Dialysis device

Abstract

The utility model discloses a dialysis device, and relates to the technical field of medical instruments, and the dialysis device comprises a dialysis appliance and a magnetic mechanism. The dialysis appliance comprises a shell, a membrane bundle and a movable tube with multiple holes in the side wall, the membrane bundle is arranged in the shell, and the movable tube is arranged in the middle of the membrane bundle; the magnetic mechanism comprises a magnetic bead, a magnetic block and a power assembly, the magnetic bead is movably arranged in the moving pipe, the power assembly is connected with the magnetic block, and the power assembly drives the magnetic block to move, so that the magnetic bead can move in the moving pipe under the magnetic matching action of the magnetic block and the magnetic bead. According to the dialysis device, flowing stirring of the dialysate in the middle of the membrane bundle can be achieved, flowing of the dialysate in the middle of the membrane bundle is homogenized, and therefore the bias flow phenomenon is avoided, and the problem that the mass transfer rate between toxin and the dialysate is low due to slow flowing of the dialysate in the middle of the membrane bundle is solved.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a dialysis device. Background Art

[0002] As is known to all, both patient blood and dialysate in hollow fiber blood purifiers tend to flow toward areas with less flow resistance, that is, blood or dialysate is less likely to flow near the central axis of the membrane bundle than near the edge. This phenomenon is called bias flow. When bias flow occurs, the solute removal efficiency decreases.

[0003] At present, in order to make the dialysate flow more uniform, manufacturers adopt various design methods, such as inserting spinning yarn into hollow fiber bundles or using micro-wavy hollow fibers to avoid mutual contact between hollow fibers, providing tiny turbulence for the flow of dialysate and making the flow uniform; or using short cone structures at both ends of the shell and installing baffles with slits in the baffles to achieve uniform flow of dialysate. However, although the above settings have improved the flow state of the dialysate to a certain extent, the deviation phenomenon still exists. Utility Model Content

[0004] The purpose of the present application is to provide a dialysis device that solves the problem of slow mass transfer rate between toxins and dialysis fluid caused by slow flow of dialysis fluid in the middle part of the membrane bundle.

[0005] To achieve the above objectives, the present application provides a dialysis device, comprising:

[0006] The dialysis apparatus comprises a housing, a membrane bundle and a mobile tube with porous side walls, wherein the membrane bundle is arranged in the housing and the mobile tube is arranged in the middle of the membrane bundle;

[0007] The magnetic mechanism includes magnetic beads, magnetic blocks and a power component. The magnetic beads are movably arranged in the moving tube. The power component is connected to the magnetic block. The power component drives the magnetic block to move, so that the magnetic beads are configured to move in the moving tube through the magnetic force of the magnetic block.

[0008] In some embodiments, the magnetic block is movably disposed outside the dialysis apparatus, and the distance between the magnetic block and the magnetic beads is constructed so that the magnetic block always maintains magnetic force with the magnetic beads during the movement of the magnetic block between the first position and the second position.

[0009] In some embodiments, the magnetic mechanism further includes a guide rail, the magnetic block is movably disposed on the guide rail, and limit blocks are disposed at both ends of the guide rail to enable the magnetic block to move between a first position and a second position.

[0010] In some embodiments, the guide rail is arranged parallel to the moving tube, and the magnetic block moves linearly between a first position and a second position on the guide rail.

[0011] In some embodiments, the power assembly includes a rotary motor, a screw and a nut. The rotary motor is connected to the screw, and the nut is connected to the screw and the magnet. The rotary motor drives the screw to rotate, and the screw drives the nut and the magnet to move along the guide rail.

[0012] In some embodiments, the dialysis device further comprises a fixed bracket, and the magnetic mechanism and the dialysis apparatus are fixedly mounted on the fixed bracket.

[0013] In some embodiments, the moving tube is a tube body with both ends closed.

[0014] In some embodiments, the dialysis apparatus further comprises a sealant, and a sealant ring is disposed at the end of the membrane bundle, so that the movable tube is fixed to the middle part of the membrane bundle and the membrane bundle is fixed in the shell.

