Controllable medical catheter based on electrothermal driving hydrogel tip and medical equipment

Abstract

The utility model provides a controllable medical catheter based on an electric heating driving hydrogel tip and medical equipment. The controllable medical catheter comprises a body, the needle tip assembly comprises first hydrogel, a first substrate and a first heater, the first substrate is connected to the body, and the first hydrogel and the first heater are arranged on the two sides of the first substrate respectively; the medicine carrier assembly and the needle tip assembly are arranged at intervals, the medicine carrier assembly comprises second hydrogel, a second substrate and a second heater, the second hydrogel and the second heater are arranged on the two sides of the second substrate respectively, and the medicine is wrapped in the second hydrogel. According to the medical catheter, the use direction of the medical catheter can be flexibly adjusted and controlled, the injection precision of the catheter is improved, meanwhile, the accurate control over the drug release effect can be improved, and compared with a conventional medical catheter and other structures, the medical catheter is more convenient to use. The device has the remarkable advantages of controllable needle tip steering capability, wide application range, flexibility and safety in use, convenience in adjustment, high controllability and the like.

Description

Technical Field

[0001] The utility model relates to the technical field of medical instruments, and in particular to a controllable medical catheter and medical equipment based on an electrothermal driven hydrogel tip. Background Art

[0002] As an important medical device, medical catheters play a vital role in modern medical surgery, especially in cardiovascular surgery, neurosurgery and tumor interventional therapy. Through the shape and flexibility of the tip, medical catheters can accurately reach specific locations in the body under the control of doctors to achieve multiple functions such as drug treatment, tissue sampling, and lesion resection.

[0003] However, existing medical catheters have some limitations. First, the steering ability of the tip of traditional medical catheters is limited, and doctors often need to make multiple attempts and adjustments, which not only increases the operation time, but also increases the risk to patients. Secondly, due to the complex and changeable structure of blood vessels and other channels inside the human body, existing medical catheters have certain limitations when adapting to these structures, and sometimes they cannot even reach the target location. In addition, the friction and collision between the medical catheter and the blood vessel wall may cause complications such as vascular damage and thrombosis. To solve these problems, researchers have been exploring new materials and designs to create more flexible and safer medical catheters. Utility Model Content

[0004] Therefore, the technical problem to be solved by the present invention is to overcome the problems of limited control of the needle tip of a medical catheter and inflexible use in the prior art, and to provide a controllable medical catheter and medical device based on an electrothermal driven hydrogel tip.

[0005] In order to solve the above technical problems, the utility model provides a controllable medical catheter based on an electrothermally driven hydrogel tip, which includes: a body; a needle tip assembly, the needle tip assembly is arranged at one end of the body, and includes: a first hydrogel, a first substrate and a first heater, the first substrate is connected to the edge of the body, and the first hydrogel and the first heater are respectively arranged on both sides of the first substrate; a drug carrier assembly, the drug carrier assembly is connected to one end of the body where the needle tip assembly is provided, and is spaced apart from the needle tip assembly, and includes: a second hydrogel, a second substrate and a second heater, the second substrate is connected to the edge of the body, the second hydrogel and the second heater are respectively arranged on both sides of the second substrate, and the drug is coated inside the second hydrogel.

[0006] In one embodiment of the present invention, it further includes a wire, wherein the wire is respectively connected to the first heater and the second heater, and the wire is externally connected to a power supply device.

[0007] In one embodiment of the present invention, it also includes a control system, and the first heater and the second heater are respectively connected to the control system.

[0008] In one embodiment of the utility model, a first circuit groove is provided on the first substrate, and the first heater is embedded in the first circuit groove; a second circuit groove is provided on the second substrate, and the second heater is embedded in the second circuit groove.

[0009] In one embodiment of the utility model, the first circuit slot and the second circuit slot are respectively configured to be one of a serpentine shape, a grid shape, and a spiral shape; the first heater and the second heater are respectively configured to be one of a conductive polymer, a metal layer structure, or a metal nanowire.

[0010] In one embodiment of the present invention, the second hydrogel is arranged horizontally, and the drug is filled in the gaps of the second hydrogel.

[0011] In one embodiment of the present invention, the second hydrogel is configured as a capsule structure, and the drug is encapsulated in the capsule structure.

