Cryopreservation tube picking assembly and biological sample cryopreservation device

Abstract

The utility model discloses a cryopreservation tube picking assembly and a biological sample cryopreservation device. The pipe taking piece is arranged at the lower end of the main body, the pipe taking piece is provided with a pipe taking part used for picking the picked cryopreservation pipes from a cryopreservation box, and the cryopreservation box is used for containing a plurality of cryopreservation pipes; and the sensor is arranged on the main body and corresponds to the tube taking part in height so as to detect whether the picked cryopreservation tube is picked by the tube taking part or not. The cryopreservation tube picking assembly and the biological sample cryopreservation device are provided with the sensor, whether the picked cryopreservation tube is picked by the tube taking part or not can be detected, so that after the picked cryopreservation tube is put down by the tube taking part, when the picked cryopreservation tube is adhered to the tube taking part due to frost and the like, the information can be grasped in time, and in addition, the operation is convenient. And when the cryopreservation tube is picked by the tube taking part but is not picked, the cryopreservation tube can also be detected.

Description

Technical Field

[0001] The present application relates to the technical field of biological sample cryopreservation, and in particular to a cryopreservation tube picking assembly and a biological sample cryopreservation device. Background Art

[0002] With the rapid development of the biopharmaceutical industry, large-scale biobanks have emerged, and the storage volume of biological samples is increasing. Generally, biological samples such as tissues and cells in clinical or laboratory settings are placed in cryotubes, which are then placed in cryoboxes for storage. However, in practice, it is necessary to pick the cryotubes out of the cryobox and put them in another cryobox. However, in this process, it is not convenient to understand the selection of the cryotubes. Utility Model Content

[0003] In view of the above problems, the present application is proposed to provide a cryotube picking tube assembly and a biological sample freezing device that overcome the above problems or at least partially solve the above problems.

[0004] The present application provides a cryotube picking assembly, comprising: a main body; a tube picking piece, arranged at the lower end of the main body, the tube picking piece having a tube picking portion for picking up a picked cryotube from a cryobox, the cryobox being used to place a plurality of cryotubes; a sensor, arranged on the main body and corresponding in height to the tube picking portion, so as to detect whether the tube picking portion has picked up the picked cryotube.

[0005] Optionally, the sensor includes a transmitting terminal sensor and a receiving terminal sensor, and the transmitting terminal sensor is used to transmit a detection signal to the receiving terminal sensor.

[0006] Optionally, the cryotube picking assembly further includes: a connecting piece, one end of which is connected to the main body, the other end of which is located at the lower end of the main body, and the sensor is fixed to the other end of the connecting piece.

[0007] Optionally, the cryotube picking assembly also includes: a tube pressing plate, which is connected to the other end of the connecting piece, and the tube pressing plate is provided with a tube picking hole corresponding to the position of the tube picking piece, and the tube picking hole is used for the tube picking piece to pick up the picked cryotube, and the tube pressing plate is used to press at least part of the cryotubes in the cryobox when the tube picking piece picks up the picked cryotube.

[0008] Optionally, one end of the connecting member is slidably connected to the main body, and the other end of the connecting member is fixedly connected to the tube pressing plate.

[0009] Optionally, the connecting member is connected to an elastic member, and the elastic member is used to make the tube pressing plate be located below the tube taking member when no external force is applied thereto.

[0010] Optionally, the sensor is fixed to the other end of the connecting member through the tube pressing plate.

[0011] Optionally, the sensor is fixed to the other end of the connecting member via threads.

[0012] Optionally, there are multiple connecting members, including a first connecting member and a second connecting member that are arranged opposite to each other.

[0013] The present application also provides a biological sample freezing device comprising: a cavity, which defines a storage area for storing a freezing box and a tube picking area for picking up a frozen tube from the freezing box; and a freezing tube picking assembly as described above, wherein the tube picking assembly is arranged in the tube picking area.

[0014] The cryotube picking assembly and biological sample freezing device provided in the present application have a sensor that can detect whether the tube picking part has picked up a picked cryotube, so that when the picked cryotube sticks to the tube picking part due to frost or other reasons after the tube picking part puts down the picked cryotube, the information can be obtained in time, and it can also be detected when the tube picking part fails to pick up the picked cryotube. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Other objects and advantages of the present application will be apparent from the following description of the present application with reference to the accompanying drawings, and will help to provide a comprehensive understanding of the present application.

