Liquid sample collector

Abstract

The utility model discloses a liquid sample collector. The liquid sample collector comprises an absorption element and a liquid sample collecting element, the fixing disc is used for fixing the absorption part; the fixed disc is connected with a rod containing a channel, the channel is used for containing an indication strip for indicating whether liquid is sufficient or not or a test element for testing analyte in a liquid sample, the channel comprises an outlet, and the outlet is in fluid communication with the fixed disc.

Description

Technical Field

[0001] The utility model belongs to the field of in vitro diagnosis and is used for testing analyzed substances in liquid samples, in particular to provide a collecting device for collecting liquid samples. Background Art

[0002] In the field of detection, a detection device is a commonly used medical detection instrument, which is mostly used to detect samples stored in liquids. The samples usually include urine, blood, sewage, semi-solid substances (semi-solid substances refer to samples that are converted into liquids by any suitable method), etc. The commonly used detection tool for detecting liquid samples is a reagent strip. Usually, there are two ways for a reagent strip to obtain a liquid sample. One is to put the reagent strip directly into the liquid sample. At this time, the bottom of the reagent strip will contact the liquid sample, so that the reagent strip obtains the liquid sample; the other is the dripping method, which uses a dropper or other tool to absorb the liquid sample and then drips it into the reagent strip, so that the reagent strip obtains the liquid sample. In both of these common methods, the reagent strip is in partial contact with the liquid sample, and can often only be used to detect one item. When changing the test item, a different reagent strip needs to be replaced.

[0003] In the field of detection, collection devices for collecting liquids are often used, such as cotton swabs and flocked swabs to absorb liquids, and sponge polyester is often used to absorb liquids, and then the liquid is released by compressing the polyester, especially in saliva collection. Traditional saliva collectors are generally glued to an absorption tray with glue, but the process of glue bonding is complicated, and the glue contains harmful substances, causing damage to the environment or human body. In addition, sometimes healthy and harmless glue is used, the gluing process is complicated, and it causes other processes, making it difficult to mass produce.

[0004] This makes it necessary to improve the structure of the traditional collector to avoid the use of glue. When glue is used, it will not affect the auxiliary functional structure. Utility Model Content

[0005] In order to overcome the deficiencies of the prior art, the utility model provides a device for collecting liquid samples. The device comprises an absorption element for absorbing the liquid sample, the element is used to absorb the liquid sample and store the liquid sample on the absorption element, and a fixing element, the fixing element allows the absorption element to be fixed on the fixing element.

[0006] In some embodiments, the absorbent element may be an absorbent component, the component comprising a first end and a second end, the first end being connected to the fixing element. In some embodiments, the fixing element is a non-absorbent material. In some embodiments, the fixing element is a sheet or a segment structure with a recess, and one end of the absorbent component is fixed to the sheet structure.

[0007] In some embodiments, an elastic sheet is disposed in the depression of the fixing element, and the elastic sheet has an opening or through hole. In some embodiments, a rod-shaped structure is also provided, and the rod-shaped structure is connected to the fixing element, wherein the rod-shaped structure contains a channel, and the outlet of the channel is the same as the opening on the elastic sheet. In some embodiments, the channel is used to accommodate an indicator strip used to indicate whether the absorbing element has absorbed a sufficient amount of liquid sample. Of course, a test strip can also be disposed in the channel, and the indicator strip or the test strip is in contact with the absorbing element.

[0008] In some embodiments, there is a layer of glue between the elastic sheet and the absorbent element, and the absorbent element is bonded to the elastic sheet by the glue. In some embodiments, the fixing element also bonds the absorbent element to the fixing element by the glue. The elastic sheet is surrounded by the fixing element, and the absorbent element is fixed by the glue applied to the elastic sheet and the fixing element.

[0009] In some embodiments, a protrusion extends outward from the opening of the elastic sheet, similar to a channel, and one end of the indicator strip or the test strip extends out of the channel, and a glue layer is provided around the channel, through which the absorbing element and the fixing element are bonded together. The channel with the protrusion will not cause glue leakage when applying glue, and if glue is applied to the channel, the indicator strip cannot be inserted into the channel.

[0010] The absorbent element comprises polyester, sponge, cotton and filter paper.

[0011] In some embodiments, the absorbent element is a polyester foam, which is rigid and incompressible when dry and can be compressed after absorbing liquid. In some embodiments, the absorbent element is a sponge, a melamine foam, which can be compressed whether dry or wet, or a flexible and compressible material.

