Sterile microsphere crushing and mixing equipment

Abstract

The utility model relates to sterile microsphere crushing and mixing equipment, which comprises a hood, a control unit, a tailing collecting unit, a feeding unit, a crushing unit, a mixing unit and a discharging unit, the feeding unit, the crushing unit, the mixing unit and the discharging unit are sequentially communicated, the mixing unit comprises a mixing chamber and a mixer positioned at the bottom of the mixing chamber, and a plurality of air inlet nozzles are circumferentially distributed in the mixer. An air outlet is formed in the mixing chamber, and the tailing collecting unit comprises a plurality of air inlets formed in the crushing unit and the mixing unit. The equipment simultaneously has dual functions of crushing and mixing, and can promote the texture uniformity of collected materials, reduce the tedious steps of drying post-treatment of microspheres, increase the industrialization accessibility and reduce the residue of powder in the equipment.

Description

Technical Field

[0001] The utility model relates to the field of medical supplies, in particular to a sterile microsphere crushing and mixing device. Background Art

[0002] At present, the most common industrial preparation method for microspheres is the (complex) emulsification solvent evaporation method, which is to dissolve the raw and auxiliary materials for preparation separately / together to form a dispersed phase, and then use mechanical energy to precipitate the dispersed phase in the incompatible external continuous phase, remove the dissolving solvent, and obtain the initial blastocyst of the microspheres. Before removing a small amount of residual solvent and water, a dispersant is added and the product is obtained by reduced pressure drying or freeze drying.

[0003] After drying and before packaging, microspheres usually need to be granulated to obtain good dispersibility. During the drying period, the microspheres and dispersants are not strictly uniformly distributed. The wet microspheres have a large specific gravity and usually settle in the lower part of the suspension, while the dispersants are mostly in the space above the wet microspheres. Even if dispersants are added, the aggregation of microspheres during drying cannot be completely avoided, so screening and sorting are very necessary. Screening can remove microsphere aggregates during drying through particle size screening. At the same time, screening also has a certain dispersing effect, promoting the mixing of microspheres and dispersants. But this is not enough. The microsphere powder that passes the granulation screen needs to be further fully mixed, usually after mixing in a three-dimensional mixer, to achieve true uniformity. Since microspheres are basically aseptic production processes, the transfer of microsphere powder between multiple aseptic equipment is not only inconvenient to operate, but also invisibly increases the powder transfer residue, which causes a lot of economic losses for high value-added microsphere products.

[0004] Existing granulation mills, such as those shown in Chinese patents CN217699535U, CN218394051U, and CN218834701U, have similar equipment structures. The centrifugal force generated by the high-speed operation of the granulation knife drives the material to the inner surface of the conical screen, and a shear force is generated between the granulation knife and the screen plane, so that the material is crushed and scattered, and then falls into the receiving bucket through the screen holes. Patent CN217699535U proposes a technical solution for how to replace the receiving bucket without stopping the machine. Patent CN218394051U proposes a new explosion-proof granulation machine for improving the safety of equipment and personnel during the crushing process. Patent CN218834701U provides a laboratory high-speed granulation machine, and proposes technical improvements on how to improve the crushing efficiency of the material and simultaneously ensure the smooth operation of the equipment. The above granulation mill structures do not solve the problem of uniformity of collected materials. Summary of the invention

[0005] The technical dilemma to be solved by this application is how to endow a device with both crushing and mixing functions simultaneously, promote the texture uniformity of the collected materials, reduce the cumbersome steps of post-treatment of microspheres after drying, increase industrial accessibility, and reduce the residue of powder materials in the device. Accordingly, this application proposes a microsphere crushing and mixing device to meet the above working conditions and requirements.

[0006] The technical solution adopted by the present utility model to solve its technical problems is a sterile microsphere crushing and mixing device, which includes a machine cover, and also includes a control unit, a tail material collecting unit, and a feeding unit, a crushing unit, a mixing unit, and a discharging unit that are connected in sequence. The mixing unit includes a mixing chamber and a mixer located at the bottom of the mixing chamber. A number of air inlet nozzles are distributed in a circular pattern in the mixer. An air outlet is provided in the mixing chamber. The tail material collecting unit includes a number of air inlets provided in the crushing unit and the mixing unit.

[0007] As a preferred solution of the above solution, the feeding unit includes a feeding hopper. The feeding hopper is sequentially provided with a protective cover and a protective fence from top to bottom. An induction limiter is provided on the side of the feeding hopper close to the machine cover.