[0012] In one embodiment of the present invention, the main substrate is one of polyvinyl alcohol, polyimide, and polyether block polyamide; the first hydrogel substrate is one of poly(N-isopropylacrylamide), poly(N,N-diethylacrylamide) and polymethyl vinyl ether; the second hydrogel substrate is one of poly(N-isopropylacrylamide), polyN,N-diethylacrylamide and poly-2-carboxy-N-isopropylacrylamide; the substrates of the first substrate and the second substrate are one of polyimide and polyethylene terephthalate.

[0013] In one embodiment of the present invention, it further comprises a packaging structure, wherein the packaging structure is coated on the outer surface of the body, the needle tip assembly and the drug carrier assembly.

[0014] The utility model also provides a medical device, which comprises the above-mentioned controllable medical catheter based on the electrothermal driven hydrogel tip.

[0015] The above technical solution of the utility model has the following advantages compared with the prior art:

[0016] The controllable medical catheter and medical device based on the electrothermal driven hydrogel tip described in the utility model can change the deflection and bending angle of the needle tip according to actual needs by changing the temperature of the first hydrogel, thereby realizing flexible adjustment and control of the use direction of the medical catheter, improving the injection accuracy of the catheter, and at the same time controlling the release rate of the internal drug by changing the temperature of the second hydrogel, thereby improving the precise control of the drug release effect. Compared with conventional medical catheters and other structures, the present application has significant advantages such as controllable needle tip steering ability, wide application range, flexible use, safe use, easy adjustment and high controllability. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to make the content of the utility model more clearly understood, the utility model is further described in detail below based on specific embodiments of the utility model in combination with the accompanying drawings.

[0018] Figure 1 It is a schematic diagram of the three-dimensional structure of a controllable medical catheter based on electrothermal driven hydrogel tip in a preferred embodiment of the utility model;

[0019] Figure 2 yes Figure 1 A front view of a controllable medical catheter based on an electrothermally driven hydrogel tip is shown.

[0020] Explanation of the reference numerals in the specification: 100, main body; 200, needle tip assembly; 210, first hydrogel; 220, first substrate; 230, first heater; 300, drug carrier assembly; 310, second hydrogel; 320, second substrate; 330, second heater; 400, wire; 500, packaging structure. DETAILED DESCRIPTION

[0021] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0022] Embodiment 1

[0023] See also Figure 1 and Figure 2As shown, this embodiment provides a controllable medical catheter based on an electrothermal driven hydrogel tip, which includes: a body 100; a needle tip assembly 200, wherein the needle tip assembly 200 is arranged at one end of the body 100, and includes: a first hydrogel 210, a first substrate 220 and a first heater 230, wherein the first substrate 220 is connected to the edge of the body 100, and the first hydrogel 210 and the first heater 230 are respectively arranged on both sides of the first substrate 220; a drug carrier assembly 300, wherein the drug carrier assembly 300 is connected to one end of the body 100 where the needle tip assembly 200 is provided, and the drug carrier assembly 300 is spaced apart from the needle tip assembly 200, and includes: a second hydrogel 310, a second substrate 320 and a second heater 330, wherein the second substrate 320 is connected to the edge of the body 100, and the second hydrogel 310 and the second heater 330 are respectively arranged on both sides of the second substrate 320, and the drug is coated inside the second hydrogel 310.

[0024] The controllable medical catheter based on the electrothermal driven hydrogel tip described in this embodiment enables the needle tip to change its deflection and bending angle according to actual needs by changing the temperature of the first hydrogel 210, thereby achieving flexible adjustment and control of the use direction of the medical catheter, improving the injection accuracy of the catheter, and at the same time controlling the release rate of the internal drug by changing the temperature of the second hydrogel 310, thereby improving the precise control of the drug release effect. Compared with conventional medical catheters and other structures, the present application has significant advantages such as controllable needle tip steering ability, wide application range, flexible use, safe use, easy adjustment and high controllability.

[0025] See also Figure 1 As shown, the controllable medical catheter based on the electrothermal driven hydrogel tip in this embodiment needs to be able to bend and move freely in the complex blood vessels and channels in the human body without damaging the tissue, so it is preferably a hollow cylindrical element made of polyether block polyamide. This material is non-toxic and non-irritating to the human body, and will not cause allergic or rejection reactions. At the same time, it can always maintain its mechanical properties during repeated bending and use. In addition, polyether block polyamide also has antibacterial properties and temperature stability, which can prevent infection during actual use and will not cause the risk of uncontrolled deformation. In other embodiments, the base material of the body 100 can also be selected from polyimide, polyvinyl alcohol and other materials with the same effect, and the utility model does not make specific restrictions on this.

