Universal immunohistochemical pen
By designing a universal immunohistochemistry pen with double pen tips, the problem of fixed pen tip specifications in the existing technology cannot be quickly switched, and flexible adaptation to experimental scenarios and saving pen fluids are achieved, and scientific research work efficiency is improved.
Patent Information
- Application Number
- CN202422051956.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-23
- Publication Date
- 2025-06-20
- Estimated Expiration
- 2034-08-23
AI Technical Summary
The nib specifications of the existing immunohistochemical pens are fixed and cannot be replaced quickly as needed, making it more troublesome to use.
A universal immunohistochemical pen is designed, with a double pen tip structure, including two pen tips of different specifications. By integrating into one pen stick, it can be quickly switched to use as needed. At the same time, the sealing ball and spring mechanism is adopted to automatically seal the runner when the pen tip is not used, reducing the waste of pen liquid evaporation.
It has achieved flexible adaptation to different experimental scenarios and sample types, reducing the hassle of scientific researchers to frequently change pen tools, improving work efficiency, and reducing the waste of pen fluid.
Smart Images
Figure CN223002916U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of immunohistochemistry pens, in particular to a universal immunohistochemistry pen. Background Technique
[0002] RNA in-situ hybridization is a hybridization method that provides information on the spatial expression of RNA in tissue cells. Its basic principle is that, due to the complementary base sequences between single strands of nucleic acid molecules, a radioactive or non-radioactive exogenous nucleic acid (i.e., a probe) is paired with the RNA to be detected on tissues, cells, or chromosomes in a complementary manner, forming a specific nucleic acid hybridization molecule. Through certain detection means, the position of the RNA to be detected on tissues, cells, or chromosomes is displayed.
[0003] When performing RNA in-situ hybridization, using an immunohistochemistry pen to seal the edges of the glass slide is a crucial step. This helps to avoid unnecessary diffusion and spillage of reagents, thereby reducing the consumption of reagents and effectively lowering the experimental cost. When using an immunohistochemistry pen, drawing a circle around the tissue on the glass slide can achieve the purpose of edge sealing.
[0004] However, when using such immunohistochemistry pens in the prior art, various nib specifications are required. For example, the conventional size: a 4-mm tip, which can draw a relatively wide waterproof circle. They are suitable for staining tissues or cells with a relatively large area and can ensure an adequate liquid capacity. Miniature size: Compared with the conventional size, the immunohistochemistry pen with a miniature size has a finer nib, such as a 2.5-mm tip. This pen is suitable for experiments that require precise control of the staining area, such as staining of tiny tissues or cells. The pen with a miniature size usually has higher precision and flexibility. However, in the prior art, the nib specifications of each immunohistochemistry pen are fixed and cannot be quickly swapped according to needs, so it is rather troublesome to use. Therefore, a universal immunohistochemistry pen is needed to improve this problem. Content of the Utility Model
[0005] The purpose of the utility model is to provide a universal immunohistochemistry pen to solve the problems raised in the above background technique.
[0006] To achieve the above object, the present utility model provides the following technical solution: A general-purpose immunohistochemical pen, comprising a pen barrel, wherein painting and calligraphy mechanisms for drawing waterproof circles are arranged at both ends of the pen barrel. The painting and calligraphy mechanisms include a first connector, a connecting ring, a second connector, a first flow channel, a second flow channel, a first pen tip, and a second pen tip. A first connector is arranged at one end of the pen barrel, a connecting ring is fixedly arranged on the outer surface of the first connector, the connecting ring is rotatably and threadedly engaged inside the pen barrel, a second connector is fixedly arranged at the end of the pen barrel away from the first connector, a first flow channel is opened inside the first connector, a second flow channel is opened inside the second connector, a first pen tip is movably clamped inside the first flow channel, a second pen tip is movably clamped inside the second flow channel, and a sealing mechanism is arranged between the pen barrel and the first connector and the second connector.
[0007] Preferably, the sealing mechanism includes a cavity, a narrow opening, a sealing ball, and a spring. Cavities are arranged inside both the first connecting joint and the second connecting joint. A narrow opening is arranged on one side inside the cavity, a sealing ball is movably clamped inside the narrow opening, and a spring is arranged on one side of the sealing ball inside the cavity; through the sealing mechanism, the first flow channel or the second flow channel can be automatically sealed when the first pen tip or the second pen tip is not in use, so as to reduce unnecessary evaporation and waste of pen liquid.