[0008] As a preferred solution of the above solution, the crushing unit includes a crushing chamber, a crushing knife, a conical screen, a blanking chamber, a crushing fixing component, a crushing drive shaft, a right-angle steering device, a crushing drive coupling, and a crushing drive motor. The crushing knife is located in the conical screen, and there is a slit between the crushing knife and the conical screen. The crushing knife is fixedly arranged on the crushing drive shaft through the crushing fixing component. The crushing drive shaft is connected to the crushing drive motor through the right-angle steering device and the crushing drive coupling.

[0009] As a preferred solution of the above solution, the discharging unit includes a pneumatic cone valve, a reducer, and a material receiving cylinder connected in sequence.

[0010] As a preferred solution of the above solution, the air inlet nozzles, the air outlet, and the air inlets are all connected to a circulating gas path.

[0011] As a preferred solution of the above solution, the circulating gas path includes a main air inlet, a high-pressure air outlet, a low-pressure air outlet, a return air port, a pressure reducing valve, an air inlet filter, a first return air valve, and a second return air valve. One end of the main air inlet is connected to a gas source. The main air inlet is connected to the second return air valve and the air inlet filter through the first return air valve. The second return air valve is connected to the return air port. The return air port is connected to the air outlet. A gas outlet filter is provided at the air outlet. The air inlet filter is respectively connected to the high-pressure air outlet and the pressure reducing valve. The high-pressure air outlet is connected to the air inlet nozzles. The pressure reducing valve is connected to the low-pressure air outlet. The low-pressure air outlet is connected to the air inlets.

[0012] As a preferred embodiment of the above scheme, the air inlet is arranged at the upper arm of the pulverizing drive coupling.

[0013] As a preferred embodiment of the above scheme, the air inlet is arranged above the pneumatic cone valve.

[0014] As a preferred embodiment of the above scheme, the feeding unit, the crushing unit, the mixing unit and the discharging unit are arranged on the side of the machine cover and are connected in sequence along the central axis from top to bottom.

[0015] As a preferred embodiment of the above scheme, the air inlet nozzle is an angle-adjustable nozzle.

[0016] The advantages of the micro-ball crushing and mixing equipment of the utility model are:

[0017] 1) The feeding unit, crushing unit, mixing unit and discharging unit are connected in sequence, integrating the crushing and mixing functions in the same closed space within the equipment, meeting the post-drying processing conditions of the microspheres, achieving the removal of microsphere aggregates in the same space, promoting the uniform mixing of microspheres and dispersants, and no further processing is required before packaging;

[0018] 2) The air inlet nozzle at the bottom of the mixing chamber can provide a spiral airflow along the cylinder wall, promoting the full mixing of the microspheres and the dispersant, and the mixing force is gentle;

[0019] 3) It saves the area occupied by the sterile site, is conducive to sterile operation, the equipment is easy to disassemble and install, the screen is easy to clean, suitable for sterile working conditions, resistant to VHP, and can be placed in an isolator for use;

[0020] 4) Through the purge function of multiple air inlets in the equipment, all materials under the screen in the equipment are recovered without any tailings. At the same time, the loss of materials transferred from the crushing system to the mixing system in conventional operations is effectively avoided, and it is also suitable for the application of other high value-added microparticle products;

[0021] 5) The microspheres obtained after being processed by the utility model equipment have good uniformity of content and good needle permeability. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the structure of sterile crushing and mixing equipment.

[0023] Figure 2 Schematic diagram of the structure of the crushing unit.

[0024] Figure 3 Schematic diagram of the results of the mixing unit and the discharging unit.

[0025] 1. Hood; 2. Frame; 3. Display screen; 4. Maintenance door; 5. Distribution box; 6. Support part; 7. Crushing drive motor; 8. Main air inlet; 9. Feed hopper; 10. Guardrail; 11. Protective cover; 12. Crushing chamber; 13. Crushing knife; 14. Conical screen; 15. Crushing fixing component; 16. Limiter; 17. Crushing drive shaft; 18. Right-angle steering gear; 19. Crushing drive coupling; 20. Discharge chamber; 21. Air inlet of discharge chamber; 22. Air inlet filter; 23. Mixing chamber; 24. Mixer; 25. Air inlet nozzle; 26. Pressure reducing valve; 27. Return air valve; 28. Air inlet of mixing chamber; 29. Air outlet; 30. Gas outlet filter; 31. Pneumatic cone valve; 32. Diameter change; 33. Material receiving cylinder; a high-pressure port, b low-pressure port, c return air port. Detailed implementation mode

[0026] The technical solution of the present utility model will be further described below through embodiments in conjunction with the accompanying drawings.

