Liposome extruder

Abstract

The utility model discloses a lipidosome extruder which comprises a pressing unit, a filtering unit and a jacket support unit which are sequentially arranged from top to bottom. The jacket support unit comprises a discharge port, a supporting belt and a flow guide channel, wherein the supporting belt is of a protruding structure on the jacket support unit. According to the utility model, the raised support belt is arranged on the jacket support unit, so that the contact area between the support plate and the jacket support is reduced, and meanwhile, the area of the flow guide channel is increased. Compared with a traditional plane contact design, the protruding supporting belt structure can effectively reduce the flowing resistance of materials, so that the working pressure needed by the extruder is remarkably reduced, energy consumption is reduced, and the service life of equipment is prolonged.

Description

Technical Field

[0001] The utility model belongs to the field of liposome preparation equipment, and particularly relates to a liposome extruder. Background Art

[0002] A liposome is a vesicle structure formed by one or more lipid molecules, having a lipophilic inner cavity and a hydrophilic outer surface. This unique amphiphilic structure enables it to encapsulate active substances such as drugs, cosmetics, and food additives, and deliver them to specific sites. Therefore, it has broad application prospects in the fields of biomedicine, cosmetics, and functional foods. Among numerous liposome preparation methods, the extrusion method is favored due to its advantages such as simple operation, no need to use organic solvents, and easy large-scale production.

[0003] However, the existing liposome extrusion equipment in the prior art still has many deficiencies and urgently needs further improvement and optimization. Among them, the most prominent problem is that the extruder usually needs to apply a large pressure to ensure the normal flow of materials, which not only increases the energy consumption of the equipment but also may affect the service life of the equipment. The main reason for this problem is that the jacket supports and support plates of common extrusion equipment mostly adopt a planar structure. Under this design, a narrow bending channel is formed between the mesh holes on the support plate and the planar jacket support. When the material passes through these parts, backpressure is extremely likely to occur, resulting in a significant increase in extrusion resistance.

[0004] In addition, the material guiding grooves and the discharge ports of traditional liposome extruders are usually horizontally designed. This structure is likely to cause tailing materials to remain inside the equipment, which not only affects the product quality but also brings many inconveniences to equipment cleaning. If the remaining materials are not thoroughly cleaned, long-term accumulation may breed bacteria, thereby causing problems such as product contamination.

[0005] At the same time, the filtering devices of existing liposome extruders generally have defects such as low filtering accuracy and easy clogging. Liposome preparation has high requirements for the purity and uniformity of raw materials. However, the currently used filtering components are often difficult to effectively remove impurities, restricting the further improvement of product quality. The filter plates and filter membranes are also prone to failure due to clogging, thereby affecting production efficiency.

[0006] Although some improvement measures have been proposed in the prior art, such as setting an inclined surface between the material guiding groove and the discharge port, and adopting a columnar or conical jacket support, these solutions have not fundamentally solved the technical problems such as high extrusion pressure requirements, difficult residue cleaning, and poor filtering performance. In order to further improve the efficiency and quality of liposome preparation, developing a brand-new liposome extruder has become an urgent need in the industry. Summary of the Utility Model

[0007] To solve the problems existing in the existing liposome extruder, such as large extrusion demand pressure and material residue, the present utility model proposes a liposome extruder.

[0008] The liposome extruder includes a downward pressing unit, a filtering unit, and a jacket support unit. The downward pressing unit is arranged above the filtering unit and is used to apply pressure to the material; the filtering unit is arranged above the jacket support unit and is used to filter the material; the jacket support unit is arranged below the filtering unit and is used to support and guide the flow of the material.

[0009] The jacket support unit includes a discharge port, a support belt, and a diversion channel. The discharge port, the support belt, and the diversion channel are all arranged on the jacket support unit, and one end of the diversion channel points to the discharge port. The support belt is a protruding structure arranged on the jacket support unit and is used to support the filtering unit and guide the flow of the material.

[0010] Further, the jacket support unit further includes a base and a fence, and the fence is arranged on the base. The support belt is arranged on the base, and the connection surface with the base is a sector ring, and the support belt protrudes away from the base. The support belt points to the discharge port, and the support belt is radially arranged and connected to the fence.

[0011] Specifically, the cross-section of the support belt in the direction perpendicular to its radial direction is an isosceles trapezoid, and the cross-sectional area of the isosceles trapezoid gradually increases when extending towards the fence along its radial direction.

[0012] Preferably, both the base and the discharge port are circular and share the same center, the fence is a circular ring concentric with the base, and the height of the fence is higher than that of the support belt. This structural design is beneficial for the material to uniformly converge towards the discharge port.

