Cell subpackaging device and multifunctional automatic precise cell subpackaging equipment

Abstract

The utility model provides a cell subpackaging device and multifunctional automatic precise cell subpackaging equipment, and relates to the technical field of biomedical treatment. The cell subpackaging device comprises a subpackaging shell and an injector push-and-pull part, the injector push-and-pull part comprises a first linear driving assembly, an injector supporting plate, an injector clamping plate and a positioning assembly, the first linear driving assembly is arranged in the cavity and connected with the subpackaging shell, and the injector supporting plate is connected with the first linear driving assembly; the positioning assembly is arranged on the split charging shell and used for being matched with an injector in a positioning mode. The bottom of a piston of the injector is clamped through cooperation of the injector clamping plate and the injector supporting plate. The first linear driving assembly is adopted to drive the injector supporting plate to move so as to push and pull the piston of the injector for split charging, the amount of injection liquid can be accurately controlled, and the split charging speed can be flexibly adjusted.

Description

Technical Field

[0001] The utility model relates to the field of biomedical technology, in particular to a cell sub-packaging device and a multi-functional cell automatic precision sub-packaging equipment. Background Art

[0002] The cell preparation sub-packaging technology is an important part of the biomedical technology field and is crucial for cell therapy and medicine preparation. If the requirements of stable and high-precision sub-packaging cannot be met, it will affect the therapeutic effect of cell preparations and delay the treatment time of patients. In the prior art, the measurement of the liquid volume during sub-packaging is usually achieved by manually starting and stopping a peristaltic pump, weighing, and manual recording. The above methods have a slow sub-packaging speed and cannot quickly sub-package a large dose of cell preparation products into sub-packaging bags within a short time. The above methods have a slow sub-packaging speed and low sub-packaging accuracy during the sub-packaging process. Summary of the Utility Model

[0003] The utility model provides a cell sub-packaging device to solve the problems of slow sub-packaging speed and low sub-packaging accuracy existing in the prior art.

[0004] The utility model provides a cell sub-packaging device, including:

[0005] A sub-packaging housing with a cavity inside;

[0006] A syringe pushing and pulling component, including a first linear driving component, a syringe support plate, a syringe clamping plate, and a positioning component. The first linear driving component is arranged in the cavity and connected to the sub-packaging housing. The syringe support plate is connected to the first linear driving component. The positioning component is arranged on the sub-packaging housing and is used for positioning and cooperating with the syringe. The first linear driving component is used to drive the syringe support plate and the syringe clamping plate to move in a first direction. The first linear driving component is used to drive the syringe support plate and the syringe clamping plate to move in a first direction to drive the piston rod of the syringe to move up and down in the first direction, so that the syringe discharges or sucks in liquid. According to a cell sub-packaging device provided by the utility model, the syringe pushing and pulling component further includes:

[0007] A second linear driving component, which is arranged on the syringe support plate and connected to the syringe clamping plate. The second linear driving component is used to drive the syringe clamping plate to approach or move away from the syringe support plate in the first direction, so as to clamp or loosen the bottom of the piston of the syringe.

[0008] According to a cell sub-packaging device provided by the present utility model, a limiting groove is provided at the first end of the syringe clamping plate, and the syringe clamping plate is in clamping fit with the end of the push rod of the syringe through the limiting groove, and the second end of the syringe clamping plate is connected to the second linear driving assembly.

[0009] According to a cell sub-packaging device provided by the present utility model, a clamping groove is provided at the second end of the syringe clamping plate, a floating joint is provided on the telescopic shaft of the second linear driving assembly, and the floating joint is in clamping fit with the clamping groove.

[0010] According to a cell sub-packaging device provided by the present utility model, a limiting hole is provided at the first end of the syringe supporting plate, the syringe supporting plate is sleeved on the syringe through the limiting hole, and the second end of the syringe supporting plate is connected to the first linear driving assembly.

[0011] According to a cell sub-packaging device provided by the present utility model, the first linear driving assembly includes:

[0012] A first linear driving member;

[0013] A connecting mechanism, the first linear driving member is connected to the second end of the syringe supporting plate through the connecting mechanism;

[0014] A fixing plate, which is connected to the first linear driving member and the sub-packaging housing.

[0015] According to a cell sub-packaging device provided by the present utility model, the syringe pushing and pulling member further includes:

[0016] A first sensor assembly, including a first position sensor and a first position sensing piece, the first position sensor is arranged on the first linear driving member, and the first position sensing piece is arranged on the connecting mechanism.

[0017] According to a cell sub-packaging device provided by the present utility model, the syringe pushing and pulling member further includes:

[0018] A second sensor assembly, including a second position sensor and a second position sensing piece, the second position sensor is arranged on the connecting mechanism, and the second position sensing piece is arranged on one side of the syringe clamping plate.

[0019] According to a cell sub-packaging device provided by the present utility model, the syringe pushing and pulling member further includes:

[0020] The guiding assembly includes a guiding shaft and an oil-free bushing. The guiding shaft is disposed on one of the syringe support plate and the syringe clamping plate, and the oil-free bushing is disposed on the other of the syringe support plate and the syringe clamping plate. The oil-free bushing is sleeved on the outer periphery of the guiding shaft and is slidably engaged with the guiding shaft in the first direction.

[0021] A cell dispensing device according to the present invention further includes:

[0022] A positioning member, disposed on the dispensing housing, for positioning and cooperating with the clamping plate of the consumable.

[0023] A stopcock chuck member, disposed on the dispensing housing, for driving the stopcock of the consumable to switch channels.

[0024] A cell dispensing device according to the present invention further includes:

[0025] A fixing member, which includes a rotating handle, a connecting shaft, a fixing base, and a positioning disk. The fixing base is connected to the dispensing housing. The interior of the fixing base is hollow. The positioning disk is rotatably disposed inside the fixing base. One end of the connecting shaft is connected to the rotating handle, and the other end of the connecting shaft is connected to the positioning disk. A groove is provided on the outer peripheral surface of the positioning disk, and at least one third ball screw for positioning and cooperating with the groove is provided on the inner wall of the fixing base. A locking hole is provided on the clamping plate, and the rotating handle locks the clamping plate through the locking hole.