[0012] In some embodiments, the fixing element includes a cavity having an opening and a bottom, the bottom being connected to the rod-shaped structure, and containing a portion of the absorption element in the cavity. The cavity also includes an elastic element, and the elastic element is located between the cavity wall and the absorption element. The elastic element is compressed, and the absorption element is fixed in the cavity through the rebound force of the elastic element.

[0013] The elastic fixing element is an annular rubber or latex, and the absorption component is fixed in the cavity on the fixing plate through the interaction force between the annular elastic rubber or latex and the absorption element and the inner surface of the side wall.

[0014] In some embodiments, there are two elastic elements, which are located on both sides of the absorbent element, and the absorbent element is fixed in the cavity through the rebound force of the two elastic elements. In some embodiments, the absorbent element is a cylinder, and the elastic element is annular, and the annular elastic element surrounds the outer surface of the cylinder to fix the absorbent element on the cavity.

[0015] In some embodiments, the bottom of the cavity has an opening, and the opening is the same as the channel in the tubular structure, so that an indicator strip or a test element can be inserted through the opening, and the indicator element or the test element is in contact with the absorption element. When the absorption element is used to collect a liquid sample, if enough liquid sample is absorbed, the liquid will flow to the indicator strip, and the indicator strip also has liquid, indicating that enough liquid has been collected. If it is a test strip, if liquid flows into the test strip, the properties of the liquid or the substance to be analyzed can be tested. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Schematic diagram of a traditional collector (prior art).

[0017] Figure 2 It is a schematic structural diagram of a collector in a specific implementation manner of the utility model.

[0018] Figure 3 It is a schematic diagram of the longitudinal section structure of a collector according to a specific embodiment of the utility model.

[0019] Figure 4 It is a schematic diagram of the exploded three-dimensional structure of a collector in a specific implementation manner of the utility model.

[0020] Figure 5 It is a schematic diagram of the three-dimensional structure decomposition of a collector in a specific embodiment of the utility model.

[0021] Figure 6 It is a schematic diagram of the longitudinal section structure of a collector in a specific implementation manner of the utility model.

[0022] Figure 7 It is a schematic diagram of the three-dimensional structure of a collector in a specific implementation manner of the utility model.

[0023] Figure 8 It is a schematic diagram of the longitudinal section structure of a collector in a specific implementation manner of the utility model.

[0024] Fig. 9 It is a schematic diagram of the exploded structure of a collector in a specific implementation manner of the utility model.

[0025] Fig.10It is a partial structural cross-sectional view (principle schematic diagram) of a collector in a specific implementation manner of the utility model.

[0026] Fig.11 It is a schematic diagram of the principle of fixing the absorption element in the collector of a specific embodiment of the utility model.

[0027] Fig.12 It is a schematic diagram of the principle of fixing the absorption element in the collector of a specific embodiment of the utility model. DETAILED DESCRIPTION

[0028] Detailed description

[0029] Detection

[0030] Detection means to test or examine a substance or material for the presence or absence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolite, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein, or a polymer. In addition, detection means to test the amount of a substance or material. Furthermore, assay also means immunoassay, chemical assay, enzyme assay, etc.

[0031] sample

[0032] The samples that can be detected by the detection device of the utility model include biological fluids (such as case fluids or clinical samples). Liquid samples or liquid samples can be derived from solid or semi-solid samples, including excrement, biological tissues and food samples. Solid or semi-solid samples can be converted into liquid samples by any appropriate method, such as mixing, mashing, macerating, incubating, dissolving or digesting solid samples by enzymatic action in a suitable solution (such as water, phosphate solution or other buffer solution). "Biological samples" include samples derived from animals, plants and food samples, such as urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, tissue and organ cultures, cell cultures and media derived from humans or animals. Preferably, the biological sample is urine, preferably, the biological sample is saliva, sputum, nasal secretions, etc. Food samples include food processed substances, final products, meat, cheese, wine, milk and drinking water. Plant samples include any plant, plant tissue, plant cell culture and medium. An "environmental sample" is derived from the environment (eg, a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a wastewater sample). An environmental sample may also include sewage or other wastewater.

[0033] In some embodiments, the sample of the present invention can be a urine sample of a human or mammal, or a saliva sample, a sputum sample, or a liquid sample secreted from the nasal cavity.

