Sample collection device based on intestinal microorganism detection

Abstract

The utility model provides a sample collection device based on intestinal microorganism detection, and belongs to the technical field of sample collection. The sampling cup comprises an outer cup body and a sampling assembly, a sleeve is arranged on the inner wall of the outer cup body, and a sealing rubber ring is arranged on the inner wall of the sleeve; the sampling assembly comprises a sampling barrel with two open ends, a rubber plug is arranged in the sampling barrel, and the rubber plug is slidably connected with the inner wall of the sampling barrel; one end of the rubber plug is connected with a plug shaft; the top end of the plug shaft is fixedly connected with a plug handle; the plug shaft and the rubber plug form a negative pressure suction structure; the sampling barrel can be adaptively inserted into the sleeve, and the outer wall of the sampling barrel is in sealed sliding connection with the sealing rubber ring to form a first sealing layer; the top end of the sampling barrel is sleeved with a sealing plug, and the sealing plug and the outer cup body can be adaptively sealed and inserted to form a second sealing layer; the outer wall of the top of the sampling barrel is fixedly connected with a wing plate, and the locking piece is used for realizing clamping connection between the outer cup body and the wing plate. The device is simple in structure and convenient to operate, and the sample quality and the detection accuracy can be improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample collection, and specifically relates to a sample collection device for intestinal microorganism detection. Background Art

[0002] Fecal sampling is a key link in studying the relationship between intestinal microorganisms and irritable bowel syndrome (IBS), and can provide a scientific basis for disease mechanism analysis, typing diagnosis, and evaluation of the efficacy of traditional Chinese medicine. Combining the brain-gut axis theory, fecal flora detection can not only guide individualized treatment (such as probiotic supplementation and diet adjustment), but also lay a foundation for the development of new "flora-intestine-brain axis" targeted therapies.

[0003] In the relevant research of IBS, a fecal sample collection device is required for the fecal sampling link. The structures of existing collection devices are mostly bottle bodies, bottle caps, and sampling spoons. For example, the sealed feces collection and submission box announced in the Chinese utility model patent with the application number 201020126625X includes a box body and a lid. The box body is cylindrical, there is a lid on the box body, a handle is provided in the middle of the lid, and a sampling shovel is provided at the lower end of the handle.

[0004] The existing such structure still has the following problems:

[0005] a. The overall length of the sampling spoon is short, and it is easy to contaminate the hand during the sampling process; feces are easily adhered to the sampling spoon, resulting in too little sample taken, a high sample loss rate during the transfer process, and it is easy to affect the test results.

[0006] b. The existing sample collector only uses one spoon-like method for collection, but the shape of the patient's feces cannot be determined. It may be hard or may be in a thin state. When collecting thin feces, spoon-like sampling is likely to cause leakage due to hand shaking, resulting in problems of contamination and insufficient sampling volume.

[0007] c. Poor sealing performance: The bottle cap uses a traditional screw cap, which has a thread gap. Some elderly patients may not be able to tighten it firmly, resulting in sample leakage or contamination during transportation, and it is difficult to preserve volatile substances, involving problems in multiple links such as sample quality, operation safety, and test accuracy. Utility Model Content

[0008] An object of the utility model is to solve one of the problems in the background art, and the utility model proposes a sample collection device for intestinal microorganism detection.

[0009] The technical solution is as follows:

[0010] A sample collection device for intestinal microorganism detection includes an outer cup body and a sampling assembly used in cooperation with the outer cup body. A sleeve is provided on the inner wall of the outer cup body, and at least one sealing rubber ring is provided on the inner wall of the sleeve;

[0011] The sampling component includes a sampling cylinder with openings at both ends. Inside the sampling cylinder, there is a rubber stopper, which is slidably connected to the inner wall of the sampling cylinder; one end of the rubber stopper is connected to a plug shaft, and the top of the plug shaft is fixedly connected to a plug handle; the plug shaft and the rubber stopper form a negative pressure suction structure;

[0012] The sampling cylinder can be adaptively inserted into the sleeve, and the outer wall of the sampling cylinder is in sealed sliding connection with the sealing rubber ring to form a first sealing layer;

[0013] A sealing plug is sleeved on the top of the sampling cylinder, and the sealing plug can be adaptively and sealingly inserted into the outer cup to form a second sealing layer.

[0014] Optionally, a wing plate is fixedly connected to the outer wall of the top of the sampling cylinder, and the top of the sealing plug is connected to the bottom surface of the wing plate.

[0015] Optionally, the bottom end of the sampling cylinder has a shovel-shaped part, and the rubber stopper can slide along the entire shovel-shaped part when moving.