[0026] A positioning assembly of a cell dispensing device according to the present invention includes a syringe positioning plate, which is disposed on one side of the dispensing housing. The syringe positioning plate is provided with two positioning protrusions, and the two positioning protrusions are arranged at intervals in the up and down direction. Both of the two positioning protrusions are provided with clamping grooves for clamping and cooperating with the syringe. A positioning groove is formed between the two positioning protrusions for clamping and cooperating with the syringe mounting plate.

[0027] The present invention also provides a multifunctional cell automatic precision dispensing device, including the cell dispensing device described in any one of the above.

[0028] The cell dispensing device provided by the present invention clamps the bottom of the piston of the syringe through the cooperation of the syringe clamping plate and the syringe support plate; by adopting a first linear driving assembly to drive the movement of the syringe support plate to push and pull the piston of the syringe for dispensing, the amount of injected liquid can be accurately controlled, and the dispensing speed can be flexibly adjusted. Description of the Drawings

[0029] To more clearly illustrate the technical solutions in the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are some embodiments of the present utility model. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0030] Figure 1 It is a schematic three-dimensional structure diagram of the multi-functional cell automatic precision dispensing device provided by the present utility model.

[0031] Figure 2 It is a schematic three-dimensional structure diagram of the cell dispensing device provided by the present utility model.

[0032] Figure 3 It is a schematic structure diagram of the syringe push-pull component provided by the present utility model.

[0033] Figure 4 It is a schematic structure diagram of the cock chuck assembly provided by the present utility model.

[0034] Figure 5 It is a schematic three-dimensional structure diagram of the cell dispensing device and the consumables provided by the present utility model.

[0035] Figure 6 It is a schematic three-dimensional structure diagram of the positioning component provided by the present utility model.

[0036] Figure 7 It is a schematic three-dimensional structure diagram of the positioning block provided by the present utility model.

[0037] Figure 8 It is a schematic three-dimensional structure diagram of the fixing component provided by the present utility model.

[0038] Figure 9 It is a schematic three-dimensional structure diagram of the positioning assembly provided by the present utility model.

[0039] Figure 10 It is a schematic three-dimensional structure diagram of the consumables provided by the present utility model.

[0040] Figure 11 It is a schematic three-dimensional structure diagram of the cell constant temperature shaking device provided by the present utility model.

[0041] Figure 12 It is a schematic three-dimensional structure diagram of the control device provided by the present utility model.

[0042] Reference numerals:

[0043] 1. Cell constant temperature shaking device; 11. Shaking housing; 12. Constant temperature component; 13. Shaking component; 14. Heat preservation opening and closing door; 15. Glass;

[0044] 2. Cell sub-packaging device; 21. Sub-packaging housing; 22. Syringe pushing and pulling component; 24. Stopcock chuck assembly; 25. Positioning component; 26. Fixing component;

[0045] 221. Syringe support plate; 222. Syringe clamping plate; 223. Second linear drive assembly; 224. Positioning assembly; 225. Limit groove; 226. Floating joint; 227. Limit hole; 228. First linear drive member; 229. Connection mechanism; 230. Fixing plate; 231. First position sensor; 232. First position sensing piece; 233. Second position sensor; 234. Second position sensing piece; 235. Guide shaft; 236. Oil-free bushing; 237. Positioning protrusion; 238. Positioning groove; 239. First guiding inclined surface; 240. Stopcock chuck; 241. Rotating shaft; 242. First drive mechanism; 243. First sensor; 244. Angular position sensing piece; 245. Second sensor; 246. Origin sensing piece; 247. First ball screw; 248. Second ball screw; 249. Snap ring; 250. Positioning block; 251. Elastic buckle; 252. Elastic member; 253. Limiting member; 254. Third sensor; 256. Second guiding inclined surface; 257. Motor mounting plate; 258. Syringe positioning plate; 261. Rotating handle; 262. Connecting shaft; 263. Fixed base; 264. Positioning disk; 265. Groove; 266. Third ball screw; 270. Industrial camera; 271. Bubble sensor group; 272. Second bubble sensor; 273. Alarm light for cell sub-packaging module; 274. Consumable installation confirmation key; 275. Power key for cell sub-packaging module;

[0046] 3. Control device; 31. Outer housing; 32. Display screen; 33. Movable arm; 34. Power key for control and operation module; 35. Alarm light for control and operation module; 36. Data cable interface; 220. First linear drive assembly;

[0047] 4. Consumables; 41. Cardboard; 42. Liquid path hose; 43. Syringe mounting plate; 44. Stopcock valve. Detailed implementation manners

[0048] To make the objectives, technical solutions and advantages of the present utility model clearer, the technical solutions in the present utility model will be clearly and completely described below in conjunction with the accompanying drawings in the present utility model. Obviously, the described embodiments are some, but not all, of the embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present utility model without making creative efforts shall fall within the protection scope of the present utility model.

[0049] In the description of the embodiments of the present utility model, it should be noted that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the embodiments of the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it should not be construed as a limitation to the embodiments of the present utility model. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0050] In the description of the embodiments of the present utility model, it should be noted that unless otherwise clearly specified and defined, the terms "connected" and "connected to" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the embodiments of the present utility model can be understood according to specific circumstances.

[0051] In the embodiments of the present utility model, unless otherwise clearly specified and defined, the first feature being "on" or "under" the second feature can be that the first and second features are in direct contact, or the first and second features are indirectly in contact through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature can be that the first feature is directly above or obliquely above the second feature, or merely indicates that the first feature has a higher horizontal height than the second feature. The first feature being "under", "beneath" and "underneath" the second feature can be that the first feature is directly below or obliquely below the second feature, or merely indicates that the first feature has a lower horizontal height than the second feature.

[0052] The following Figures 1 - 12 describes the specific structure and working principle of the syringe pushing and pulling component of the present utility model.

