Ion exchange column structure for synthesizing and purifying phosphorylcholine

Abstract

The utility model relates to the technical field of phosphorylcholine processing, and discloses an ion exchange column structure for synthesis and purification of phosphorylcholine, which comprises a support, an annular heating ring is annularly arranged on the inner wall of the upper end of the support, a cylinder is arranged on the inner side of the heating ring, a pressure release valve is embedded in the outer wall of the upper end of the cylinder, and the pressure release valve is connected with the support. An electromagnetic valve is assembled at an opening in the lower end of the barrel, an exchange column base is fixed to the upper surface of the interior of the barrel, and a resin exchange column is fixed to the lower end of the exchange column base; and the liquid injection pipe is connected to the upper surface of one side of the cylinder body. The ion exchange column structure for synthesizing and purifying phosphorylcholine is provided with the plurality of liquid injection pipes which are sequentially arranged at the joint of the liquid separation pipe and the cylinder body, so that a to-be-purified phosphorylcholine solution input by the feeding pipe is in contact with the resin exchange column in different strands, and compared with the contact of a single strand of solution and the resin exchange column, the volume of a working layer of the resin exchange column is increased; further, the purification efficiency of the phosphorylcholine solution is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of phosphorylcholine processing, in particular to an ion exchange column structure for phosphorylcholine synthesis and purification. Background Art

[0002] Phosphocholine is a white crystal or crystalline powder. It is an important intermediate in the biosynthesis of phosphatidylcholine in eukaryotic cells. It is formed by the condensation of choline and ATP under the catalysis of choline kinase present in animals and yeast. When purifying synthetic phosphocholine solutions, it is sometimes purified by ion exchange by fully contacting with a fixed ion exchange resin layer or a flowing ion exchange resin bed in an ion exchange column.

[0003] In chemical industry production, a single-line input ion exchange column structure is often used to purify the prepared phosphorylcholine solution. The contact surface between the phosphorylcholine solution injected through a single line and the resin exchange column is relatively concentrated, which easily leads to a small working layer volume of the resin exchange column and low purification efficiency. Therefore, we propose an ion exchange column structure for phosphorylcholine synthesis and purification. Utility Model Content

[0004] The utility model aims to provide an ion exchange column structure for the synthesis and purification of phosphorylcholine to solve the problems raised in the above-mentioned background technology.

[0005] To achieve the above object, the utility model provides the following technical solution: an ion exchange column structure for the synthesis and purification of phosphorylcholine, comprising:

[0006] A bracket, wherein an annular heating ring is arranged on the inner wall of the upper end of the bracket, a cylinder is arranged on the inner side of the heating ring, a pressure relief valve is embedded on the outer wall of the upper end of the cylinder, a solenoid valve is installed at the opening of the lower end of the cylinder, an exchange column base is fixed on the inner upper surface of the cylinder, and a resin exchange column is fixed on the lower end of the exchange column base;

[0007] An injection pipe is connected to the upper surface of one side of the cylinder, the other end of the injection pipe is connected to a liquid dispensing pipe, the other end of the liquid dispensing pipe is connected to a feeding pipe on the middle outer wall, a first flow meter is installed at the connection between the feeding pipe and the liquid dispensing pipe through a flange, and a pipe valve is installed in the middle of the feeding pipe.

[0008] Furthermore, the heating ring is tightly fitted to the outer wall of the lower end of the cylinder, and the resin exchange column, the exchange column base and the central axis of the cylinder coincide with each other.

[0009] Furthermore, the injection pipes are evenly distributed along the upper surface of one side of the cylinder body at equal intervals, and the injection pipes are connected to the feeding pipe through the liquid distribution pipe, the first flow meter and the pipe valve.

[0010] Furthermore, the outer wall of the lower end of the cylinder is connected to a recoil pipe through an electromagnetic valve, a recoil liquid pump is installed in the middle of the recoil pipe, and the recoil liquid pump is installed on the inner wall of one side of the bracket through bolts, and the recoil pipe is connected through the recoil liquid pump, the cylinder and the injection pipe.

