Multifunctional portable liquid biopsy sample collection box

Abstract

The utility model discloses a multifunctional portable liquid biopsy sample collection box which comprises a box body, a lifting handle, an inner cover, a middle cover and an outer cover, the inner cover, the middle cover and the outer cover are all provided with groove structures, fixing devices are arranged in the groove structures, the rear end of the outer cover is hinged to the box body through hinges, and the front end of the outer cover is connected with the box body through groove buckles. Movable rods are connected to the two sides of the middle cover and hinged to the inner wall of the box body, a first temperature control chamber and a second temperature control chamber which are independent are arranged in the box body, the first temperature control chamber is provided with a first inner frame and a first outer frame, and the second temperature control chamber is provided with a second inner frame, a middle frame and a second outer frame; the first inner cover is in mortise and tenon connection with the first inner frame, the second inner cover is in mortise and tenon connection with the middle frame, each corner of the first inner frame and the bottom of the first outer frame corresponding to each corner of the first inner frame are connected with a group of magnetic shockproof devices, and each corner of the middle frame and the bottom of the second outer frame corresponding to each corner of the middle frame are connected with a group of magnetic shockproof devices.

Description

Technical Field

[0001] The utility model relates to the field of liquid biopsy sample collection and refrigeration devices, in particular to a multifunctional portable liquid biopsy sample collection box. Background Art

[0002] With the development of precision medicine technology, liquid biopsy is becoming increasingly frequent. Liquid biopsy, which is a concept relative to tissue biopsy, refers to an in vitro diagnostic technology that obtains tumor bioinformatics using body fluids as detection materials. The specimens applicable to liquid biopsy include: blood, urine, feces, cerebrospinal fluid, saliva, pleural and abdominal pelvic effusions, etc. The detection objects of liquid biopsy are free nucleic acids, circulating tumor cells, extracellular vesicles, platelets, etc. in the specimens. These detection objects are very sensitive to environmental temperature, and vesicles, cells, platelets, etc. are easily damaged and lose their integrity and activity due to external vibration. It can be seen that the quality of liquid biopsy samples is greatly affected by temperature changes and vibration during transportation. Therefore, controlling temperature and preventing vibration during transportation are important links to ensure the stability of liquid biopsy samples. Currently, liquid biopsy samples are usually collected in different places, and the biological sample transportation boxes used for liquid biopsy transportation do not consider the particularity of the nature of liquid biopsy samples. The temperature control system is single, the refrigeration partition is fuzzy, and there is rarely an anti-vibration and buffering effect, which seriously affects the sample quality and reduces the accuracy of detection. When storing different liquid biopsy samples, more transportation equipment is required, and the carrying is cumbersome and complex. It is worth noting that there is currently no dedicated liquid biopsy collection equipment. When going out to perform collection tasks, it is very cumbersome for the collection personnel to prepare items, which not only delays time but also easily leads to situations such as missing, mis-taking, and mess of the items required for liquid biopsy collection, resulting in delays in collection time and delays in test results. Therefore, there is an urgent need for a collection box that is suitable for liquid biopsy samples and can integrate the functions of collection, storage, and transportation. Summary of the Utility Model

[0003] To overcome the deficiencies of the above-mentioned prior art, the purpose of the present utility model is to provide a multifunctional portable liquid biopsy sample collection box, which adopts a mortise and tenon type multi-control greenhouse integration, sets two adjustable control greenhouses with different temperatures to meet the needs of low-temperature, ultra-low-temperature and normal-temperature storage and sealing, and uses the principle of magnetic levitation to set multiple groups of magnetic force anti-vibration devices in the control greenhouse to achieve a buffering and anti-vibration effect.

[0004] To achieve the above purpose, the present utility model provides a multifunctional portable liquid biopsy sample collection box, including:

[0005] A box body, carrying handles connected to both sides of the box body, and an inner cover, a middle cover, and an outer cover connected to the box body. Groove structures are provided on the inner cover, the middle cover, and the outer cover, and fixing devices are connected inside the groove structures for fixing liquid biopsy collection tools. The rear end of the outer cover is hinged to the box body through a hinge, and the front end of the outer cover is connected to the box body through a groove buckle. Activity rods are connected to both sides of the middle cover, and the activity rods are hinged to the inner wall of the box body. Two independent temperature control chambers are provided inside the box body, namely a first temperature control chamber and a second temperature control chamber. The first temperature control chamber is provided with a first inner frame and a first outer frame, and the second temperature control chamber is provided with a second inner frame, a middle frame, and a second outer frame. The inner cover includes a first inner cover and a second inner cover. The first inner cover is connected to the first inner frame in a mortise and tenon manner, and the second inner cover is connected to the middle frame in a mortise and tenon manner. A set of magnetic shockproof devices are connected to the bottom of the first outer frame at the corresponding positions of each corner of the four corners of the first inner frame and the bottom of the first outer frame at the corresponding positions of each corner of the four corners of the first inner frame. A set of the magnetic shockproof devices are connected to the bottom of the second outer frame at the corresponding positions of each corner of the four corners of the middle frame and the bottom of the second outer frame at the corresponding positions of each corner of the four corners of the middle frame.