[0053] As Figure 2 and Figure 3As shown, the cell aliquoting device 2 includes an aliquoting housing 21 and a syringe pushing and pulling member 22. The interior of the aliquoting housing 21 has a cavity. The syringe pushing and pulling member 22 includes a first linear drive assembly 220, a syringe support plate 221, a syringe clamping plate 222, and a positioning assembly 224. The first linear drive assembly 220 is disposed within the cavity and connected to the aliquoting housing 21. The syringe support plate 221 is connected to the first linear drive assembly 220. The positioning assembly 224 is disposed on the aliquoting housing 21 and is used for positioning and mating with the syringe. The first linear drive assembly 220 is used to drive the syringe support plate 221 and the syringe clamping plate 222 to move in a first direction, so as to drive the piston rod of the syringe to move up and down in the first direction, so that the syringe discharges or aspirates liquid.

[0054] For the cell aliquoting device 2 provided by the present utility model, the piston bottom of the syringe is clamped by the cooperation of the syringe clamping plate 222 and the syringe support plate 221. By using the first linear drive assembly to drive the movement of the syringe support plate 221 to push and pull the piston of the syringe for aliquoting, the amount of injected liquid can be accurately controlled, and the aliquoting speed can be flexibly adjusted.

[0055] It should be noted here that the movement in the first direction refers to the up and down direction. Of course, the first direction can also refer to the horizontal direction.

[0056] In an embodiment of the present utility model, the syringe pushing and pulling member 22 further includes a second linear drive assembly 223. The second linear drive assembly 223 is disposed on the syringe support plate 221 and connected to the syringe clamping plate 222. The second linear drive assembly 223 is used to drive the syringe clamping plate 222 to approach or move away from the syringe support plate 221 in the first direction, so as to clamp or loosen the piston bottom of the syringe.

[0057] In an embodiment of the present utility model, as Figure 2 and Figure 9 shown, the positioning assembly 224 includes a syringe positioning plate 258. The syringe positioning plate 258 is disposed on one side of the aliquoting housing 21. The syringe positioning plate 258 is provided with two positioning protrusions 237. The two positioning protrusions 237 are arranged at intervals in the up and down direction. Both of the two positioning protrusions 237 are provided with clamping grooves for clamping and mating with the syringe. A positioning groove 238 is formed between the two positioning protrusions 237 for clamping and mating with the syringe mounting plate 43. The width of the positioning groove 238 is adapted to the thickness of the syringe mounting plate 43. When installing the syringe, since the openings of the clamping grooves and the opening of the positioning groove 238 both face away from the side of the aliquoting housing 21, the syringe can be easily clamped in the clamping groove, and the syringe mounting plate 43 can be easily clamped in the positioning groove 238.

[0058] In a preferred embodiment of the present utility model, a first guiding inclined surface 239 is provided at the edge of the opening of the positioning groove 238. The first guiding inclined surface 239 inclines towards the inside of the positioning groove 238. By providing the first guiding inclined surface 239, the width of the positioning groove 238 is increased, enabling the syringe mounting plate 43 to be easily clamped within the positioning groove 238.

[0059] In a preferred embodiment of the present utility model, mounting holes are provided on the inner wall of the positioning groove 238, and elastic positioning members are arranged in the mounting holes. A positioning hole is provided on one side of the syringe mounting plate 43, and the positioning hole is in positioning cooperation with the elastic positioning members to fix the syringe to the syringe positioning plate 258. Preferably, the elastic positioning member is a first ball screw 247.

[0060] In an embodiment of the present utility model, as Figure 3 shown, the syringe clamping plate 222 has a plate-like structure and is horizontally arranged. A vertical strip-shaped hole is provided on one side of the dispensing housing 21. The first end of the syringe clamping plate 222 extends out of the dispensing housing 21 through the vertical strip-shaped hole, and the width of the first end of the syringe clamping plate 222 is greater than the width of the second end of the syringe clamping plate 222.

[0061] A limiting groove 225 is provided at the first end of the syringe clamping plate 222. The limiting groove 225 is semi-circular, and the size of the limiting groove 225 is adapted to the size of the syringe. The syringe clamping plate 222 is in clamping engagement with the end of the push rod of the syringe through the limiting groove 225, and the second end of the syringe clamping plate 222 is connected to the second linear driving assembly 223.

[0062] In an embodiment of the present utility model, since the width of the vertical strip-shaped hole is relatively large, affecting the aesthetics of the dispensing device, a baffle is provided in the vertical strip-shaped hole, and the baffle is vertically arranged. Correspondingly, a horizontal strip-shaped through hole is provided in the middle of the syringe clamping plate 222, and the baffle passes through the horizontal strip-shaped through hole. The provision of the baffle can both block the vertical strip-shaped hole and does not affect the movement of the syringe clamping plate 222.

[0063] In an embodiment of the present utility model, as Figure 3 shown, a clamping groove is provided at the second end of the syringe clamping plate 222. The clamping groove extends along the width direction of the syringe clamping plate 222. A floating joint 226 is provided on the telescopic shaft of the second linear driving assembly 223, and the floating joint 226 is in clamping engagement with the clamping groove. Preferably, there is a gap between the floating joint 226 and the clamping groove. The clamping engagement between the floating joint 226 and the clamping groove facilitates the installation and disassembly of the dispensing device.

[0064] In an embodiment of the present utility model, as Figure 3As shown, the syringe support plate 221 is a plate-like structure, and the syringe support plate 221 is horizontally arranged. A limiting hole 227 is arranged at the first end of the syringe support plate 221. The limiting hole 227 is a circular through hole. The size of the limiting hole 227 is adapted to the size of the syringe. The syringe support plate 221 is sleeved on the syringe through the limiting hole 227, and the second end of the syringe support plate 221 is connected to the first linear drive component 220.

[0065] In one embodiment of the present invention, the width of the first end of the syringe support plate 221 is greater than the width of the second end of the syringe support plate 221, a horizontal strip through hole is provided in the middle of the syringe support plate 221, and the baffle is penetrated in the horizontal strip through hole.

