve the above purpose, the technical solution of the embodiment of the present application is implemented as follows:

[0008] On the one hand, an embodiment of the present application provides a clamping positioning pin, comprising a pin body, a clamping block respectively arranged in the internal cavity of the pin body, and a driving guide device; a protruding opening connected to the internal cavity is provided on the side wall of the pin body; the clamping block is drivingly connected to the driving guide device, and the clamping block is at least partially located in the protruding opening; the driving guide device is connected to the clamping block, and is used to drive the clamping block to move outward and upward in the protruding opening, and drive the clamping block to move inward and downward in the protruding opening.

[0009] In one embodiment, the pin body includes a main body and a fixed seat, the main body is a shell structure having the internal cavity, the main body has an open end, the fixed seat is fixed to the open end of the main body, and the drive guide device is at least partially arranged on the fixed seat.

[0010] In one embodiment, the driving guide device includes an electromagnetic spring and a first inclined surface structure; the first inclined surface structure is arranged on the main body above the clamping block, the clamping block is fixed on the electromagnetic spring, and the clamping block is provided with a second inclined surface structure corresponding to the first inclined surface structure; the electromagnetic spring is extended to drive the clamping block to move upward and outward, and the electromagnetic spring is contracted to drive the clamping block to move downward and inward.

[0011] In one embodiment, the electromagnetic spring includes an electromagnet, a spring and a magnetic ball; the two ends of the spring are fixedly connected to the electromagnet and the magnetic ball respectively, and the electromagnet is used to increase the attraction to the magnetic ball by changing the current so that the magnetic ball drives the spring to contract; or reduce the attraction to the magnetic ball so that the spring drives the magnetic ball to move upward; the clamping block is fixed on the magnetic ball.

[0012] In one embodiment, the driving guide device also includes a third inclined plane structure, and the third inclined plane structure is arranged on the main body below the clamping block; the clamping block is provided with a fourth inclined plane structure corresponding to the third inclined plane structure, and the clamping block is used to move toward the outside or toward the inside of the extension port along the guiding direction of the first inclined plane structure and the third inclined plane structure.

[0013] In one embodiment, the clamping block includes a clamping portion and a connecting portion, the clamping portion and the connecting portion are arranged in a T shape, the clamping portion is arranged on the top of the connecting portion, one end of the clamping portion is used to extend or retract from the extension port, the second inclined surface structure is arranged on the clamping portion, the fourth inclined surface structure is arranged on the connecting portion, and the connecting portion is fixedly connected to the magnetic ball.

[0014] On the other hand, an embodiment of the present application provides a gene sequencing chip platform, including a workbench and a positioning pin group and a chip fixing platform arranged on the workbench, the positioning pin group is used to position the gene sequencing chip on the chip fixing platform, and the positioning pin group includes the clamping positioning pins as described above.

[0015] In one embodiment, the positioning pin group of the gene sequencing chip platform includes a first positioning pin and a second positioning pin, the first positioning pin is used to position the long side of the gene sequencing chip, the second positioning pin is used to position the short side of the gene sequencing chip, and at least one of the first positioning pins is the clamping positioning pin.

[0016] In one embodiment, the number of the first positioning pins is 4, and the number of the second positioning pins is 2; the four first positioning pins are respectively arranged near the two ends of the length direction of the gene sequencing chip, and the two first positioning pins that are farthest apart are the clamping positioning pins.

[0017] In one embodiment, the gene sequencing chip platform also includes an inlet and outlet liquid block, and the inlet and outlet liquid block and the chip fixing platform are both arranged in the space surrounded by the positioning pin group; the inlet and outlet liquid blocks are arranged at both ends of the length direction of the chip fixing platform; the chip fixing platform is used to fix the gene sequencing chip and perform temperature control.

[0018] The present application has at least the following beneficial effects: the clamping positioning pin provided in the embodiment of the present application has a protruding opening in the middle of the pin body, a clamping block and a driving guide device are provided in the pin body, and the pin body itself can play the function of rough positioning of a general positioning pin. At the same time, when the driving guide device drives the clamping block upward and extends it out of the protruding opening, it can be used to push the gene sequencing chip to achieve precise positioning of the gene sequencing chip. The driving guide device drives the clamping block downward to assist in clamping the gene sequencing chip to avoid the deflection of the gene sequencing chip when it is fixed, which is beneficial to improve the accuracy of the placement of the gene sequencing chip, thereby improving the accuracy of the entire gene sequencing result. The gene sequencing chip platform provided in the embodiment of the present application includes the above-mentioned clamping positioning pin, and therefore also has the above-mentioned beneficial effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the overall structure of the gene sequencing chip platform of an embodiment of the present application.