[0013] The diversion channel is radially arranged, one end points to the discharge port, and the end far from the discharge port is higher than the discharge port, so that the material can flow smoothly towards the discharge port. Further, the diversion channel is preferably in the shape of a sector ring and matches the shape of the support belt, which is beneficial for the diversion of the material.

[0014] The filtering unit includes an O-ring, a filter membrane, a filter plate, and a support plate, which are arranged in sequence from top to bottom. Specifically, a number of through holes are arranged on the support plate, which are used to support the filter plate and the filter membrane and at the same time allow the material to pass through.

[0015] Compared with the prior art, the liposome extruder of the present utility model has the following advantages and beneficial effects:

[0016] The utility model reduces the contact area between the support plate and the jacket support by providing a protruding support belt on the jacket support unit, increasing the diversion channel. This design effectively reduces the resistance of material flow, thus significantly reducing the pressure required by the extruder. The smaller working pressure not only saves the energy consumption of the equipment, but also extends the service life of the equipment, improving production efficiency and economic benefits.

[0017] Furthermore, one end of the diversion channel of the utility model is higher than the discharge port and radially points to the discharge port. This unique structural design is conducive to the full flow and collection of materials. Different from the traditional horizontal layout, the inclined diversion channel can effectively avoid the retention and residue of materials inside the equipment, ensuring that the materials can be fully extruded, improving the quality and uniformity of the products. At the same time, the reasonable design of the diversion channel also greatly improves the cleaning efficiency of the equipment, reduces the risk of bacteria breeding caused by residual materials, and ensures the hygienic safety of production.

[0018] Preferably, the utility model optimizes and improves the structure of the filtering unit. The combination of the O-ring, filter membrane, filter plate and support plate significantly improves the filtering accuracy and effect. The multiple holes penetrating the support plate provide sufficient channels for the passage of materials while ensuring the support strength, reducing the risk of blockage. The optimized filtering unit can effectively remove impurities and non-uniform components in the materials, ensuring the quality and uniformity of the prepared liposomes, and ultimately improving the performance and stability of the products.

[0019] The utility model cleverly utilizes the design of the circular base, discharge port and fence to enable the materials to uniformly converge towards the discharge port. At the same time, the support belt with an isosceles trapezoidal cross-section and the fan-shaped ring-shaped diversion channel form a gradually increasing cross-sectional area in the radial direction, further optimizing the diversion effect of the materials. These structural details ensure the smoothness and uniformity of material flow, improving the efficiency and quality of liposome preparation.

[0020] In summary, the liposome extruder provided by the utility model effectively solves the problems of large extrusion pressure and material residue existing in the prior art by optimizing key structures such as the jacket support. This extruder not only improves the efficiency and quality of liposome preparation, but also has the advantages of energy saving, environmental protection and hygiene, and has broad application prospects and significant practical value in the fields of biomedicine, cosmetics and food. Brief Description of the Drawings

[0021] Figure 1 is the overall structural schematic diagram of the liposome extruder in an embodiment of the utility model,

[0022] Figure 2 is the structural schematic diagram of the support plate and the jacket support unit in an embodiment of the utility model,

[0023] Figure 3 This is a schematic structural diagram of the filtering unit in an embodiment of the present utility model.

[0024] Figure 4 This is a three-dimensional structural diagram of the jacket support unit in an embodiment of the present utility model.

[0025] Figure 5 is a schematic structural diagram of the support plate and the jacket support unit in the prior art.

[0026] Figure 6 This is a schematic structural diagram of the jacket support unit in the prior art.

[0027] Figure 7 This is a schematic structural diagram of the support plate in the prior art.

[0028] Explanation of reference numerals:

[0029] 1. Lower pressing unit; 2. Filtering unit, 21. O-ring, 22. Filter membrane, 23. Filter plate, 24. Support plate, 25. Through hole; 3. Jacket support unit, 31. Base, 32. Discharge port, 33. Fence, 34. Support belt, 35. Diversion channel. Detailed implementation manners

[0030] Next, in combination with the accompanying drawings and specific embodiments, the technical solutions of the present utility model will be elaborated in detail. It should be noted that the described embodiments are only used to explain the technical principle of the present utility model, rather than limiting the scope of its protection. Those skilled in the art should understand that without departing from the spirit and scope of the present utility model, various transformations, modifications or equivalent replacements can be made to these embodiments. These transformations, modifications or equivalent replacements should all be regarded as falling within the protection scope defined by the claims of the present utility model.

[0031] In addition, in the description of the present utility model, unless otherwise specifically stated, the words "front", "rear", "upper", "lower", "left", "right" and similar expressions are only for the purpose of illustration, rather than limiting the protection scope of the present utility model.