[0066] In one embodiment of the present invention, Figure 3 As shown, the second linear drive assembly 223 includes a second screw motor, which is arranged on the side of the syringe support plate 221 away from the syringe clamping plate 222, and the housing of the second screw motor is connected to the syringe support plate 221 by screws. The telescopic shaft of the second screw motor passes through the syringe support plate 221 and is connected to the floating joint 226. When the telescopic shaft of the second screw motor is extended, the syringe clamping plate 222 is away from the syringe support plate 221; when the telescopic shaft of the second screw motor is shortened, the syringe clamping plate 222 approaches the syringe support plate 221. In the process of the syringe clamping plate 222 approaching or moving away from the syringe support plate 221, the syringe clamping plate 222 pushes and pulls the piston of the syringe for dispensing. Due to the high movement accuracy of the screw motor, the amount of the injected liquid can be accurately controlled, thereby improving the dispensing accuracy.

[0067] Of course, the specific type of the second linear driving component is not limited to a screw motor, and may also be a cylinder or other linear driving components.

[0068] In one embodiment of the present invention, Figure 3 As shown, the first linear drive assembly 220 includes a first linear drive member 228, a connecting mechanism 229 and a fixed plate 230, and the first linear drive member 228, the connecting mechanism 229 and the fixed plate 230 are all located in the cavity. The fixed plate 230 is used to provide a mounting base for the first linear drive member 228, and the fixed plate 230 is connected to the first linear drive member 228 and the sub-packaging shell 21. Specifically, a connecting plate is provided at the bottom of the fixed plate 230, and the connecting plate is connected to the sub-packaging shell 21 by screws. The first linear drive member 228 is arranged on one side of the fixed plate 230 in the vertical direction, and the first linear drive member 228 is connected to the fixed plate 230 by screws. The first linear drive member 228 is connected to the second end of the syringe support plate 221 by the connecting mechanism 229.

[0069] Preferably, the first linear driving member 228 is a lead screw motor module. The base of the lead screw motor module is connected to the fixing plate 230 by screws, and the slider of the lead screw motor module is connected to the connecting mechanism 229 by screws. Of course, the specific type of the first linear driving member 228 is not limited to the lead screw motor module, and it can also be a cylinder or other linear driving members.

[0070] In an embodiment of the present invention, the connecting mechanism 229 includes a mounting plate. The mounting plate is connected to the slider of the lead screw motor module by screws, and the second end of the syringe tray 221 is connected to the mounting plate by screws.

[0071] In an embodiment of the present invention, as Figure 3 shown, the syringe pushing and pulling member 22 further includes a first sensor assembly. The first sensor assembly includes a first position sensor 231 and a first position sensing piece 232. The first position sensor 231 is disposed on the first linear driving member 228, and the first position sensing piece 232 is disposed on the connecting mechanism 229. Specifically, the first position sensing piece 232 is disposed on one side of the mounting plate. When the first linear driving member 228 drives the connecting mechanism 229 to move, the connecting mechanism 229 drives the first position sensing piece 232 to move. The first position sensor 231 determines the position of the connecting mechanism 229 by detecting the position of the first position sensing piece 232, and finally calculates the positions of the syringe tray 221, the syringe clamping plate 222, and the second linear driving assembly 223.

[0072] Preferably, the first sensor assembly includes three first position sensors 231 and two first position sensing pieces 232. The three first position sensors 231 are arranged at intervals in the up and down direction on one side of the base of the lead screw motor module, and the two first position sensing pieces 232 are arranged at intervals in the up and down direction on one side of the mounting plate.

[0073] When the lead screw motor module drives the mounting plate to move up and down, the first position sensing piece 232 moves up and down together with the mounting plate. The first position sensor 231 determines the position of the syringe tray 221 by detecting the position of the first position sensing piece.

[0074] In an embodiment of the present invention, as Figure 3 shown, the syringe pushing and pulling member 22 further includes a second sensor assembly. The second sensor assembly includes a second position sensor 233 and a second position sensing piece 234. The second position sensor 233 is disposed on the connecting mechanism 229. Specifically, the second position sensor 233 is disposed on the mounting plate; the second position sensing piece 234 is disposed on one side of the syringe clamping plate 222.

[0075] When the telescopic shaft of the second lead screw motor extends, the syringe clamping plate 222 moves away from the syringe support plate 221, causing the second position sensing piece 234 to move away from the second position sensor 233; when the telescopic shaft of the second lead screw motor shortens, the syringe clamping plate 222 moves closer to the syringe support plate 221, causing the second position sensing piece 234 to move closer to the second position sensor 233 and finally enter the sensing range of the second position sensor 233. At this time, the second position sensor 233 outputs an electrical signal, indicating that the liquid in the syringe has been completely discharged.

[0076] In an embodiment of the present utility model, as Figure 3 shown, the syringe pushing and pulling component 22 further includes a guiding component, which includes a guiding shaft 235 and an oil-free bushing 236. The guiding shaft 235 is arranged on one of the syringe support plate 221 and the syringe clamping plate 222. The guiding shaft 235 is vertically arranged. The oil-free bushing 236 is arranged on the other of the syringe support plate 221 and the syringe clamping plate 222. Preferably, the other of the syringe support plate 221 and the syringe clamping plate 222 is provided with a mounting hole, and the oil-free bushing 236 is embedded in the mounting hole. The position of the oil-free bushing 236 corresponds to the position of the guiding shaft 235 one by one. The oil-free bushing 236 is sleeved on the outer periphery of the guiding shaft 235 and is slidably matched with the guiding shaft 235 in the first direction.

[0077] Preferably, the syringe pushing and pulling component 22 further includes two guiding components, which are symmetrically arranged on both sides of the floating joint 226. Two connecting holes are arranged on the side of the syringe clamping plate 222 facing the syringe support plate 221, and one end of each of the two guiding shafts 235 is inserted into the two connecting holes correspondingly. Two mounting holes are arranged on the side of the syringe support plate 221 facing the syringe clamping plate 222, and the two oil-free bushings 236 are embedded in the two mounting holes correspondingly. The other ends of the two guiding shafts 235 are inserted into the two oil-free bushings 236 correspondingly.