[0006] Further, each set of the magnetic shockproof devices includes a pair of mutually repulsive first magnetic elements and second magnetic elements. The first magnetic elements are embedded in the four corners of the first inner frame and the four corners of the middle frame, and the second magnetic elements are connected to the bottom of the first outer frame at the corresponding positions of the first magnetic elements and the bottom of the second outer frame at the corresponding positions of the first magnetic elements.

[0007] Further, the first magnetic element includes a non-ferrite hollow column, and a first hollow concentric circle magnetic element nested inside the non-ferrite hollow column. The second magnetic element includes a non-ferrite solid column, and a second hollow concentric circle magnetic element nested outside the non-ferrite solid column. The first hollow concentric circle magnetic element is fixedly connected to the bottom of the non-ferrite hollow column, and the second hollow concentric circle magnetic element is fixedly connected to the bottom of the non-ferrite solid column. The first hollow concentric circle magnetic element and the second hollow concentric circle magnetic element are homopolar concentric circle magnets with the same diameter. The non-ferrite hollow column sleeves the non-ferrite solid column, so that the non-ferrite solid column swings up and down under the influence of the repulsive magnetic force between the first hollow concentric circle magnetic element and the second hollow concentric circle magnetic element in the non-ferrite hollow column, forming a buffer shockproof space.

[0008] Further, one side of the first inner cover facing the box body has two protruding structures, and a first concave structure is formed between the two protruding structures. The first concave structure fits with the first inner frame. One side of the second inner cover facing the box body has two protruding structures, and a second concave structure is formed between the two protruding structures. The second concave structure fits with the middle frame. The size of the first inner cover is larger than that of the first inner frame and smaller than that of the first outer frame. The size of the second inner cover is larger than that of the middle frame and smaller than that of the second outer frame.

[0009] Further, the heights of the non-ferritic solid columns and the non-ferritic hollow columns in the first temperature control chamber both account for one-half of the height of the first inner frame. The heights of the non-ferritic solid columns and the non-ferritic hollow columns in the second temperature control chamber both account for one-half of the height of the middle frame.

[0010] Further, the first inner frame is a heat-insulating frame, the first outer frame is a heat-insulating frame, a first temperature detection device is connected to the inner wall of the first inner frame, a first temperature display device is connected to the outer wall of the first outer frame, the first temperature detection device is connected to the first temperature display device, and the middle gap of the first inner frame is used to place samples. When a refrigerant is placed in the gap between the first inner frame and the first outer frame, the first temperature control chamber is a low-temperature chamber. When no refrigerant is placed in the gap between the first inner frame and the first outer frame, the first temperature control chamber is a normal-temperature storage chamber.

[0011] Further, the second inner frame is a heat-conducting frame, the middle frame is a heat-insulating frame, the second outer frame is a heat-insulating frame, a second temperature detection device is connected to the inner wall of the second inner frame, a second temperature display device is connected to the outer wall of the second inner frame, the second temperature detection device is connected to the second temperature display device, and the middle gap of the second inner frame is used to place samples. When a refrigerant is placed in the gap between the second inner frame and the middle frame, the second temperature control chamber is an ultra-low temperature chamber. When no refrigerant is placed in the gap between the second inner frame and the middle frame, the second temperature control chamber is a normal-temperature storage chamber.

[0012] Further, the second inner cover is connected with an automatic pressure relief valve. The automatic pressure relief valve is arranged above the gap between the second inner frame and the middle frame, and an isolation ring is arranged around the automatic pressure relief valve.

[0013] Further, a heat-insulating board is connected between the first outer frame and the second outer frame, and shock-proof sampling tube racks are arranged in the middle gaps of the first inner frame and the second inner frame.

[0014] Further, there are two carrying handles, and both ends of the two carrying handles are connected to two-thirds of the middle line outside the two sides of the box body where there are no hinges and groove buckles.