[0011] Furthermore, the outer wall of the lower end of the cylinder is also connected to a discharge pipe with an L-shaped end face structure through an electromagnetic valve, the other end of the discharge pipe is connected to a telescopic hose through a flange, the other end of the telescopic hose is connected to a nozzle, and a second flow meter is installed on one side outer wall of the nozzle.

[0012] Furthermore, the cylinder is connected to the telescopic hose through the electromagnetic valve and the discharge pipe, and the telescopic hose is connected to the nozzle through the second flow meter, and the nozzle is telescopically connected to the discharge pipe through the telescopic hose.

[0013] Compared with the prior art, the beneficial effects of the utility model are:

[0014] The ion exchange column structure for phosphocholine synthesis and purification is provided with a plurality of injection pipes, which are sequentially arranged at the connection between the liquid separation pipe and the cylinder body, so that the phosphocholine solution to be purified input by the feeding pipe is divided into strands and contacts with the resin exchange column. Compared with the contact of a single strand of solution with the resin exchange column, the working layer volume of the resin exchange column is increased, thereby improving the efficiency of the purification operation of the phosphocholine solution. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the main structure of the utility model in the combined working state;

[0016] Figure 2 This is a schematic diagram of the cross-sectional structure of the cylinder part of the utility model;

[0017] Figure 3 This is a schematic diagram of the enlarged structure of the feeding pipe and the liquid dispensing pipe of the utility model;

[0018] Figure 4 It is a schematic diagram of the enlarged structure of the liquid discharge pipe part of the utility model.

[0019] In the figure: 1. bracket; 2. heating coil; 3. cylinder; 4. pressure relief valve; 5. exchange column base; 6. resin exchange column; 7. solenoid valve; 8. injection pipe; 9. dispensing pipe; 10. feeding pipe; 11. first flow meter; 12. pipe valve; 13. recoil pipe; 14. recoil liquid pump; 15. discharge pipe; 16. telescopic hose; 17. nozzle; 18. second flow meter. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0021] The utility model provides an ion exchange column structure for the synthesis and purification of phosphorylcholine through improvement. Figure 1-Figure 3 , including: a bracket 1, an annular heating coil 2 is arranged on the inner wall of the upper end of the bracket 1, a barrel 3 is arranged on the inner side of the heating coil 2, the heating coil 2 is tightly fitted with the outer wall of the lower end of the barrel 3, and the heating coil 2 is used to increase the reaction environment temperature in the barrel 3 to achieve the effect of increasing the ion exchange rate and improving the purification operation efficiency; a pressure relief valve 4 is embedded in the outer wall of the upper end of the barrel 3, and the pressure relief valve 4 is used to relieve pressure when the hydraulic pressure in the barrel 3 is too large to prevent the barrel 3 from breaking; a solenoid valve 7 is installed at the opening of the lower end of the barrel 3, an exchange column base 5 is fixed on the inner upper surface of the barrel 3, a resin exchange column 6 is fixed on the lower end of the exchange column base 5, and the resin exchange column 6 and the exchange column base 5 coincide with the central axis of the barrel 3, and an injection pipe 8 is connected to the upper surface of one side of the barrel 3, and the injection pipes 8 are evenly distributed along the upper surface of one side of the barrel 3, and a plurality of injection pipes 8 are arranged, and are arranged according to The second arrangement is at the connection between the liquid separation tube 9 and the cylinder 3, so that the phosphorylcholine solution to be purified input by the feeding tube 10 is in contact with the resin exchange column 6 when injected into the cylinder 3. Compared with the single-strand solution contacting the resin exchange column 6, the working layer volume of the resin exchange column 6 is increased, thereby improving the purification efficiency of the phosphorylcholine solution; the other end of the injection tube 8 is connected to the liquid separation tube 9, and the middle outer wall of the other end of the liquid separation tube 9 is connected to the feeding tube 10. The connection between the feeding tube 10 and the liquid separation tube 9 is equipped with a first flow meter 11 through a flange, and the middle part of the feeding tube 10 is equipped with a pipe valve 12, and the injection tube 8 is connected to the feeding tube 10 through the liquid separation tube 9, the first flow meter 11 and the pipe valve 12. The first flow meter 11 and the pipe valve 12 are used to regulate the injection rate of the phosphorylcholine solution into the cylinder 3, so as to open and close the pipe valve 12 according to the consumption of the resin exchange column 6.