[0008] Preferably, connecting rods are fixedly arranged between the first pen tip, the second pen tip, and the sealing ball. Through the connecting rods, the first pen tip, the second pen tip, and the sealing ball can be connected together. In this way, when pressing the first pen tip or the second pen tip, the sealing ball can be linked, so that a gap is generated between the sealing ball and the narrow opening to allow the pen liquid to flow out.
[0009] Preferably, the pen barrel is made of transparent plastic material. Through the transparent plastic pen barrel, it can be clearly seen how much pen liquid is left inside.
[0010] Preferably, pen caps are movably clamped on the outer surface of the pen barrel on the outer sides of the first connector and the second connector. The pen caps can play a role in protecting the first connector and the second connector.
[0011] Preferably, a label is arranged on the outer surface of the pen cap. Through this label, it can be indicated what type of pen tip is at the lower end of this pen cap.
[0012] Compared with the prior art, the beneficial effects of the present utility model are:
[0013] The utility model designs a double-tip immunohistochemistry pen, aiming to meet the needs of different experimental scenarios and sample types by integrating two different specifications of tips. This can not only improve the flexibility of the experiment, but also reduce the trouble of researchers frequently replacing pen tools and improve work efficiency; when a certain type of tip is needed, that type of tip is made to face downwards.
[0014] When the first tip or the second tip is not in use, the utility model can automatically seal the first flow channel or the second flow channel through a spring and a sealing ball to reduce unnecessary evaporation and waste of pen liquid. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 is a schematic diagram of the overall structure of a general-purpose immunohistochemistry pen of the utility model;
[0016] Figure 2 is an installation view of the pen cap in a general-purpose immunohistochemistry pen of the utility model;
[0017] Figure 3 is a cross-sectional view of a general-purpose immunohistochemistry pen of the utility model;
[0018] Figure 4 is a front view of a general-purpose immunohistochemistry pen of the utility model Figure 3 of the utility model.
[0019] In the figure: 1. pen barrel; 2. first connector; 3. connecting ring; 4. second connector; 5. first flow channel; 6. second flow channel; 7. first tip; 8. second tip; 9. cavity; 10. narrow opening; 11. sealing ball; 12. spring; 13. connecting rod; 14. pen cap. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0020] The following will clearly and completely describe the technical solutions in the embodiments of the utility model with reference to the accompanying drawings in the embodiments of the utility model. Obviously, the described embodiments are only a part of the embodiments of the utility model, rather than all the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the utility model.
[0021] Please refer to Figures 1-4, the present utility model provides a technical solution: a general-purpose immunohistochemical pen, including a pen barrel 1. Both ends of the pen barrel 1 are provided with painting and calligraphy mechanisms for drawing waterproof circles. The painting and calligraphy mechanisms include a first connector 2, a connecting ring 3, a second connector 4, a first flow channel 5, a second flow channel 6, a first pen tip 7, and a second pen tip 8. A first connector 2 is provided at one end of the pen barrel 1. A connecting ring 3 is fixedly provided on the outer surface of the first connector 2. The connecting ring 3 is rotatably and threadedly engaged inside the pen barrel 1. A second connector 4 is fixedly provided at the end of the pen barrel 1 away from the first connector 2. A first flow channel 5 is opened inside the first connector 2. A second flow channel 6 is opened inside the second connector 4. A first pen tip 7 is movably engaged inside the first flow channel 5. A second pen tip 8 is movably engaged inside the second flow channel 6. A sealing mechanism is provided between the pen barrel 1 and the first connector 2 and the second connector 4.
[0022] The sealing mechanism includes a cavity 9, a narrow opening 10, a sealing ball 11, and a spring 12. Cavities 9 are provided inside both the first connecting joint and the second connecting joint. A narrow opening 10 is provided on one side inside the cavity 9. A sealing ball 11 is movably engaged inside the narrow opening 10. A spring 12 is provided on one side of the sealing ball 11 inside the cavity 9. When the first pen tip 7 or the second pen tip 8 is not in use, the first flow channel 5 or the second flow channel 6 can be automatically sealed through the sealing mechanism to reduce unnecessary evaporation and waste of pen liquid.