[0027] Embodiment:

[0028] A microsphere crushing and mixing device in this embodiment, as Figures 1 to 3 shown, includes a hood 1, a frame 2, a control unit, a feeding unit, a crushing unit, a mixing unit, a discharging unit and a tailing collecting unit. The whole device is mounted on the frame 2, and a support part 6 is provided below the frame. The support part 6 can be a fixed support foot or a moving wheel. The fixed support foot is suitable for the working condition of fixing the crushing position, and the moving wheel facilitates the movement of the whole device and is suitable for the working condition of not fixing the crushing position. The hood 1 is arranged on the frame 2. The feeding unit, the crushing unit, the mixing unit and the discharging unit are arranged on the left side of the hood 1 and are connected in sequence along the central axis from top to bottom. The functions realized are feeding, crushing, mixing and discharging, and finally the collection of the residual tailings of the whole device.

[0029] The control unit includes a display screen 3 and a distribution box 5. The display screen 3 is arranged above the right side of the hood 1. The operating parameters of the device can be set on the display screen 3. An emergency stop button and device start / stop buttons are arranged beside the display screen. A maintenance door 4 is arranged below the display screen to facilitate the maintenance of the interior of the device. The distribution box 5 is arranged inside the hood to drive the crushing drive motor 7.

[0030] The feeding unit includes a feed hopper 9, which is provided with a protective cover 11 and a protective fence 10 from top to bottom. The feed hopper 9 is provided with an inductive limiter 16 near the hood. The feed hopper 9 is in the shape of a funnel that is wide at the top and narrow at the bottom, and a quick-connect chuck is provided at the bottom. The protective fence 10 is provided at 1 / 5 to 4 / 5 of the height of the funnel. The protective fence can prevent foreign objects from the top, such as auxiliary tools such as a collecting shovel, from accidentally falling into the crushing process, causing equipment failure. At the same time, the powder block material with too large a volume can be preliminarily dispersed and crushed to facilitate it to fall into the crushing chamber for further crushing. The protective cover 11 is provided at the upper end of the feed hopper and matches the feed hopper 9. The protective cover can prevent dust particles from floating out during the crushing period, thereby protecting personnel. The inductive limiter can prevent the equipment from being installed in place during assembly to ensure that the equipment operates in the correct working conditions.

[0031] The crushing unit includes a crushing chamber 12, a crushing blade 13, a conical screen 14, a feeding chamber 20, a crushing fixing assembly 15, a crushing drive shaft 17, a right-angle deflector 18, a crushing drive coupling 19, and a crushing drive motor 7. The feeding chamber 20 is a cylindrical structure, located below the feed hopper, and the two are connected by a quick-connect chuck. The conical screen 14 is located in the feeding chamber 20 and is arranged below the feed hopper. The lower boundary of the feed hopper 9 and the conical screen 14 constitute the crushing chamber 12. A crushing blade 13 is arranged in the crushing chamber 12. The crushing blade 13 and the conical screen 14 are coaxial with the crushing drive shaft. The crushing blade 13 is fixed on the crushing drive shaft 17 through the crushing fixing assembly 15. The crushing drive shaft 17 is connected to the crushing drive coupling 19 through the right-angle deflector 18. The crushing drive coupling 19 is connected to the mounting shaft of the crushing drive motor 7 and connected through a quick-connect chuck. This design structure is convenient for disassembly and sterilization of the equipment body.

[0032] The conical screen 14 is in the shape of a funnel that is wide at the top and narrow at the bottom. Its side walls are covered with mesh holes, which can be square holes, round holes or fish scale holes. The average aperture of the conical screen is 0.1-1 mm. The crushing knife 13 is an inverted A structure, and its two outer blades are adapted to the conical screen and form a fixed slit. When the crushing knife runs at high speed on the inner surface of the conical screen, the centrifugal force drives the material to the inner surface of the conical screen, generating shear force in the slit to crush the material. The crushing fixed component is set to facilitate the disassembly, installation and positioning of the crushing knife and the conical screen.

[0033] The mixing unit comprises a mixing chamber, a mixer, an air inlet nozzle, a high-pressure air inlet filter, and a gas outlet filter.