[0034] Downstream and Upstream

[0035] Downstream or upstream is divided according to the direction of liquid flow, and generally the liquid flows from the upstream to the downstream area. The downstream area receives liquid from the upstream area, and the liquid can also flow along the upstream area to the downstream area. Here it is generally divided according to the direction of liquid flow. For example, on some materials that use capillary force to promote the flow of liquid, the liquid can flow in the direction opposite to gravity due to gravity. At this time, the upstream and downstream are still divided according to the flow direction of the liquid. For example, in the collection device of the utility model, in some preferred modes, the absorption element is used to absorb the liquid sample, and the indicator strip connected to one end of the absorption element is also used to absorb the liquid from the absorption element. When the absorption element absorbs enough liquid, the indicator strip has a color to indicate that the liquid is sufficient. The flow of this liquid relies on capillary action and can also flow in the direction opposite to the direction of gravity.

[0036] Gas connection or liquid connection

[0037] Gas connectivity or liquid connectivity means that liquid or gas can flow from one place to another, and may pass through some physical structures to guide the flow. The so-called passing through physical structures generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures to passively or actively flow to another place. Passive flow is generally caused by external force, such as flow under capillary action. The flow here can also be the liquid or gas due to its own action (gravity or pressure), or it can be passive flow.

[0038] Detachable combination

[0039] A detachable combination refers to a connection relationship between two components that is in several different states or positional relationships. For example, when there are two components in a physical sense, they can be separated at the beginning, connected or combined together in a suitable first situation, and the two components can be separated in a suitable second situation. This separation is a physical spatial separation without contact. Alternatively, the two components are combined together at the beginning, and when in a suitable situation, the two components can be separated in a physical spatial separation. In short, the combination of the two or the separation between the two can be easily carried out, and this combination or separation can be repeated for many cycles. Of course, it can also be a one-time combination and separation. In addition, it can be a detachable combination between two components, or a detachable combination between three or more components. For example, there are a first, a second and a third component, a detachable combination of the first component and the second component, and the second component and the third component can also be a detachable combination. For example, the elastic sheet 203 and the fixed disk here belong to a detachable combination, and of course, after assembly, they cannot be disassembled; the elastic fixing elements 801, 802, 901, 902 and the cavity of the fixed disk belong to a detachable combination, and can be disassembled from the cavity of the fixed disk after assembly.

[0040] Test components

[0041] The test element can be a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention. Any element that can detect whether a sample or specimen contains an analyte of interest can be called a test element. This detection can be based on any technical principle, such as immunology, chemistry, electricity, optics, physics, etc. Various test elements can be combined and applied to the present invention. One form is a test strip.

[0042] The test strip applied to the utility model can be a so-called lateral flow test strip, and the specific structure and detection principle of these test strips are well-known technologies to those skilled in the art in the prior art. Common test strips include a sample collection area, a labeling area, a test area and a water absorption area, wherein the sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area can include a water absorption pad, wherein the test area includes necessary chemical substances that can detect whether the analyzed substance is contained, such as an immunoreagent or an enzyme chemical reagent. The commonly used test strip is a nitrocellulose membrane test strip, that is, the test area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the test result; it can also be a cellulose acetate membrane or a nylon membrane, etc., of course, the test result control area (C line) can also be included downstream of the test area (T line), and usually, the control area and the test area appear in the form of a horizontal line, which is a test line or a control line. Such a test strip is a traditional test strip, and of course, it can also be other types of test strips that utilize capillary action to detect. In addition, generally, the test strips carry dry chemical reagent components, such as fixed antibodies or other reagents. When encountering liquid, the liquid flows along the test strips due to capillary action. As it flows, the dry reagent components are dissolved in the liquid, and then processed in the next area to react with the dry reagent in that area, thereby performing necessary tests. The liquid flows mainly through capillary action. Using the utility model and suitable detection elements, any analyte can be detected. The utility model is preferably used to detect small drug molecules in saliva and urine. Of course, the collection device of the utility model can collect any of the above forms of samples, whether solid or liquid at the beginning, as long as these liquids or liquid samples flow into the absorption element and flow from one end of the absorption element to the test element, the test can be performed.