[0015] In some embodiments, the moving tube is an integrally formed structure.

[0016] Relative to the above background technology, the dialysis device provided in the embodiment of the present application includes a dialysis apparatus and a magnetic mechanism. Among them, the dialysis apparatus includes a shell, a membrane bundle and a mobile tube with porous side walls, the membrane bundle is arranged in the shell, and the mobile tube is arranged in the middle part of the membrane bundle; the magnetic mechanism includes magnetic beads, magnetic blocks and a power assembly, the magnetic beads are movably arranged in the mobile tube, the power assembly is connected to the magnetic block, and the power assembly drives the magnetic block to move, so that under the magnetic force cooperation of the magnetic block and the magnetic beads, the magnetic beads can move in the mobile tube. Compared with the traditional setting, the dialysis device provided in the embodiment of the present application adds a mobile tube with porous side walls in the middle part of the membrane bundle, the mobile tube serves as a movement channel for the magnetic beads, and drives the movement of the magnetic beads through the movement of the magnetic block, which is equivalent to adding a flow stirring structure in the middle part of the membrane bundle to realize the flow stirring of the dialysate in the middle part of the membrane bundle, so that the flow of the dialysate in the middle part of the membrane bundle is uniform, thereby avoiding the occurrence of the bias flow phenomenon, and solving the problem of slow mass transfer rate between toxins and dialysate caused by slow flow (bias flow) of the dialysate in the middle part of the membrane bundle. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the related technologies, the drawings required for use in the embodiments or the related technical descriptions are briefly introduced below. Obviously, the drawings described below are merely embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0018] Figure 1 This is a schematic diagram of the structure of the dialysis device in the embodiment of the present application;

[0019] Figure 2 for Figure 1 A schematic diagram of the structure of a power assembly in the dialysis device shown;

[0020] Figure 3 for Figure 1 A schematic diagram of the coordination of the moving tube and the magnetic beads in the dialysis device shown;

[0021] Figure 4 This is a connection diagram of a performance test experiment of a dialysis device in an embodiment of the present application;

[0022] Figure 5 is a first distribution diagram of barium sulfate in the dialysate chamber;

[0023] Figure 6 This is the second distribution diagram of barium sulfate in the dialysate chamber.

[0024] in:

[0025] 10-dialysis apparatus, 11-housing, 12-membrane bundle, 13-moving tube;

[0026] 20-magnetic mechanism, 21-magnetic beads, 22-magnetic blocks, 23-power components, 231-rotating motors, 232-screws, 233-nuts, 24-guide rails, 25-limiting blocks, 26-fixed brackets;

[0027] 30-first container, 31-first pipeline, 32-second pipeline;

[0028] 40-second container, 41-third pipeline, 42-fourth pipeline;

[0029] 50-first pump;

[0030] 60 - second pump;

[0031] 70 - Third pump. DETAILED DESCRIPTION

[0032] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0033] In order to enable those skilled in the art to better understand the present application, the present application is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0034] See also Figure 1 The dialysis device provided in the embodiment of the present application includes a dialysis apparatus 10 and a magnetic mechanism 20.

[0035] The dialysis apparatus 10 includes a shell 11, a membrane bundle 12 and a movable tube 13 with porous side walls. The membrane bundle 12 is disposed in the shell 11, and the movable tube 13 is disposed in the middle part of the membrane bundle 12. Considering that the membrane bundle 12 is a cylindrical structure, the movable tube 13 can be disposed at the central axis position of the membrane bundle 12.

[0036] It should be noted that the above-mentioned shell 11 is a tubular shell, and the membrane bundle 12 is a hollow fiber membrane bundle, which is composed of a large number of hollow fiber membrane filaments, each of which is a hollow structure with porous side walls. The inner cavities of the large number of hollow fiber membrane filaments together form a blood chamber for blood flow during blood purification. At the same time, the gap between the hollow fiber membrane bundle and the shell 11, as well as the gap between each hollow fiber membrane filament, together form a dialysate chamber for dialysate flow during blood purification. In this way, the toxins in the blood can be removed by the flow of dialysate in the dialysate chamber.