[0020] Figure 2 for Figure 1 Schematic diagram of the main structure of the gene sequencing chip platform.

[0021] Figure 3 This is a schematic diagram of the overall structure of the clamping positioning pin according to an embodiment of the present application.

[0022] Figure 4 for Figure 3 Schematic diagram of the cross-sectional structure of the clamping positioning pin.

[0023] Figure 5 A schematic diagram of a state in which a gene sequencing chip is placed with the positioning pins pressed down in an embodiment of the present application.

[0024] Figure 6 A schematic diagram of another state of placing a gene sequencing chip with pressing positioning pins according to an embodiment of the present application.

[0025] Figure 7 This is a schematic diagram of the state when the positioning pins are pressed to accurately position the gene sequencing chip in an embodiment of the present application.

[0026] Figure 8 Schematic diagram of the state of the compression positioning pin in the embodiment of the present application when compressing the gene sequencing chip.

[0027] The meanings of the symbols in the accompanying drawings are as follows:

[0028] 1. Workbench; 2. Liquid inlet and outlet block; 3. Chip fixing platform; 4. Gene sequencing chip; 5. First positioning pin; 6. Second positioning pin; 50. Pressing positioning pin; 51. Main body; 511. Extension port; 52. Fixed seat; 53. Pressing block; 531. Pressing part; 5311. Second inclined surface structure; 532. Connecting part; 5321. Fourth inclined surface structure; 54. Driving guide device; 541. First inclined surface structure; 542. Magnetic ball; 543. Third inclined surface structure; 544. Spring; 545. Electromagnet; 60. Fixing pin. DETAILED DESCRIPTION

[0029] The technical solution of the present application is further elaborated in detail below in conjunction with the accompanying drawings and specific embodiments of the specification.

[0030] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit the implementation of this application. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0031] In the description of the present application, it should be understood that the terms "center", "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating positions or positional relationships, are based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific position, be constructed and operated in a specific position, and therefore cannot be understood as a limitation on the present application. In the description of the present application, unless otherwise specified, "multiple" means two or more.

[0032] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0033] See also Figure 1 and Figure 2 The gene sequencing chip platform of the embodiment of the present application includes a workbench 1, a positioning pin group arranged on the workbench 1, an inlet and outlet liquid block 2 arranged in a space surrounded by the positioning pin group, and a chip fixing platform 3. The gene sequencing chip 4 provides a carrier for reagents and sequencing samples during the gene sequencing process, and the gene sequencing chip 4 is positioned and fixed on the gene sequencing chip platform, and the gene sequencing chip 4 can be processed as required by the experimental steps related to the gene sequencing experiment.

[0034] The workbench 1 structurally provides support and fixation for the entire gene sequencing chip platform.

[0035] The inlet and outlet liquid block 2 is fixed on the workbench 1 through the platform connector. The inlet and outlet liquid block 2 can be set with different flow channels for flowing into and out of the gene sequencing chip 4 according to the structure of the gene sequencing chip 4, and is used to inject liquid into the gene sequencing chip 4 and receive liquid from the gene sequencing chip 4. The liquid can be a liquid required for use in a gene sequencing experiment such as a reaction reagent and a cleaning agent. In the illustrated embodiment, the inlet and outlet liquid blocks 2 are respectively arranged at both ends of the length direction of the chip fixing platform 3, one end is a liquid inlet block, and the other end is a liquid outlet block.

[0036] The chip fixing platform 3 is used to fix the gene sequencing chip 4 and can process the gene sequencing chip 4. For example, the chip fixing platform 3 can fix the gene sequencing chip 4 thereon by vacuum adsorption; or, the chip fixing platform 3 can also fix the gene sequencing chip 4 to the chip fixing platform 3 by providing mechanical thrust such as a motor push rod; or, the chip fixing platform 3 can also fix the gene sequencing chip 4 to the chip fixing platform 3 by the magnetic force of a permanent magnet or an electromagnetic part. In addition, the chip fixing platform 3 can also provide temperature control functions such as heating to control the temperature of the gene sequencing chip 4 fixed on the chip fixing platform 3.