[0043] In some ways, such as Figure 2-9A cavity 201 can be set in the rod-shaped body 200 of the collector, and the test element described in the utility model is arranged in the cavity. The test element contains a test area. One end of the test element contacts one end 102 of the absorption element 100. When the absorption element 100 absorbs enough liquid, the excess liquid will be absorbed by the test element 300. If there is a substance to be analyzed in the liquid sample, it can be tested in the test area to obtain the test result. In some ways, the water absorption capacity of the absorption element is less than the water absorption capacity of the test element. The water absorption capacity here does not refer to the amount of absorbed liquid, but the magnitude of the capillary force. If the capillary force of the absorption element is less than the capillary force of the test element, the test element in contact with the absorption element has a greater traction force on the liquid, which can accelerate the flow of the liquid on the absorption element. At the same time, the absorption element can be quickly filled. If there is excess liquid, it can flow from one end to the other end along the test strip. If there is a color change in the test area, on the one hand, the substance to be analyzed can be tested, and on the other hand, it can also indicate that the liquid absorbed by the absorption element has reached the maximum saturation capacity. In some embodiments, the test area includes a test line (T) and a test result control line (C). Regardless of whether the analyte is present, as long as the C line appears, it indicates that the absorption element 100 has reached the saturated absorption capacity, and the liquid sample collection is sufficient. In some embodiments, the test area of ​​the test element and the test result control area facing the rod-shaped structure 200 are transparent, and the color change of the test area and the test result control area can be observed. In some embodiments, the end of the sample application area of ​​the test element contacts one end 102 of the absorption element 100 without being inserted into the absorption element 100, so that all parts of the absorption element can be filled with liquid samples.

[0044] Indicator element

[0045] The indicator element here is also made of water-absorbing material. One end of the element is in contact with the absorption element 100. When the absorption element absorbs liquid, the liquid always flows from one end 101 to the other end 102. When it contacts the other end 102, if there is excess sample, it will flow to the indicator element. The indicator element indicates that the absorption element has collected enough sample or that the absorption element has reached saturation absorption. In some ways, the indicator strip has an indication area, and the area is processed with color pigments. The color pigments are covered and cannot be seen by the naked eye. After the liquid flows through the indication area, the liquid drives the color pigments to flow together and flows outside the covered area. Then, it can be observed by the naked eye that there is color on the indicator element, indicating that the absorption element has absorbed enough liquid. Of course, there are also colorless chemical reagents that can be processed on the indicator reagent strip. When encountering a liquid sample, a colored substance is displayed, for example, the color is displayed by acting on certain substances in the liquid sample or the properties (PH value) of the liquid sample. The indication area here cannot be used to test the analyzed substance in the sample, but only serves to indicate whether the absorption element 100 has collected enough liquid sample. When the liquid can automatically flow from one end 101 of the absorption element to the other end 102, it means that the absorption element is full of liquid sample. If there is excess liquid sample that can flow to the indicator element of the cavity 201 of the rod, it can be said that the absorption element 100 has absorbed enough liquid or the absorption element has reached the maximum saturation absorption capacity. Here, the sufficient liquid sample or the maximum saturation absorption capacity of the absorption element can be 50 microliters-5 milliliters, such as 100 microliters, 200 microliters, 300 microliters, 400 microliters, 500 microliters, 600 microliters, 700 microliters, 800 microliters, 1000 microliters, 1500 microliters, 2000 microliters, 2500 microliters, 3000 microliters, etc.

[0046] In the conventional technology, one end of the indicating element is generally inserted into the absorbing element ( Figure 1 ), it is necessary to make a hole in the reabsorption element in advance to allow one end of the indicator strip to extend into the hole. This actually has the following defects, for example, in U.S. Patent No. US9,414,813B2 Figure 7 As shown (Appendix of the present utility model Figure 1In the collector 44, a portion 56 of the indicator strip 48 is directly located in the absorption element 51, and another portion is located in the channel 54 of the rod structure 52, and the indicator strip has indicator areas 48 and 46. This method has the following defects: first, generally, the absorption element 51 is used for saliva collection, and needs to be put into the mouth and chewed to collect. If a portion of the indicator element is located on the absorption element, during the collection process, some chemicals on the indicator element will flow back to the absorption head, causing pollution or even damage to the collector's mouth. In addition, when the absorption element 51 is absorbed and softened, if it is still chewed in the mouth, it can press on the end of the indicator strip located in the absorption element, which may damage the indicator strip. The purpose of chewing is to hope that more saliva can be secreted to collect more saliva samples. Second, such a setting often cannot fully represent that the absorption element has reached the saturated absorption amount, because part of the indicator strip is located on the absorption element, and the liquid is always absorbed by the indicator element first, but the absorption area around the partial area 56 where the indicator element is inserted into the absorption element 51 may not have liquid samples absorbed. Third, the absorbing element 21 needs to be punched in advance so that the indicating element can be inserted into the hole of the absorbing element, which is a complicated process. In addition, if the absorbing element is a soft material, such as melamine foam, it is very difficult to punch holes in the absorbing element. Finally, it needs to be fixedly connected with the rod 52. Generally, glue is applied on the disc of the rod. If one end of the indicator strip is inserted into the absorber, glue must be applied on the disc, which is inconvenient. Whether the test strip is inserted into the absorption element 51 first or glue is applied on the surface of the disc first, it is not very convenient and the assembly steps are complicated. In addition, if glue is applied on the disc first, the test strip may also come into contact with the glue. If the indicator strip is connected to the absorption element first, it is also inconvenient to apply glue on the disc.