[0016] Optionally, scale lines are provided on the outer wall of the sampling cylinder.

[0017] Optionally, a cap is connected to the top of the wing plate, and the center of the cap has a central hole, and the plug shaft freely passes through the central hole and can move up and down along the central hole.

[0018] Optionally, the circumferential side wall of the cap has anti-slip lines or is provided with a number of concave holes.

[0019] Optionally, it further includes a locking member for realizing the snap connection between the outer cup and the wing plate.

[0020] Optionally, the locking member includes an elastic first clamping head, and the bottom end of the first clamping head is fixedly connected to the outer wall of the outer cup; a positioning hole is provided on the wing plate, and the first clamping head is adaptively clamped with the positioning hole.

[0021] Optionally, the locking member includes an elastic second clamping head, and the second clamping head can be clamped on the edge of the wing plate.

[0022] Optionally, the locking member includes a clamping part, and the wing plate forms the clamping part after being cut; a vertical notch is provided on the top edge of the outer cup, and the outer cup is further provided with a horizontal slot, and the vertical notch is communicated with the horizontal slot; the clamping part can be screwed into the horizontal slot through the vertical notch for positioning and locking.

[0023] The above technical solutions have the following advantages:

[0024] 1. The sampling component of the present utility model is made by self - manufacturing with a common syringe, which has low cost and high transformability. By utilizing the sliding of the rubber stopper in the syringe, negative pressure suction can be achieved, which is especially suitable for thin feces and can efficiently and accurately collect samples.

[0025] 2. A double - seal layer is provided between the sampling component and the outer cup body. Abandoning the traditional screw - twisting sealing method, it is changed to plug - in double - sealing, which is easy for the elderly to operate and only needs to be pressed in place. Moreover, due to the structural setting of the double - seal layer, the sealing performance is high, which can greatly reduce the probability of sample leakage or contamination during transportation, ensure the high quality of the sample, and facilitate the subsequent detection accuracy. Through the analysis of high - quality fecal samples, the relationship between the flora and psychological symptoms can be explored, providing a basis for the targeted treatment of the "gut - microbiota - brain axis".

[0026] 3. One end of the sampling cylinder has a spatula - shaped part. With the setting of the rubber stopper, two collection methods can be formed, which can easily extract fecal samples in different states and meet the diverse needs of fecal samples.

[0027] 4. Optimize the traditional sampling spoon into a syringe - type sampling component. First, the overall length can be extended, making it not easy to contaminate the hands. Second, after obtaining the sample, the sample can be pushed out of the sampling cylinder by the movement of the piston, and there will be no residue on the inner wall of the sampling cylinder, reducing the sample loss rate during the transfer process and effectively solving the problem of sample residue.

[0028] 5. This device is also designed with a locking part. By using the locking part, the locking connection between the sampling component and the outer cup body can be further realized, preventing the problem that the double - seal is damaged due to the displacement between the outer cup body and the sampling cylinder caused by jolting during transportation, thus further ensuring the sealing performance, effectively reducing the leakage rate, and ensuring the qualified rate of sample collection. Description of the Drawings

[0029] In order to more clearly illustrate the specific implementation manners of the present utility model or the technical solutions in the prior art, the following will briefly introduce the drawings required for use in the description of the specific implementation manners or the prior art. In all the drawings, similar elements or parts are generally marked with similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0030] Figure 1 is the exploded view of the present utility model from the first perspective in Embodiment 1 or Embodiment 2.

[0031] Figure 2 is Figure 1 the enlarged view of the structure of the spatula - shaped part from the first perspective in

[0032] Figure 3 is Figure 1 the structural cross - sectional view of the outer cup body in

[0033] Figure 4 It is a perspective view of the present utility model in Embodiment 3 (the outer cup body is omitted).

[0034] Figure 5 It is Figure 4 the front view of the present utility model (the outer cup body is omitted).

[0035] Figure 6 It is a perspective view of the present utility model in Embodiment 4.

[0036] Figure 7 It is Figure 6 the exploded view of the structure of the present utility model.

[0037] Figure 8 It is Figure 6 the sectional view of the structure of the present utility model.

[0038] Figure 9 It is a partial perspective view of the present utility model in Embodiment 5.

[0039] Figure 10 It is a perspective view of the present utility model in Embodiment 6.

[0040] Figure 11 It is Figure 10 the enlarged schematic view of the structure of Area E.