[0022] See also Figure 1, an ion exchange column structure for phosphocholine synthesis and purification, comprising: a backwash pipe 13 is connected to the outer wall of the lower end of a cylinder 3 through an electromagnetic valve 7, a backwash liquid pump 14 is installed in the middle of the backwash pipe 13, the backwash liquid pump 14 is used to pump the flushing liquid input into the backwash pipe 13 into the cylinder 3 through the opened electromagnetic valve 7, and the resin exchange column 6 is backwashed; and the backwash liquid pump 14 is installed on the inner wall of one side of a bracket 1 through bolts, the backwash pipe 13 is connected to the cylinder 3 and the injection pipe 8 through the backwash liquid pump 14, the backwash pipe 13 and the backwash liquid pump 14 are arranged to pump the flushing liquid for backwashing into the cylinder 3 through the electromagnetic valve 7 opened at the lower end of the cylinder 3, so as to realize the backwashing of the resin exchange column 6 and the feeding pipe 10, so as to realize the reuse of the exchange column structure after backwashing, and can realize multiple cycles of use, thereby reducing the equipment loss of the phosphocholine purification operation.

[0023] See also Figure 1 and Figure 4 , an ion exchange column structure for phosphocholine synthesis and purification, comprising: a lower end outer wall of a cylinder 3 is also connected to a drain pipe 15 with an L-shaped end face structure through an electromagnetic valve 7, the other end of the drain pipe 15 is connected to a telescopic hose 16 through a flange, the cylinder 3 is connected to the telescopic hose 16 through the electromagnetic valve 7 and the drain pipe 15, the other end of the telescopic hose 16 is connected to a nozzle 17, and the nozzle 17 is telescopically connected to the drain pipe 15 through the telescopic hose 16, the drain pipe 15 is used to discharge the purified phosphocholine solution through the opened electromagnetic valve 7, and is connected to a recovery container through the telescopic hose 16 and the nozzle 17, so that the applicability is better; a second flow meter 18 is installed on one side outer wall of the nozzle 17, and the telescopic hose 16 is connected to the nozzle 17 through the second flow meter 18, and the second flow meter 18 is used to record and calculate the output rate and output amount of the purified phosphocholine solution, so as to compare with the data recorded by the first flow meter 11.

[0024] Working principle: For this type of ion exchange column structure for phosphocholine synthesis and purification, firstly, the support 1 and the barrel 3 of the ion exchange column structure are placed on a stable and horizontal working surface in the working environment, and then the feed pipe 10 is connected to the crude phosphocholine solution storage container, so that the phosphocholine solution to be purified can be injected into the barrel 3 through the feed pipe 10, and the purified phosphocholine solution flows into the separator 9 through the opened pipe valve 12 and the first flowmeter 11, and then the separator 9 is injected into the inner side of the barrel 3 through multiple injection pipes 8. The multiple injected phosphocholine solutions are in contact with the resin exchange column 6 on the exchange column base 5 in the barrel 3 in multiple layers, thereby increasing the volume of the working layer of the resin exchange column 6, thereby improving the ion exchange rate and the purification rate of the phosphocholine solution. The reaction rate can be increased by the heating coil 2 to increase the reaction temperature and control The pipe valve 12 increases the injection rate of the solution to a certain extent. If the hydraulic pressure in the cylinder 3 is too large during the subsequent reaction, the pressure can be relieved through the top pressure relief valve 4. The purified phosphorylcholine solution flows into the discharge pipe 15 through the opened solenoid valve 7. The nozzle 17 and the telescopic hose 16 are adjusted to be connected to different containers, so that the purified phosphorylcholine solution can be stored. The output solution rate and total amount can be collected and calculated through the data displayed by the second flow meter 18, which is convenient for comparison with the data of the first flow meter 11. Finally, after the operation is completed, the cylinder 3 and the resin exchange column 6 can be backwashed by inputting flushing liquid through the opened solenoid valve 7 and the backwash pipe 13. The backwashing liquid pump 14 pumps the flushing liquid into the cylinder 3, and the overflow is discharged through the injection pipe 8, so as to achieve the overall cleaning of the device and facilitate subsequent reuse.