[0047] In one embodiment of the present invention, Figure 5-6In the collector shown, one end 102 of the absorption element 100 of the utility model is in direct contact with the fixed disk 207. An elastic disk 203 is arranged in the fixed disk. The elastic disk 203 has an opening or through hole 210. The elastic disk is arranged in a recessed area 212 in the middle of the disk. The recessed area 212 is an outlet 215 of the inner cavity 201 of the rod-shaped structure 200. When the elastic disk is arranged in the recessed area 212, the upper surface 205 of the elastic disk and the edge surface 202 of the fixed disk are on the same surface. When assembling, the test element or indicator element 300 is directly passed through or inserted from the hole 210 of the elastic disk, so that the end 301 of the test element or indicator element is located in the hole 210 or slightly exposed from the hole 210. If it is through, the test strip 300 can be inserted into the hole 210 on the elastic disk alone, and then one end of the test strip is inserted into the inner cavity 201 of the rod-shaped structure, and then the elastic disk 203 is pressed into the recessed area 212. Since it is an elastic disk, it is fixed in the recessed area by the elastic force of the elastic disk 203 itself, and then one end 301 of the test strip or indicator strip is pressed, so that the end 301 is slightly exposed from the hole 210. Alternatively, the elastic disk is first fixed in the recessed area 212, and then the test element or indicator element is inserted from the hole 210, so that the end 301 is slightly exposed from the through hole. After installation, a layer of glue can be applied on the surface 205 of the elastic disk 206, and then the absorbing element 102 is brought into contact with the glue layer. Generally, one end 102 of the absorbing element 100 needs to be pressed on the fixed disk with a force. During the pressing, the glue previously applied on the surface 205 of the elastic disk 203 extends to the area of ​​the edge surface 202 of the fixed disk, so that the absorbing element is fixed on the fixed disk 207. Here, the material of the absorbing element 100 is generally relatively rigid or hard, so that it can be pressed better by applying pressure, so that the glue can adhere the absorbing element 100 to the fixed disk 207. For example, these hard water-absorbing materials are generally: polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene and other materials. These materials are hard materials when they are dry, and become soft after absorbing liquid. Therefore, during the assembly process, the absorption element is relatively rigid, so that pressure can be applied to allow the absorption element 100 to be bonded to the fixing plate edge surface 202 of the fixing plate 207 through glue. The separate elastic plate 203 simplifies the assembly process and steps, separates the step of applying glue from the step of inserting the test strip, and does not allow one end of the test element to be inserted into the absorption element 100, thus overcoming the defects of the conventional prior art.

[0048] In some ways, although in Figure 5-6In the implementation example, the structure is improved compared with the prior art, and both the assembly step and the coating of glue bring convenience and simplicity. However, there is still a defect. When the glue is coated on the surface 205 of the elastic disk 203, the glue easily flows into the hole 210, thereby sealing the hole 210. Some of the glue will flow into the cavity 201 along the hole 210. Once the glue changes from liquid to solid, it actually blocks the flow of liquid between the end 102 of the absorbing element 100 and the end 301 of the test strip or the indicator strip. Even if one end of the indicator strip 300 is slightly exposed from the hole 210 for a certain length, for example, a few millimeters, on the surface 205 of the elastic disk, the glue will not flow into the hole 210. When applying glue on the surface 205 of the absorbent element 100, it may be accidentally applied to the hole 210. Or, when one end 102 of the absorbent element 100 contacts and presses against the surface 205 of the elastic disk, the glue is in liquid state at this time, and the squeezing process is fluid, which will also cause the end 301 of the test strip to shrink into the hole 210, at least below the hole 210, and the glue will also form a thin layer at the hole. After the glue dries naturally, the thin layer of glue (non-absorbent) blocks the flow of liquid between the absorbent element and the end 301 of the indicator strip, so the liquid on the absorbent element 100 cannot flow into the indicator strip 300, and the indication of whether the liquid sample is sufficient cannot be realized. After all, when applying glue on such a small area, such as the elastic disk 203 with a size of 0.3 square centimeters to 1 square centimeters, the precision requirement is very high, and the glue is applied manually, which is even more difficult to control and allow the liquid glue to flow into the hole 210 and block the hole 210.

