Liquid chromatography mobile phase adding device

Abstract

The utility model discloses a liquid chromatography mobile phase adding device, which belongs to the technical field of liquid chromatography, and comprises a liquid chromatograph and an adding mechanism, the adding mechanism comprises an adding assembly, the adding assembly comprises an outer cylinder and a piston rod, the piston rod slides in an inner piston of the outer cylinder, and the piston rod is connected with the liquid chromatograph. A mobile phase is arranged between the outer cylinder and the piston rod, and the adding mechanism is arranged in the liquid chromatograph; the auxiliary transmission mechanism comprises an extrusion assembly and a displacement assembly, the extrusion assembly is connected with the outer cylinder and the piston rod in a clamped mode, the extrusion assembly drives the piston rod to slide in the outer cylinder, the displacement assembly is installed on the displacement assembly in a limited sliding mode, and the extrusion assembly is used for pushing out the mobile phase in the adding assembly; the displacement assembly is used for driving the adding assembly to displace, so that the adding assembly corresponds to the flowing phase on the paper, and the flowing phase can be conveniently added for multiple times.

Description

Technical Field

[0001] The utility model relates to the field of liquid chromatography, and more specifically, to a liquid chromatography mobile phase adding device. Background Art

[0002] Liquid chromatography is a class of separation and analysis techniques, characterized by using a liquid as the mobile phase, and the stationary phase can have various forms, such as paper, thin plates, and packed beds, etc. During the development of chromatography technology, in order to distinguish various methods, respective names were generated according to the form of the stationary phase, such as paper chromatography, thin layer chromatography, and column liquid chromatography.

[0003] In the prior art, there is a liquid chromatography mobile phase automatic adder with the application number CN201820912706.9. In the above solution, "the mobile phase reservoir is installed on the liquid chromatography instrument body, and a liquid level detection structure is used to detect the liquid level height of the mobile phase in the mobile phase reservoir and transmit it to the main board controller. When the liquid level detection structure detects that the liquid level of the mobile phase in the mobile phase reservoir is low, the main board controller controls the liquid adding mechanism to add mobile phase to the mobile phase reservoir." The mobile phase slowly flows through the chromatographic column by gravity. However, when the mobile phase flows on the paper and if the mobile phase dries up halfway, it is necessary to add the mobile phase again at the top of the paper, resulting in the mobile phase still needing to flow down continuously from above. It is not convenient to re-add the mobile phase at the position where the mobile phase dries up to make the mobile phase continue to flow downward. How to invent a liquid chromatography mobile phase adding device to improve these problems has become an urgent problem for those skilled in the art. Summary of the Utility Model

[0004] To make up for the above deficiencies, the utility model provides a liquid chromatography mobile phase adding device, aiming to improve the problem that when the mobile phase flows on the paper and if the mobile phase dries up halfway, it is necessary to re-add the mobile phase at the top of the paper.

[0005] The utility model is realized as follows: A liquid chromatography mobile phase adding device includes a liquid chromatography instrument, and also includes

[0006] An adding mechanism, the adding mechanism includes an adding component, the adding component includes an outer cylinder and a piston rod, the piston rod slides piston-like inside the outer cylinder, and a mobile phase is provided between the outer cylinder and the piston rod. The adding mechanism is arranged inside the liquid chromatography instrument;

[0007] An auxiliary transmission mechanism, the auxiliary transmission mechanism includes an extrusion component and a displacement component. The extrusion component is respectively clamped with the outer cylinder and the piston rod. The extrusion component drives the piston rod to slide inside the outer cylinder, and the displacement component is installed in a limited sliding manner on the displacement component.

[0008] In a preferred technical solution of the present utility model, the adding component further includes an output needle, the output needle is connected and installed at the end of the outer cylinder, the piston rod is hermetically and slidably installed inside the outer cylinder, an input pipe is connected and communicated to the outside of one end of the outer cylinder close to the output needle, and electromagnetic valves are connected and installed on both the input pipe and the output needle.

[0009] In a preferred technical solution of the present utility model, a limiting plate is fixedly sleeved at the tail of the outer cylinder, and the limiting plate is oval.

[0010] In a preferred technical solution of the present utility model, a rubber stopper is fixedly connected to the end of the piston rod, the rubber stopper is hermetically and slidably connected to the inner wall of the outer cylinder, and a push handle is fixedly connected to the tail of the piston rod.

[0011] In a preferred technical solution of the present utility model, the extrusion component includes an assembly plate and a fixing plate. One end of the assembly plate is fixedly connected with an end positioning ring, the other end of the assembly plate is fixedly connected with a clamping plate, the outside of the clamping plate is connected with the fixing plate, the two sides of the fixing plate and the clamping plate are limited and rotatably connected with a first lead screw, the first lead screw is drivingly connected with a transmission plate, both ends of the transmission plate are respectively drivingly connected with the first lead screw, and the ends of the two first lead screws are drivingly connected with a motor through gears.