[0041] Explanation of reference numerals:

[0042] 1. Outer cup body; 2. Sampling cylinder; 3. Shovel-shaped part; 4. Sealing plug; 5. Wing plate; 6. Cap; 61. Concave hole; 7. Plug shaft; 8. Plug handle; 9. Sleeve; 10. Sealing rubber ring; 11. Positioning hole; 12. First chuck; 13. Rubber plug; 14. Second chuck; 15. Vertical notch; 16. Clamping part; 17. Horizontal slot. Detailed implementation manners

[0043] Next, embodiments of the technical solution of the present utility model will be described in detail with reference to the drawings. The following embodiments are only used to illustrate the technical solution of the present utility model more clearly, so they are only examples and cannot be used to limit the protection scope of the present utility model.

[0044] Embodiment 1:

[0045] As Figure 1 - Figure 3As shown in the figure, this embodiment proposes a sample collection device based on intestinal microbiota detection, including an outer cup body 1 and a sampling assembly used in cooperation with the outer cup body 1. Among them, the outer cup body 1 is a cylindrical structure with an open top and a closed bottom; a sleeve 9 is provided on the inner wall of the outer cup body 1. The sleeve 9 can be designed in the middle or above the middle of the outer cup body 1. The sleeve 9 is fixedly connected to the inside of the outer cup body 1. The inner wall of the sleeve 9 has at least one sealing rubber ring 10. The inner wall of the sleeve 9 has a sealing groove along the circumferential direction, and the sealing rubber ring 10 is installed in the sealing groove.

[0046] The sampling assembly includes a sampling cylinder 2 with openings at both ends. A rubber plug 13 is provided inside the sampling cylinder 2. The rubber plug 13 is slidably connected to the inner wall of the sampling cylinder 2; one end of the rubber plug 13 is connected to a plug shaft 7, and the top of the plug shaft 7 is fixedly connected to a plug handle 8; the plug shaft 7 and the rubber plug 13 form a negative pressure suction structure; in this embodiment, the sampling cylinder 2 can be made by processing a common syringe, which is easy to obtain materials, convenient to manufacture, and low in cost; cut off the end of the syringe barrel with a nipple, and a cylindrical structure with openings at both ends is obtained. At this time, the obtained is the sampling cylinder 2 in this embodiment.

[0047] In this embodiment, the size of the sampling cylinder 2 is adapted to the size of the sleeve 9. The sampling cylinder 2 can be inserted into the sleeve 9 in an adapted manner. The outer wall of the sampling cylinder 2 is hermetically slidably connected to the sealing rubber ring 10 to form a first sealing layer. The sealing rubber ring 10 tightly wraps around the outer wall of the sampling cylinder 2 for effective sealing. As a first guarantee, it can prevent leakage.

[0048] In this embodiment, a sealing plug 4 is further sleeved on the top of the sampling cylinder 2. The sealing plug 4 is a ring-shaped structure and is sleeved and fixed at the top position of the outer wall of the sampling cylinder 2. The sealing plug 4 can be hermetically inserted into the inner wall of the outer cup body 1 in an adapted manner to form a second sealing layer.

[0049] In this embodiment, the structure of the sealing plug 4 can be a sealing plug 4 with a smooth outer surface or a multi-lip sealing plug 4 with an uneven outer surface.

[0050] As a feasible technical solution, a wing plate 5 is fixedly connected to the top outer wall of the sampling cylinder 2, and the top of the sealing plug 4 is connected to the bottom surface of the wing plate 5.

[0051] Application effect:

[0052] 1. The sampling assembly is made by self-making a common syringe, which is low in cost and highly modifiable; by using the sliding of the rubber plug 13 in the syringe, negative pressure suction can be achieved, which is especially suitable for thin feces and can efficiently and accurately collect samples.

[0053] 2. A double-sealing layer is provided between the sampling component and the outer cup body 1, abandoning the traditional screw-threading sealing method and changing to a plug-in double-sealing method, which is easy for the elderly to operate and only requires pressing in place. Moreover, due to the structural setting of the double-sealing layer, the sealing performance is high, which can greatly reduce the probability of sample leakage or contamination during transportation, ensure the high quality of the sample, and facilitate the subsequent detection accuracy. Through the analysis of high-quality fecal samples, the association between the flora and psychological symptoms can be explored, providing a basis for the targeted treatment of the "flora-intestine-brain axis".

[0054] Embodiment 2:

[0055] As Figure 1 - Figure 3 shown, on the basis of Embodiment 1, the sample collection device for intestinal microorganism detection proposed in this embodiment further has the following structural features:

[0056] The bottom end of the sampling cylinder 2 has a shovel-shaped part 3, and the rubber plug 13 can slide along the entire shovel-shaped part 3 when moving. The purpose of this design is to use the scraping effect of the rubber plug 13 to reduce sample residue. The shovel-shaped part 3 can be obtained by cutting the empty cylinder of the syringe, and the design of the shovel-shaped part 3 can be used for thick stools and dry stools. The combination of the shovel-shaped part 3 and the rubber plug 13 can form two sampling methods, enabling easy extraction of fecal samples in different states and meeting the diversity requirements of fecal samples.