[0025] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An ion exchange column structure for the synthesis and purification of phosphorylcholine, characterized in that: include: A bracket (1), wherein an annular heating coil (2) is arranged on the inner wall of the upper end of the bracket (1), a cylinder (3) is arranged on the inner side of the heating coil (2), a pressure relief valve (4) is embedded in the outer wall of the upper end of the cylinder (3), a solenoid valve (7) is installed at the lower opening of the cylinder (3), an exchange column base (5) is fixed on the inner upper surface of the cylinder (3), and a resin exchange column (6) is fixed at the lower end of the exchange column base (5); An injection pipe (8) is connected to the upper surface of one side of the cylinder (3); the other end of the injection pipe (8) is connected to a liquid dispensing pipe (9); the other end of the liquid dispensing pipe (9) is connected to a feed pipe (10) at the middle outer wall thereof; a first flow meter (11) is installed at the connection between the feed pipe (10) and the liquid dispensing pipe (9) via a flange; and a pipe valve (12) is installed in the middle of the feed pipe (10).

2. The ion exchange column structure for the synthesis and purification of phosphorylcholine according to claim 1, characterized in that: The heating coil (2) is tightly fitted to the outer wall of the lower end of the cylinder (3), and the central axis of the resin exchange column (6), the exchange column base (5) and the cylinder (3) coincides.

3. The ion exchange column structure for the synthesis and purification of phosphorylcholine according to claim 1, characterized in that: The injection pipes (8) are evenly distributed along the upper surface of one side of the cylinder (3) at equal intervals, and the injection pipes (8) are connected to the feeding pipe (10) through the liquid distribution pipe (9), the first flow meter (11) and the pipe valve (12).

4. The ion exchange column structure for the synthesis and purification of phosphorylcholine according to claim 1, characterized in that: The outer wall of the lower end of the cylinder (3) is connected to a recoil pipe (13) via a solenoid valve (7); a recoil liquid pump (14) is installed in the middle of the recoil pipe (13); and the recoil liquid pump (14) is installed on the inner wall of one side of the bracket (1) via bolts; the recoil pipe (13) is connected to the cylinder (3) and the injection pipe (8) via the recoil liquid pump (14).

5. The ion exchange column structure for the synthesis and purification of phosphorylcholine according to claim 1, characterized in that: The outer wall of the lower end of the cylinder (3) is also connected to a liquid discharge pipe (15) having an L-shaped end face structure through a solenoid valve (7); the other end of the liquid discharge pipe (15) is connected to a telescopic hose (16) through a flange; the other end of the telescopic hose (16) is connected to a nozzle (17); and a second flow meter (18) is mounted on one side outer wall of the nozzle (17).

6. The ion exchange column structure for the synthesis and purification of phosphorylcholine according to claim 5, characterized in that: The cylinder (3) is connected to the telescopic hose (16) through the electromagnetic valve (7) and the liquid discharge pipe (15), and the telescopic hose (16) is connected to the nozzle (17) through the second flow meter (18), and the nozzle (17) is connected to the liquid discharge pipe (15) through the telescopic hose (16).

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