Chemical adding regulation and control system

By designing the dosing control system, using multiple tanks and control pipelines, the rapid replacement and regulation of drugs are achieved, and the problem of unstable drug addition in existing equipment under abnormal working conditions is solved, and the stability and compatibility of the production process are improved.

CN222864714UActive Publication Date: 2025-05-13GUIZHOU JINZE NEW ENERGY TECH CO LTD
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Patent Information

Application Number
CN202421649076.2
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-11
Publication Date
2025-05-13
Estimated Expiration
2034-07-11

AI Technical Summary

Technical Problem

If there are abnormal working conditions during the drug addition process of existing biochemical production equipment, such as errors in the drug addition or concentration errors, it will not be timely regulated, resulting in production interruption and increased costs.

Method used

A dosing control system was designed, including production pipelines, multiple tanks and regulation pipelines. Through components such as the dosing main branch, dosing branch, return main branch and return branch, the rapid exchange and regulation of drugs are realized to ensure the continuity of the production process.

Benefits of technology

The system can quickly optimize drug addition and adjustment, reduce the time and energy of drug replacement, maintain the normal production process, improve equipment regulation compatibility, and is suitable for various abnormal working conditions.

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Abstract

The utility model discloses a dosing regulation and control system, which belongs to the technical field of biochemical production equipment, and comprises a production pipeline for producing biological or chemical products; the plurality of tank bodies are respectively used for storing medicines; the regulation and control pipeline comprises a chemical adding main branch, a plurality of chemical adding branch pipelines, a backflow main branch, a plurality of backflow branch pipelines and a material injection pipeline; the dosing main branch and the backflow main branch are respectively connected to the production pipeline at intervals, the plurality of dosing branches are respectively communicated with one end of the dosing main branch, the other end of each dosing branch is connected with an outlet of the tank body, each dosing branch is provided with a dosing branch regulation and control valve, the plurality of backflow branches are respectively communicated with one end of the backflow main branch, and each backflow branch is provided with a backflow branch regulation and control valve. The other end of the backflow branch is connected with the inlet of the tank body, the backflow branch is provided with a backflow regulation and control valve, and the material injection pipeline is communicated with each tank body. According to the method, process optimization can be carried out on medicine addition and adjustment of the production line, medicine switching is rapidly carried out, the normal production process can be maintained, and the compatibility of equipment regulation and control is improved.
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Description

Technical Field

[0001] The present application belongs to the technical field of biochemical production equipment, and in particular, relates to a drug addition control system. Background Art

[0002] In the production equipment of biochemical products, new drugs need to be added to the production line during the production process, such as chemicals, raw materials or biological additives. The production equipment is widely used. Taking the field of biological fermentation as an example, in the production line, biological cells or bacteria are cultivated by fermentation, and biochemical drugs, beverages, fuels, etc. are produced through the metabolic mechanism of the cells or bacteria themselves. The selectivity of metabolites or the growth environment of strains in the fermentation process can be screened through the culture medium. By adjusting the nutrient components of the culture medium, the engineered strains can be controlled to be dominant strains in production to improve production efficiency. Adjusting the usage can also achieve metabolic selectivity and cost control.

[0003] Among the existing production equipment, some require the addition of large amounts of new drugs and require high work intensity. If abnormal operating conditions occur on the production line, such as incorrect drug addition, incorrect concentration addition, or maintenance, etc., they cannot be adjusted in time, and it often takes a lot of time and effort to switch drugs, which not only affects production, but also increases production costs. Utility Model Content

[0004] The present application aims to solve the technical problem of adding and switching drugs at least to a certain extent. To this end, the present application provides a drug adding and control system that can optimize the process of adding and adjusting drugs in the production line, quickly switch drugs, maintain the normal production process, and improve the compatibility of equipment control.

