Temperature-adjustable stirring equipment for nadroparin calcium injection

Abstract

The utility model discloses a temperature-adjustable stirring device for nadroparin calcium injection. The temperature-adjustable stirring device comprises a bottom plate, a stirring device and a heating device, a temperature adjusting mechanism is arranged on the upper side of the bottom plate and comprises an inlet, a constant-temperature adjusting device and a backflow pipe, and the constant-temperature adjusting device is arranged on the left side of the upper side of the bottom plate and fixedly connected with the lower end of the inlet. According to the temperature-adjustable stirring equipment for the nadroparin calcium injection, stirring blades stir in the stirring box, dissolution of the nadroparin calcium injection in the stirring box can be accelerated, time is saved, constant-temperature gas is conveyed into a circulating pipe through an inlet by a constant-temperature adjusting device, and the constant-temperature gas is conveyed into the circulating pipe through a circulating pipe; and then the nadroparin calcium injection returns to the interior of the constant-temperature adjusting device through the backflow pipe to be refrigerated again, the temperature adjusting function is achieved, and the connecting ring drives the scraper to move downwards, so that the inner wall of the stirring box is scraped cleanly through the scraper, and the nadroparin calcium injection in the stirring box is conveniently discharged cleanly.

Description

Technical Field

[0001] The utility model relates to the technical field of nadroparin calcium injection, in particular to a stirring device for nadroparin calcium injection with adjustable temperature. Background Technique

[0002] Nadroparin calcium injection is an important anticoagulant drug. Nadroparin calcium inhibits the activities of coagulation factor Xa and thrombin through antithrombin III. It has the advantages of strong antithrombotic effect and small side effects. After subcutaneous injection, the peak value is reached in 3 hours, the half-life is 3.35 - 3.79 hours, and the bioavailability is close to 100%. It is mainly used for the prevention and treatment of thromboembolic diseases, such as atrial fibrillation, pulmonary embolism, deep vein thrombosis of the lower extremities, etc., to prevent thromboembolic diseases in general surgical operations or orthopedic operations, and to prevent the formation of blood clots in extracorporeal circulation during hemodialysis; when preparing, heparin sodium crude product is used as the raw material, through pretreatment and degradation with sodium nitrite under magnetic field conditions to obtain a degradation solution, through reduction reaction with sodium borohydride to obtain a reduction solution, adding calcium chloride, stirring and mixing evenly, stirring at room temperature under magnetic field conditions to obtain a reaction solution, extracting with n-butanol, ultrafiltration and concentration to obtain a concentrated solution, and alcohol precipitation to obtain nadroparin calcium; then stirring and mixing evenly, transferring to a thin film evaporator, rotating to form a film, adding ether to dissolve the film, then adding the PBS solution of nadroparin calcium, ultrasonic oscillation treatment, high-voltage pulsed electric field treatment, adding magnetic nitrogen-doped activated carbon, stirring and adsorbing, magnetic separation to remove magnetic nitrogen-doped activated carbon, microfiltration membrane filtration, rotary evaporation, and vacuum freeze-drying to obtain;

[0003] However, during the stirring and preparation process of the common stirring device for nadroparin calcium injection, the nadroparin calcium injection will generate heat. If no cooling treatment is carried out, through the effect of natural volatilization, the preparation time will be prolonged, which is not conducive to mass production;

[0004] Therefore, we propose a stirring device for nadroparin calcium injection with adjustable temperature to facilitate solving the problems raised above. Content of the Utility Model

[0005] The purpose of the utility model is to provide a stirring device for nadroparin calcium injection with adjustable temperature to solve the problem that during the stirring and preparation process of the currently common stirring device for nadroparin calcium injection, the nadroparin calcium injection will generate heat. If no cooling treatment is carried out, through the effect of natural volatilization, the preparation time will be prolonged, which is not conducive to mass production as proposed in the above background technique.