[0049] So, if Figure 2-4 In the specific embodiment shown in Figure 10, a protruding pipe 211 is provided on the hole 210 of the elastic disk, that is, a pipe-like structure is extended outward from the hole 210, and the pipe is higher than the surface of the elastic disk 205, for example, 1-5 mm high, or higher than the thickness of the glue coated on the surface 205, for example, 1, 2, 3, 4, 5 mm high. In this way, when glue is coated on the surface 205 of the elastic disk 203, the glue will not overflow onto the pipe opening 204. In this way, one end 301 of the indicating element inserted from the opening 204 will not contact the glue, and the glue will naturally not seal the opening 204. When one end 102 of the absorbing element 100 is pressed against the surface 205 of the elastic disk 203, the glue layer coated on the surface 205 around the pipe allows the absorbing element to be bonded to the elastic disk. Although there is a slightly protruding channel 211, after all, the absorption element 100 is rigid, but this slight protrusion (channel 211) does not affect the adhesion between the absorption element 100 and the elastic disk. In some embodiments, the elastic disk 203 is still arranged in the recessed area 212 of the fixed disk 207, and the surface 205 of the elastic disk is on the same surface as the fixed disk edge surface 202 of the fixed disk (such as Figure 3As shown in FIG. 2 , the pipe 211 protrudes upward from the elastic disk surface 205 and the fixed disk edge surface 202 of the fixed disk 207. Fig.10 As shown, in an optional manner, the recessed area 212 of the fixed disk 207 can be made deeper, so that when the elastic disk 203 is fixed in the recessed area, the opening 204 of the pipe 211 and the surface 205 of the fixed disk 207 are at the same horizontal position. For example, the pipe is 2 mm higher than the surface 205 of the elastic disk 203. In this way, a 2 mm deep depression 289 is formed in the recessed area of ​​the fixed disk. When applying glue, one or two drops of glue 701 are directly added to the depression. At this time, the thickness of the squeezed glue is basically 1.5-2 mm, so that one end 102 of the water absorbing element can directly contact the elastic disk 203. As explained above, although the absorption element is hard and rigid, it is not 100% incapable of deformation or compression, especially when made of materials such as polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene, etc. These materials can still have a slight elasticity even when dry, and can still withstand 1-2 mm of compression. In this way, when one end 102 of the absorption element is released from the elastic disk 203 and the fixed disk edge surface 202 of the fixed disk 207, the glue has a thin layer of approximately 1-1.5, and the protruding pipe 211 can slightly enter the absorption element, so that other areas of one end 102 of the absorption element 100 are in contact with the glue, thereby adhering to the fixed disk 207. In addition, since the protruding pipe 211 slightly enters the absorption element, one end 301 of the indicator strip 300 is in closer contact with one end 102 of the absorption element 100. In order to allow the absorbing element to be more precisely glued to the fixed plate 207, a relatively rough surface can be formed on the surface 205 of the elastic plate. Of course, a rough surface can also be formed on the edge surface of part of the fixed plate. This allows the absorbing element to be more firmly fixed to the fixed plate 207.

[0050] In the above embodiments, for those absorbent elements that are hard when dry and become soft after absorbing water, glue can be used for bonding. However, for materials that are soft and rarely harden, such as melamine foam and sponge, it is difficult to use glue for bonding. Figure 8-9 , Fig.11, as shown in FIG. 12 , in some embodiments, the utility model provides a collector, which includes a cavity 501 on the collector, and the cavity has a cavity 502, which is surrounded by a bottom 504 and a side wall 503. A water absorbing element 400 is arranged in the space, and part of the water absorbing element is located in the cavity 502. An elastic fixing member 801 is also provided in the space, and the elastic fixing member contacts the surface of the absorbing element on one side and contacts the inner surface of the side wall 503 on the other side, and the absorbing element is fixed in the cavity by the elastic force of the elastic element. The elastic element can be of any shape, and the cavity can be arranged on a fixed plate 207. Of course, in some embodiments, the bottom of the cavity 504 can be connected to a rod-shaped structure 500, and the rod-shaped structure contains a channel 501, and the channel 501 communicates with the cavity 501. If an indicator strip 300 is arranged in the channel 501, one end 301 of the indicator strip contacts one end 402 of the absorbing element. The elastic fixing element is used because it can be compressed and has the natural property of rebounding, or the elastic element has the ability to be compressed by external force and then return to its original position after the external force disappears. In this way, when assembling, the absorption element can be first placed in the cavity 502, with a gap between the absorption element and the cavity, and then the elastic element can be inserted into the gap. Generally, the width of the elastic element is larger than the width of the gap. When the elastic element is inserted, it must be compressed. Therefore, after the elastic element is compressed, once the external force is released, there can be a force between the absorption element and the inner surface of the side wall 503 of the cavity 501, thereby fixing the absorption element in the cavity. In some embodiments, the elastic element has a pair of 901, 902, which are respectively located on both sides of the absorption element. When the absorption element itself is soft, such as melamine foam, such as the material described in patent application CA3167464, which is fully cited as part of this application. When the absorption element 400 is squeezed by two elastic elements in the direction of relative force, the absorption element 403 will shrink (such as Fig.12 , the absorption element does not absorb any liquid and is dry), but the elastic element also needs to be inserted into the cavity 502. In this way, the absorption element 400 is fixed in the cavity 502 by still relying on the interaction force of the elastic element (with a compressive force toward the absorption element, as shown by the arrow), so that the absorption element is fixed on the collector. In this way, the step of applying glue is omitted.