[0057] In this embodiment, a scale line is provided on the outer wall of the sampling cylinder 2, and the push-rod type sampler is combined with a volume mark to achieve quantitative sampling.

[0058] In order to prevent hand contamination, the hand position should be kept as far away from the shovel-shaped part 3 as possible to extend the distance from the shovel-shaped part 3. Under such a goal, holding the plug handle 8 by hand can meet the requirement of extending the distance. However, the plug handle 8 and the rubber plug 13 are rotatably arranged, and the plug handle 8 can rotate relative to each other. Such a function determines that it cannot be used as a hand-holding point because once it rotates, it may cause the sample to spill. Based on this, after comprehensive consideration, the hand-holding position needs to be designed at the wing plate 5. However, considering that it is not very convenient and comfortable to hold the wing plate 5 by hand for sampling, the following improvements have been made under the overall optimization:

[0059] The top of the wing plate 5 is connected with a cap 6. The center of the cap 6 has a central hole, and the plug shaft 7 freely passes through the central hole and can move up and down along the central hole. The bottom end of the cap 6 is fixedly connected to the top surface of the wing plate 5. For the convenience of operation, the circumferential side wall of the cap 6 has anti-slip patterns, and the design of the anti-slip patterns increases the friction and is conducive to holding.

[0060] Application effect:

[0061] The traditional sampling spoon is optimized into a syringe-type sampling component. Firstly, the overall length can be extended and it is not easy to contaminate the hands. Secondly, after obtaining the sample, the sample can be pushed out of the sampling tube 2 by the movement of the piston, and there will be no residue on the inner wall of the sampling tube 2, thereby reducing the sample loss rate during the transfer process and effectively solving the problem of sample residue.

[0062] Embodiment 3:

[0063] like Figures 4 - 5 As shown, the other structures are the same as those of the embodiment 2, except that a plurality of recessed holes 61 are provided on the circumferential side wall of the cap 6. The recessed holes 61 are designed to reduce weight and to use the recessed holes 61 as a fulcrum for easy pinching.

[0064] Embodiment 4:

[0065] like Figures 6 - 8 As shown, based on Example 1 or Example 2, the sample collection device based on intestinal microorganism detection proposed in this embodiment further includes a locking member for realizing the snap connection between the outer cup body 1 and the wing plate 5. There are three types of locking members, and the first structural form is introduced in this embodiment:

[0066] The locking member includes an elastic first clamp 12, which can be made of slightly elastic plastic; there are two groups of the first clamps 12, which are symmetrically arranged; the bottom end of the first clamp 12 is fixedly connected to the outer wall of the outer cup body 1; the wing plate 5 is provided with a positioning hole 11, which is also in two groups, and the first clamp 12 is adapted to be engaged with the positioning hole 11. In this embodiment, the idea of ​​"inward retraction" is adopted. When the wing plate 5 moves downward, the positioning hole 11 squeezes the first clamp 12, and the two groups of first clamps 12 shrink inward, so that the first clamp 12 enters the positioning hole 11 and is adapted to be engaged with the positioning hole 11.

[0067] Embodiment 5:

[0068] like Figure 9 As shown, in the sample collection device based on intestinal microorganism detection proposed in this embodiment, the locking member adopts an "outward expansion" structure:

[0069] The locking member includes an elastic second clamp 14, which can be clamped on the edge of the wing plate 5. When the wing plate 5 moves downward, it will squeeze the second clamp 14, and the second clamp 14 will be stretched outward to achieve the purpose of outward expansion, so that the wing plate 5 and the second clamp 14 are engaged.

[0070] Embodiment 6:

[0071] like Figures 10 - 11 As shown, the third structural form of the locking member in this embodiment adopts the form of "rotational engagement", which is as follows:

[0072] The locking piece includes a snap-on portion 16, which is formed by cutting the wing plate 5; a vertical slot 15 is provided on the top edge of the outer cup body 1, and a transverse slot 17 is also provided on the outer cup body 1, and the vertical slot 15 is connected to the transverse slot 17; the snap-on portion 16 can be screwed into the transverse slot 17 through the vertical slot 15 for positioning and locking.