[0006] To achieve the above purpose, the utility model provides the following technical solution: A stirring device for nadroparin calcium injection with adjustable temperature, including: a bottom plate;

[0007] It further includes:

[0008] Stirring tank, a stirring mechanism is arranged inside the stirring tank, wherein the stirring mechanism includes a motor, a stirring shaft and stirring blades. The stirring tank is fixedly installed above the right side of the bottom plate, and a motor is fixedly installed on the upper side of the stirring tank;

[0009] A temperature regulating mechanism is arranged on the upper side of the bottom plate, wherein the temperature regulating mechanism includes an inlet, a constant temperature regulating device and a return pipe. The constant temperature regulating device is arranged on the upper left side of the bottom plate, and the constant temperature regulating device is fixedly connected to the lower end of the inlet.

[0010] Preferably, the output shaft of the motor is fixedly connected to the stirring shaft, stirring blades are arranged on the side surface of the stirring shaft, and the stirring blades are distributed in an array.

[0011] Preferably, a circulation pipe is arranged inside the stirring tank, the upper left side of the circulation pipe is fixedly connected to the upper end of the inlet, the lower left side of the circulation pipe is fixedly connected to one end of the return pipe, and the other end of the return pipe is fixedly connected to the constant temperature regulating device.

[0012] Preferably, electric telescopic rods are fixedly connected above the inner side of the stirring tank, the electric telescopic rods are symmetric about the vertical central axis of the stirring tank, the lower sides of the electric telescopic rods are fixedly connected to a connecting ring, and a scraping plate is arranged on the outer side of the connecting ring.

[0013] Preferably, a feeding port is arranged on the upper right side of the stirring tank, a discharging port is arranged on the lower side of the stirring tank, an exhaust pipe is arranged on the upper left side of the stirring tank, and a disinfection cotton is arranged inside the exhaust pipe.

[0014] Preferably, a thermometer is arranged on the right side wall of the stirring tank, and an observation window is arranged on the front side of the stirring tank.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows: for the stirring equipment for the temperature-adjustable calcium nadroparin injection, the stirring blades stir inside the stirring tank, which can accelerate the dissolution of the calcium nadroparin injection inside the stirring tank, save time. The constant temperature regulating device transfers the constant temperature gas to the inside of the circulation pipe through the inlet, and then returns to the inside of the constant temperature regulating device through the return pipe for refrigeration again, having the function of temperature regulation. The connecting ring drives the scraping plate to move downward, so that the scraping plate scrapes the inner wall of the stirring tank clean, which is convenient for discharging the calcium nadroparin injection inside the stirring tank completely;

[0016] 1. It is provided with a motor, a stirring shaft and stirring blades. By starting the motor, the stirring shaft drives the stirring blades to stir inside the stirring tank, which can accelerate the dissolution of the calcium nadroparin injection inside the stirring tank and save time;

[0017] 2. An inlet, a constant temperature regulating device and a return pipe are provided. The constant temperature gas is transmitted through the inlet to the inside of the circulation pipe by the constant temperature regulating device, and then returns to the inside of the constant temperature regulating device through the return pipe for re-cooling, having the function of temperature regulation;

[0018] 3. An electric telescopic rod, a connecting ring and a scraper are provided. By starting the electric telescopic rod, the connecting ring drives the scraper to move downward, so that the scraper scrapes the inner wall of the mixing tank clean, facilitating the discharge of the nadroparin calcium injection in the mixing tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 is a front sectional structure schematic diagram of the present utility model;

[0020] Figure 2 For the present utility model Figure 1 is an enlarged structure schematic diagram at A in;

[0021] Figure 3 is a front structure schematic diagram of the present utility model;

[0022] Figure 4 is a top sectional structure schematic diagram of the present utility model;

[0023] Figure 5 is a top structure schematic diagram of the present utility model.