[0078] During the process of the telescopic shaft of the second lead screw motor driving the syringe clamping plate 222 to move up and down, due to the guiding cooperation between the guiding shaft 235 and the oil-free bushing 236, the movement of the syringe clamping plate 222 can be made more stable.

[0079] In an embodiment of the present utility model, as Figure 2 and Figure 3 shown, the cell dispensing device 2 further includes a positioning component 25 and a stopcock chuck component. The positioning component 25 is arranged on the dispensing housing 21. The positioning component 25 is used for positioning and cooperating with the clamping plate 41 of the consumable 4 so as to fix the consumable 4 on one side of the dispensing housing 21. The stopcock chuck component is arranged on the dispensing housing 21. Preferably, the stopcock chuck component is located on one side of the dispensing housing 21. The stopcock chuck component is used for driving the stopcock 44 of the consumable 4 to switch channels.

[0080] In one embodiment of the present invention, Figure 3 As shown, the positioning component 25 includes two positioning blocks 250, which are arranged at intervals along the width direction of the sub-packaging shell 21, and the positioning blocks 250 are connected to the sub-packaging shell 21. Preferably, the positioning blocks 250 are connected to the sub-packaging shell 21 by screws, and the positioning blocks 250 are positioned and matched with the clamping plate 41 of the consumables 4. Specifically, the positioning block 250 is provided with a notch, and the clamping plate 41 is clamped in the notch.

[0081] Preferably, the cell dispensing device 2 further comprises two positioning components 25, one positioning component 25 is arranged at the upper part of one side of the dispensing housing 21, and the other positioning component 25 is arranged at the middle part of one side of the dispensing housing 21, the notches of the two positioning blocks 250 at the upper part face downward, and the notches of the two positioning blocks 250 at the lower part face upward. During installation, the four corners of the clamping plate 41 are clamped in the notches of the four positioning blocks 250 to fix the clamping plate 41.

[0082] In one embodiment of the present invention, Figure 6 As shown, the positioning component 25 also includes at least one locking assembly, which includes an elastic buckle 251, an elastic member 252 and a limiting member 253. The limiting member 253 and the elastic buckle 251 are arranged on the positioning block 250 relative to each other. The elastic buckle 251 is rotatably matched with the positioning block 250 through a pin shaft. The elastic member 252 is arranged between the elastic buckle 251 and the limiting member 253. The elastic buckle 251 is used to lock the card plate 41. The elastic member 252 can be a V-shaped spring or a torsion spring. Under the elastic action of the elastic member 252, the elastic buckle 251 abuts against the side of the card plate 41 away from the packaging shell 21, thereby preventing the consumables 4 from separating from the positioning block 250.

[0083] Preferably, one positioning block 250 in each positioning component 25 is provided with a locking component, such as Figure 1 As shown, in the upper positioning component 25, the left positioning block 250 is provided with a locking assembly, and in the lower positioning component 25, the right positioning block 250 is provided with a locking assembly, so that one diagonal of the card plate 41 can be locked, effectively improving the stability of the consumables 4 after installation. Of course, in the upper positioning component 25, the right positioning block 250 can also be provided with a locking assembly, and in the lower positioning component 25, the left positioning block 250 can be provided with a locking assembly.

[0084] In one embodiment of the present invention, Figure 7 As shown, the positioning component 25 also includes a positioning piece, which is arranged on the positioning block 250. The side of the card plate 41 is provided with a positioning hole, and the positioning piece cooperates with the positioning hole. The positioning piece cooperates with the positioning hole to further improve the stability of the card plate 41 after it is installed in place.

[0085] Preferably, the positioning member is the second ball screw 248. An installation hole is provided on the side wall of the notch. The second ball screw 248 is embedded in the installation hole. The ball of the second ball screw 248 protrudes from the edge of the installation hole. When the clamping plate 41 is installed in place, the ball abuts against the positioning hole to achieve positioning cooperation with the positioning hole.

[0086] Preferably, a second guiding inclined surface 256 is provided at the edge of the notch, and the second guiding inclined surface 256 inclines towards the inside of the notch. When installing the clamping plate 41, the clamping plate 41 is in sliding cooperation with the second guiding inclined surface 256, which can make the clamping plate 41 easily enter the notch and be locked by the positioning member and the locking member. Through the cooperation of the second guiding inclined surface 256 with the positioning member and the locking member, the rapid installation of the consumable 4 can be realized, the assembly time of the consumable 4 is shortened, and the sub-packaging efficiency is improved.

[0087] In an embodiment of the present utility model, as Figure 5 and Figure 6 shown, the positioning member 25 further includes a third sensor 254. The third sensor 254 is arranged on the positioning block 250, and the third sensor 254 is used to detect whether the clamping plate 41 is installed in place. The third sensor 254 can be a contact switch or other sensors. After the clamping plate 41 is clamped into the notch, the clamping plate 41 contacts the third sensor 254, triggering the third sensor 254 to output an electrical signal, indicating that the clamping plate 41 is installed in place.

[0088] In an embodiment of the present utility model, as Figure 8 shown, the cell sub-packaging device 2 further includes a fixing member 26. The fixing member 26 includes a rotating handle 261, a connecting shaft 262, a fixing base 263 and a positioning disk 264. The fixing base 263 is connected to the sub-packaging housing 21. The inside of the fixing base 263 is hollow. The positioning disk 264 is rotatably arranged inside the fixing base 263. One end of the connecting shaft 262 is connected to the rotating handle 261, and the other end of the connecting shaft 262 is connected to the positioning disk 264.

[0089] A groove 265 is provided on the outer peripheral surface of the positioning disk 264, and the groove 265 extends along the central axis of the positioning disk 264. In this embodiment, four grooves 265 are provided, and the four grooves 265 are symmetrically arranged in pairs. Preferably, two first grooves 265 are in a first plane, and the other two first grooves 265 are in a second plane, and the first plane is perpendicular to the second plane. Of course, the number of the grooves 265 is not limited to four, and six, eight or more can also be set. Two third ball screws 266 are provided on the inner wall of the fixing base 263, and the two third ball screws 266 are symmetrically arranged.