[0073] Considering that the wing plate 5 of the original syringe is too large and inconvenient to rotate and engage, the wing plate 5 is cut and reduced to obtain a processed engaging portion 16. When in use, the wing plate 5 is inserted into the vertical slot 15, and then the wing plate 5 is screwed so that the wing plate 5 is screwed into the transverse slot 17 and positioned and engaged.

[0074] It should be noted that, in the present embodiment, the transverse slot 17 is a gradual structure, with the end connected to the vertical slot 15 being recorded as the head end, and the other end being recorded as the tail end, and the opening gradually becomes smaller from the head end to the tail end. In this way, as the clamping portion 16 rotates, the purpose of tightening can be achieved, thereby realizing the positioning of the clamping portion 16.

[0075] It can be seen that the locking piece can further realize the locking connection between the sampling assembly and the outer cup body 1, preventing the double seal from being destroyed due to displacement between the outer cup body 1 and the sampling tube 2 caused by bumps during transportation, thereby further ensuring the sealing, effectively reducing the leakage rate, and ensuring the qualified rate of sample collection.

[0076] The above description is only a preferred embodiment of the present invention, and does not limit the implementation mode and protection scope of the present invention. For those skilled in the art, it should be aware that all solutions obtained by equivalent substitutions and obvious changes made using the description and illustrations of the present invention should be included in the protection scope of the present invention.

Claims

1. A sample collection device based on intestinal microorganism detection, comprising an outer cup body (1) and a sampling component used in conjunction with the outer cup body (1), characterized in that: The inner wall of the outer cup body (1) is provided with a sleeve (9), and the inner wall of the sleeve (9) has at least one sealing rubber ring (10); The sampling assembly comprises a sampling tube (2) with openings at both ends, a rubber plug (13) being provided inside the sampling tube (2), the rubber plug (13) being slidably connected to the inner wall of the sampling tube (2); one end of the rubber plug (13) is connected to a plug shaft (7), the top end of the plug shaft (7) being fixedly connected to a plug handle (8); the plug shaft (7) and the rubber plug (13) forming a negative pressure suction structure; The sampling tube (2) can be adapted to be plugged into the sleeve (9), and the outer wall of the sampling tube (2) is sealingly and slidably connected to the sealing rubber ring (10) to form a first sealing layer; The top end of the sampling tube (2) is sleeved with a sealing plug (4), and the sealing plug (4) can be plugged into the matching sealing portion of the outer cup body (1) to form a second sealing layer.

2. The sample collection device based on intestinal microorganism detection according to claim 1, characterized in that: A wing plate (5) is fixedly connected to the top outer wall of the sampling tube (2), and the top of the sealing plug (4) is connected to the bottom surface of the wing plate (5).

3. The sample collection device based on intestinal microorganism detection according to claim 1, characterized in that: The bottom end of the sampling tube (2) has a shovel-shaped portion (3), and the rubber plug (13) can slide along the entire shovel-shaped portion (3) when moving.

4. The sample collection device based on intestinal microorganism detection according to claim 1, characterized in that: The outer wall of the sampling tube (2) is provided with scale lines.

5. The sample collection device based on intestinal microorganism detection according to claim 2, characterized in that: The top of the wing plate (5) is connected to a cap (6), the center of the cap (6) has a center hole, and the plug shaft (7) freely passes through the center hole and can move up and down along the center hole.

6. The sample collection device based on intestinal microorganism detection according to claim 5, characterized in that: The circumferential side wall of the cap (6) has anti-slip grooves or is provided with a plurality of recessed holes (61).

7. The sample collection device based on intestinal microorganism detection according to claim 2, characterized in that: It also includes a locking piece for realizing a snap-fit ​​connection between the outer cup body (1) and the wing plate (5).

8. The sample collection device based on intestinal microorganism detection according to claim 7, characterized in that: The locking member comprises a first elastic clamp (12), the bottom end of the first clamp (12) being fixedly connected to the outer wall of the outer cup body (1); the wing plate (5) is provided with a positioning hole (11), and the first clamp (12) is adapted to be clamped with the positioning hole (11).

9. The sample collection device based on intestinal microorganism detection according to claim 7, characterized in that: The locking member comprises a second elastic clamp (14), wherein the second clamp (14) can be clamped on the edge of the wing plate (5).

10. The sample collection device based on intestinal microorganism detection according to claim 7, characterized in that: The locking member comprises a clamping portion (16), the wing plate (5) being formed by cutting the clamping portion (16); a vertical notch (15) is provided on the top edge of the outer cup body (1), the outer cup body (1) is further provided with a transverse slot (17), the vertical notch (15) being connected to the transverse slot (17); the clamping portion (16) can be screwed into the transverse slot (17) through the vertical notch (15) to be positioned and locked.

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