[0051] Of course, if the absorbent element is composed of a material that is rigid when dry but becomes soft when wet, it is also possible to fix the absorbent element with elastic elements, such as Fig.11As shown, the absorption element 400 is fixed in the cavity by two elastic elements 801, 802 inserted in the cavity 501. At this time, it is dry. This method can also fix the absorption element that is hard when dry. When it absorbs liquid and becomes soft, the elastic element originally has the force to return to the center (when it is dry, it has not completely recovered to the normal state). Therefore, when the absorption element becomes soft, the two elastic elements continue to have the ability to squeeze the absorption element, causing it to shrink partially (such as Fig.11 As shown in the exemplary description), the absorption element can still be fixed in the cavity 501 without falling off.

[0052] Here, the elastic element can be a spring, or a silicone plug, a rubber plug or other similar material, which can be uncompressed and can be restored to a natural state when the external force disappears. When it cannot be restored to a natural state, it has an action force. The utility model uses this action force to fix the absorption element on the collector, reducing the steps of applying glue and saving costs. These materials can also be used as elastic disks or elastic fixing blocks.

[0053] Analyte

[0054] Examples of analytes that can be used in the present invention include some small molecules, including drugs (such as drugs of abuse). "Drugs of abuse" (DOA) refer to the use of drugs for non-medical purposes (usually to paralyze nerves). Abuse of these drugs can cause physical and mental damage, dependence, addiction and / or death. Examples of drug abuse include cocaine; amphetamine AMP (for example, Black Beauty, White Amphetamine Pills, Dextroamphetamine, Dextroamphetamine Pills, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturates BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleeping aids); lysergic acid diethylamide (LSD); depressants (downers, goofballs, barbs, blue devils, yellowjackets, methaqualone); tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); MDMA; PCP; tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e. morphine MOP or opium, cocaine COC, heroin, hydroxydihydrocodeine); antianxiety drugs and sedatives and hypnotics. Antianxiety drugs are a class of drugs mainly used to relieve anxiety, tension, fear, and Drugs that stabilize mood and have hypnotic and sedative effects include benzodiazepines BZO (benzodiazepines), atypical BZs, fused diazepines NB23C, benzodiazepines, ligands of BZ receptors, open-ring BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazine and thiazole derivatives, other heterocyclics, imidazole sedatives / analgesics (such as oxycodone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, etc. The detection device of the utility model can also be used to detect drugs that are for medical purposes but are prone to overdose, such as tricyclic antidepressants (imipramine or analogs) and acetaminophen, etc. These drugs will be metabolized into small molecules after being absorbed by the human body. These small molecules exist in body fluids such as blood, urine, saliva, sweat, etc., or some body fluids contain the above-mentioned small molecules.

[0055] For example, the analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic villus stimulating hormone, progesterone hormone, follicle stimulating hormone, etc.), blood, white blood cells, sugar, heavy metals or toxins, bacterial substances (such as proteins or sugar substances for specific bacteria, such as Escherichia coli 0157:H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Bacillus cactus) and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemistry analysis can be detected using the lateral flow detection format in conjunction with the present invention. Any analyte can be detected using the appropriate detection element or test element of the present invention. Preferably, the present invention is used to detect small molecules of drugs in saliva and urine. Preferably, small molecules such as viruses and bacteria can be detected in saliva, throat or nasal fluid. It can also be the white blood cells, red blood cells, urobilinogen, urine vitamin C, urine crystals, urine specific gravity, urine albumin, urine ketones, urine colony count, urine pH, and nitrite in the liquid sample. For example, the white blood cells, red blood cells, urobilinogen, urine vitamin C, urine crystals, urine specific gravity, urine albumin, urine ketones, urine colony count, urine pH, and nitrite in the urine sample.