[0037] The magnetic mechanism 20 includes magnetic beads 21, magnetic blocks 22 and a power component 23. The magnetic beads 21 are movably arranged in the moving tube 13. The power component 23 is connected to the magnetic block 22. The power component 23 drives the magnetic block 22 to move. In this way, under the magnetic force cooperation between the magnetic block 22 and the magnetic beads 21, the magnetic beads 21 can move in the moving tube 13.

[0038] Among them, the magnetic block 22 can be movably arranged on the outside of the dialysis device 10, and the movement of the magnetic block 22 includes but is not limited to linear movement, spiral rotation, etc., so that through the magnetic attraction between the magnetic block 22 and the magnetic beads 21, the movement of the magnetic block 22 can drive the magnetic beads 21 to move in the moving tube 13.

[0039] It can be understood that the dialysis device provided in the embodiment of the present application adds a movement channel for the magnetic beads 21 in the middle part of the membrane bundle 12, and drives the movement of the magnetic beads 21 through the movement of the magnetic block 22, which is equivalent to adding a flow stirring structure in the middle part of the membrane bundle 12 to achieve flow stirring of the dialysate in the middle part of the membrane bundle 12, so as to make the dialysate flow in the middle part of the membrane bundle 12 uniform, thereby avoiding the occurrence of bias flow, and solving the problem of slow mass transfer rate between toxins and dialysate caused by slow flow of dialysate (bias flow) in the middle part of the membrane bundle 12.

[0040] It should be emphasized that in order to change the movement of the dialysate in the middle part of the membrane bundle 12 by the up and down movement of the magnetic beads 21, solve the problem of bias flow, and further increase the exchange of substances between the blood and the dialysate, the movable tube 13 is a tube body with porous side walls. The purpose of setting the porous wall is to promote the flow of the dialysate in the middle part of the membrane bundle 12. The dialysate is stirred by the movement of the magnetic beads 21 in the movable tube 13, so that the uniformity of the flow of the dialysate in the middle part of the membrane bundle 12 is achieved.

[0041] Among them, the movement of the magnetic beads 21 is equivalent to stirring. The dialysate molecules in the moving tube 13 collide with each other under the action of mechanical force. The collision causes the change of the interaction force between the molecules, increasing the "Brownian motion" of the dialysate in the middle part of the membrane bundle 12, thereby improving the problem of slow mass transfer rate between toxins and dialysate caused by the slow flow (bias flow) of the dialysate in the middle part of the membrane bundle 12.

[0042] In order to facilitate the movement of the magnetic beads 21, the magnetic block 22 can be movably arranged on the outside of the dialysis apparatus 10. The magnetic block 22 can be arranged on the outside of the dialysis apparatus 10 in a movable manner, or can be arranged on the outside of the dialysis apparatus 10 in a manner of spirally moving around the dialysis apparatus 10 or around the axis of the dialysis apparatus 10. In this way, through the magnetic attraction between the magnetic block 22 and the magnetic beads 21, the movement of the magnetic block 22 can drive the magnetic beads 21 to move in the moving tube 13.

[0043] To this end, the distance between the magnetic block 22 and the magnetic beads 21 is configured so that the magnetic block 22 always maintains magnetic force with the magnetic beads 21 during the movement between the first position and the second position. That is to say, during the entire movement of the magnetic block 22, the magnetic beads 21 will not stop moving after the magnetic attraction disappears due to the sudden increase in the distance between the magnetic block 22 and the magnetic beads 21, thereby ensuring the stability of the movement of the magnetic beads 21 in the moving tube 13 and maintaining a continuous dialysate stirring effect.

[0044] In order to facilitate the guidance of the movement of the magnetic block 22, the magnetic mechanism 20 also includes a guide rail 24, on which the magnetic block 22 is movably disposed, and limit blocks 25 are disposed at both ends of the guide rail 24, so that the magnetic block 22 moves between the first position and the second position.