[0034] The mixing unit includes a mixing chamber 23 and a mixer 24. The mixing chamber 23 is connected to the blanking chamber 20 and is docked through a quick-connect chuck. The upper part of the mixing chamber 23 is cylindrical. An air outlet 29 is provided on the side wall of the cylindrical part of the mixing chamber 23. A gas outlet filter 30 is provided at the air outlet. The inner diameter is kept the same as that of the blanking chamber 20. The lower part is conical, and a mixer 24 is provided at the bottom. A number of upwardly arranged intake nozzles 25 are circumferentially distributed in the mixer 24. The intake nozzles 25 are angle-adjustable nozzles, that is, the angle between the intake nozzles 25 and the mixing chamber 23 can be adjusted. In addition, by replacing the conical part of the mixing chamber, the conical part of the mixing chamber can have different angles. The intake nozzles 25 are connected to a high-pressure gas source through an intake filter. By adjusting the intake gas flow rate of the high-pressure gas source, the angle of the intake nozzles, and the angle of the conical part of the mixing chamber, different mixing effects can be provided. After being filtered by the intake filter, the high-pressure gas source enters the mixing chamber 23 through the intake nozzles 25. At this time, the powder in the mixing chamber 23 instantly rises spirally along the cylinder wall with the compressed gas, forming a fluidized mixing state. After a number of pulsed intakes and pause intervals, the material can be repeatedly tumbled, and the powder in the mixing chamber can be quickly mixed evenly. The gas in the mixing chamber is filtered by the gas outlet filter 30 and discharged through the air outlet.

[0035] The discharging unit is located below the mixing chamber 23 and includes a pneumatic cone valve 31, a reducer 32, and a receiving barrel 33 that are connected in sequence. During the material mixing period, the pneumatic cone valve 31 remains closed. After the staged mixing is completed, the pneumatic cone valve 31 moves upward, and the material falls into the receiving barrel 33 through the reducer 32 under the action of gravity until all the material is emptied and then closes again. The reducer 32 is a detachable structure, connected to the pneumatic cone valve 31 through a quick-connect chuck at the upper part and adapted to the receiving barrel 33 at the lower part. The receiving barrel is matched with the material batch.

[0036] The tailing aggregate unit includes a number of intake ports in the blanking chamber 20 and a number of intake ports in the mixing chamber 23, which are respectively denoted as the blanking chamber intake port 21 and the mixing chamber intake port 28 according to their positions. The blanking chamber intake port 21 is provided at the upper arm of the crushing drive coupling 19 in the blanking chamber, and the mixing chamber intake port 28 is provided above the pneumatic cone valve. The blanking chamber intake port 21 and the mixing chamber intake port 28 are connected to a low-pressure gas source through a filter. When the low-pressure gas source discharges gas, the blanking chamber intake port 21 sprays low-pressure gas to blow off the material accumulated on the upper arm of the crushing drive coupling 19.

[0037] In the open state of the pneumatic cone valve 31, the mixing chamber intake port 28 makes the material fall into the lower receiving barrel by means of low-pressure gas purging. According to different material particle sizes, bulk densities, water contents, and adsorption properties to the chamber, there is material residue in other parts of the blanking chamber and the mixing chamber. Multiple intake ports can also be set to recover all the material. The gas entering the equipment through the blanking chamber intake port 21 and the mixing chamber intake port 28 can be discharged through the air outlet 29.

[0038] In this embodiment, the air inlet nozzle, the air outlet and the air inlet are all connected to the circulating air circuit, and the circulating air circuit provides high-pressure gas to the air inlet nozzle and low-pressure gas to the air inlet 21 of the material feeding chamber and the air inlet 28 of the mixing chamber. The circulating air circuit includes the main air inlet 8, the high-pressure port a, the low-pressure port b, the return air port c, the pressure reducing valve 26, the air inlet filter 22 and the return air valve 27. The return air valve 27 is provided with two, namely the first return air valve and the second return air valve. One end of the main air inlet 8 is connected to the air source, and the main air inlet 8 is connected to the second return air valve and the air inlet filter 22 respectively through the first return air valve, the second return air valve is connected to the return air port c, the return air port c is connected to the air outlet 29, and a gas outlet filter 30 is provided at the air outlet 29. The air inlet filter 22 is respectively connected to the high-pressure port a and the pressure reducing valve 26, the high-pressure port a is connected to the air inlet nozzle 25, the pressure reducing valve 26 is connected to the low-pressure port b, and the low-pressure port b is respectively connected to the unloading chamber air inlet 21 and the mixing chamber air inlet 28.