[0015] Compared with the prior art, an embodiment disclosed by the present utility model has the following beneficial effects:

[0016] In view of the actual situation of off-site collection, the present utility model solves the timeliness problem of liquid biopsy samples, makes the collection process portable, fast and standardized, realizes the integration of the entire process of collection, storage and transportation, and can also ensure smooth sample collection, convenient transportation and safety protection;

[0017] By setting different temperature control zones with mortise and tenon structures, the concave and convex parts of the components are cleverly connected, enhancing the airtightness of the storage space to meet the storage temperature conditions of different liquid biopsy samples, making the temperature control effect better, solving the problem that the storage temperature of the current transfer box is only applicable to conventional biological samples, and ensuring the quality of liquid biopsy samples;

[0018] The present utility model designs a "magnetic spring" using the "magnetic levitation" principle and combines it with a shock-proof sampling test tube rack with buffering performance. Through the combination of internal and external, and the combined action of up and down, left and right, the samples can achieve a three-dimensional surrounding and stereoscopic anti-seismic and anti-collision effect in the space they are in, which is a significant improvement compared to the current two-dimensional anti-seismic or anti-sloshing devices. The "magnetic spring" is safer and more durable than ordinary springs; at the same time, the design of the magnetic spring is economical and practical, and the production materials are easy to obtain. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 is a schematic diagram of the overall structure of the liquid biopsy sample collection box disclosed by the embodiment of the present utility model;

[0020] Figure 2 is a top view of the open state of the liquid biopsy sample collection box disclosed by the embodiment of the present utility model;

[0021] Figure 3 is a schematic diagram of the mortise and tenon connection disclosed by the embodiment of the present utility model;

[0022] Figure 4 is a schematic diagram of the structure of the magnetic shock-proof device in the first temperature control chamber disclosed by the embodiment of the present utility model;

[0023] Figure 5 is a schematic diagram of the setting position of the first magnetic element in the first temperature control chamber disclosed by the embodiment;

[0024] Figure 6 is a schematic diagram of the setting position of the second magnetic element in the first temperature control chamber disclosed by the embodiment;

[0025] Figure 7 is a partial view of a group of magnetic shock-proof devices disassembled disclosed by the embodiment of the present utility model;

[0026] Figure 8Schematic diagram of the nested state of a set of magnetic shockproof devices disclosed in the embodiments of the present utility model;

[0027] Figure 9 Top view of the shockproof sampling tube rack disclosed in the embodiments of the present utility model;

[0028] Figure 10 Cross-sectional view of the U-shaped card slot disclosed in the embodiments of the present utility model;

[0029] Figure 11 Cross-sectional view of the elastic band and lug structure disclosed in the embodiments of the present utility model.

[0030] In the figure: 1 - box body; 11 - first temperature control chamber; 111 - first inner frame; 113 - first outer frame; 12 - second temperature control chamber; 121 - second inner frame; 122 - middle frame; 123 - second outer frame; 2 - inner cover; 21 - first inner cover; 22 - second inner cover; 3 - middle cover; 31 - movable rod; 4 - outer cover; 41 - hinge; 42 - groove buckle; 5 - handle; 6 - magnetic shockproof device; 61 - first magnetic element; 611 - non-ferrite hollow column; 612 - first hollow concentric magnetic element; 62 - second magnetic element; 621 - non-ferrite solid column; 622 - second hollow concentric magnetic element; 7 - shockproof sampling tube rack. Specific embodiments

[0031] The following uses specific specific examples and combines with the accompanying drawings to illustrate the embodiments of the present utility model. Those skilled in the art can easily understand other advantages and effects of the present utility model from the content disclosed in this specification. The present utility model can also be implemented or applied through other different specific examples, and various details in this specification can also be modified and changed based on different viewpoints and applications without departing from the spirit of the present utility model.

[0032] As Figures 1-3 shown, a multifunctional portable liquid biopsy sample collection box disclosed by the present utility model includes:

[0033] The box body 1, the handle 5 connected to both sides of the box body 1, and the inner cover 2, the middle cover 3 and the outer cover 4 connected to the box body 1. The inner cover 2, the middle cover 3 and the outer cover 4 are all groove structures, and a fixing device is connected inside the groove structure for fixing liquid biopsy collection tools. The rear end of the outer cover 4 is hinged to the box body 1 through a hinge 41, and the front end of the outer cover 4 is connected to the box body 1 through a groove buckle 42. Both sides of the middle cover 3 are connected with movable rods 31, and the movable rods 31 are hinged to the inner wall of the box body 1. After the outer cover 4 is opened, the middle cover 3 is pushed backward to open the inner cover 2. There are two independent liquid biopsy sample temperature control storage rooms inside the box body 1, namely the first temperature control room 11 and the second temperature control room 12. The first temperature control room 11 is provided with a first inner frame 111 and a first outer frame 113, and the second temperature control room 12 is provided with a second inner frame 121, a middle frame 122 and a second outer frame 123. The inner cover 2 includes two independent and freely openable movable inner covers, namely the first inner cover 21 and the second inner cover 22. The first inner cover 21 is connected to the first inner frame 111 in a mortise and tenon manner so that the first inner cover 21 fits with the first inner frame 111, and the second inner cover 22 is connected to the middle frame 122 in a mortise and tenon manner so that the second inner cover 22 fits with the middle frame 122. A set of magnetic shockproof devices 6 are connected to the bottom of each corner of the four corners of the first inner frame 111 and the bottom of the first outer frame 113 at the corresponding positions of each corner of the four corners of the first inner frame 111. A set of the magnetic shockproof devices 6 are connected to the bottom of each corner of the four corners of the middle frame 122 and the bottom of the second outer frame 123 at the corresponding positions of each corner of the four corners of the middle frame 122.

[0034] Specifically, the structure of the collection box includes the box body 1, the inner cover 2, the middle cover 3 and the outer cover 4. There are two rectangular handles 5 at both ends of the box body 1. According to the collection process and detection requirements of liquid biopsy samples, a process partition design is carried out on the structure of the collection box for sequential collection. This collection box can be divided into a collection function area, a storage function area and a transportation function area, including:

[0035] Sampling functional area: The inner cover 2, middle cover 3, and outer cover 4 all have groove structures. Inside the groove structures, there are fixing devices for fixing liquid biopsy utensils, etc. The liquid biopsy utensils include special sampling utensils for liquid biopsy, general sampling utensils for liquid biopsy, and preparatory utensils for liquid biopsy before sampling. Specifically, the surface of the inner cover 2 is a groove structure, in which a number of elastic card slots arranged horizontally are provided. Different specifications and shapes of clean utensils such as special sampling syringes for liquid biopsy can be fixed in the card slots; the folded middle cover 3 is also a groove structure, similar to a tray, with partitioned areas, and utensils can be placed according to their uses, such as: general utensils such as disinfection utensils, collectors (blood collection tubes, stool tubes, body fluid tubes, etc.). There are also card slots in the grooves on the inner wall of the outer cover, arranged horizontally, which can hold the preparatory utensils for liquid biopsy before sampling; among them, both sides of the middle cover 3 are connected with movable rods 31, which can rotate backward by 180 degrees. Preferably, two movable rods 31 are connected to one side, and the movable rods 31 are hinged to the inner wall of the box body 1. It should be noted that the fixing devices provided on the inner cover 2, middle cover 3, and outer cover 4 can be any existing structures for fixing the above-mentioned utensils, and are not limited herein.

[0036] In a preferred embodiment of the present utility model, the fixing device in the groove structure of the inner cover 2, middle cover 3, or outer cover 4 includes, but is not limited to, a U-shaped card slot. Refer to Figure 10 , Figure 10 is a cross-sectional view of the U-shaped card slot provided in the middle cover 3. The U-shaped card slot includes two types, a large one and a small one. The large U-shaped card slot can be used to fix test tubes, etc., and the small U-shaped card slot can be used to fix puncture needles, etc. It should be noted that the present utility model does not limit the number, position, size, etc. of the U-shaped card slots.

[0037] In a preferred embodiment of the present utility model, the fixing device in the groove structure of the inner cover 2, middle cover 3, or outer cover 4 includes, but is not limited to, an elastic band and a lug structure. Refer to Figure 11 , Figure 11 is a cross-sectional view of the elastic band and lug structure provided in the outer cover 4. The lugs are fixedly connected in the groove structure. By connecting an elastic band between two circular lugs, it can be used to fix sampling utensils of different sizes and shapes. It should be noted that the present utility model does not limit the number, position, size, etc. of the elastic band and lug structure.