[0045] It should be noted that the so-called first position refers to the upper end surface of the limit block 25 at the lower end of the guide rail 24, and the second position refers to the lower end surface of the limit block 25 at the upper end of the guide rail 24. That is, under the limiting action of the two limit blocks 25, the magnetic block 22 moves between the upper end surface of the limit block 25 at the lower end of the guide rail 24 and the lower end surface of the limit block 25 at the upper end of the guide rail 24.

[0046] It should be noted that the distance between the two limit blocks 25 on the guide rail 24 should be at least equal to the length of the moving tube 13. In this way, when the magnetic block 22 moves from the first position to the second position, it is at least ensured that the magnetic bead 21 moves from one end of the moving tube 13 to the other end.

[0047] In some embodiments, the magnet 22 is movable, and the guide rail 24 is parallel to the movable tube 13. The magnet 22 is movable between a first position and a second position on the guide rail 24, and the magnet 22 moves along a straight line between the first position and the second position.

[0048] In order to further increase the stirring effect, the number of magnetic beads 21 in the moving tube 13 is set to at least two. In this case, the size of the magnetic block 22 in the moving direction should be greater than the sum of the diameters of at least two magnetic beads 21, so as to ensure that the magnetic attraction generated by the magnetic block 22 can cover at least two magnetic beads 21.

[0049] Please also read Figure 2 , the power assembly 23 can adopt a ball screw. Specifically, the power assembly 23 includes a rotary motor 231, a screw 232 and a nut 233. The output shaft of the rotary motor 231 is connected to the screw 232. The nut 233 is connected to the screw 232 through threaded fitting. The nut 233 is connected to the magnet 22. The rotary motor 231 drives the screw 232 to rotate, and the screw 232 drives the nut 233 and the magnet 22 to move along the guide rail 24. Of course, the nut 233 and the magnet 22 can also be an integrated structure.

[0050] With such arrangement, when the rotating motor 231 drives the screw 232 to rotate clockwise, the magnetic block 22 can move upward, and when the rotating motor 231 drives the screw 232 to rotate counterclockwise, the magnetic block 22 can move downward, thus realizing the up and down reciprocating motion of the magnetic block 22 and the magnetic beads 21.

[0051] With such an arrangement, the rotational motion of the screw 232 is converted into the linear motion of the magnetic block 22, thereby driving the magnetic beads 21 in the moving tube 13 to move, thereby achieving the effect of stirring the dialysate.

[0052] In order to facilitate the fixation of the magnetic mechanism 20 and the dialysis apparatus 10, the dialysis device further comprises a fixing bracket 26, on which the magnetic mechanism 20 and the dialysis apparatus 10 are fixedly mounted, and the fixing bracket 26 plays a supporting role, thereby ensuring the stability of the overall structure.

[0053] Please also read Figure 3 The moving tube 13 is a tube body with both ends closed.

[0054] The so-called closing of both ends means that the magnetic beads 21 are sealed in the moving tube 13 , so that when the magnetic beads 21 move from one end to the other end, the travel of the magnetic beads 21 is ensured to be in the moving tube 13 and will not escape from the moving tube 13 .

[0055] Of course, according to actual needs, the moving tube 13 is an integrally formed structure. The material of the moving tube 13 is PVC (Polyvinyl chloride in English, PVC in English, and polyvinyl chloride in Chinese). The moving tube 13 can be integrally injection molded.

[0056] In some embodiments, the mobile tube 13 is fixed in the dialyzer by sealant together with the hollow fiber membrane bundle 12 through the dialyzer "end-sealing" process. Specifically, the dialysis apparatus 10 further includes sealant, which is arranged between the membrane bundle 12 and the housing 11, that is, the sealant ring is arranged at the end of the membrane bundle 12, so that the mobile tube 13 can be fixed to the middle part of the membrane bundle 12 and the membrane bundle 12 can be fixed in the housing 11.