[0037] In the illustrated embodiment, the chip fixing platform 3 is a heating adsorption platform, which fixes the gene sequencing chip 4 positioned on the chip fixing platform 3 by adsorption, and can heat the gene sequencing chip 4. More specifically, the chip fixing platform 3 has a built-in Peltier module for temperature regulation of sequencing samples and reagent reactions, and contains a vacuum air channel inside, which can provide negative pressure to fix the gene sequencing chip 4 on the workbench 1 by adsorption. A water-cooling heat dissipation component can also be provided below the chip fixing platform 3. When the Peltier module is heated or cooled, heat is generated, and the water-cooling heat dissipation component is used to provide a water-cooling cycle to dissipate heat.

[0038] The chip fixing platform 3 is provided with a positioning pin group to position the gene sequencing chip 4 before fixing. The positioning pin group includes a plurality of positioning pins, including a clamping positioning pin 50 and a fixing pin 60. The clamping positioning pin 50 is a special structure positioning pin that can achieve positioning and clamping at the same time, and the fixing pin 60 is a common positioning pin that can achieve positioning. Specifically, Figure 1 and Figure 2As shown, in this embodiment, the positioning pin group includes a first positioning pin 5 and a second positioning pin 6. The first positioning pin 5 is used to position the long side of the gene sequencing chip 4, and the second positioning pin 6 is used to position the short side of the gene sequencing chip 4. At least one of the first positioning pins 5 is a pressing positioning pin 50. In this embodiment, the number of first positioning pins 5 is 4, and the number of second positioning pins 6 is 2; the four first positioning pins 5 are respectively arranged near the two ends of the length direction of the gene sequencing chip 4, and the two first positioning pins 5 with the farthest distance (i.e., arranged diagonally) are the pressing positioning pins 50, and the other two first positioning pins 5 with the farthest distance are fixing pins 60. In this embodiment, the number of positioning pins is 6 in total, and the six positioning pins are used to surround the outer periphery of the gene sequencing chip 4. The outer contour of the rectangular space surrounded by the six positioning pins is slightly larger than the outer dimensions of the gene sequencing chip 4, so as to facilitate the placement of the gene sequencing chip 4. The four first positioning pins 5 are respectively symmetrically arranged on the outside of the two long sides of the gene sequencing chip 4, and are arranged near the two ends of the length of the gene sequencing chip 4. That is, the four first positioning pins 5 are symmetrically arranged near the two ends of the length direction of the two inlet and outlet liquid blocks 2, and the two second positioning pins 6 are symmetrically arranged on both sides of the width direction of the two inlet and outlet liquid blocks 2. The two second positioning pins 6 can be arranged near one long side of the gene sequencing chip 4, that is, one positioning pin is respectively arranged at the sharp corners of the two ends of one long side of the gene sequencing chip 4, and one positioning pin is respectively arranged at the sharp corners of the two ends of the other long side of the gene sequencing chip 4. In this embodiment, the connecting line of the projection of the positions of the four first positioning pins 5 on the chip fixing platform 3 is rectangular, the two positioning pins arranged on the diagonal line of the rectangle are the clamping positioning pins 50, and the other two positioning pins arranged on the other diagonal line are the fixing pins 60. In other embodiments, the type and number of positioning pins can be selected according to the different positioning requirements of the gene sequencing chip 4, the number and position of the clamping positioning pins 50 can be freely set, and the purpose of setting the clamping positioning pins 50 is to achieve accurate positioning of the gene sequencing chip 4.

[0039] like Figure 3 and Figure 4 As shown, in this embodiment, the clamping positioning pin 50 includes a pin body, a clamping block 53 respectively arranged in the internal cavity of the pin body, and a driving guide device 54. A protruding opening 511 is provided on the middle side wall of the pin body, and the protruding opening 511 is connected to the internal cavity of the pin body. The clamping block 53 is drivingly connected to the driving guide device 54, and the clamping block 53 is at least partially located in the protruding opening 511. The driving guide device 54 is connected to the clamping block 53, and is used to drive the clamping block 53 to move outward and upward in the protruding opening 511, so that the clamping block 53 pushes the gene sequencing chip 4 to be positioned to achieve precise positioning; and drives the clamping block 53 to move inward and downward in the protruding opening 511, so that the clamping block 53 clamps the gene sequencing chip 4 to prevent it from being displaced before being fixed on the chip fixing platform 3.