[0038] Storage functional area: According to the storage temperature requirements of the detection objects of liquid biopsy, the collected samples are selectively placed in different temperature-controlled chambers in the storage area. Specifically, the storage functional area is divided into two areas, which are respectively combined with two independently freely openable and closable movable inner covers 2 to make the two areas into relatively airtight temperature-controlled chambers, including a first temperature-controlled chamber 11 and a second temperature-controlled chamber 12. The first temperature-controlled chamber 11 is provided with a first inner frame 111 and a first outer frame 113. The second temperature-controlled chamber 12 is provided with a second inner frame 121, a middle frame 122 and a second outer frame 123. The inner cover 2 includes a first inner cover 21 and a second inner cover 22. The first inner cover 21 is connected to the first inner frame 111 in a mortise and tenon manner, and the second inner cover 22 is connected to the middle frame 122 in a mortise and tenon manner. Further, one side of the first inner cover 21 facing the box body has two protruding structures, and a first concave structure is formed between the two protruding structures. The first concave structure fits with the first inner frame 111. Similarly, one side of the second inner cover 22 facing the box body has two protruding structures, and a second concave structure is formed between the two protruding structures. The second concave structure fits with the middle frame 122; Refer to Figure 3 , for highlighting, Figure 3 The protruding structure parts of the first inner cover 21 and the second inner cover 22, the first inner frame 111 and the middle frame 122 are all represented by shadows. The depression between the two square protruding structures of different sizes of the first inner cover 21 (that is, between the two shaded parts of the first inner cover) fits with the first inner frame 111. Similarly, the depression between the two square protruding structures of different sizes of the second inner cover 22 (that is, between the two shaded parts of the second inner cover) fits with the middle frame 122, realizing a relatively sealed space for the two temperature-controlled chambers.

[0039] Further, the size of the first inner cover 21 is larger than the size of the first inner frame 111 and smaller than the size of the first outer frame 113. The size of the second inner cover 22 is larger than the size of the middle frame 122 and smaller than the size of the second outer frame, so that the edge of the first inner cover 21 is located between the first inner frame 111 and the first outer frame 113, and the edge of the second inner cover 22 is located between the middle frame 122 and the second outer frame 123, which is convenient for opening.

[0040] Further, an insulating board is connected between the first outer frame 113 and the second outer frame 123, that is, the first temperature-controlled chamber 11 and the second temperature-controlled chamber 12 are separated by the insulating board.

[0041] Further, the storage area is mainly for refrigeration function and can also have the function of normal temperature preservation. Specifically:

[0042] When stored in a refrigerated environment, the first temperature control chamber 11 is a low-temperature chamber. The first inner frame 111 is a heat-insulating frame, and the first outer frame 113 is a heat-insulating frame. A low-strength refrigerant, preferably ice cubes, is placed in the gap between the first inner frame 111 and the first outer frame 113. A sample is placed in the middle gap of the first inner frame 111. The first inner frame 111 and the first inner cover 21 are connected by mortise and tenon joints to form a relatively airtight space. The second temperature control chamber 11 is an ultra-low temperature chamber. The second inner frame 121 is a heat-conducting frame, the middle frame 122 is a heat-insulating frame, and the second outer frame 123 is a heat-insulating frame. A forced refrigerant, preferably dry ice, is placed in the gap between the second inner frame 121 and the middle frame 122. A sample is placed in the middle gap of the second inner frame 121. The second inner cover 22 and the middle frame 122 are connected by mortise and tenon joints to form a relatively airtight space.

[0043] When stored at room temperature, both the first temperature control chamber 11 and the second temperature control chamber 11 can be used as room temperature storage chambers. In the first temperature control chamber 11, no low-strength refrigerant is placed in the gap between the first inner frame 111 and the first outer frame 113. In the second temperature control chamber 12, no forced refrigerant is placed in the gap between the second inner frame 121 and the middle frame 122.

[0044] Furthermore, the storage functional area has a temperature control function. In the first temperature control chamber 11, a first temperature detection device (not marked in the attached drawing) is connected to the inner wall of the first inner frame 111, and a first temperature display device (not marked in the attached drawing) is connected to the outer wall of the first outer frame 113. The first temperature detection device is connected to the first temperature display device. In the second temperature control chamber 12, a second temperature detection device (not marked in the attached drawing) is connected to the inner wall of the second inner frame 121, and a second temperature display device (not marked in the attached drawing) is connected to the outer wall of the second inner frame 121. The second temperature detection device is connected to the second temperature display device. Through the above temperature control structure settings, the real-time temperature of the specimen placement area can be dynamically reflected.

[0045] Furthermore, an automatic pressure relief valve (not marked in the attached drawing) is connected to the groove structure of the second inner cover 22. The automatic pressure relief valve is arranged above the gap between the second inner frame 121 and the middle frame 122. An isolation ring (not marked in the attached drawing) is arranged around the automatic pressure relief valve. The isolation ring is cylindrical and hollow inside for placing the automatic pressure relief valve. Its height is not limited, but it should ensure that the middle cover can be normally closed. Specifically, when the second temperature control chamber is an ultra-low temperature chamber, dry ice is placed in the gap between the second inner frame 121 and the middle frame 122. Since dry ice will sublime into a gaseous state in the air, an automatic pressure relief valve is set to ensure safety and prevent explosion. The opening of the automatic pressure relief valve is at the corner of the inner cover groove, and an isolation ring is connected around it to prevent other items in the inner cover groove from falling in. It should be noted that the automatic pressure relief valve can be arranged at any position that meets the above description, and the present invention does not limit it.