[0016] Figure 1 is a front view of a cryotube pick assembly with the sensor hidden according to some embodiments of the present application;

[0017] Figure 2 is a stereoscopic diagram of a cryotube pick assembly with the tube removal fittings hidden according to some embodiments of the present application;

[0018] Figure 3 is a first perspective view of a connector, a tube pressing plate, and an anti-wear component of a cryotube pick-up assembly according to some embodiments of the present application;

[0019] Figure 4 This is a second perspective view of the connector, tube pressing plate and anti-wear parts of the cryotube pick assembly according to some embodiments of the present application.

[0020] In the figure, 10 is a tube picking device for cryopreservation tubes, 100 is a main body, 200 is a tube taking member, 20 is a tube pressing device, 300 is a connecting member, 310 is a first connecting member, 320 is a second connecting member, 400 is a tube pressing plate, 410 is a tube picking hole, 420 is a tube pressing protrusion, 500 is an anti-wear member, 600 is a sensor, 610 is a transmitting terminal sensor, and 620 is a receiving terminal sensor. DETAILED DESCRIPTION

[0021] In order to make the purpose, technical solution and advantages of the present application clearer, the technical solution of the present application will be clearly and completely described below in conjunction with the drawings of the embodiments of the present application. Obviously, the described embodiment is one embodiment of the present application, not all embodiments. Based on the described embodiments of the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0022] Unless otherwise defined, technical or scientific terms used in this application should have the common meanings understood by persons having ordinary skills in the field to which this application belongs.

[0023] The present embodiment provides a cryotube picking assembly, which includes: a main body 100; a tube picking member 200, which is arranged at the lower end of the main body 100, and the tube picking member 200 has a tube picking portion for picking up a selected cryotube from a cryobox, and the cryobox is used to place multiple cryotubes; a sensor, which is arranged on the main body 100 and corresponds to the tube picking portion in height to detect whether the tube picking portion has picked up the selected cryotube.

[0024] Cryotubes are special containers used in laboratories to store biological samples at low temperatures. These biological samples may include cells, tissues, DNA, RNA, etc. A cryobox is a storage device specifically used to store biological samples in a low-temperature environment. There are several small slots inside the box for storing cryotubes. A cryobox can hold multiple cryotubes. When a user uses a cryotube, the user needs to pick it out. The cryotube that needs to be picked is called the picked cryotube (for the convenience of description only, and does not mean that the shape, structure, etc. of the picked cryotube are necessarily different from other cryotubes). The cryotube picking assembly can be used to pick the picked cryotube.

[0025] The main body 100 of the cryotube picking assembly can be a disc, a square or other structure, which is used to install the tube picking device 200. The tube picking device 200 can be a clamp, an adsorption device, a clamping device, etc., which is used to clamp, adsorb or hold the picked cryotube.

[0026] The cryotube picking assembly and biological sample freezing device provided in the present application have a sensor that can detect whether the tube picking part has picked up a picked cryotube, so that when the picked cryotube sticks to the tube picking part due to frost or other reasons after the tube picking part puts down the picked cryotube, the information can be obtained in time, and it can also be detected when the tube picking part fails to pick up the picked cryotube.

[0027] In some embodiments, the sensor includes a transmitting terminal sensor and a receiving terminal sensor, and the transmitting terminal sensor is used to transmit a detection signal to the receiving terminal sensor. That is, the transmitting terminal sensor transmits a detection signal such as a laser to the receiving terminal sensor. If the receiving terminal sensor receives the laser, it means that the tube-taking unit does not hold the selected cryopreserved tube. If the receiving terminal sensor does not receive the laser, it means that the tube-taking unit holds the selected cryopreserved tube.

[0028] The cryotube pick assembly further includes a connector 300 , one end of which is connected to the main body 100 , the other end of which is located at the lower end of the main body 100 , and the sensor is fixed to the other end of the connector 300 .

[0029] The connecting member 300 may include a connecting rod. In other embodiments, the connecting member 300 may also be a connecting plate or other structures.

[0030] In some embodiments, the cryotube picking assembly also includes a tube pressing plate 400, which is connected to the other end of the connecting member 300. The tube pressing plate 400 is provided with a tube picking hole 410 corresponding to the position of the tube picking member 200. The tube picking hole 410 is used for the tube picking member 200 to pick up the picked cryotube. The tube pressing plate 400 is used to press at least part of the cryotubes in the cryobox when the tube picking member 200 picks up the picked cryotube.