[0056] The method of testing the analytes in these urines can be done by immunological methods or chemical methods. The chemical method is to treat the absorbent material with chemical substances. When the urine contains a specific analyte and reaches a certain amount, a chemical reaction will occur on the absorbent material, and a color substance will be produced. These color substances will make the absorbent material colored. By comparing with the standard colorimetric card, it can be known whether the analyte in the urine sample exists or how much it exists. Generally, the thicker the color, the higher the content of the analyte. For example, when testing nitrous acid, aromatic aminosulfonamide diazo is treated on the test area. The compound reacts with nitrous acid to form a diazo compound. The compound reacts with 2,3,4-tetrahydrobenzo(h)quinoline-3-phenol to form a pink color substance. The substance will precipitate on the test area, making the test area appear pink. The white blood cells in the urine contain esterases, which can catalyze the hydrolysis of privatized pyrrole amino acid esters to release 3-hydroxy-5-phenylpyrrole. Then this pyrrole reacts with diazonium salts to form purple. This reaction is used to test the level or number of white blood cells in the urine.

[0057] All patents and publications mentioned in the specification of this utility model indicate that these are public technologies in the field and can be used by the utility model. All patents and publications cited here are also listed in the references, just as each publication is specifically cited separately. The utility model described here can be implemented in the absence of any element or elements, one limitation or multiple limitations, and such limitations are not specifically stated here. For example, the terms "comprising", "essentially consisting of..." and "consisting of..." in each example here can be replaced by the other two terms of one of the two. The terms and expressions used here are descriptive and not limited by them, and there is no intention to indicate that these terms and explanations described here exclude any equivalent features, but it can be understood that any appropriate changes or modifications can be made within the scope of the utility model and the claims.

Claims

1. A liquid sample collector, comprising: an absorbent element for absorbing a liquid sample; a fixing plate for fixing the absorbent element; The fixed disk is connected to a rod having a channel, the channel is used to accommodate an indicator strip indicating whether the liquid is sufficient or a test element for testing the analyte in the liquid sample, the channel has an outlet, and the outlet is in fluid communication with the fixed disk.

2. The collector according to claim 1, wherein: An elastic sheet is fixed on the fixed disk, and the elastic sheet has the outlet. When the absorbing element is fixed on the fixed disk, one end of the absorbing element contacts the elastic sheet.

3. The collector according to claim 2, wherein: A layer of glue is provided between the surface of the elastic sheet and one end of the absorption element, and the absorption element is bonded to the fixing plate through the glue.

4. The collector according to claim 3, wherein: When the rod containing the channel contains an indicator strip or a test element, one end of the indicator strip or the test strip contacts one end of the absorption element through the outlet.

5. The collector according to claim 4, wherein: The outlet of the elastic sheet extends outward to form a channel, and the indicator strip contacts one end of the absorption element through the channel.

6. The collector according to claim 5, wherein: The glue is spread on the surface of the elastic sheet around the pipe, but not on the outlet of the elastic sheet.

7. The collector according to claim 1, wherein: The fixing plate has a cavity with an open bottom and side walls. The opening of the channel is arranged on the bottom of the cavity. One end of the absorption element is located in the cavity. An elastic fixing part is contained around the absorption part, and the absorption element is fixed in the cavity through the elastic fixing part.

8. The collector according to claim 7, wherein: There are two elastic fixing members, which are arranged around the absorption component so that the absorption component is fixed in the cavity.

9. The collector according to claim 8, wherein: The absorption component is a cylinder, and the elastic fixing piece is annular rubber or latex. The absorption component is fixed in the cavity on the fixing plate through the interaction force between the annular elastic rubber or latex and the absorption element and the inner surface of the side wall.

10. The collector according to claim 9, wherein: The channel of the rod contains an indicator strip, and one end of the indicator strip contacts one end of the absorption element.

11. The collector according to claim 1, wherein: The liquid sample is saliva, urine, sputum or nasal secretion fluid.

12. The collector according to claim 1, wherein: The absorbent element comprises polyester, sponge, cotton and filter paper.

13. The collector according to claim 1, wherein: The absorbent element is hard and substantially incompressible when dry, and can be compressed and deformed when wet.

14. The collector according to claim 1, wherein: The absorbent element is in a soft and compressible state both when dry and when absorbing liquid.

15. The collector according to claim 1, wherein the absorption element is composed of polypropylene sponge (PP), polyvinyl alcohol sponge PVA, polypropylene or melamine foam.

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