[0032] In the description of the present utility model, it should also be noted that unless otherwise clearly defined and limited, the terms "installation", "connection" and "coupling" should be understood in a broad sense. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.

[0033] Combined with the specification and drawings of the present utility model, those skilled in the art can implement the present utility model. In the description of the present utility model, several specific details are elaborated. However, the protection scope of the present utility model is not limited thereto. In other cases, in order not to obscure the key principles of the present utility model, the descriptions of well-known technologies and structures are omitted.

[0034] The preferred embodiments of the present utility model will be described in detail below in conjunction with the accompanying drawings;

[0035] As Figure 1 shown, the present utility model provides a liposome extruder, which includes a pressing unit 1, a filtering unit 2, and a jacket support unit 3. The pressing unit 1 is arranged above the filtering unit 2 and is used to apply pressure to the material; the filtering unit 2 is arranged above the jacket support unit 3 and is used to filter the material; the jacket support unit 3 is arranged below the filtering unit 2 and is used to support and guide the flow of the material.

[0036] Referring to Figure 2 and Figure 4 , the jacket support unit 3 includes a base 31, a discharge port 32, a fence 33, a support belt 34, and a diversion channel 35. The discharge port 32 is located at the center of the base 31, and both the base 31 and the discharge port 32 are circular and concentric. The fence 33 is arranged on the base 31, surrounds the discharge port 32 in an annular shape, and is concentric with the base 31. The height of the fence 33 is higher than that of the support belt 34, which is used to limit the flow range of the material.

[0037] The support belt 34 is a protruding structure arranged on the base 31, which is used to support the filtering unit 2 and guide the flow of the material. The support belts 34 are evenly distributed on the base 31 in a radial pattern, with one end connected to the fence 33 and the other end pointing to the discharge port 32. The connection surface of the support belt 34 and the base 31 is a fan-shaped ring, and the support belt 34 protrudes away from the base 31.

[0038] Furthermore, the cross-section of the support belt 34 in the direction perpendicular to its radial direction is an isosceles trapezoid, and the upper base of the isosceles trapezoid is in contact with the bottom surface of the filtering unit 2. The cross-sectional area of the isosceles trapezoid gradually increases along the radial direction, that is, the width of the support belt 34 gradually increases towards the fence 33, and the horizontal height remains unchanged. This variable cross-section design is beneficial to the flow of the material from the fence 33 to the discharge port 32 and reduces the flow resistance.

[0039] The diversion channel 35 is located between adjacent support belts 34 and is distributed on the base 31 in a fan-shaped ring. One end of the diversion channel 35 points to the discharge port 32, and the other end is connected to the fence 33. The end of the diversion channel 35 far from the discharge port 32 is higher than the discharge port 32, forming a certain inclination angle, so that the material can flow smoothly towards the discharge port 32 under the action of gravity, avoiding material residue.

[0040] Figure 2 also shows that through holes 25 are provided on the support plate 24, enabling the material to flow into the jacket support unit 3 through the support plate 24.

[0041] Referring to Figure 3, the filtering unit 2 includes an O-ring 21, a filter membrane 22, a filter plate 23 and a support plate 24, which are arranged in sequence from top to bottom. The O-ring 21 is placed on the filter plate 23 for sealing. The filter membrane 22 is located between the O-ring 21 and the filter plate 23 for filtering impurities in the material. The filter plate 23 plays a supporting role and is provided with a plurality of through holes thereon to allow the filtered material to pass through.

[0042] The support plate 24 is located below the filter plate 23 and plays a supporting role for the filter plate 23. A number of through holes 25 corresponding to the through holes of the filter plate 23 are provided on the support plate 24, so that the material can flow through the support plate 24 into the jacket support unit 3.

[0043] See Figures 5 to Figure 7 , there are the following problems with the support plate and the jacket support unit in the prior art: the base 31 of the jacket support unit is in direct plane contact with the support plate 24, and the contact area is large, resulting in a large extrusion resistance of the material after flowing through the support plate 24; the diversion channel 35 inside the jacket support unit is parallel to the base 31, which is not conducive to the flow and discharge of the material.

[0044] The working mode of the liposome extruder in this embodiment is as follows:

[0045] Put the material to be processed below the pressing unit 1 and apply pressure to the material. Under the action of the pressure, the material is filtered through the filtering unit 2. When the extruder is working, the material passes through the filter membrane 22, the filter plate 23 and the support plate 24 in sequence. During this process, the filter membrane 22 intercepts the impurities in the material, and the filtered material enters the jacket support unit 3 through the through holes 25 on the filter plate 23 and the support plate 24.

