Depth-limiting injector for constructing intervertebral disc degeneration model of mouse annulus fibrosus puncture

Abstract

According to the technical scheme, the depth-limiting injector for constructing the intervertebral disc degeneration model of mouse fibrous ring puncture is characterized in that the depth-limiting injector comprises a pipe barrel part, one end of the pipe barrel part is provided with an end pipe part integrally formed with the pipe barrel part, one side of the end pipe part is provided with a needle tip, and the other side of the end pipe part is provided with a needle head; one end of the needle tip is provided with an adjusting part integrally formed with the needle tip, the adjusting part is in threaded connection in the end tube part, a piston is slidably connected in the tube barrel part, and a push rod is fixed on the piston. According to the depth-limiting injector, the depth can be adjusted, puncture and injection are integrated, the consistency and stability of a mouse model are improved, and the reliability and repeatability of an experiment are improved.

Description

Technical Field

[0001] The utility model relates to the field of syringes, and particularly relates to a depth-limiting syringe for constructing a disc degeneration model by puncturing the annulus fibrosus of a mouse. Background Art

[0002] Syringes are widely used, and various types of syringes are diverse. Generally, they are composed of a syringe barrel and a needle.

[0003] The existing Chinese patent with the publication number CN102725014B discloses a replaceable needle assembly for a retractable and pre-filled syringe. The syringe includes a syringe barrel having a mounting member and a plunger, so that the retractable needle can be replaced by the user without affecting the retraction mechanism. The replaceable needle assembly includes a needle adapted to a retractable needle seat and a needle holder. The needle seat is removably threadably mountable to the mounting member of the syringe barrel. The needle holder includes a plurality of fingers that releasably engage the retractable needle to prevent accidental retraction of the retractable needle before being engaged by the plunger. The plunger includes a plunger seal.

[0004] In the field of intervertebral disc research, due to research needs, drugs often need to be locally injected into the intervertebral discs of large and small mice. Currently, the following micro-syringes are often used. Because their puncture needles are too thin to be used for constructing a disc degeneration model, it is often necessary to use a micro-syringe first and then use a micro-syringe for drug injection for the second time, which causes secondary damage to the intervertebral disc. And due to uncontrollable depth limitation, it is also easy to cause spinal cord or cauda equina injury, or failed injection. For the existing shorter syringes with depth limitation, due to the larger needle tail and the limited abdominal cavity space of mice and rats, the visual field is blocked and it is not easy to puncture the intervertebral disc. Summary of the Invention

[0005] Aiming at the problems mentioned in the background art, the purpose of the utility model is to provide a depth-limiting syringe for constructing a disc degeneration model by puncturing the annulus fibrosus of a mouse to solve the problems mentioned in the background art.

[0006] The above technical purpose of the utility model is achieved by the following technical solutions:

[0007] A depth-limiting syringe for constructing a disc degeneration model by puncturing the annulus fibrosus of a mouse includes a barrel part. One end of the barrel part has an end tube part integrally formed with the barrel part. A needle tip is installed on one side of the end tube part. One end of the needle tip has an adjustment part integrally formed with the needle tip. The adjustment part is threadedly connected in the end tube part. A piston is slidably connected in the barrel part, and a push rod is fixed on the piston.

[0008] By adopting the above technical solution, the depth-limiting syringe of the present invention has adjustable depth limitation, integrates puncture and injection, improves the consistency and stability of the mouse model, and increases the reliability and repeatability of the experiment. When depth-limiting operation is required, the needle tip can be rotated to drive the adjustment part at the end of the needle tip to adjust the length spirally in the end tube part, so that the length of the needle tip can be adjusted. After adjustment, the piston can be driven by the push rod to push in the barrel part to achieve injection.

[0009] Preferably, a first scale line is provided on the outer part of the end tube part.

[0010] By adopting the above technical solution, the first scale line can facilitate the observation of the position of the adjustment part at the end of the needle tip in the end tube part.

[0011] Preferably, a second scale line is provided on the outer part of the barrel part.

[0012] By adopting the above technical solution, the second scale line can facilitate the observation of the liquid level in the barrel part.

[0013] Preferably, a sealing ring is sleeved and fixed on the outer part of the piston.

[0014] By adopting the above technical solution, the sealing ring can increase the sealing performance of the piston sliding in the barrel part.

[0015] Preferably, a protruding ring integrally formed with the piston is provided on the outer part of the piston, and an embedding ring groove for the protruding ring to be embedded is provided on the sealing ring.

[0016] By adopting the above technical solution, the arrangement of the protruding ring and the embedding ring groove can improve the reliability of the fixing of the sealing ring.

[0017] Preferably, the cross section of the protruding ring is a dovetail shape.

[0018] By adopting the above technical solution, the protruding ring with a dovetail cross section can improve the stability of the fixing of the sealing ring.

[0019] Preferably, the barrel part and the end tube part are made of PP tubes.

[0020] By adopting the above technical solution, the PP tubes have excellent material quality, moderate structural strength and low price.

[0021] In summary, the main beneficial effects of the present invention are as follows:

[0022] The depth-limiting syringe of the present invention has adjustable depth limitation, integrates puncture and injection, improves the consistency and stability of the mouse model, and increases the reliability and repeatability of the experiment. When depth-limiting operation is required, the needle tip can be rotated to drive the adjustment part at the end of the needle tip to adjust the length spirally in the end tube part, so that the length of the needle tip can be adjusted. After adjustment, the piston can be driven by the push rod to push in the barrel part to achieve injection. Brief Description of the Drawings

[0023] Figure 1 is one of the structural schematic diagrams of the present utility model.