[0046] Transportation functional area: The transportation process of liquid biopsy samples requires stability. A magnetic shock-proof device 6 is designed using the principle of magnetic levitation. In order to ensure that the overall box 1 is stable and does not shake after being carried, and does not affect the opening of the outer cover 4, two rectangular handles 5 are respectively arranged at both ends of the storage area of the box (not on the sides of the buckle and hinge of the outer cover). The rear end of the outer cover 4 of the box 1 is hinged to the box 1 through a hinge 41, and the front end of the outer cover 4 is connected to the box 1 through a groove buckle 42. The concave buckle design not only avoids scratching the carrier but also prevents the outer cover from being accidentally opened. Among them, there are eight groups of the magnetic shock-proof devices 6. Four groups of magnetic shock-proof devices 6 are respectively connected to the bottom of the first outer frame 113 at the corresponding positions of the four corners of the first inner frame 111 and the four corners of the first inner frame 111. Four groups of the magnetic shock-proof devices 6 are respectively connected to the bottom of the second outer frame 123 at the corresponding positions of the four corners of the middle frame 122 and the four corners of the middle frame 122. That is, a set of magnetic shock-proof device is provided at each corner of the first inner frame 111 and the corresponding position at the bottom of the first outer frame 113, and the positions where the middle frame 122 and the second outer frame 123 are provided with magnetic shock-proof devices are the same.

[0047] Further, referring to Figure 4 、 Figure 5 、 Figure 6 ,each set of the magnetic shock-proof devices 6 includes a pair of mutually exclusive first magnetic elements 61 and second magnetic elements 62. The first magnetic elements 61 are embedded in the four corners of the first inner frame 111 and the four corners of the middle frame 122. The second magnetic elements 62 are connected to the bottom of the first outer frame 113 at the corresponding positions of the first magnetic elements 61 and the bottom of the second outer frame 123 at the corresponding positions of the first magnetic elements 61. It should be noted that Figures 4-6 only the first temperature control room is taken as an example, and the setting of the magnetic shock-proof mechanism 6 in the second temperature control room is the same; as Figure 7 、 Figure 8As shown, the first magnetic element 61 includes a non-ferrite hollow column 611 and a first hollow concentric circular magnetic element 612 nested inside the non-ferrite hollow column 611. The second magnetic element 62 includes a non-ferrite solid column 621 and a second hollow concentric circular magnetic element 622 nested outside the non-ferrite solid column 621. The first hollow concentric circular magnetic element 612 is fixedly connected to the bottom of the non-ferrite hollow column 611. The second hollow concentric circular magnetic element 622 is fixedly connected to the bottom of the non-ferrite solid column 621 and fixedly connected to the bottom of the outer frame of the box. The first hollow concentric circular magnetic element 612 and the second hollow concentric circular magnetic element 622 are same-sex concentric circular magnets with the same diameter. The non-ferrite hollow column 611 encloses the non-ferrite solid column 621, so that the non-ferrite solid column 621 swings up and down under the influence of the repulsive magnetic force between the first hollow concentric circular magnetic element 612 and the second hollow concentric circular magnetic element 622 in the non-ferrite hollow column 611, forming a buffer and shock-proof space.

[0048] Specifically, the materials of the non-ferrite hollow column 611 and the non-ferrite solid column 621 are preferably austenitic stainless steel. The non-ferrite columns are provided to prevent the hollow concentric circular magnetic elements from attracting to the columns. The hollow column can just enclose the solid column, and at the same time allow the solid column to swing freely up and down in the hollow column, thus forming a certain buffer space, just like the effect of a "spring".

[0049] Further, the heights of the non-ferrite solid column 621 and the non-ferrite hollow column 611 in the first temperature control chamber 11 both account for one-half of the height of the first inner frame 111. The heights of the non-ferrite solid column 621 and the non-ferrite hollow column 611 in the second temperature control chamber 12 both account for one-half of the height of the middle frame 122.

[0050] Further, as Figure 9 shown, shock-proof sampling tube racks 7 made of Pu sponge material are provided in the middle gaps between the first inner frame 111 and the second inner frame 121, so that the samples stored therein achieve a three-dimensional surrounding and stereoscopic anti-seismic and anti-collision effect.