[0090] The pallet 41 is provided with locking holes, and the positions of the locking holes correspond to the positions of the rotary handle 261 one by one. The shape of the locking holes is adapted to the shape of the rotary handle 261. The rotary handle 261 locks the pallet 41 through the locking holes. The rotary handle 261 is adapted to switch between an open state and a locked state. In the open state, the rotary handle 261 is in a vertical state, and the third ball screw 266 in the fixed base 263 is in positioning cooperation with the groove 265 to keep the rotary handle 261 in the open state. In the open state, the rotary handle 261 can pass through the locking holes of the pallet 41. When the rotary handle 261 is rotated 90°, the rotary handle 261 is in the locked state. In the locked state, the rotary handle 261 is in a horizontal state, and the third ball screw 266 in the fixed base 263 is in positioning cooperation with the groove 265 to keep the rotary handle 261 in the locked state; at this time, the rotary handle 261 cannot pass through the locking holes of the pallet 41, thereby realizing the locking of the pallet 41.

[0091] In an embodiment of the present utility model, the cell dispensing device 2 further includes a second circuit board, which is disposed inside the dispensing housing 21 and is electrically connected to the third sensor 254. The second circuit board is electrically connected to the corresponding interface through a wire.

[0092] In an embodiment of the present utility model, Figure 2 As shown, the plug valve chuck assembly includes a plurality of plug valve chuck components 24, and the plurality of plug valve chuck components 24 are disposed on the dispensing housing 21 and are arranged at intervals along the width direction of the dispensing housing 21. The distance between two adjacent plug valve chuck components 24 is equal. The plug valve chuck component 24 is used to drive the plug valve 44 of the consumable 4 to switch channels. The number of the plug valve chuck components 24 is the same as the number of the plug valves 44, and the positions of the plug valve chuck components 24 correspond to the positions of the plug valves 44 one by one.

[0093] In an embodiment of the present utility model, as Figure 2 and Figure 4 shown, the plug valve chuck component 24 includes a plug valve chuck 240, a rotating shaft 241 and a first driving mechanism 242. The plug valve chuck 240 is located outside the dispensing housing 21 and is used for clamping and rotating the plug valve 44. A plug valve positioning groove is provided at the end of the plug valve chuck 240, and the plug valve positioning groove is in snap-fit with the plug valve 44. The shape of the plug valve positioning groove is adapted to the shape of the plug valve 44. In this embodiment, the cross section of the plug valve positioning groove is in a T shape. Of course, the cross-sectional shape of the plug valve positioning groove is not limited thereto and is specifically determined according to the shape of the plug valve 44. By adopting the snap-fit manner of the plug valve chuck 240 and the plug valve 44, the installation of the consumable 4 can be facilitated.

[0094] The rotating shaft 241 is horizontally arranged and is used to connect the first driving mechanism 242 and the plug valve 44. The dispensing housing 21 is provided with a mounting hole, and the first end of the rotating shaft 241 passes through the mounting hole and is then connected to the plug valve chuck 240. The rotating shaft 241 and the plug valve chuck 240 can be connected by welding, integrally formed, or threadedly connected. Preferably, the rotating shaft 241 and the plug valve chuck 240 are integrally formed.

[0095] The first driving mechanism 242 is connected to the dispensing housing 21 through the motor mounting plate 257. Specifically, the first driving mechanism 242 is connected to the motor mounting plate 257 by screws, and the motor mounting plate 257 is connected to the side wall of the dispensing housing 21 by screws.

[0096] The rotating shaft of the first driving mechanism 242 is connected to the second end of the rotating shaft 241. The first driving mechanism 242 is used to drive the plug valve chuck 240 to rotate so as to switch the channels of the plug valve 44. The first driving mechanism 242 is a servo motor. The first driving mechanism 242 is electrically connected to the second circuit board, and the second circuit board controls the rotation of the first driving mechanism 242.

[0097] In an embodiment of the present invention, the plug valve chuck assembly 24 further includes a home position sensing mechanism and a first sensor mechanism. The home position sensing mechanism includes a second sensor 245 and a home position sensing piece 246. The home position sensing piece 246 is sleeved on the outer periphery of the rotating shaft 241 and is located between the angular position sensing piece 244 and the plug valve chuck 240. The home position sensing piece 246 is coaxially arranged with the rotating shaft 241. A second notch is provided at the edge of the home position sensing piece 246. The second sensor 245 is connected to the motor mounting plate 257. The second sensor 245 is used to detect whether the home position sensing piece 246 is in the initial position. The second sensor 245 is electrically connected to the second circuit board, and the type of the second sensor 245 is the same as that of the first sensor 243. When the second notch of the home position sensing piece 246 rotates to align with the second sensor 245, the second sensor 245 outputs an electrical signal to the second circuit board, indicating that the home position sensing piece 246 rotates to the initial position.

[0098] The first sensor mechanism includes a first sensor 243 and an angular position sensing piece 244. The angular position sensing piece 244 is sleeved on the outer periphery of the rotating shaft 241. Preferably, a snap ring 249 is sleeved on the outer periphery of the rotating shaft 241. The snap ring 249 is located on the side of the angular position sensing piece 244 away from the cock chuck 240. The snap ring 249 abuts against the angular position sensing piece 244, and the snap ring 249 is used to limit the angular position sensing piece 244. A plurality of first notches are arranged at intervals on the edge of the angular position sensing piece 244, and the plurality of first notches are arranged at equal intervals in the circumferential direction. The first sensor 243 is connected to the motor mounting plate 257, and the first sensor 243 is used to detect the angle of rotation of the angular position sensing piece 244. The first sensor 243 is a photoelectric sensor, and the first sensor 243 is electrically connected to the second circuit board.

[0099] When the angular position sensing piece 244 rotates until the first notch is aligned with the first sensor 243, the light beam emitted by the output end of the first sensor 243 passes through the first notch and is received by the receiving end of the first sensor 243. The first sensor 243 outputs an electrical signal to the second circuit board, indicating that the angular position sensing piece 244 rotates a predetermined angle. Since the distances between adjacent two first notches are equal, the second circuit board can calculate the rotation angle of the angular position sensing piece 244 according to the number of electrical signals received.