[0031] Since the cryotube is placed in a low-temperature environment, ice may form between the picked cryotube and other cryotubes, causing the picked cryotube to stick together with other surrounding cryotubes. When the picked cryotube is lifted up, other surrounding cryotubes will be lifted up, resulting in the risk of other cryotubes being lost, difficult to trace, and difficult to find. If other cryotubes are lifted up and fall, they may get stuck in some mechanisms, causing the risk of the biological sample freezing device being unable to complete automated operations.

[0032] The cryotube picking tube assembly provided in this embodiment can press at least part of the cryotubes attached to the cryotubes to be picked up by pressing the tubes during the process of picking out the cryotubes to be picked up, thereby preventing these cryotubes from being picked up.

[0033] In some embodiments, one end of the connector 300 may be fixedly connected to the main body 100. The tube-taking fitting 200 may be higher than the tube-pressing plate 400, so that after the tube-pressing plate 400 presses other cryopreservation tubes, the tube-taking fitting 200 moves downward to pick up the cryopreservation tubes to be picked, that is, the tube-taking fitting 200 needs to move relative to the main body 100 in the up-down direction. The tube-taking fitting 200 may be flush with the tube-pressing plate 400, so that when the tube-pressing plate 400 presses other cryopreservation tubes, the tube-taking fitting 200 can pick up the cryopreservation tubes to be picked.

[0034] One end of the connecting member 300 is slidably connected to the main body 100, and the other end of the connecting member 300 is fixedly connected to the tube pressing plate 400. For example, the main body 100 is provided with a slide groove or a slide hole, and one end of the connecting member 300 is arranged in the slide groove or the slide hole. When the tube pressing plate 400 is located below the tube taking member 200 when no external force is applied, the tube taking member 200 does not need to move relative to the main body 100 in the up-down direction.

[0035] In some embodiments, the connector 300 is connected to an elastic member, and the elastic member is used to make the tube pressing plate 400 located below the tube taking member 200 when no external force is applied. The elastic member keeps the tube pressing plate 400 in position when no external force is applied, so as to better press other cryopreservation tubes.

[0036] The elastic member may include a spring sleeved outside the connecting member 300. Thus, the structure is stable and reliable. In other embodiments, a spring sheet, a rubber strip, etc. may be used.

[0037] In some embodiments, the other end of the connector 300 is fixed with the sensor via the tube pressing plate 400, so as to facilitate the fixing of the sensor and ensure the fixing effect.

[0038] In some embodiments, the sensor is fixed to the other end of the connector 300 by threads. Threaded connection is stable and reliable.

[0039] In some embodiments, the connector 300 may be multiple and include a first connector 310 and a second connector 320 that are arranged opposite to each other. Thus, the compression tube can be used to compress other cryopreservation tubes. The arrangement direction of the first connector 310 and the second connector 320 is not parallel to the arrangement direction of the transmitting terminal sensor and the receiving terminal sensor, for example, vertical.

[0040] This embodiment also provides a biological sample freezing device, comprising: a cavity, the cavity defining a storage area for storing a freezing box and a tube picking area for picking a selected freezing tube from the freezing box; any of the above-mentioned freezing tube picking assemblies, the tube picking assembly being arranged in the tube picking area. The biological sample freezing device can be a refrigerator, a cold storage, a storage device including a liquid nitrogen tank, etc.

[0041] The present embodiment also provides a tube pressing device 20 for a freezing tube picking device 10, the freezing tube picking device 10 comprises a main body 100 and a tube picking member 200 arranged at the lower end of the main body 100, the tube picking member 200 is used to pick up the picked freezing tube from a freezing box, the freezing box is used to place multiple freezing tubes, the tube pressing device 20 comprises: a connecting member 300, one end of the connecting member 300 is connected to the main body 100, and the other end of the connecting member 300 is located at the lower end of the main body 100; a tube pressing plate 400, the tube pressing plate 400 is connected to the other end of the connecting member 300, the tube pressing plate 400 is provided with a tube picking hole 410 corresponding to the position of the tube picking member 200, the tube picking hole 410 is used for the tube picking member 200 to pick up the picked freezing tube, and the tube pressing plate 400 is used to press at least part of the freezing tubes in the freezing box when the tube picking member 200 picks up the picked freezing tube.

[0042] In some embodiments, a wear-resistant member 500 is disposed at a position where one end of the connecting member 300 is slidably connected to the main body 100, thereby preventing the sliding member from being severely worn when sliding.

[0043] In some embodiments, the tube picking hole 410 is located at the center of the tube pressing plate 400. Thus, other cryopreservation tubes around the picked cryopreservation tube can be prevented from being lifted up.