[0040] Specifically, the pin body includes a main body 51 and a fixed seat 52. The main body 51 is a shell structure with an internal cavity. The main body 51 has an open end. The fixed seat 52 is fixed to the open end of the main body 51. The driving guide device 54 is at least partially arranged on the fixed seat 52, and the fixed seat 52 is fixed on the workbench 1.

[0041] The driving guide device 54 includes an electromagnetic spring 544 and a first inclined surface structure 541. The first inclined surface structure 541 is arranged on the main body 51 above the clamping block 53. The clamping block 53 is fixed on the electromagnetic spring 544, and a second inclined surface structure 5311 corresponding to the first inclined surface structure 541 is provided on the clamping block 53; the electromagnetic spring 544 is extended to drive the clamping block 53 to move upward and outward, and the electromagnetic spring 544 is contracted to drive the clamping block 53 to move downward and inward. Specifically, the electromagnetic spring 544 includes an electromagnet 545 (integrally designed with the fixing seat 52), a spring 544 and a magnetic ball 542; the two ends of the spring 544 are fixedly connected to the electromagnet 545 and the magnetic ball 542, respectively.

[0042] The electromagnet 545 is used to increase the attraction to the magnetic ball 542 by changing the current, so that the magnetic ball 542 drives the spring 544 to contract; or reduce the attraction to the magnetic ball 542, so that the spring 544 drives the magnetic ball 542 to move upward. For example, the electromagnet 545 can be powered to a certain current to generate a magnetic force, which attracts the magnetic ball 542 to move toward the electromagnet 545, thereby driving the spring 544 to contract; or the electromagnet 545 can be powered off or the current can be reduced, so that the rebound force on the spring 544 is greater than the gravity and magnetic force on the magnetic ball 542, and the spring 544 stretches to drive the magnetic ball 542 to move upward. The clamping block 53 is fixed on the magnetic ball 542. The driving guide device 54 may further include a third inclined surface structure 543, which is disposed on the main body 51 below the pressing block 53; the pressing block 53 is provided with a fourth inclined surface structure 5321 corresponding to the third inclined surface structure 543, and the pressing block 53 is used to move toward the outside of the extension opening 511 or toward the inside of the extension opening 511 along the guiding direction of the first inclined surface structure 541 and the third inclined surface structure 543. The first inclined surface structure 541 and the third inclined surface structure 543 are parallel and opposite to each other.

[0043] The clamping block 53 includes a clamping portion 531 and a connecting portion 532 which are connected. The clamping portion 531 and the connecting portion 532 are arranged in a T shape. The clamping portion 531 is arranged at the top of the connecting portion 532. One end of the clamping portion 531 is used to extend or retract from the extension port 511. The second inclined surface structure 5311 is arranged on the clamping portion 531. The fourth inclined surface structure 5321 is arranged on the connecting portion 532. The connecting portion 532 is fixedly connected to the magnetic ball 542. The second inclined surface structure 5311 and the fourth inclined surface structure 5321 are arranged in parallel. The second inclined surface structure 5311 is located at the inner upper corner of the clamping portion 531. The fourth inclined surface structure 5321 is located at the outer lower corner of the connecting portion 532. The inner side and the outer side refer to the side close to the extension port 511 of the pin body as the outer side, and the side away from the extension port 511 of the pin body as the inner side.