[0024] In the figure: 1, bottom plate; 2, mixing tank; 3, motor; 4, mixing shaft; 5, mixing blades; 6, circulation pipe; 7, inlet; 8, constant temperature regulating device; 9, return pipe; 10, electric telescopic rod; 11, connecting ring; 12, scraper; 13, feeding port; 14, discharging port; 15, exhaust pipe; 16, disinfected cotton; 17, thermometer; 18, observation window. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0025] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0026] Please refer to Figures 1-5, the present utility model provides a technical solution: a stirring device for temperature-adjustable nadroparin calcium injection, comprising: a bottom plate 1, a stirring tank 2, a motor 3, a stirring shaft 4, stirring blades 5, a circulation pipe 6, an inlet 7, a constant temperature adjustment device 8, a return pipe 9, an electric telescopic rod 10, a connecting ring 11, a scraper 12, a feeding port 13, a discharging port 14, an exhaust pipe 15, a disinfection cotton 16, a thermometer 17 and an observation window 18;

[0027] When using the stirring device for temperature-adjustable nadroparin calcium injection, the raw materials of crude heparin sodium are pretreated and degraded by sodium nitrite under magnetic field conditions to obtain a degradation solution, and then reduced by sodium borohydride to obtain a reduction solution. Calcium chloride is added and stirred evenly. As Figure 1 shown, open the lid on the feeding port 13 on the upper side of the stirring tank 2, add these raw materials from the feeding port 13, and then close the lid on the feeding port 13 to stir them, thereby accelerating the preparation of nadroparin calcium injection;

[0028] As Figure 1 shown, a motor 3 is provided on the upper side of the stirring tank 2, and the output shaft of the motor 3 is fixedly connected to the stirring shaft 4. In addition, stirring blades 5 are provided on the outer side of the stirring shaft 4. These arrayed stirring blades 5 increase the contact area with the raw materials, thereby further accelerating the stirring rate. Start the motor 3, and the motor 3 will drive the stirring blades 5 to stir through the stirring shaft 4, and a large amount of time can be saved through stirring;

[0029] As Figure 1 shown, a stirring tank 2 and a constant temperature adjustment device 8 are provided on the upper side of the bottom plate 1. A circulation pipe 6 is provided on the side wall of the stirring tank 2, and the circulation pipe 6 is distributed in a snake shape. The circulation pipe 6 increases the contact area with the side wall of the stirring tank 2, thereby facilitating the temperature adjustment of the side wall of the stirring tank 2. In addition, the upper side of the circulation pipe 6 is connected to the right end of the inlet 7, and the lower side of the circulation pipe 6 is connected to the right end of the return pipe 9. The constant temperature adjustment device 8 can transport the prepared constant temperature water from the inlet 7 to the inside of the circulation pipe 6 from the upper side of the circulation pipe 6, and then the water after circulating through the circulation pipe 6 will be transported back to the constant temperature adjustment device 8 through the return pipe 9 for re-temperature adjustment. This can not only save water resources but also prevent water overflow and facilitate operation. In addition, during the temperature adjustment process, the stirring blades 5 also need to stir to prevent the raw material liquid inside the circulation pipe 6 from being damaged due to uneven stirring. In addition, a thermometer 17 is provided on the lower side inside the stirring tank 2. The thermometer 17 can monitor the temperature inside the stirring tank 2 to prevent the raw material liquid from continuously cooling, resulting in energy waste, playing an energy-saving and environmental protection role;

[0030] As Figure 1 and Figure 5As shown in the figure, an exhaust pipe 15 is provided on the upper side of the mixing tank 2, and a disinfection cotton 16 is provided inside the exhaust pipe 15. During the process of stirring and mixing the raw material liquid, heat will be dissipated, and water will generate water vapor. Due to the relatively high pressure of the hot air, the water vapor will be discharged from the disinfection cotton 16. The exhaust pipe 15 can prevent external dust from entering the mixing tank 2 through the disinfection cotton 16 and prevent the liquid medicine from being contaminated;

[0031] As Figure 1 , Figure 2 and Figure 4 shown in the figure, an electric telescopic rod 10 is provided on the upper side inside the mixing tank 2, and the lower side of the electric telescopic rod 10 is fixedly connected to the connecting ring 11. The electric telescopic rod 10 is symmetric about the vertical central axis of the mixing tank 2, which enhances the stability of the connection between the electric telescopic rod 10 and the connecting ring 11. In addition, a scraper 12 is provided on the outer side of the connecting ring 11, and the outer side of the scraper 12 is closely attached to the inner wall of the mixing tank 2. When the electric telescopic rod 10 is started, the electric telescopic rod 10 will drive the connecting ring 11 and the scraper 12 to move together. The scraper 12 moving up and down will scrape off the liquid medicine adsorbed on the inner side of the mixing tank 2 to prevent liquid residue during liquid discharge;