[0023] Connecting rods 13 are fixedly provided between the first pen tip 7, the second pen tip 8, and the sealing ball 11. Through the connecting rods 13, the first pen tip 7, the second pen tip 8, and the sealing ball 11 can be connected together. In this way, when the first pen tip 7 or the second pen tip 8 is pressed, the sealing ball 11 can be linked, so that a gap is generated between the sealing ball 11 and the narrow opening 10 to allow the pen liquid to flow out.
[0024] The pen barrel 1 is made of transparent plastic material. Through the transparent plastic pen barrel 1, it can be clearly seen how much pen liquid is left inside.
[0025] Pen caps 14 are movably engaged on the outer surface of the pen barrel 1 on the outside of both the first connector 2 and the second connector 4. The pen caps 14 can play a role in protecting the first connector 2 and the second connector 4.
[0026] Labels are provided on the outer surface of the pen caps 14. Through these labels, it can be indicated what type of pen tip is at the lower end of the pen caps 14.
[0027] Working principle: When using this device, a dual-tip immunohistochemistry pen is designed. It aims to meet the needs of different experimental scenarios and sample types by integrating two different specifications of pen tips. This can not only improve the flexibility of the experiment, but also reduce the trouble for researchers to frequently replace pen tools, enhance work efficiency, and improve the versatility of the device. When a certain type of pen tip is needed, that type of pen tip is made to face downwards. At this time, under the action of gravity, all the pen liquid will gather on this side. Subsequently, the staff gently presses the first pen tip 7 or the second pen tip 8. At this time, the sealing ball 11 can be squeezed, causing the sealing ball 11 to move up a certain distance to make the narrow opening 10 conduct. Then the pen liquid can flow into the first flow channel 5 or the second flow channel 6 and contact the first pen tip 7 and the second pen tip 8. Subsequently, the first pen tip 7 and the second pen tip 8 quickly absorb the pen liquid and can start working. Moreover, when the first pen tip 7 or the second pen tip 8 is not in use, this device can automatically seal the first flow channel 5 or the second flow channel 6 through the spring 12 and the sealing ball 11 to reduce unnecessary evaporation and waste of pen liquid.
[0028] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device.
[0029] Although the embodiments of the present utility model have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.
Claims
1. A universal immunohistochemistry pen, comprising a pen holder (1), characterized in that: Both ends of the pen holder (1) are provided with a calligraphy and painting mechanism for drawing a waterproof ring. The calligraphy and painting mechanism comprises a first connector (2), a connecting ring (3), a second connector (4), a first flow channel (5), a second flow channel (6), a first pen tip (7), and a second pen tip (8). The first connector (2) is provided at one end of the pen holder (1). A connecting ring (3) is fixedly provided on the outer surface of the first connector (2). The connecting ring (3) is movably screwed into the inside of the pen holder (1) through a thread. The second connector (4) is fixedly provided at one end of the pen holder (1) away from the first connector (2). A first flow channel (5) is provided inside the first connector (2). A second flow channel (6) is provided inside the second connector (4). A first pen tip (7) is movably engaged inside the first flow channel (5). A second pen tip (8) is movably engaged inside the second flow channel (6). A sealing mechanism is provided between the pen holder (1) and the first connector (2) and the second connector (4).
2. A universal immunohistochemistry pen according to claim 1, characterized in that: The sealing mechanism comprises a cavity (9), a narrow opening (10), a sealing ball (11), and a spring (12); the first connector and the second connector are both provided with a cavity (9); a narrow opening (10) is provided on one side of the cavity (9); a sealing ball (11) is movably engaged with the narrow opening (10); and a spring (12) is provided on one side of the sealing ball (11) in the cavity (9).
3. A universal immunohistochemistry pen according to claim 2, characterized in that: A connecting rod (13) is fixedly arranged between the first pen tip (7), the second pen tip (8) and the sealing ball (11).
4. A universal immunohistochemistry pen according to claim 1, characterized in that: The pen holder (1) is made of transparent plastic material.
5. A universal immunohistochemistry pen according to claim 1, characterized in that: The outer surface of the pen shaft (1) is provided with a pen cap (14) movably engaged with the outer sides of the first connecting head (2) and the second connecting head (4).
6. A universal immunohistochemistry pen according to claim 5, characterized in that: The outer surface of the pen cover (14) is provided with a label.