[0044] The working principle of the gene sequencing chip platform of the embodiment of the present application is as follows: before placing the gene sequencing chip 4, the pressing block 53 of the pressing positioning pin 50 is in a retracted state, and the space enclosed by the positioning pin group including the pressing positioning pin 50 and the fixing pin 60 is the largest, which can accommodate the size error of the gene sequencing chip 4 within a certain range or the situation where the gene sequencing chip 4 is placed crookedly; at this time, the gene sequencing chip 4 is placed in the space enclosed by the positioning pin group of the workbench 1, so that the gene sequencing chip 4 is easy to put in and forms a rough positioning. After the gene sequencing chip 4 is placed in, the two electromagnets 545 are powered off (or the current is weakened), the electromagnets 545 lose their magnetism (or the magnetism is weakened), the rebound force on the spring 544 is greater than the gravity (or the sum of gravity and attraction) on the magnetic ball 542, the spring 544 stretches, driving the magnetic ball 542 to move upward, and the magnetic ball 542 drives the pressing block 53 to move upward and outward along the guiding direction of the first inclined surface and the third inclined surface, and the side of the connecting portion 532 facing the edge of the gene sequencing chip 4 can push the gene sequencing chip 4 to make it close to the fixing pin 60 opposite to the pressing positioning pin 50, thereby achieving accurate positioning of the gene sequencing chip 4. After the connection part 532 pushes the gene sequencing chip 4 to achieve precise positioning, the two electromagnets 545 are energized (or the current is increased), and the electromagnet 545 generates magnetism (or the magnetism increases), attracting the magnetic ball 542 to move in the direction close to the electromagnet 545 (i.e., downward movement in the figure), and the magnetic ball 542 compresses the spring 544, and drives the clamping block 53 to move downward and inward along the guiding direction of the first inclined surface and the third inclined surface. When the lower surface of the clamping part 531 contacts the upper surface of the gene sequencing chip 4, the gene sequencing chip 4 can be clamped to prevent the gene sequencing chip 4 from loosening or shifting. At this time, the fixing function of the chip fixing platform 3 can be turned on to fix it (for example, the negative pressure function), and the gene sequencing chip 4 can be fixed on the workbench 1. After fixation, the electromagnet 545 can be powered off.

[0045] The clamping positioning pin 50 of the embodiment of the present application is provided with an extension opening 511. The space enclosed by the multiple positioning pins is slightly larger than the outer dimensions of the gene sequencing chip 4. The above design is conducive to meeting the positioning requirements of the gene sequencing chips 4 of different outer dimensions caused by processing errors. That is, the gene sequencing chip 4 that is slightly smaller or slightly larger can be clamped and positioned using the gene sequencing chip platform of this embodiment. At the same time, when the gene sequencing chip 4 is placed with an error of deflection, it can also be adjusted by clamping the positioning pin 50. Figure 5 and Figure 6 As shown, it shows the placement states of two gene sequencing chips 4 of different external dimensions at the pressing positioning pin 50, or it can also show the state when the placement of the gene sequencing chip 4 is deviated; Figure 5 The size of the gene sequencing chip 4 is slightly smaller. Figure 6 The size of the gene sequencing chip 4 is slightly larger, or, Figure 5 The placement of the gene sequencing chip 4 is relative to Figure 6 The gene sequencing chip 4 is placed closer to the pressing positioning pin 50. In both cases, the gene sequencing chip 4 can be accommodated by the positioning pin group of the gene sequencing platform of the embodiment of the present application, and the gene sequencing chip 4 can be pushed by the connecting portion 532 of the pressing positioning pin 50 to achieve precise positioning. Figure 7 It indicates that the pressing block 53 is in an extended state, and the connecting portion 532 pushes the gene sequencing chip 4 to make it close to the opposite fixing pin 60. Figure 8 It indicates that the pressing block 53 is in a retracted state, and the pressing part 531 is pressing the gene sequencing chip 4.

[0046] The clamping positioning pin and gene sequencing chip platform provided by the embodiment of the present application have a simple overall structure, and multiple positioning pins are arranged on the periphery of the gene sequencing chip to provide hard limit of the gene sequencing chip in the XY direction (two vertical directions of the horizontal plane). At this time, the fixed pin and the clamping positioning pin have the same function, both of which play the role of limiting. The positioning pin group limits the gene sequencing chip on the periphery of the gene sequencing chip, and the space surrounded by the positioning pin group is slightly larger than the outer dimensions of the gene sequencing chip, so that the gene sequencing chip is easy to put in, and even if there is a certain processing error in the processing of the gene sequencing chip, it can be easily positioned. After the gene sequencing chip is placed in the space formed by the positioning pin group, the compression block of the clamping positioning pin is used to accurately position the gene sequencing chip, so that it is close to the fixing pin and is not affected by the processing error of the gene sequencing chip. Before fixing the gene sequencing chip, the clamping positioning pin can be used to initially fix it to prevent it from shifting, and assist in cooperating with the original vacuum adsorption platform and other chip fixing platforms to clamp the gene sequencing chip, so that the chip fits more closely with the workbench, and the chip fixing platform is easy to fix it, which is conducive to improving the positioning accuracy of the gene sequencing chip and ultimately improving the accuracy of gene sequencing. The clamping positioning pins of the embodiment of the present application can accurately position the gene sequencing chip, and even if there are differences in the external dimensions of the gene sequencing chip, high-precision positioning can be achieved, and the positioning accuracy can reach 0.05mm. The clamping positioning pins and the chip fixing platform can achieve stable clamping of the gene sequencing chip and reduce the risk of reagent leakage.