[0005] The present application provides a drug dosing control system, which includes:

[0006] Production pipelines for producing biological or chemical products;

[0007] Multiple tanks, each used to store medicines;

[0008] The regulating pipeline includes a dosing main branch, multiple dosing branch roads, a reflux main branch road, multiple reflux branch roads and an injection pipeline; the dosing main branch road and the reflux main branch road are respectively connected to the production pipeline at intervals, the multiple dosing branch roads are respectively connected to one end of the dosing main branch road, the other end of the dosing branch road is connected to the outlet of the tank body, the dosing branch road is provided with a dosing branch regulating valve, the multiple reflux branch roads are respectively connected to one end of the reflux main branch road, the other end of the reflux branch road is connected to the inlet of the tank body, the reflux branch road is provided with a reflux regulating valve, and the injection pipeline is connected to each tank body.

[0009] In an optional embodiment, the dosing branch road, the reflux branch road and the tank body are connected one by one, and each tank body can form an independent loop with the dosing branch road, the dosing main branch road, the production pipeline, the reflux main branch road and the reflux branch road.

[0010] In an optional implementation manner, the drug-dosing main branch is provided with a drug-dosing regulating valve, and the drug-dosing regulating valve is used to adjust the opening and closing of the drug-dosing main branch.

[0011] In an optional embodiment, the production pipeline includes an input section, a parallel section and an output section, the two ends of the parallel section are respectively connected to the input section and the output section, and the parallel section is connected to the dosing main branch and the reflux main branch.

[0012] In an optional embodiment, the connection between the input section and the parallel section is a first node, the first node is connected to the drug addition main branch, the connection between the parallel section and the output section is a second node, and the second node is connected to the reflux main branch.

[0013] In an optional embodiment, the input section includes a medicine tank and a medicine adding pipe, one end of the medicine adding pipe is connected to the medicine tank, and the other end is connected to the parallel section.

[0014] In an optional embodiment, the input section further includes an input valve, which is disposed on the drug adding pipe.

[0015] In an optional embodiment, the output section includes an output pipe and a production valve, the output pipe is connected to the parallel section, and the production valve is arranged on the output pipe.

[0016] In an optional embodiment, it also includes a drug adding and pressurizing device, which is arranged in the input section, the parallel section, the output section, the drug adding main branch or the reflux main branch.

[0017] In an optional embodiment, the dosing and pressurizing device includes a metering pump and a regulating pump, the metering pump is arranged in the input section, and the regulating pump is arranged in the dosing main branch.

[0018] It can be seen from the above technical solution that the beneficial effects of this application are:

[0019] The system of the present application is connected with the main dosing branch and the dosing branch road through multiple tanks, so as to effectively add the medicines in the tanks to the production pipeline, and then realize the self-circulation of the nutrient solution through the reflux main branch and the reflux branch road. The multiple tanks are used and reserved for convenience of backflow operation. Through the dosing branch control valve and the reflux branch control valve, the medicines in a single tank can flow into the production pipeline through the dosing main branch and the dosing branch road, and then flow back to another single tank through the reflux main branch and the reflux branch road, thus forming a tank backflow path, and then can optimize the process of drug addition and adjustment of the production line, quickly switch drugs, maintain the normal production process, improve the compatibility of equipment control, and provide the production pipeline with the drugs that need to be added. It is suitable for abnormal working conditions, including unstable low-flow addition, backflow, maintenance and the like. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other embodiments and drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 A schematic diagram of an embodiment of the drug addition control system of the utility model is shown.

[0022] Figure numerals: 100, system; 110, production pipeline; 111, input section; 111a, reagent tank; 111b, dosing pipe; 111c, input valve; 112, parallel section; 112a, first node; 112b, second node; 113, output section; 113a, delivery pipe; 113b, production valve; 120, control pipeline; 121, dosing main branch; 121a, dosing control valve; 122, dosing branch; 122a, dosing branch control valve; 123, reflux main branch; 124, reflux branch; 124a, reflux control valve; 125, injection pipeline; 130, tank body; 131, first tank body; 132, second tank body; 140, dosing booster; 141, metering pump; 142, control pump. DETAILED DESCRIPTION

[0023] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] It should be noted that all directional indications in the embodiments of the present invention are only used to explain the relative position relationship, movement status, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly.