[0039] The working process of the sterile microsphere crushing and mixing equipment in this embodiment is as follows: start the display screen, set the speed of the crushing motor, start the motor, confirm that the equipment can operate normally, put the dried block or powder material from the feed hopper, squeeze the material intercepted above the guardrail into the crushing chamber, add a protective cover, the material is crushed in the crushing chamber, and after passing through the conical screen, it falls into the mixing chamber through the unloading chamber, and the high-pressure air intake is turned on. After being filtered by the air intake filter, it passes through the mixing chamber air intake nozzle and is intermittently mixed with the material in the mixing chamber. The intermittent opening time is 2~30s. After the material is fully mixed, the pneumatic cone valve is opened, and the material enters the receiving barrel through the diameter change. During the working period, the material can be intermittently loaded or continuously loaded until all the materials are crushed, mixed, and discharged. The crushed and mixed tail material is opened by opening the unloading chamber air intake and the mixing chamber air intake, so that the powder material falling on the upper arm of the crushing drive coupling during the crushing process falls into the mixing chamber, and the residual material above the pneumatic cone valve of the mixing chamber falls into the receiving barrel until all the materials in the chamber are recovered and then stopped.

[0040] The specific embodiments described herein are merely examples of the spirit of the present invention. Those skilled in the art may make various modifications or additions to the specific embodiments described or replace them in similar ways, but they will not deviate from the spirit of the present invention or exceed the scope defined by the appended claims.

Claims

1. A sterile microsphere crushing and mixing device, including a machine cover, characterized in that: It also includes a control unit, a tailings aggregation unit, and a feeding unit, a crushing unit, a mixing unit and a discharging unit that are connected in sequence. The mixing unit includes a mixing chamber and a mixer located at the bottom of the mixing chamber, the mixer is provided with a plurality of air inlet nozzles distributed in a circumferential manner, an air outlet is provided in the mixing chamber, and the tailings aggregation unit includes a plurality of air inlets arranged in the crushing unit and the mixing unit.

2. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The feeding unit comprises a feeding hopper, and the feeding hopper is provided with a protective cover and a protective fence in sequence from top to bottom, and an inductive limiter is provided on the side of the feeding hopper close to the machine cover.

3. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The crushing unit includes a crushing chamber, a crushing knife, a conical screen, a feeding chamber, a crushing fixed assembly, a crushing drive shaft, a right-angle deflector, a crushing drive coupling and a crushing drive motor. The crushing knife is located in the conical screen, and a slit is left between the crushing knife and the conical screen. The crushing knife is fixed on the crushing drive shaft through the crushing fixed assembly, and the crushing drive shaft is connected to the crushing drive motor through the right-angle deflector and the crushing drive coupling.

4. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The discharging unit comprises a pneumatic cone valve, a reducer and a receiving barrel which are connected in sequence.

5. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The air inlet nozzle, the air outlet and the air inlet are all connected to the circulating air circuit.

6. The sterile microsphere crushing and mixing equipment according to claim 5 is characterized in that: The circulating air circuit includes a main air inlet, a high-pressure port, a low-pressure port, an air return port, a pressure reducing valve, an air inlet filter, a first return air valve and a second return air valve. One end of the main air inlet is connected to an air source. The main air inlet is connected to the second return air valve and the air inlet filter respectively through the first return air valve. The second return air valve is connected to the air return port. The air return port is connected to the air outlet. A gas outlet filter is provided at the air outlet. The air inlet filter is connected to the high-pressure port and the pressure reducing valve respectively. The high-pressure port is connected to the air inlet nozzle. The pressure reducing valve is connected to the low-pressure port. The low-pressure port is connected to the air inlet.

7. The sterile microsphere crushing and mixing equipment according to claim 3 is characterized in that: The air inlet is arranged at the upper arm of the crushing drive coupling.

8. The sterile microsphere crushing and mixing equipment according to claim 4 is characterized in that: The air inlet is arranged above the pneumatic cone valve.

9. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The feeding unit, the crushing unit, the mixing unit and the discharging unit are arranged on the side of the machine cover and are connected in sequence along the central axis from top to bottom.

10. The sterile microsphere crushing and mixing equipment according to claim 1 is characterized in that: The air inlet nozzle is an angle-adjustable nozzle.

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