[0046] After entering the jacket support unit 3, the material is under the action of continuous pressure and flows along the inclined diversion channel 35 towards the discharge port 32. The inclined design of the diversion channel 35 not only promotes the flow of the material towards the discharge port 32, but also can minimize the material residue. At the same time, the inclined diversion channel 35 also helps the pure steam condensate to be quickly discharged during the sterilization process of the equipment, further improving the sanitary performance of the equipment.

[0047] It should be noted that the present utility model adopts a unique design of the support belt 34 to replace the traditional plane contact design. In the traditional design, as shown in Figures 5 and Figure 6 shown, the base 31 of the jacket support unit is in direct contact with the support plate 24, and the contact area between the two is very large. While in the present utility model, as shown in Figures 2 and Figure 4 shown, the protruding support belt 34 is in contact with the support plate 24. This design greatly reduces the contact area between the jacket support unit 3 and the support plate 24.

[0048] Since the support belts 34 are radially distributed on the base 31, a flow guiding channel 35 is formed between adjacent support belts 34. The reduced contact area is converted into an increased flow guiding channel area, and the increase in the flow guiding channel area is approximately 70%. The increased flow guiding channel area means that the material can pass more freely through the through holes 25 in the support plate 24, thereby effectively reducing the extrusion resistance of the material after flowing through the support plate 24.

[0049] In actual material tests, compared with a conventional extrusion disk using a traditional planar design, for the new extruder using the support belt 34 design of the present utility model, the required extrusion pressure is reduced from approximately 51 bar to 39 bar, a decrease of 28%. This fully demonstrates the remarkable effect of the optimized design of the support belt 34 and the flow guiding channel 35 in reducing the flow resistance and the required pressure.

[0050] Finally, under the continuous action of the pressure, the material flows out from the discharge port 32, completing the entire extrusion process.

[0051] The scope of patent protection of the present utility model is not limited to the content disclosed in the above embodiments. Any improvement and substitution based on the present utility model, as long as it uses equivalent structural or equivalent process transformations made using the content of the specification and drawings of the present utility model, or is directly or indirectly applied to other technical fields related to the present utility model, shall similarly be included within the scope of patent protection of the present utility model.

[0052] For example, in the above embodiments, the specific shapes and sizes of the support belt 34 and the flow guiding channel 35 can be adjusted and optimized according to actual needs to further improve the material transmission efficiency and reduce energy consumption. Another example is that the material and pore size of the filter membrane 22 in the filtration unit 2 can be selected and designed according to the requirements of the liposome preparation process to obtain the best filtration effect.

[0053] In summary, the liposome extruder provided by the present utility model effectively solves the problems existing in the prior art, such as high extrusion pressure, material residue, high energy consumption, etc., by optimizing the design of the support belt and the flow guiding channel, improves the efficiency and quality of liposome preparation, and has remarkable practical value and promotion prospects. Those skilled in the art can make various improvements and substitutions inspired by the present utility model, and these improvement and substitution solutions should all be regarded as falling within the protection scope of the present utility model.

Claims

1. A liposome extruder, characterized in that, It includes a pressing unit, a filtering unit and a jacket support unit; The pressing unit is arranged above the filtering unit, and the jacket support unit is arranged below the filtering unit; The jacket support unit comprises a discharge port, a support belt and a guide channel, wherein the discharge port, the support belt and the guide channel are all arranged on the jacket support unit, and one end of the guide channel points to the discharge port; The support belt is a protruding structure arranged on the jacket support unit.

2. The liposome extruder according to claim 1, characterized in that The jacket support unit further comprises a base and a fence, wherein the fence is arranged on the base; The support belt is arranged on the base, and the connection surface with the base is a fan ring; The support belt protrudes in a direction away from the base; The support belt points to the discharge port, and the support belt is radial and connected to the fence; The cross section of the support belt perpendicular to its radiation direction is an isosceles trapezoid; The cross-sectional area of ​​the isosceles trapezoid gradually increases as it extends toward the fence along its radial direction.

3. The liposome extruder according to claim 2, characterized in that The base and the discharge port are both circular and share the same center.

4. The liposome extruder according to claim 3, characterized in that The fence is a circular ring cocentric with the base, and the height of the fence is higher than the support belt.

5. The liposome extruder according to claim 1, characterized in that One end of the guide channel is radially directed to the discharge port, and one end of the guide channel away from the discharge port is higher than the discharge port, so as to facilitate the flow of materials toward the discharge port.

6. The liposome extruder according to claim 5, characterized in that The guide channel is a fan ring.

7. The liposome extruder according to claim 1, characterized in that The filter unit comprises an O-ring, a filter membrane, a filter plate and a support plate; the O-ring, the filter membrane, the filter plate and the support plate are arranged in sequence from top to bottom.

8. The liposome extruder according to claim 7, characterized in that The support plate is provided with a plurality of through holes.

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