[0024] Figure 2 is the structural sectional view of the present utility model.

[0025] Figure 3 is Figure 2 the partial enlarged view at position A in

[0026] Reference numerals: 1, tube portion; 2, end tube portion; 3, needle tip; 4, adjustment portion; 5, piston; 6, push rod; 7, first scale line; 8, second scale line; 9, sealing ring; 10, protruding ring; 11, embedded ring groove. Detailed Description of the Preferred Embodiments

[0027] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Apparently, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts shall fall within the protection scope of the present utility model.

[0028] Referring to Figures 1 - 3 , a depth-limiting syringe for constructing a disc degeneration model by puncturing the mouse annulus fibrosus includes a tube portion 1. One end of the tube portion 1 has an end tube portion 2 integrally formed with the tube portion 1. A needle tip 3 is installed on one side of the end tube portion 2. One end of the needle tip 3 has an adjustment portion 4 integrally formed with the needle tip 3. The adjustment portion 4 is threadedly connected in the end tube portion 2. A piston 5 is slidably connected in the tube portion 1, and a push rod 6 is fixed on the piston 5. This depth-limiting syringe has adjustable depth limitation, integrating puncture and injection, improving the consistency and stability of the mouse model, and increasing the reliability and repeatability of the experiment. When depth-limiting operation is required, the needle tip 3 can be rotated to drive the adjustment portion 4 at the end of the needle tip 3 to adjust the length spirally in the end tube portion 2, so as to adjust the length of the needle tip 3. After adjustment, the push rod 6 is used to drive the piston 5 to push in the tube portion 1 to achieve injection. Since the width of the lumbar and caudal intervertebral discs in mice is mostly 2-3 mm, and the width of the annulus fibrosus is about less than 1 mm, a syringe with a depth limitation of 1 mm is designed accordingly. And this syringe is divided into two types. One is used for constructing a 26G disc degeneration model and injecting drugs in the degeneration model. The other thinner 31G one is used for only injecting drugs without causing degeneration.

[0029] Referring to Figures 1 - 3, wherein a first scale line 7 is provided on the outer part of the end tube portion 2, and the first scale line 7 can facilitate the observation of the position of the tip adjustment portion 4 at the end of the needle tip 3 in the end tube portion 2; a second scale line 8 is provided on the outer part of the tube barrel portion 1, and the second scale line 8 can facilitate the observation of the liquid level in the tube barrel portion 1.

[0030] Reference Figures 1 - 3 , wherein a sealing ring 9 is sleeved and fixed on the outer part of the piston 5, and the sealing ring 9 can increase the sealing performance of the piston 5 sliding in the tube barrel portion 1; a protruding ring 10 integrally formed with the piston 5 is provided on the outer part of the piston 5, and an embedding ring groove 11 for the protruding ring 10 to be embedded is formed on the sealing ring 9, and the arrangement of the protruding ring 10 and the embedding ring groove 11 can improve the reliability of the fixation of the sealing ring 9.

[0031] Reference Figures 1 - 3 , wherein the cross-section of the protruding ring 10 is a dovetail shape, and the dovetail-shaped cross-section of the protruding ring 10 can improve the stability of the fixation of the sealing ring 9; the tube barrel portion 1 and the end tube portion 2 are made of PP tubes, and the PP tubes have excellent materials, moderate structural strength and low prices.

[0032] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A depth-limited syringe for constructing a rat annulus fibrosus puncture model of intervertebral disc degeneration, comprising a tube portion (1), characterized in that: One end of the tube portion (1) has an end tube portion (2) integrally formed with the tube portion (1), a needle tip (3) is mounted on one side of the end tube portion (2), one end of the needle tip (3) has an adjustment portion (4) integrally formed with the needle tip (3), the adjustment portion (4) is threadedly connected to the end tube portion (2), a piston (5) is slidably connected to the tube portion (1), and a push rod (6) is fixed to the piston (5).

2. The depth-limited syringe for constructing a rat annulus fibrosus puncture intervertebral disc degeneration model according to claim 1, characterized in that: A first scale line (7) is arranged outside the end pipe portion (2).

3. The depth-limited syringe for constructing a rat annulus fibrosus puncture intervertebral disc degeneration model according to claim 1, characterized in that: A second scale line (8) is arranged outside the tube portion (1).

4. The depth-limited syringe for constructing a rat annulus fibrosus puncture intervertebral disc degeneration model according to claim 1, characterized in that: A sealing ring (9) is fixedly sleeved on the outside of the piston (5).

5. The depth-limited syringe for constructing a rat annulus fibrosus puncture intervertebral disc degeneration model according to claim 4, characterized in that: The piston (5) has a protruding ring (10) formed integrally with the piston (5) on its exterior, and the sealing ring (9) is provided with an embedding ring groove (11) for the protruding ring (10) to be embedded.

6. The depth-limited syringe for constructing a rat annulus fibrosus puncture intervertebral disc degeneration model according to claim 5, characterized in that: The cross section of the protruding ring (10) is dovetail-shaped.

7. The depth-limited syringe for constructing a rat annulus fibrosus puncture model of intervertebral disc degeneration according to claim 1, characterized in that: The tube portion (1) and the end tube portion (2) are PP tubes.

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