[0025] In the present invention, unless otherwise clearly specified and limited, the terms "connection", "fixation", etc. should be understood in a broad sense. For example, "fixation" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0026] In addition, in the present utility model, descriptions such as "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such a combination of technical solutions does not exist and is not within the scope of protection required by the present utility model.

[0027] The present application is described below with reference to the accompanying drawings and specific embodiments:

[0028] Please refer to Figure 1The first aspect of the present application provides a drug dosing control system, which can be used in a variety of scenarios, including biological product production equipment and chemical product production equipment. This embodiment takes a biological metabolism control production system 100 as an example for explanation. The system 100 includes a production pipeline 110, multiple tanks 130 and a control pipeline 120; the production pipeline 110 is used to produce biological or chemical products. The production pipeline 110 can adopt the existing one, and multiple tanks 130 and a control pipeline 120 are added on the basis of the existing production pipeline 110. The plurality of tanks 130 are used to store drugs, which are stored in liquid form. The number of the tanks 130 is greater than or equal to 2. The drugs are evenly mixed in the tanks 130. When necessary, the drugs in the tanks 130 can be injected into the production pipeline 110. The control pipeline 120 includes a drug-adding main branch 121, a plurality of drug-adding branch roads 122, a reflux main branch road 123, a plurality of reflux branch roads 124 and a material injection pipeline 125. The number of the drug-adding branch roads 122 and the reflux branch roads 124 is greater than or equal to 2. The dosing main branch 121, the dosing branch 122, the return main branch 123, and the return branch 124 can all be connected by conventional pipe fittings according to the relationship between the main road and the branch road; the dosing main branch 121 and the return main branch 123 are respectively connected to the production pipeline 110 at intervals, and the dosing main branch 121 is located at a position upstream of the return main branch 123. The drugs can be transported from the production pipeline 110 corresponding to the dosing main branch 121 to the return main branch 1 At the production line 110 corresponding to 23, a plurality of dosing branch roads 122 are respectively connected to one end of the dosing main branch road 121, each pipe fitting of the dosing branch road 122 is connected to the pipe fitting of the dosing main branch road 121, and the other end of the dosing branch road 122 is connected to the outlet of the tank body 130, and the dosing branch road 122 is provided with a dosing branch road regulating valve 122a, so that the drugs in each tank body 130 can be independently controlled by the dosing branch road regulating valve 122a and enter the dosing main branch road 121, and the plurality of reflux branch roads 122 are connected to the outlet of the tank body 130. 24 are respectively connected to one end of the reflux main branch 123, and the other end of the reflux branch 124 is connected to the inlet of the tank body 130. The reflux branch 124 is provided with a reflux regulating valve 124a, so that the refluxed medicine can be independently controlled by the reflux branch regulating valve and enter each tank body 130. The injection pipeline 125 is connected to each tank body 130. Each tank body 130 can be equipped with an injection pipe, or multiple tank bodies 130 can share one injection pipe, and each tank body 130 can be injected with medicine through the injection pipe.

[0029] In the production equipment of biological or chemical products in the prior art, drugs are generally added by directly connecting to the production pipeline 110 through a pipeline. When encountering abnormal working conditions, it is not possible to quickly and effectively control it. It takes a lot of time and effort to switch drugs, which is labor-intensive and affects the production process. However, the present application uses multiple tanks 130 to connect with the main drug-adding branch 121 and the drug-adding branch 122, so as to effectively add the drugs in the tank 130 to the production pipeline 110, and then realize the self-circulation of the nutrient solution through the reflux main branch 123 and the reflux branch 124. Multiple tanks 130 are used and reserved, which is convenient for backflow operation. Through the drug-adding branch control valve 122a and the reflux branch control valve, the drugs in a single tank 130 can be transferred through the main drug-adding branch 121 and the reflux branch 122. The branch 122 flows into the production pipeline 110, and then flows back to another single tank 130 through the reflux main branch 123 and the reflux branch 124, thus forming a tank reversing path, thereby optimizing the process of adding and adjusting drugs in the production line, quickly switching drugs, maintaining the normal production process, improving the compatibility of equipment regulation, and being able to provide the production pipeline 110 with the drugs that need to be added. It is suitable for abnormal working conditions, including unstable low-flow addition, backflow, maintenance, etc.