[0100] It should be noted here that the more the number of first notches, the higher the detection accuracy of the first sensor 243. The number of first notches is specifically determined according to actual needs. The specific structural form of the first notch is not limited to the notch, and a through hole can also be used to replace the first notch.

[0101] In an embodiment of the present invention, as Figure 5 and Figure 10 shown, the cell dispensing device 2 further includes an industrial camera 270 and a bubble sensor group 271. The industrial camera 270 and the bubble sensor group 271 are arranged on one side of the dispensing housing 21. The bubble sensor group 271 includes a plurality of first bubble sensors, and the plurality of first bubble sensors are arranged at intervals in the width direction of the dispensing housing 21. The positions of the first bubble sensors correspond to the positions of the liquid path hoses 42 on the consumable 4 one by one, and the first bubble sensors are used to detect whether there are bubbles in the liquid path hoses 42. The industrial camera 270 is located above the bubble sensor group 271, and the industrial camera 270 is used to detect whether there are bubbles in the liquid path hoses 42. The liquid path hoses 42 are connected to the preparation bags. During use, the liquid path hoses 42 are in a vertical state, the liquid path hoses 42 are stretched, and the outer diameters of the liquid path hoses 42 are reduced, reducing the frictional resistance of the liquid path hoses 42 being stuck into the first bubble sensors, realizing the rapid installation of the hoses.

[0102] In an embodiment of the present invention, Figure 2As shown, the cell dispensing device 2 further includes a second bubble sensor 272. The second bubble sensor 272 is disposed on one side of the dispensing housing 21. The second bubble sensor 272 is electrically connected to the second circuit board. The second bubble sensor 272 is used to detect whether there are bubbles in the input tube of the consumable 4.

[0103] In an embodiment of the present invention, a cell dispensing module alarm lamp 273, a consumable installation confirmation key 274, and a cell dispensing module power key 275 are further disposed on one side of the dispensing housing 21. The cell dispensing module alarm lamp 273, the consumable installation confirmation key 274, and the cell dispensing module power key 275 are all electrically connected to the second circuit board. The cell dispensing module alarm lamp 273 is used to flash when the cell dispensing device 2 has an abnormality to remind the operator to intervene in time. The consumable installation confirmation key 274 is used to control the plug valve chuck assembly 24, the syringe support plate 221, and the syringe clamping plate 222 to return to the initial position when installing the consumable 4 to facilitate the installation of the consumable 4. The cell dispensing module power key 275 is used to control the opening or closing of the cell dispensing device 2.

[0104] The present invention also provides a multi-functional cell automatic precision dispensing device. The multi-functional cell automatic precision dispensing device includes the cell dispensing device 2 described in any one of the above embodiments.

[0105] In an embodiment of the present invention, the multi-functional cell automatic precision dispensing device further includes a control device 3 and a cell constant temperature shaking device 1. The control device 3 is provided with a plurality of connection ports; the cell constant temperature shaking device 1 is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature; the cell dispensing device 2 and the cell constant temperature shaking device 1 are both electrically connected to the corresponding connection ports. Preferably, the cell dispensing device 2 and the cell constant temperature shaking device 1 are both electrically connected to the corresponding connection ports through aviation plugs.

[0106] Since the cell dispensing device 2, the control device 3, and the cell constant temperature shaking device 1 are arranged in a modular manner, and the control device 3 is provided with a plurality of connection ports, and the cell dispensing device 2 and the cell constant temperature shaking device 1 are both electrically connected to the corresponding connection ports, different numbers of cell dispensing devices 2 can be installed according to actual needs during the installation process, so as to dispense different numbers of preparation bags, accommodating production requirements of different scales.

[0107] In an embodiment of the present invention, as Figure 11As shown in the figure, the cell constant temperature shaking device 1 includes a shaking housing 11, a first circuit board, a constant temperature component 12, a shaking component 13, and a heat preservation opening and closing door 14. An opening is provided on one side of the shaking housing 11. The first circuit board is disposed inside the shaking housing 11 and is electrically connected to the corresponding connection port; the constant temperature component 12 is disposed inside the shaking housing 11, and the constant temperature component 12 is electrically connected to the first circuit board. The constant temperature component 12 is used to control the temperature inside the shaking housing 11 so that the cell preparation bag is in a predetermined constant temperature environment. The shaking component 13 is disposed inside the shaking housing 11, and the shaking component 13 is electrically connected to the first circuit board. The shaking component 13 is used to uniformly mix the cell liquid in the cell preparation bag at a predetermined temperature. The heat preservation opening and closing door 14 is disposed at the opening of the shaking housing 11, and the heat preservation opening and closing door 14 is provided with glass 15. Preferably, the heat preservation opening and closing door 14 is provided with double-layer glass, and by adopting double-layer glass, the constant temperature ability inside the shaking housing 11 is enhanced, power loss is reduced, and the generation of condensed water is reduced.

[0108] In an embodiment of the present invention, as Figure 12 shown, the control device 3 includes a housing 31, a main control circuit board, and a display screen 32. The main control circuit board is disposed inside the housing 31, and the main control circuit board is electrically connected to a plurality of connection ports; the display screen 32 is connected to the housing 31 through a movable arm 33. By fixing the display screen 32 with the movable arm 33, the angle of the display screen 32 can be adjusted according to needs, making it more convenient to use. The display screen 32 is electrically connected to the main control circuit board, and the display screen 32 is used to display the working parameters of the cell dispensing device 2 and the working parameters of the cell constant temperature shaking device 1.

[0109] In an embodiment of the present invention, a control and operation module power key 34, a control and operation module alarm lamp 35, and a data cable interface 36 are provided on one side of the housing 31. The control and operation module power key 34, the control and operation module alarm lamp 35, and the data cable interface 36 are all electrically connected to the main control circuit board. The control and operation module power key 34 is used to control the opening and closing of the control device 3, and the control and operation module alarm lamp 35 is used to alarm when the main control circuit board detects an abnormality, reminding the operator to intervene in time. The data cable interface 36 is used to connect to an external interface. Preferably, the data cable interface 36 is a USB interface.