[0032] As Figure 1 and Figure 3 shown in the figure, an observation window 18 is provided on the front side of the mixing tank 2. By opening the valve on the discharge port 14, the stirred liquid medicine can be discharged from the discharge port 14. The remaining amount of the liquid medicine in the mixing tank 2 can be observed through the observation window 18, which is convenient for adjustment. In addition, the exhaust pipe 15 on the upper side of the mixing tank 2 can also balance the atmospheric pressure inside and outside the mixing tank 2 during liquid discharge, which is beneficial to liquid discharge. The disinfection cotton 16 in the exhaust pipe 15 can also filter and disinfect the air entering the mixing tank 2.

[0033] The content not described in detail in this specification belongs to the prior art well-known to those skilled in the art. The standard parts used in the present invention can all be purchased from the market. The special-shaped parts can be customized according to the description in the specification and the drawings. The specific connection methods of each part all adopt conventional means such as bolts, rivets, and welding in the prior art. The machines, parts, and equipment all adopt conventional models in the prior art, and the circuit connection adopts the conventional connection method in the prior art, which will not be elaborated here.

[0034] Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A temperature-adjustable stirring device for nadroparin calcium injection, comprising: Bottom plate (1); It is characterized by further comprising: A stirring box (2), wherein a stirring mechanism is arranged inside the stirring box (2), wherein the stirring mechanism comprises a motor (3), a stirring shaft (4) and a stirring blade (5), the stirring box (2) is fixedly mounted on the upper right side of the bottom plate (1), and the motor (3) is fixedly mounted on the upper side of the stirring box (2); A temperature regulating mechanism is arranged on the upper side of the base plate (1), wherein the temperature regulating mechanism comprises an inlet (7), a constant temperature regulating device (8) and a return pipe (9); the constant temperature regulating device (8) is arranged on the upper left side of the base plate (1), and the constant temperature regulating device (8) is fixedly connected to the lower end of the inlet (7).

2. The temperature-adjustable stirring device for nadroparin calcium injection according to claim 1, characterized in that: The output shaft of the motor (3) is fixedly connected to the stirring shaft (4), and stirring blades (5) are arranged on the side of the stirring shaft (4), and the stirring blades (5) are distributed in an array.

3. The temperature-adjustable stirring device for nadroparin calcium injection according to claim 1, characterized in that: A circulation pipe (6) is provided inside the mixing box (2), and the upper left side of the circulation pipe (6) is fixedly connected to the upper end of the inlet (7), and the lower left side of the circulation pipe (6) is fixedly connected to one end of the return pipe (9), and the other end of the return pipe (9) is fixedly connected to the constant temperature adjustment device (8).

4. The temperature-adjustable stirring device for nadroparin calcium injection according to claim 1, characterized in that: An electric telescopic rod (10) is fixedly connected to the upper inner side of the mixing box (2), and the electric telescopic rod (10) is symmetrical about the vertical center axis of the mixing box (2). The lower side of the electric telescopic rod (10) is fixedly connected to a connecting ring (11), and a scraper (12) is arranged on the outer side of the connecting ring (11).

5. The temperature-adjustable stirring device for nadroparin calcium injection according to claim 4, characterized in that: A feeding port (13) is provided on the upper right side of the mixing box (2), a discharging port (14) is provided on the lower side of the mixing box (2), an exhaust pipe (15) is provided on the upper left side of the mixing box (2), and sterilizing cotton (16) is provided inside the exhaust pipe (15).

6. The temperature-adjustable stirring device for nadroparin calcium injection according to claim 5, characterized in that: A thermometer (17) is arranged on the right side of the side wall of the mixing box (2), and an observation window (18) is arranged on the front side of the mixing box (2).

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