[0057] In addition, in this embodiment, the inner diameter L1 of the moving tube 13 is 8 mm, the diameter L2 of the magnetic beads 21 is 6.5 mm, the inner diameter L3 of the housing 11 is 50 mm, the aperture L4 of the moving tube 13 is 1.5 mm, and the length L5 of the dialysis apparatus 10 is 150 mm. Of course, the above dimensions are only reference dimensions, and these dimensions can be adjusted and changed according to the actual application requirements of the dialysis apparatus 10, and are not specifically limited.

[0058] The performance test experiment of the dialysis device provided in this application is based on Figure 4 to connect.

[0059] Please also read Figure 4 The performance test experiment for the dialysis device requires the use of the first container 30 and the second container 40.

[0060] Among them, the first container 30 is used to contain the first simulated liquid, and the first container 30 and the first end (upper end) of the dialysis apparatus 10 are connected through a first pipeline 31, and the first container 30 and the second end (lower end) of the dialysis apparatus 10 are connected through a second pipeline 32; the second container 40 is used to contain the second simulated liquid, and the second container 40 and the side wall of the dialysis apparatus 10 close to the second end are connected through a third pipeline 41, and the second container 40 and the side wall of the dialysis apparatus 10 close to the first end are connected through a fourth pipeline 42.

[0061] In addition, a first pump 50 is provided on the first pipeline 31, and the first pump 50 is a blood pump for controlling the blood chamber flow rate. A second pump 60 is provided on the third pipeline 41, and the second pump 60 is a dialysate inlet pump. A third pump 70 is provided on the fourth pipeline 42, and the third pump 70 is a dialysate outlet pump. The dialysate inlet pump and the dialysate outlet pump are mainly used to control the inlet and outlet flow rates of the dialysate chamber to remain consistent.

[0062] Of course, according to actual needs, the first simulated liquid contained in the first container 30 can be physiological saline, and the second simulated liquid contained in the second container 40 can be a barium sulfate suspension with a concentration of 170% (w / v), wherein barium sulfate is a contrast agent that absorbs the rays in the CT scan and prevents the X-rays from passing through, thereby appearing white in the CT image.

[0063] The process of the performance test experiment of the dialysis device in this application is described in detail below.

[0064] First, set the priming flow rates of the blood chamber and the dialysate chamber to 100 mL / min and 500 mL / min, respectively, turn on the blood pump, and prime the blood chamber of the dialysis apparatus 10 to be tested with the first simulated liquid for about 30 minutes, and at the same time turn on the dialysate inlet pump and the dialysate outlet pump, and prime the dialysate chamber of the dialysis apparatus 10 to be tested with the second simulated liquid for about 5 minutes;

[0065] Turn off the blood pump, dialysate inlet pump and dialysate outlet pump, set the flow rate of the first simulated liquid to 200 mL / min, and the flow rate of the second simulated liquid to 500 mL / min, turn on the blood pump, dialysate inlet pump and dialysate outlet pump at the same time, adjust the dialysate inlet pump and dialysate outlet pump to keep the dialysate flow rate at the set flow rate, and start timing;

[0066] After 10 minutes of operation, the CT scan was performed to obtain the first distribution map of barium sulfate in the dialysate chamber, such as Figure 5 As shown;

[0067] The moving speed of the magnetic block 22 is set to 10 cm / s, and the rotating motor 231 is started, so that the screw 232 drives the magnetic block 22 to move up and down along the guide rail 24, thereby driving the magnetic bead 21 to move up and down;

[0068] After 10 minutes of operation, a CT scan was performed to obtain the second distribution map of barium sulfate in the dialysate chamber, such as Figure 6 As shown;

[0069] The first CT distribution map and the second CT distribution map are compared and analyzed to obtain the influence of the movement of the magnetic beads 21 on the flow of the dialysate.

[0070] After analyzing the image: Figure 5 This is the CT scan image when the system runs for 10 minutes, and each image in the picture is separated by 1 second; Figure 6 This is an image of the CT scan when the system runs for 10 minutes after the magnetic mechanism 20 is turned on. The interval between each image in the picture is 1 second.