[0030] In an optional embodiment, the dosing branch 122, the reflux branch 124 and the tank 130 are connected one by one, and each tank 130 can form an independent loop with the dosing branch 122, the dosing main branch 121, the production pipeline 110, the reflux main branch 123 and the reflux branch 124. During production adjustment and production research, it is easy to operate, easy to operate and highly applicable. Each tank 130 can form an independent loop, and each independent loop can be adjusted through the dosing branch regulating valve 122a and the reflux branch regulating valve, so that the outlet of the tank 130 is connected to the reflux main branch 123 and the reflux branch 124 through the dosing branch 122, the dosing main branch 121 and the production pipeline 110, and then connected to the entrance of another tank 130, so that the medicine in the tank 130 can be emptied, quickly meet the maintenance requirements, reduce the liquid level in the tank 130 when overflowing, or switch when encountering problems with drug addition.

[0031] In an optional embodiment, the production pipeline 110 includes an input section 111, a parallel section 112 and an output section 113. The two ends of the parallel section 112 are respectively connected to the input section 111 and the output section 113. The parallel section 112 is connected to the main drug addition branch 121 and the reflux main branch 123. The production pipeline 110 is a pipeline extending from the raw material addition point to the finished product production point. The production pipeline 110 can be divided into multiple sections, wherein the input section 111 is for adding raw materials, the parallel section 112 is for introducing added drugs and facilitating tank pouring operations, and the output section 113 is connected to the production reaction device. In an optional embodiment, the connection between the input section 111 and the parallel section 112 is a first node 112a, and the first node 112a is connected to the main drug adding branch 121, that is, the main drug adding branch 121 is connected to the connection between the input section 111 and the parallel section 112, and the main drug adding branch 121 is communicated with the parallel section 112, so that the drugs in the main drug adding branch 121 can enter the parallel section 112, and the connection between the parallel section 112 and the output section 113 is a second node 112b, and the second node 112b is connected to the reflux main branch 123, that is, the reflux main branch 123 is connected to the connection between the parallel section 112 and the output section 113, and the reflux main branch 123 is communicated with the parallel section 112, so that the drugs in the parallel section 112 can enter the reflux main branch 123.

[0032] In an optional embodiment, the input section 111 includes a medicine tank 111a and a dosing tube 111b, one end of the dosing tube 111b is connected to the medicine tank 111a, and the other end is connected to the parallel section 112, and the medicine in the medicine tank 111a can be added to the parallel section 112 through the dosing tube 111b; in an optional embodiment, the dosing tube 111b adopts a hose, and an existing threaded joint is provided at one end, and the hose can be connected to different medicine tanks 111a through the joint. Different medicine tanks 111a can be set, and the outlet of the medicine tank 111a is also provided with an external thread. The above-mentioned threaded joint can quickly realize the connection between the hose and the medicine tank 111a, and each medicine tank 111a can contain different trace medicines. According to production needs, different trace medicines can be added through the instant connection of the hose, such as defoaming agents, vitamins and other trace additives. In an optional embodiment, the input section 111 further includes an input valve 111c, which is arranged on the dosing pipe 111b. The input valve 111c is a valve for regulating the flow rate and opening and closing of the dosing pipe 111b. The input valve 111c can be installed on the dosing pipe 111b in the form of a conventional flange connection. In an optional embodiment, the output section 113 includes an output pipe and a production valve 113b, the output pipe is connected to the parallel section 112, and the production valve 113b is arranged on the output pipe. Similarly, the production valve 113b also uses an existing valve and is installed on the output pipe. One end of the output pipe is connected to the second node 112b of the parallel section 112, and the other end of the output section 113 is connected to the production reaction device. The various pipe fittings involved in the above pipeline can be hoses or hard pipes, such as PVC, steel pipes, etc.