[0012] In a preferred technical solution of the present utility model, the output needle penetrates through the end positioning ring, the end of the outer cylinder is clamped with the end positioning ring, the limiting plate abuts against the clamping plate, the piston rod penetrates through the clamping plate, and the push handle is limited and clamped with the transmission plate.

[0013] In a preferred technical solution of the present utility model, a matching limiting ring is arranged on one side of the clamping plate, the matching limiting ring is fixedly installed on the assembly plate, and the limiting plate is located between the matching limiting ring and the clamping plate.

[0014] In a preferred technical solution of the present utility model, a limiting clamping ring is fixedly connected to one side of the transmission plate, the limiting clamping ring is sleeved on the push handle, and the push handle is located between the limiting clamping ring and the transmission plate.

[0015] In a preferred technical solution of the present utility model, the displacement component includes a mounting plate, a strip-shaped groove is formed in the middle of the mounting plate, a second lead screw is arranged inside the groove, both ends of the second lead screw are connected with bearing seats, the bearing seats are respectively fixedly installed at both ends of the mounting plate, grooves are formed on both sides of the mounting plate where the second lead screw is located, and a limiting sliding rail is fixedly installed at the bottom of the assembly plate, and the limiting sliding rail is slidably connected with the grooves on both sides of the assembly plate.

[0016] In a preferred technical solution of the present utility model, the limiting slide rail is arranged in an isosceles trapezoid shape, and the grooves on both sides of the assembly plate are correspondingly arranged with the limiting slide rail.

[0017] The beneficial effects of the present utility model are as follows: A liquid chromatography mobile phase adding device obtained by the above design of the present utility model, when in use, the motor drives the second lead screw to rotate, the second lead screw drives the assembly plate to displace, so that the output needle is aligned with the dry position, the motor drives the first lead screw through transmission, the first lead screw drives the transmission plate to displace, and the transmission plate pushes the piston rod to displace inside the outer cylinder, which is used to push out the mobile phase inside the outer cylinder, and the mobile phase is discharged through the output needle. (At this time, the solenoid valve on the input pipe needs to be closed). If the mobile phase inside the outer cylinder is used up, close the solenoid valve on the output needle and open the solenoid valve on the input pipe. At this time, the motor drives the first lead screw to drive the transmission plate to move backward, the transmission plate moves backward to pull the piston rod to extract the mobile phase in the input pipe, and after the extraction is completed, close the solenoid valve on the input pipe and open the solenoid valve on the output needle, which is convenient for adding the mobile phase next time. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the following will briefly introduce the drawings required for use in the embodiments. It should be understood that the following drawings only show some embodiments of the present utility model, and therefore should not be regarded as limiting the scope. For those of ordinary skill in the art, without creative efforts, other related drawings can also be obtained based on these drawings.

[0019] Figure 1 It is a schematic diagram of one side structure provided by the embodiment of the present utility model;

[0020] Figure 2 It is a schematic diagram of the other side structure provided by the embodiment of the present utility model;

[0021] Figure 3 It is a schematic diagram of the structure of the extrusion assembly provided by the embodiment of the present utility model;

[0022] Figure 4 It is a schematic diagram of the structure of the displacement assembly provided by the embodiment of the present utility model.

[0023] In the figure: 100 - adding mechanism; 110 - adding component; 111 - outer cylinder; 112 - output needle; 113 - limit plate; 114 - piston rod; 115 - push handle; 116 - input pipe; 200 - auxiliary transmission mechanism; 210 - extrusion component; 211 - assembly plate; 212 - end positioning ring; 213 - matching limit ring; 214 - clamping plate; 215 - transmission plate; 216 - limit clamping ring; 217 - fixing plate; 218 - first lead screw; 219 - limit slide rail; 220 - displacement component; 221 - mounting plate; 222 - second lead screw; 223 - bearing seat. Detailed implementation manners

[0024] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present utility model. Apparently, the described embodiments are some but not all of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0025] Please refer to Figure 1 and Figure 2 The present utility model provides a technical solution: a liquid chromatography mobile phase adding device, including a liquid chromatograph, and further including

[0026] an adding mechanism 100, the adding mechanism 100 includes an adding component 110, the adding component 110 includes an outer cylinder 111 and a piston rod 114, the piston rod 114 slides in the inner part of the outer cylinder 111 in a piston manner, a mobile phase is arranged between the outer cylinder 111 and the piston rod 114, and the adding mechanism 100 is arranged in the liquid chromatograph; an auxiliary transmission mechanism 200, the auxiliary transmission mechanism 200 includes an extrusion component 210 and a displacement component 220, the extrusion component 210 is respectively clamped with the outer cylinder 111 and the piston rod 114, the extrusion component 210 drives the piston rod 114 to slide in the outer cylinder 111, the displacement component 220 is slidably installed in the displacement component 220 in a limited manner, the extrusion component 210 is used to push out the mobile phase in the adding component 110, and the displacement component 220 is used to drive the adding component 110 to displace so that the adding component 110 corresponds to the mobile phase on the paper.