[0026] See also Figure 1As shown, the needle tip assembly 200 and the drug carrier assembly 300 are arranged at the same end of the body 100, and the two are arranged opposite to each other, wherein the first substrate 220 is used to connect the first hydrogel 210 and the first heater 230 on the one hand, and to provide support strength for the needle tip assembly 200 on the other hand. Specifically, in this embodiment, the base material of the first substrate 220 is a highly flexible polyimide, which has good flexibility and durability, thereby being able to adapt to the complex anatomical structure of the human body and also being convenient for subsequent processing. Further, in this embodiment, a first circuit groove is provided on the first substrate 220, and the first heater 230 is embedded in the first circuit groove, thereby not only being able to further reduce the curvature of the needle tip, but also being able to improve the connection strength between the first heater 230 and the first substrate 220, thereby improving the service life of the catheter. Specifically, the first circuit slot and the second circuit slot in this embodiment are both set to a serpentine structure. This structural setting is most helpful to improve the uniformity of heating. The first heater 230 is preferably a copper metal nanowire with high conductivity and low cost. In actual use, the actual resistance can be adjusted by adjusting the arrangement shape, spacing and thickness of the metal nanowires in the first heater 230, thereby achieving the purpose of changing the temperature distribution by adjusting the heating power. When the first heater 230 is working, it can transfer the temperature to the first hydrogel 210. The first hydrogel 210 has good controllability above 35°C, thereby achieving the purpose of adjusting the tip deformation by controlling the temperature. In other embodiments, the first circuit slot can also be designed in other patterns such as grids and spirals according to actual use requirements; the first heater 230 can also be set to other conductive polymers, metal layer structures or metal nanowire structures; the base material of the first substrate 220 can also be set to one of polyimide and polyethylene terephthalate, and the utility model does not make specific restrictions on this.

[0027] In this embodiment, the first hydrogel 210 is disposed on the inner side of the first substrate 220, and can produce thermal deformation at 35°C to 40°C, that is, the first hydrogel 210 in the normal state is a straight-extending element. When it is heated by the first heater 230 and heated to above 35°C, it will produce a larger and larger bending deformation as the temperature gradually increases, thereby achieving a change in the direction of the needle tip, and this deformation is highly controllable. Using this mechanism, this embodiment changes the temperature of the first heater 230 by changing the electric power applied to the first heater 230, thereby controlling the bending angle of the active tip. Further, the first hydrogel 210 in this embodiment is preferably poly (N-isopropylacrylamide), which has good flexibility and biocompatibility, and is sensitive to thermal effects. It can expand or contract under electrothermal drive to achieve precise control of the catheter. In this embodiment, the first hydrogel 210 is cured on the first substrate 220 by photopolymerization.

[0028] See also Figure 1 and Figure 2 As shown, the drug carrier assembly 300 in this embodiment is spaced apart from the needle tip assembly 200, which is used to weaken the rejection reaction or the precursor drug of the operation, and plays the role of an auxiliary medical catheter, wherein the second substrate 320 is the same as the material and structure of the first substrate 220, and a second circuit groove is correspondingly arranged thereon, and the second heater 330 is embedded in the second circuit groove, and the second heater 330 is the same as the material and structure of the first heater 230, which will not be described in detail here. In this embodiment, the second hydrogel 310 is also selected as poly (N-isopropyl acrylamide), which is arranged horizontally, and the drug is filled in the gap of the second hydrogel 310. When it is heated, the gap of the second hydrogel 310 will shrink, thereby continuously squeezing out the drug inside it, thereby achieving rapid release of the drug. Further, in other embodiments, the substrate of the second hydrogel 310 can also be set to one of poly N, N-diethyl acrylamide and poly 2-carboxyl-N-isopropyl acrylamide.

[0029] The present embodiment also includes a wire 400 and a control system. The wire 400 is respectively connected to the first heater 230 and the second heater 330, and the wire 400 is externally connected to a power supply device. The first heater 230 and the second heater 330 are respectively connected to the control system. During actual use, the operator can adjust the needle tip assembly 200 and the drug carrier assembly 300 in real time through the control system, and can also preset parameters to make the catheter have a higher degree of motorization and accuracy.

[0030] This embodiment further includes a packaging structure 500 , which is coated on the outer surfaces of the body 100 , the needle tip assembly 200 and the drug carrier assembly 300 , and the base material of the packaging structure 500 is a flexible material with high bioaffinity.