[0033] In an optional embodiment, the tank body 130 includes a first tank body 131 and a second tank body 132. One of the two tank bodies 130 is used in the production process, and the other is used as a backup. The first tank body 131 is correspondingly connected to a dosing branch road 122, and the second tank body 132 is correspondingly connected to another dosing branch road 122. The two dosing branch roads 122 are simultaneously connected to the dosing main branch road 121, and each dosing branch road 122 is provided with a dosing branch regulating valve. By opening one of the dosing branch regulating valves and closing the other dosing branch regulating valve, the medicine in one of the tank bodies 130 can be added to the parallel section 112. When pouring the tanks, if it is necessary to switch the medicine from the first tank body 131 to the second tank body 132, first close the medicine adding branch regulating valve corresponding to the second tank body 132, open the medicine adding branch regulating valve corresponding to the first tank body 131, close the reflux branch regulating valve corresponding to the first tank body 131, open the reflux branch regulating valve corresponding to the second tank body 132, and then close the input valve 111c set in the input section 111 and the production valve 113b set in the output section 113. Only the first tank body 131 and the parallel section 112 form a parallel relationship. The medicine enters the medicine adding branch 122 from the first tank body 131 and then enters the medicine adding main branch 121. It flows back to the reflux main branch 123 and the reflux branch 124 corresponding to the second tank body 132 through a partial section of the production pipeline 110, and finally enters the second tank body 132, thus realizing the tank pouring operation.

[0034] In an optional embodiment, the drug-adding main branch 121 is provided with a drug-adding regulating valve 121a, which is used to adjust the opening and closing of the drug-adding main branch 121. The drug-adding regulating valve 121a is installed on the drug-adding main branch 121 in a conventional manner. When the drug in the tank body 130 is introduced or the tank is turned over, the drug-adding regulating valve 121a is kept open. In an optional embodiment, a drug-adding boosting device 140 is also included, which is arranged in the input section 111, the parallel section 112, the output section 113, the drug-adding main branch 121 or the reflux main branch 123. The drug-adding boosting device 140 is arranged in the drug-adding regulating system 100 to provide conveying power for the fluid drug in the drug-adding regulating system 100. The drug-adding boosting device 140 can use a booster pump to increase the pumping pressure of the drug solution. In an optional embodiment, the dosing and pressurizing device 140 includes a metering pump 141 and a regulating pump 142. The metering pump 141 is arranged in the input section 111, and the regulating pump 142 is arranged in the dosing main branch 121. The metering pump 141 can be used to meter the drugs entering the parallel section 112 through the dosing pipe 111b, and the regulating pump 142 can be used to pump the drugs in the tank body 130 into the parallel section 112 of the production pipeline 110 to participate in the production process; through the use of the metering pump 141 and the regulating pump 142, the drugs in the drug tank 111a can be added to the production pipeline 110 in proportion.

[0035] In an optional embodiment, the dosing main branch 121, the dosing branch 122, the reflux main branch 123, and the reflux branch 124 all use pipelines, such as hoses, hard pipes, and hard pipes such as steel pipes or PVC pipes; in an optional embodiment, the above-mentioned input valve 111c, production valve 113b, dosing control valve 121a, and dosing branch control valve 122a can use existing valves, such as butterfly valves, ball valves or gate valves, and other forms of valves can also be used. The valves of the input valve 111c, production valve 113b, dosing control valve 121a and dosing branch control valve 122a are connected to each pipeline using an existing installation method, such as the dosing control valve 121a is installed on the dosing main branch 121 through a flange.