[0110] In an embodiment of the present invention, a speaker is further provided on one side of the housing 31. The speaker is electrically connected to the main control circuit board, and the speaker is used to play the voice information output by the main control circuit board.

[0111] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A cell packaging device, characterized in that: include: A subassembly housing (21) having a cavity therein; The syringe push-pull component (22) comprises a first linear drive component (220), a syringe support plate (221), a syringe clamping plate (222) and a positioning component (224); the first linear drive component (220) is arranged in the cavity and connected to the sub-packaging shell (21); the syringe support plate (221) is connected to the first linear drive component (220); the positioning component (224) is arranged on the sub-packaging shell (21); the positioning component (224) is used to cooperate with the syringe in positioning; the first linear drive component (220) is used to drive the syringe support plate (221) and the syringe clamping plate (222) to move along a first direction; the first linear drive component (220) is used to drive the syringe support plate (221) and the syringe clamping plate (222) to move along the first direction, so as to drive the piston rod of the syringe to move up and down along the first direction, so as to enable the syringe to discharge or inlet liquid.

2. The cell packaging device according to claim 1, characterized in that: The syringe push-pull component (22) further comprises: A second linear drive component (223), the second linear drive component (223) is arranged on the syringe support plate (221) and connected to the syringe clamping plate (222); the second linear drive component (223) is used to drive the syringe clamping plate (222) to approach or move away from the syringe support plate (221) along a first direction, so as to clamp or release the bottom of the syringe piston.

3. The cell packaging device according to claim 2, characterized in that: A limiting groove (225) is provided at the first end of the syringe clamping plate (222), and the syringe clamping plate (222) is engaged with the end of the push rod of the syringe via the limiting groove (225), and the second end of the syringe clamping plate (222) is connected to the second linear drive assembly (223).

4. The cell packaging device according to claim 2, characterized in that: The second end of the syringe clamping plate (222) is provided with a card slot, and the telescopic shaft of the second linear drive assembly (223) is provided with a floating joint (226), and the floating joint (226) is card-engaged with the card slot.

5. The cell packaging device according to claim 1, characterized in that: A limiting hole (227) is provided at the first end of the syringe support plate (221), and the syringe support plate (221) is sleeved on the syringe through the limiting hole (227). The second end of the syringe support plate (221) is connected to the first linear drive assembly (220).

6. The cell packaging device according to any one of claims 1 to 5, characterized in that: The first linear drive assembly (220) comprises: A first linear drive member (228); A connecting mechanism (229), wherein the first linear drive member (228) is connected to the second end of the syringe support plate (221) via the connecting mechanism (229); A fixing plate (230) is connected to the first linear drive component (228) and the subassembly housing (21).

7. The cell packaging device according to claim 6, characterized in that: The syringe push-pull component (22) further comprises: The first sensor assembly comprises a first position sensor (231) and a first position sensing sheet (232); the first position sensor (231) is arranged on the first linear drive member (228); and the first position sensing sheet (232) is arranged on the connecting mechanism (229).

8. The cell packaging device according to claim 6, characterized in that: The syringe push-pull component (22) further comprises: The second sensor assembly comprises a second position sensor (233) and a second position sensing sheet (234); the second position sensor (233) is arranged on the connecting mechanism (229); and the second position sensing sheet (234) is arranged on one side of the syringe clamping plate (222).

9. The cell packaging device according to claim 6, characterized in that: The syringe push-pull component (22) further comprises: A guide assembly comprises a guide shaft (235) and an oil-free bushing (236); the guide shaft (235) is arranged on one of the syringe support plate (221) and the syringe clamping plate (222); the oil-free bushing (236) is arranged on the other of the syringe support plate (221) and the syringe clamping plate (222); the oil-free bushing (236) is sleeved on the outer periphery of the guide shaft (235) and slidably cooperates with the guide shaft (235) in a first direction.

10. The cell packaging device according to any one of claims 1 to 5, characterized in that: The cell packaging device also includes: A positioning component (25) is arranged on the packaging housing (21), and the positioning component (25) is used to cooperate with the card plate (41) of the consumable material (4) in a positioning manner; A plug valve chuck component is arranged on the packaging housing (21), and the plug valve chuck component is used to drive the plug valve (44) of the consumable material (4) to switch the channel.

11. The cell packaging device according to claim 10, characterized in that: The cell packaging device also includes: A fixing component (26), the fixing component (26) comprising a rotating handle (261), a connecting shaft (262), a fixing base (263) and a positioning plate (264); the fixing base (263) is connected to the sub-packaging shell (21); the interior of the fixing base (263) is hollow; the positioning plate (264) is rotatably arranged inside the fixing base (263); one end of the connecting shaft (262) is connected to the rotating handle (261); the other end of the connecting shaft (262) is connected to the positioning plate (264); a groove (265) is arranged on the outer peripheral surface of the positioning plate (264); at least one third ball screw (266) which is positioned and matched with the groove (265) is arranged on the inner wall of the fixing base (263); a locking hole is arranged on the clamping plate (41); the rotating handle (261) locks the clamping plate (41) through the locking hole.

12. The cell packaging device according to any one of claims 1 to 5, characterized in that: The positioning assembly (224) comprises a syringe positioning plate (258), wherein the syringe positioning plate (258) is arranged on one side of the packaging shell (21), and the syringe positioning plate (258) is provided with two positioning protrusions (237), wherein the two positioning protrusions (237) are spaced apart in the up-down direction, and the two positioning protrusions (237) are both provided with a snap-fitting groove, and the snap-fitting groove is used for snap-fitting with the syringe; a positioning groove (238) is formed between the two positioning protrusions (237), and the positioning groove (238) is used for snap-fitting with the syringe mounting plate (43).

13. A multifunctional cell automated precision packaging device, characterized in that: A cell packaging device comprising any one of claims 1 to 12.

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