[0031] Embodiment 2

[0032] The present embodiment provides another controllable medical catheter based on an electrothermally driven hydrogel tip, wherein the structural settings of the body 100 and the needle tip assembly 200 are the same as those in the first embodiment, and no further details are given here. In the present embodiment, only the structural setting of the second hydrogel 310 is different, specifically: the second hydrogel 310 in the present embodiment is configured as a capsule structure, the drug is encapsulated in the capsule structure, and the substrate of the second hydrogel 310 is poly-N,N-diethylacrylamide. Based on this, in the present embodiment, when the second hydrogel 310 is heated, its gap shrinks, and the channel for drug release to the outside becomes smaller, thereby achieving the purpose of reducing the drug release rate by heating. Therefore, compared with conventional catheter technology, the catheter in the present embodiment has the advantages of improving drug solubility, controlling drug sustained release time, and reducing drug side effects, and can be integrated into a catheter containing a thermal drive system, thereby further enriching the function of the medical catheter.

[0033] Embodiment 3

[0034] This embodiment provides a medical device, which includes the controllable medical catheter based on the electrothermal driven hydrogel tip described in the first embodiment.

[0035] In summary, the controllable medical catheter and medical device based on the electrothermal driven hydrogel tip described in the utility model can change the deflection and turning angle of the needle tip according to actual needs by changing the temperature of the first hydrogel 210, thereby realizing flexible adjustment and control of the use direction of the medical catheter, improving the injection accuracy of the catheter, and at the same time, by changing the temperature of the second hydrogel 310, the release rate of the internal drug is controlled, thereby improving the precise control of the drug release effect. Compared with conventional medical catheters and other structures, the present application has significant advantages such as controllable needle tip steering ability, wide application range, flexible use, safe use, easy adjustment and high controllability. Obviously, the above embodiments are only examples for clear explanation, not for limiting the implementation methods. For ordinary technicians in the field, other different forms of changes or modifications can be made on the basis of the above description. It is not necessary and impossible to list all the implementation methods here. And the obvious changes or modifications derived from this are still within the scope of protection of the invention of the utility model.

Claims

1. A controllable medical catheter based on an electrothermally driven hydrogel tip, characterized in that: include: ontology; A needle tip assembly, the needle tip assembly is arranged at one end of the body, and comprises: a first hydrogel, a first substrate and a first heater, the first substrate is connected to the edge of the body, the first hydrogel and the first heater are respectively arranged on both sides of the first substrate; A drug carrier component, wherein the drug carrier component is connected to one end of the body where the needle tip component is provided, and is spaced apart from the needle tip component, and comprises: a second hydrogel, a second substrate and a second heater, wherein the second substrate is connected to the edge of the body, the second hydrogel and the second heater are respectively arranged on both sides of the second substrate, and the drug is coated inside the second hydrogel.

2. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: It also includes wires, which are respectively connected to the first heater and the second heater, and the wires are externally connected to a power supply device.

3. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: It also includes a control system, and the first heater and the second heater are respectively connected to the control system.

4. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: A first circuit groove is provided on the first substrate, and the first heater is embedded in the first circuit groove; a second circuit groove is provided on the second substrate, and the second heater is embedded in the second circuit groove.

5. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 4, characterized in that: The first circuit slot and the second circuit slot are respectively configured in one of a serpentine shape, a grid shape, and a spiral shape; the first heater and the second heater are respectively configured in one of a conductive polymer, a metal layer structure, or a metal nanowire.

6. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: The second hydrogel is arranged horizontally, and the drug is filled in the gaps of the second hydrogel.

7. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: The second hydrogel is configured as a capsule structure, and the drug is encapsulated in the capsule structure.

8. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: The main body substrate is one of polyvinyl alcohol, polyimide, and polyether block polyamide; the first hydrogel substrate is one of poly(N-isopropylacrylamide), poly(N,N-diethylacrylamide) and polymethyl vinyl ether; the second hydrogel substrate is one of poly(N-isopropylacrylamide), polyN,N-diethylacrylamide and poly-2-carboxy-N-isopropylacrylamide; the substrates of the first substrate and the second substrate are one of polyimide and polyethylene terephthalate.

9. The controllable medical catheter based on electrothermal driven hydrogel tip according to claim 1, characterized in that: It also includes a packaging structure, which is coated on the outer surface of the body, the needle tip component and the drug carrier component.

10. A medical device, characterized in that: A controllable medical catheter based on an electrothermally driven hydrogel tip as described in any one of claims 1 to 9.

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