[0036] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", "optional example" or "optional implementation" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification.

[0037] In addition, the technical solutions between the various embodiments can be combined with each other, but they must be based on the fact that they can be implemented by ordinary technicians in this field. When the combination of technical solutions is contradictory or cannot be implemented, it should be deemed that such combination of technical solutions does not exist and is not within the scope of protection required by this application.

[0038] Although the embodiments of the present application have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present application, and that the scope of the present application is defined by the claims and their equivalents.

Claims

1. A drug dosing control system, characterized in that: include: A production pipeline (110) for producing biological or chemical products; A plurality of tanks (130), each used for storing medicines; The control pipeline (120) comprises a drug-adding main branch (121), a plurality of drug-adding branch roads (122), a reflux main branch road (123), a plurality of reflux branch roads (124) and a material injection pipeline (125); the drug-adding main branch road (121) and the reflux main branch road (123) are respectively connected to the production pipeline (110) at intervals, the plurality of drug-adding branch roads (122) are respectively connected to one end of the drug-adding main branch road (121), and the drug-adding branch road (122) is connected to the production pipeline (110) at intervals. The other end is connected to the outlet of the tank body (130), the dosing branch road (122) is provided with a dosing branch road regulating valve (122a), the plurality of reflux branch roads (124) are respectively connected to one end of the reflux main branch road (123), the other end of the reflux branch road (124) is connected to the inlet of the tank body (130), the reflux branch road (124) is provided with a reflux regulating valve (124a), and the injection pipeline (125) is connected to each of the tank bodies (130).

2. The drug addition control system according to claim 1, characterized in that: The dosing branch lines (122), the reflux branch lines (124) and the tank bodies (130) are connected in a one-to-one correspondence, and each tank body (130) can form an independent loop with the dosing branch lines (122), the dosing main branch lines (121), the production pipeline (110), the reflux main branch lines (123) and the reflux branch lines (124).

3. The drug addition control system according to claim 1, characterized in that: The drug-adding main branch (121) is provided with a drug-adding regulating valve (121a), and the drug-adding regulating valve (121a) is used to adjust the opening and closing of the drug-adding main branch (121).

4. The drug addition control system according to any one of claims 1 to 3, characterized in that: The production pipeline (110) comprises an input section (111), a parallel section (112) and an output section (113); two ends of the parallel section (112) are respectively connected to the input section (111) and the output section (113); the parallel section (112) is connected to the dosing main branch (121) and the reflux main branch (123).

5. The drug addition control system according to claim 4, characterized in that: The connection point between the input section (111) and the parallel section (112) is a first node (112a), and the first node (112a) is connected to the drug addition main branch (121). The connection point between the parallel section (112) and the output section (113) is a second node (112b), and the second node (112b) is connected to the reflux main branch (123).

6. The drug addition control system according to claim 4, characterized in that: The input section (111) comprises a medicine tank (111a) and a medicine adding pipe (111b), one end of the medicine adding pipe (111b) is connected to the medicine tank (111a), and the other end is connected to the parallel section (112).

7. The drug addition control system according to claim 6, characterized in that: The input section (111) further comprises an input valve (111c), and the input valve (111c) is arranged on the drug adding pipe (111b).

8. The drug addition control system according to claim 4, characterized in that: The output section (113) comprises an output pipe and a production valve (113b), the output pipe is connected to the parallel section (112), and the production valve (113b) is arranged on the output pipe.

9. The drug addition control system according to claim 4, characterized in that: It also includes a drug adding and pressurizing device (140), which is arranged on the input section (111), the parallel section (112), the output section (113), the drug adding main branch (121) or the reflux main branch (123).

10. The drug addition control system according to claim 9, characterized in that: The drug adding and pressurizing device (140) comprises a metering pump (141) and a regulating pump (142); the metering pump (141) is arranged at the input section (111), and the regulating pump (142) is arranged at the drug adding main branch (121).