[0047] It should be noted that, in this article, the terms "include", "comprises" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, an element defined by the sentence "comprises a ..." does not exclude the existence of other identical elements in the process, method, article or device including the element.

[0048] The above is only a specific implementation of the present application, but the protection scope of the present application is not limited thereto. Any person skilled in the art who is familiar with the present technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A clamping positioning pin, characterized in that: It comprises a pin body, a pressing block and a driving guide device respectively arranged in the internal cavity of the pin body; a protruding opening communicating with the internal cavity is arranged on the side wall of the pin body; the pressing block is drivingly connected to the driving guide device, and the pressing block is at least partially located in the protruding opening; The driving guide device is connected to the pressing block and is used to drive the pressing block to move outward and upward in the extension opening, and to drive the pressing block to move inward and downward in the extension opening.

2. The hold-down positioning pin according to claim 1, characterized in that: The pin body includes a main body and a fixing seat, the main body is a shell structure with the internal cavity, the main body has an open end, the fixing seat is fixed to the open end of the main body, and the driving guide device is at least partially arranged on the fixing seat.

3. The hold-down positioning pin according to claim 2, characterized in that: The driving guide device includes an electromagnetic spring and a first inclined surface structure; the first inclined surface structure is arranged on the main body above the clamping block, the clamping block is fixed on the electromagnetic spring, and the clamping block is provided with a second inclined surface structure corresponding to the first inclined surface structure; the electromagnetic spring is extended to drive the clamping block to move upward and outward, and the electromagnetic spring is contracted to drive the clamping block to move downward and inward.

4. The hold-down positioning pin according to claim 3, characterized in that: The electromagnetic spring includes an electromagnet, a spring and a magnetic ball; the two ends of the spring are fixedly connected to the electromagnet and the magnetic ball respectively, and the electromagnet is used to increase the attraction to the magnetic ball by changing the current so that the magnetic ball drives the spring to contract; or reduce the attraction to the magnetic ball so that the spring drives the magnetic ball to move upward; the clamping block is fixed on the magnetic ball.

5. The hold-down positioning pin according to claim 4, characterized in that: The driving guide device also includes a third inclined plane structure, which is arranged on the main body below the clamping block; the clamping block is provided with a fourth inclined plane structure corresponding to the third inclined plane structure, and the clamping block is used to move toward the outside or inside of the extension port along the guiding direction of the first inclined plane structure and the third inclined plane structure.

6. The hold-down positioning pin according to claim 5, characterized in that: The pressing block includes a pressing part and a connecting part, and the pressing part and the connecting part are arranged in a T shape. The pressing part is arranged on the top of the connecting part, and one end of the pressing part is used to extend or retract from the extension port. The second inclined surface structure is arranged on the pressing part, and the fourth inclined surface structure is arranged on the connecting part. The connecting part is fixedly connected to the magnetic ball.

7. A gene sequencing chip platform, characterized in that: It comprises a workbench, a positioning pin group and a chip fixing platform arranged on the workbench, wherein the positioning pin group is used to position the gene sequencing chip on the chip fixing platform, and the positioning pin group comprises the clamping positioning pin according to any one of claims 1 to 6.

8. The gene sequencing chip platform according to claim 7, characterized in that: The positioning pin group includes a first positioning pin and a second positioning pin, the first positioning pin is used to position the long side of the gene sequencing chip, the second positioning pin is used to position the short side of the gene sequencing chip, and at least one of the first positioning pins is the clamping positioning pin.

9. The gene sequencing chip platform according to claim 8, characterized in that: The number of the first positioning pins is 4, and the number of the second positioning pins is 2; the four first positioning pins are respectively arranged close to the two ends of the length direction of the gene sequencing chip, and the two first positioning pins that are farthest apart are the clamping positioning pins.

10. The gene sequencing chip platform according to claim 8, characterized in that: It also includes an inlet and outlet liquid block, and the inlet and outlet liquid block and the chip fixing platform are both arranged in the space surrounded by the positioning pin group; the inlet and outlet liquid block is arranged at both ends of the length direction of the chip fixing platform; the chip fixing platform is used to fix the gene sequencing chip and control the temperature.

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