[0027] The auxiliary transmission mechanism 200 is installed on one side of the paper placement in the chromatograph, and the adding component 110 is arranged corresponding to the paper, which is convenient to cooperate with the auxiliary transmission mechanism 200 to place the mobile phase in the adding component 110 at the dry position of the paper.

[0028] Please refer to Figure 2 and Figure 3, the adding component 110 further includes an output needle 112, the output needle 112 is connected and installed at the end of the outer cylinder 111, the piston rod 114 is hermetically and slidably installed inside the outer cylinder 111, an input pipe 116 is connected to the outside of one end of the outer cylinder 111 near the output needle 112, electromagnetic valves are connected and installed on both the input pipe 116 and the output needle 112, and the input pipe 116 is connected to the mobile phase storage position.

[0029] A limiting plate 113 is fixedly sleeved at the tail of the outer cylinder 111, and the limiting plate 113 is oval. A rubber plug is fixedly connected to the end of the piston rod 114, the rubber plug is hermetically and slidably connected to the inner wall of the outer cylinder 111, a push handle 115 is fixedly connected to the tail of the piston rod 114, and pushing the push handle 115 causes the piston rod 114 to squeeze the mobile phase inside the outer cylinder 111, and the mobile phase is discharged through the output needle 112.

[0030] Please refer to Figure 2 and Figure 3 , the squeezing component 210 includes an assembly plate 211 and a fixing plate 217. One end of the assembly plate 211 is fixedly connected with an end positioning ring 212, the other end of the assembly plate 211 is fixedly connected with a clamping plate 214, the outside of the clamping plate 214 is connected with the fixing plate 217, first lead screws 218 are rotatably connected to both sides of the fixing plate 217 and the clamping plate 214, the first lead screws 218 are drivingly connected with a transmission plate 215, both ends of the transmission plate 215 are respectively drivingly connected with the first lead screws 218, the ends of the two first lead screws 218 are drivingly connected with a motor through gears, the motor drives the first lead screws 218 to rotate, and the first lead screws 218 are used to drive the transmission plate 215 to displace, so that the transmission plate 215 pushes or pulls the push handle 115 to move.

[0031] The output needle 112 penetrates through the end positioning ring 212, the end of the outer cylinder 111 is clamped with the end positioning ring 212, the limiting plate 113 abuts against the clamping plate 214, the piston rod 114 penetrates through the clamping plate 214, and the push handle 115 is limit-clamped with the transmission plate 215. A matching limiting ring 213 is arranged on one side of the clamping plate 214, the matching limiting ring 213 is fixedly installed on the assembly plate 211, and the limiting plate 113 is located between the matching limiting ring 213 and the clamping plate 214. A limiting clamping ring 216 is fixedly connected to one side of the transmission plate 215, the limiting clamping ring 216 is sleeved on the push handle 115, and the push handle 115 is located between the limiting clamping ring 216 and the transmission plate 215.

[0032] Please refer to Figure 2 and Figure 3, the displacement component 220 includes a mounting plate 221. A strip-shaped groove is formed in the middle of the mounting plate 221. A second lead screw 222 is arranged inside the groove. Both ends of the second lead screw 222 are connected with bearing seats 223. The bearing seats 223 are respectively fixedly installed at both ends of the mounting plate 221. Grooves are formed on both sides of the mounting plate 221 where the second lead screw 222 is located. A limiting slide rail 219 is fixedly installed at the bottom of the assembly plate 211. The limiting slide rail 219 is slidably connected with the grooves on both sides of the assembly plate 211. The limiting slide rail 219 is arranged in an isosceles trapezoid shape. The grooves on both sides of the assembly plate 211 are correspondingly arranged with the limiting slide rail 219. The motor drives the second lead screw 222 to rotate. The second lead screw 222 is used to drive the assembly plate 211 to move up and down. The assembly plate 211 is in transmission connection with the second lead screw 222.