[0071] From the image we can get: Figure 5 The medium barium sulfate (white development) is mainly distributed around the shell 11, and less distributed in the middle of the membrane bundle 12, because the flow resistance of the simulated liquid in the middle of the membrane bundle 12 is large; Figure 6 Barium sulfate (white development) is relatively distributed around the shell 11 and in the middle of the membrane bundle 12. Figure 5 Therefore, magnetic stirring is beneficial to the distribution of the dialysate in the middle of the membrane bundle 12.

[0072] In summary, the present application provides a dialysis device for improving the flow state of dialysate, that is, adding a movement channel of magnetic beads 21 in the middle of the hollow fiber membrane bundle 12, and driving the movement of the magnetic beads 21 through the movement of the external magnetic block 22 to achieve dialysate flow stirring, so that the dialysate flows evenly in the middle part of the hollow fiber bundle, thereby avoiding the occurrence of bias flow. The movement of the magnetic beads 21 is equivalent to stirring, and the dialysate molecules collide under the action of mechanical force. The collision causes the change of the interaction force between molecules, increases the "Brownian motion" of the dialysate in the middle of the hollow fiber membrane bundle 12, and improves the problem of slow mass transfer rate between toxins and dialysate caused by slow flow (bias flow) of the dialysate in the middle of the hollow fiber membrane bundle 12.

[0073] It should be noted that, in this specification, relational terms such as first and second are merely used to distinguish one entity from other entities, but do not necessarily require or imply any actual relationship or order between these entities.

[0074] The dialysis device provided by the present application is described in detail above. Specific examples are used herein to illustrate the principles and implementation methods of the present application, and the description of the above embodiments is only used to help understand the scheme and its core idea of ​​the present application. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the present application, several improvements and modifications can be made to the present application, and these improvements and modifications also fall within the scope of protection of the present application.

Claims

1. A dialysis device, characterized in that: include: A dialysis apparatus, comprising a housing, a membrane bundle and a mobile tube with porous side walls, wherein the membrane bundle is arranged in the housing and the mobile tube is arranged in the middle of the membrane bundle; The magnetic mechanism includes magnetic beads, magnetic blocks and a power component. The magnetic beads are movably arranged in the moving tube. The power component is connected to the magnetic block. The power component drives the magnetic block to move, so that the magnetic beads are configured to move in the moving tube through the magnetic force of the magnetic block.

2. The dialysis device according to claim 1, characterized in that The magnetic block is movably disposed outside the dialysis apparatus, and the distance between the magnetic block and the magnetic beads is constructed so that the magnetic block always maintains magnetic force with the magnetic beads during the movement of the magnetic block between the first position and the second position.

3. The dialysis device according to claim 2, characterized in that The magnetic mechanism further comprises a guide rail, the magnetic block is movably arranged on the guide rail, and both ends of the guide rail are provided with limit blocks, so that the magnetic block moves between the first position and the second position.

4. The dialysis device according to claim 3, characterized in that The guide rail is arranged in parallel with the moving tube, and the magnetic block moves linearly between the first position and the second position on the guide rail.

5. The dialysis device according to claim 4, characterized in that The power assembly includes a rotary motor, a screw and a nut. The rotary motor is connected to the screw, and the nut is connected to the screw and the magnet. The rotary motor drives the screw to rotate, and the screw drives the nut and the magnet to move along the guide rail.

6. The dialysis device according to claim 1, characterized in that The dialysis device further comprises a fixed bracket, and the magnetic mechanism and the dialysis apparatus are fixedly mounted on the fixed bracket.

7. The dialysis device according to any one of claims 1 to 6, characterized in that: The moving tube is a tube body with two ends closed.

8. The dialysis device according to claim 7, characterized in that The dialysis apparatus further comprises a sealant, wherein the sealant ring is arranged at the end of the membrane bundle, so that the moving tube is fixed to the middle part of the membrane bundle and the membrane bundle is fixed in the shell.

9. The dialysis device according to claim 7, characterized in that The moving pipe is an integrally formed structure.

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