[0044] In some embodiments, a tube pressing protrusion 420 is provided at the bottom of the tube pressing plate 400, and the tube pressing plate 400 presses at least part of the cryotubes in the cryopreservation box through the tube pressing protrusion 420. Thus, the contact area between the tube pressing plate 400 and other cryotubes is reduced, thereby preventing other cryotubes from adhering to the tube pressing plate 400. There may be a plurality of tube pressing protrusions 420, for example, a plurality of protrusions 420 evenly arranged at circumferential intervals.

[0045] The present embodiment also provides a cryotube picking assembly, comprising: a cryotube picking device 10, comprising a main body 100 and a tube picking member 200 arranged at the lower end of the main body 100, the tube picking member 200 is used to pick up the picked cryotube from a cryobox, and the cryobox is used to place multiple cryotubes; any of the above-mentioned tube pressing devices 20, one end of the connecting member 300 of the tube pressing device 20 is connected to the main body 100, and the other end of the connecting member 300 is located at the lower end of the main body 100, the tube picking hole 410 of the tube pressing device 20 is used for the tube picking member 200 to pick up the picked cryotube, and the tube pressing plate 400 is used to press at least part of the cryotubes in the cryobox when the tube picking member 200 picks up the picked cryotube.

[0046] This embodiment also provides a biological sample freezing device, including: a cavity, which defines a storage area for storing a freezing box and a tube picking area for picking up a frozen tube from the freezing box; the above-mentioned freezing tube picking assembly, which is arranged in the tube picking area.

[0047] The tube pressing device 20, the cryotube picking assembly and the biological sample freezing device provided in this embodiment can press at least part of the cryotubes attached to the picked cryotubes through the tube pressing plate 400 during the process of picking out the picked cryotubes, thereby preventing these cryotubes from being picked up.

[0048] Regarding the embodiments of the present application, it should also be noted that, in the absence of conflict, the embodiments of the present application and the features therein can be combined with each other to obtain new embodiments.

[0049] The above are only specific implementation methods of the present application, but the protection scope of the present application is not limited thereto. The protection scope of the present application shall be based on the protection scope of the claims.

Claims

1. A cryotube picking assembly, characterized in that: include: main body; A tube taking member is arranged at the lower end of the main body, and the tube taking member has a tube taking portion for taking a selected cryogenic tube from a cryogenic box, wherein the cryogenic box is used for placing a plurality of cryogenic tubes; The sensor is arranged on the main body and corresponds to the tube taking part in height so as to detect whether the tube taking part has picked up the frozen tube.

2. The cryotube picking assembly according to claim 1, characterized in that: The sensor includes a transmitting terminal sensor and a receiving terminal sensor, and the transmitting terminal sensor is used to transmit a detection signal to the receiving terminal sensor.

3. The cryotube picking assembly according to claim 1, characterized in that: Also includes: A connecting piece, one end of which is connected to the main body, the other end of which is located at the lower end of the main body, and the sensor is fixed to the other end of the connecting piece.

4. The cryotube picking assembly according to claim 3, characterized in that: Also includes: A tube pressing plate is connected to the other end of the connecting piece, and the tube pressing plate is provided with a tube picking hole corresponding to the position of the tube taking piece, and the tube picking hole is used for the tube taking piece to pick up the picked frozen tube. The tube pressing plate is used to press at least part of the frozen tubes in the freezing box when the tube taking piece picks up the picked frozen tube.

5. The cryotube picking assembly according to claim 4, characterized in that: One end of the connecting piece is slidably connected to the main body, and the other end of the connecting piece is fixedly connected to the tube pressing plate.

6. The cryotube picking assembly according to claim 4, characterized in that: The connecting member is connected to an elastic member, and the elastic member is used to make the tube pressing plate be located below the tube taking member when no external force is applied thereto.

7. The cryotube picking assembly according to claim 4, characterized in that: The sensor is fixed to the other end of the connecting member through the tube pressing plate.

8. The cryotube picking assembly according to claim 3, characterized in that: The sensor is fixed to the other end of the connecting piece via threads.

9. The cryotube picking assembly according to claim 3, characterized in that: The connecting members are multiple and include a first connecting member and a second connecting member that are arranged opposite to each other.

10. A biological sample freezing device, characterized in that: include: A cavity, wherein the cavity defines a storage area for storing the cryopreservation box and a tube picking area for picking the selected cryopreservation tube from the cryopreservation box; According to any one of claims 1 to 9, the cryotube picking assembly is arranged in the tube picking area.

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