[0051] Further, there are two handles 5. Both ends of the two handles 5 are connected to two-thirds of the outer side of the middle lines of the two sides of the box body 1 that do not have the hinge 41 and the groove buckle 42, which are symmetrical to each other and can be unfolded by more than 90 degrees.

[0052] Meanwhile, to make the transfer process more convenient to carry, lightweight cryogenic heat-conducting, heat-insulating and heat-preserving materials are used to construct the box body 1, the inner cover 2, the middle cover 3 and the outer cover 4. The outer frame of the box (including the first outer frame 113 and the second outer frame 123), the outer cover 4 and the middle cover 3 are made of PE material, which has good mechanical properties, strong impact resistance and is environmentally friendly; the bottoms of the first temperature control chamber 11 and the second temperature control chamber 12, the inner wall of the middle frame 122 of the second temperature control chamber 12 and the second inner frame 121, and the inner wall of the first inner frame 111 of the first temperature control chamber 11 are made of non-ferritic stainless steel, such as austenitic stainless steel; the outer wall of the middle frame 122 of the second temperature control chamber 12, the inner side of the second inner cover 22, the outer wall of the first inner frame 111 of the first temperature control chamber 11 and the inner side of the first inner cover 21 are made of polyurethane (EPS foam), which is an ideal heat-insulating material for refrigeration and cold storage equipment. The outside of the polyurethane (EPS foam) is coated with PP material, which is resistant to heat and cold, has stable performance and does not absorb water.

[0053] In summary, the present utility model relates to a multifunctional portable liquid biopsy sample collection box. In view of the collection process and detection requirements of liquid biopsy samples, the structure of the collection box is designed with process zoning, adopting a mortise and tenon multi-temperature control chamber integration, setting two adjustable temperature control chambers with different temperatures to meet the needs of low-temperature, ultra-low-temperature and normal-temperature storage and sealing, and using the principle of magnetic levitation to set multiple groups of magnetic shock-absorbing devices in the temperature control chambers, so as to form an elastic buffer space between the inner frame and the outer frame of the first temperature control chamber, and an elastic buffer space between the middle frame and the outer frame of the second temperature control chamber, achieving a buffer and shock-absorbing effect; the inner cover, the middle cover and the outer cover of the box body are all groove structures for placing liquid biopsy tools, which is convenient for collection; the present utility model can realize the integration of the entire process of collection, storage and transfer, making the collection process portable, fast and standardized, and ensuring the temperature control requirements and shock-absorbing requirements of liquid biopsy samples during the transfer process after collection, and ensuring the integrity and activity of the samples.

[0054] The above embodiments are only illustrative of the principles and effects of the present utility model, and are not used to limit the present utility model. Any person skilled in the art can modify and change the above embodiments without departing from the spirit and scope of the present utility model. Therefore, the scope of the protection of the present utility model shall be as listed in the claims.

Claims

1. A multifunctional portable liquid biopsy sample collection box, comprising a box body (1) and handles (5) connected to two sides of the box body (1), characterized in that: The collection box also includes: An inner cover (2), a middle cover (3) and an outer cover (4) connected to the box body (1); the inner cover (2), the middle cover (3) and the outer cover (4) are all provided with a groove structure; a fixing device is connected inside the groove structure for fixing a liquid biopsy collection tool; the rear end of the outer cover (4) is hinged to the box body (1) via a hinge (41); the front end of the outer cover (4) is connected to the box body (1) via a groove buckle (42); both sides of the middle cover (3) are connected with movable rods (31); the movable rods (31) are hinged to the inner wall of the box body (1); two independent control chambers are provided inside the box body (1), namely a first control chamber (11) and a second control chamber (12); the first control chamber (11) is provided with a first inner frame (111) and a first outer frame (112); 3), the second temperature-controlled chamber (12) is provided with a second inner frame (121), a middle frame (122) and a second outer frame (123), the inner cover (2) comprises a first inner cover (21) and a second inner cover (22), the first inner cover (21) is connected to the first inner frame (111) by mortise and tenon joints, the second inner cover (22) is connected to the middle frame (122) by mortise and tenon joints, each of the four corners of the first inner frame (111) and each of the four corners of the first inner frame (111) are connected to the bottom of the first outer frame (113) at a position corresponding to each of the four corners, and each of the four corners of the middle frame (122) and each of the four corners of the middle frame (122) are connected to the bottom of the second outer frame (123) at a position corresponding to each of the four corners.

2. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: Each group of the magnetic shockproof devices (6) comprises a pair of mutually exclusive first magnetic elements (61) and second magnetic elements (62), wherein the first magnetic elements (61) are embedded in the four corners of the first inner frame (111) and the four corners of the middle frame (122), and the second magnetic elements (62) are connected to the bottom of the first outer frame (113) at a position corresponding to the first magnetic elements (61) and the bottom of the second outer frame (123) at a position corresponding to the first magnetic elements (61).

3. The multifunctional portable liquid biopsy sample collection box according to claim 2, characterized in that: The first magnetic element (61) comprises a non-ferrite hollow column (611) and a first hollow concentric magnetic element (612) nested inside the non-ferrite hollow column (611); the second magnetic element (62) comprises a non-ferrite solid column (621) and a second hollow concentric magnetic element (622) nested outside the non-ferrite solid column (621); the first hollow concentric magnetic element (612) is fixedly connected to the bottom of the non-ferrite hollow column (611), and the second hollow concentric magnetic element (622) is fixedly connected to the bottom of the non-ferrite hollow column (611). Connected to the bottom of the non-ferrite solid column (621), the first hollow concentric magnetic element (612) and the second hollow concentric magnetic element (622) are concentric magnets of the same polarity with the same diameter, and the non-ferrite hollow column (611) covers the non-ferrite solid column (621), so that the non-ferrite solid column (621) swings up and down in the non-ferrite hollow column (611) under the influence of the repulsive magnetic force of the first hollow concentric magnetic element (612) and the second hollow concentric magnetic element (622), thereby forming a buffering and shockproof space.

4. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: The first inner cover (21) has two protruding structures on one side facing the box body, a first recessed structure is formed between the two protruding structures, and the first recessed structure is matched with the first inner frame (111). The second inner cover (22) has two protruding structures on one side facing the box body, a second recessed structure is formed between the two protruding structures, and the second recessed structure is matched with the middle frame (122). The size of the first inner cover (21) is larger than the size of the first inner frame (111) and smaller than the size of the first outer frame (113), and the size of the second inner cover (22) is larger than the size of the middle frame (122) and smaller than the size of the second outer frame (123).

5. The multifunctional portable liquid biopsy sample collection box according to claim 3, characterized in that: The heights of the non-ferrite solid columns (621) and the non-ferrite hollow columns (611) in the first temperature-controlled chamber (11) are both one-half of the height of the first inner frame (111), and the heights of the non-ferrite solid columns (621) and the non-ferrite hollow columns (611) in the second temperature-controlled chamber (12) are both one-half of the height of the middle frame (122).

6. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: The first inner frame (111) is a heat preservation frame, the first outer frame (113) is a heat insulation frame, the inner wall of the first inner frame (111) is connected to a first temperature detection device, the outer wall of the first outer frame (113) is connected to a first temperature display device, the first temperature detection device is connected to the first temperature display device, the middle space of the first inner frame (111) is used to place a sample, when a refrigerant is placed in the space between the first inner frame (111) and the first outer frame (113), the first temperature control room (11) is a low temperature room, and when a refrigerant is not placed in the space between the first inner frame (111) and the first outer frame (113), the first temperature control room (11) is a normal temperature storage room.

7. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: The second inner frame (121) is a heat-conducting frame, the middle frame (122) is a heat-insulating frame, the second outer frame (123) is a heat-insulating frame, the inner wall of the second inner frame (121) is connected to a second temperature detection device, the outer wall of the second inner frame (121) is connected to a second temperature display device, the second temperature detection device is connected to the second temperature display device, the middle space of the second inner frame (121) is used to place a sample, when a refrigerant is placed in the space between the second inner frame (121) and the middle frame (122), the second control room (12) is an ultra-low temperature room, and when a refrigerant is not placed in the space between the second inner frame (121) and the middle frame (122), the second control room (12) is a normal temperature storage room.

8. The multifunctional portable liquid biopsy sample collection box according to claim 7, characterized in that: The second inner cover (22) is connected to an automatic pressure relief valve, the automatic pressure relief valve is arranged above the gap between the second inner frame (121) and the middle frame (122), and an isolation ring is arranged around the automatic pressure relief valve.

9. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: An insulation board is connected between the first outer frame (113) and the second outer frame (123), and a shockproof sampling tube rack is provided in the gap between the first inner frame (111) and the second inner frame (121).

10. The multifunctional portable liquid biopsy sample collection box according to claim 1, characterized in that: Two handles (5) are provided, and both ends of the two handles (5) are connected to two thirds of the outside of the center line of two side surfaces of the box body (1) where the hinge (41) and the groove buckle (42) are not provided.

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