[0033] Working principle: The mobile phase flows on the chromatography paper (or other objects). If the mobile phase dries up, the motor drives the second lead screw 222 to rotate. The second lead screw 222 drives the assembly plate 211 to move, so that the output needle 112 is aligned with the dried position. The motor drives the first lead screw 218. The first lead screw 218 drives the transmission plate 215 to move. The transmission plate 215 pushes the piston rod 114 to move inside the outer cylinder 111, for pushing out the mobile phase inside the outer cylinder 111. The mobile phase is discharged through the output needle 112. (At this time, the solenoid valve on the input pipe 116 needs to be closed). If the mobile phase inside the outer cylinder 111 is used up, close the solenoid valve on the output needle 112 and open the solenoid valve on the input pipe 116. At this time, the motor drives the first lead screw 218 to make the first lead screw 218 drive the transmission plate 215 to move backward. The transmission plate 215 moves backward to pull the piston rod 114 to extract the mobile phase in the input pipe 116. After the extraction is completed, close the solenoid valve on the input pipe 116 and open the solenoid valve on the output needle 112, which is convenient for adding the mobile phase next time.

[0034] The above is only the preferred embodiment of the present invention and is not used to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A liquid chromatography mobile phase addition device, comprising a liquid chromatograph, characterized in that: Also includes An adding mechanism, the adding mechanism comprises an adding assembly, the adding assembly comprises an outer cylinder and a piston rod, the piston rod slides in the inner piston of the outer cylinder, a mobile phase is arranged between the outer cylinder and the piston rod, and the adding mechanism is arranged in a liquid chromatograph; The auxiliary transmission mechanism comprises an extrusion assembly and a displacement assembly. The extrusion assembly is respectively clamped with the outer tube and the piston rod. The extrusion assembly drives the piston rod to slide in the outer tube. The displacement assembly is limitedly slidably installed on the displacement assembly.

2. A liquid chromatography mobile phase addition device as claimed in claim 1, characterized in that: The adding component also includes an output needle, which is connected and installed at the end of the outer cylinder. The piston rod is sealingly and slidably installed inside the outer cylinder. The end of the outer cylinder close to the output needle is connected to the outside with an input tube, and the input tube and the output needle are both connected and installed with a solenoid valve.

3. A liquid chromatography mobile phase addition device as claimed in claim 2, characterized in that: The tail of the outer cylinder is fixedly sleeved with a limiting plate, and the limiting plate is elliptical.

4. A liquid chromatography mobile phase addition device as claimed in claim 2, characterized in that: The end of the piston rod is fixedly connected with a rubber plug, the rubber plug slides with the inner wall of the outer tube in a sealed manner, and the tail of the piston rod is fixedly connected with a push handle.

5. A liquid chromatography mobile phase addition device as claimed in claim 4, characterized in that: The extrusion assembly includes an assembly plate and a fixed plate, one end of the assembly plate is fixedly connected to an end positioning ring, the other end of the assembly plate is fixedly connected to a clamping plate, the outer side of the clamping plate is connected to a fixed plate, the fixed plate and both sides of the clamping plate are rotationally limitedly connected to a first screw rod, the first screw rod is transmission-connected to a transmission plate, the two ends of the transmission plate are respectively transmission-connected to the first screw rod, and the ends of the two first screw rods are connected to a motor through gear transmission.

6. A liquid chromatography mobile phase addition device as claimed in claim 5, characterized in that: The output needle passes through the end positioning ring, the end of the outer tube is clamped with the end positioning ring, the limit plate abuts against the clamping plate, the piston rod passes through the clamping plate, and the push handle is limitedly clamped with the transmission plate.

7. A liquid chromatography mobile phase addition device as claimed in claim 6, characterized in that: A matching limiting ring is arranged on one side of the clamping plate, the matching limiting ring is fixedly mounted on the assembling plate, and the limiting plate is located between the matching limiting ring and the clamping plate.

8. A liquid chromatography mobile phase addition device as claimed in claim 6, characterized in that: A limiting snap ring is fixedly connected to one side of the transmission plate. The limiting snap ring is sleeved with the push handle. The push handle is located between the limiting snap ring and the transmission plate.

9. A liquid chromatography mobile phase addition device as claimed in claim 7, characterized in that: The displacement assembly includes a mounting plate, a strip-shaped groove is opened in the middle of the mounting plate, a second screw rod is arranged inside the groove, both ends of the second screw rod are connected with bearing seats, the bearing seats are fixedly installed on both ends of the mounting plate, and the mounting plate is located on both sides of the second screw rod. A limiting slide rail is fixedly installed on the bottom of the assembly plate, and the limiting slide rail is slidably connected to the grooves on both sides of the assembly plate.

10. A liquid chromatography mobile phase addition device as claimed in claim 9, characterized in that: The limiting slide rail is arranged in an isosceles trapezoidal shape, and the grooves on both sides of the assembly plate are arranged corresponding to the limiting slide rail.

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