Multi-flux microfluidic preparation instrument

Abstract

The utility model relates to a multi-flux micro-flow control preparation instrument which comprises a box body with an operation opening, a box door, a preparation mechanism and two groups of liquid supply mechanisms, wherein the preparation mechanism and the liquid supply mechanisms are arranged in the box body; the liquid supply mechanism comprises a connecting frame, a plurality of liquid supply pipes which are vertically arranged and arranged on the connecting frame in the horizontal direction, and a switching valve set which is connected to the upper ends of the liquid supply pipes and communicates with the injector conical head and the preparation mechanism, and the connecting frame is connected with a rotating shaft which is rotationally arranged at the bottom of the box body, and the axis of the rotating shaft is arranged in the vertical direction; the rotating shaft is connected with a driving assembly driving the rotating shaft to rotate. The device is simple in structure and convenient to use, an enough operation space can be provided for an operator when the operator carries out manual operation in the box body, the operator is prevented from touching all parts on the liquid supply mechanism and the preparation mechanism by mistake, the cleanliness in the box body is ensured, the pollution risk is reduced, meanwhile, the operation difficulty of the operator is also reduced, and the production efficiency is improved. And the use convenience is improved.

Description

Technical Field

[0001] The utility model relates to a multi-flux microfluidic control preparation instrument, which is applicable to the technical field of biomedical processing. Background Art

[0002] A microfluidic control preparation instrument is a commonly used reagent preparation device in industries such as biological vaccine and medicine preparation. Due to its small structure, it can prepare trace reagents and is usually applicable to the preparation process with experimental nature in laboratories. The existing microfluidic control preparation instrument usually connects a container loaded with a solution to the liquid suction end of the preparation instrument by personnel, and sucks the liquid in the container through the driving mechanism in the device and pumps it into the preparation chip for mixing and preparation. In order to reduce the pollution risk in reagent preparation, the mechanism for transporting the solution and preparation is usually arranged in a closable box. When the operator finishes the feeding operation, the box will be closed until the product is collected after the preparation is completed. However, the overall structure of the existing preparation instrument is usually small, and the internal space of its box is very narrow. It is very easy for personnel to accidentally touch the structures such as pipelines in the device during the process of loading the raw material solution and collecting the product, which greatly increases the pollution risk. Especially in order to meet the use requirement of preparing multiple groups of reagents simultaneously under the same conditions for comparison in the experimental preparation, the preparation instrument needs to increase the flux, which will inevitably make the structure in the box more complex, bringing great inconvenience to the operator and further increasing the pollution risk. Summary of the Utility Model

[0003] In order to solve the defects existing in the above-mentioned prior art, the utility model provides a multi-flux microfluidic control preparation instrument.

[0004] The technical solution adopted by the present utility model is as follows: A multi-flux microfluidic control preparation instrument includes a box body with an operation opening on its surface, a box door covering the operation opening, a preparation mechanism and a liquid supply mechanism arranged inside the box body. There are two groups of liquid supply mechanisms, which are respectively rotatably arranged on the left and right sides of the preparation mechanism. The liquid supply mechanism includes a connecting frame, a plurality of liquid supply pipes arranged vertically and horizontally on the connecting frame, and a switching valve group connected to the upper ends of the plurality of liquid supply pipes and respectively communicating with the syringe cone head and the preparation mechanism. The connecting frame is connected to a rotating shaft rotatably arranged at the bottom of the box body and having an axis arranged vertically. The rotating shaft is connected with a driving component for driving its rotation; the multi-flux microfluidic control preparation instrument has at least two working states. When it is in the first working state, the two groups of liquid supply mechanisms approach each other, and the liquid supply pipes in each group of liquid supply mechanisms are arranged in the front-rear direction. When the multi-flux microfluidic control preparation instrument is in the second working state, the two groups of liquid supply mechanisms are relatively opened, and the liquid supply pipes in each group of liquid supply mechanisms are arranged in the left-right direction. By respectively arranging liquid supply mechanisms on both sides of the preparation mechanism, and arranging a plurality of liquid supply pipes in the liquid supply mechanism, and controlling the input and output channels of the liquid supply pipes through the switching valve group, so as to simultaneously carry out the preparation of multiple preparation processes to meet the high-throughput preparation requirements; at the same time, by arranging a rotating shaft to connect the connecting frame in the industrial mechanism, the two groups of liquid supply mechanisms can be rotated to be relatively opened during the operation of the operator, so that the liquid supply mechanism faces the operator, and the preparation mechanism located between the two is exposed, which is convenient for the operator to load the syringe or take the collection container; and when the operator completes the loading or taking operation, the driving component drives the two liquid supply mechanisms to rotate to be relatively close to each other, which is convenient for normal preparation. By rotating the liquid supply mechanism, enough operation space is provided for the operator to prevent the operator from accidentally touching the various components on the liquid supply mechanism and the preparation mechanism, ensuring the cleanliness inside the box body, reducing the pollution risk, and at the same time reducing the operation difficulty of the operator and improving the use convenience.

[0005] Further, the driving component includes a fixed seat fixedly arranged on the bottom surface of the box body, a transmission component arranged in the fixed seat and connected to the rotating shaft, and a driver connected to the transmission component. The rotating shaft is inserted into the fixed seat and pivotally connected to the fixed seat. The driving component is installed in the box body through the fixed seat to provide support for the liquid supply mechanism, then provides power through the driver, and the power provided by the driver is transmitted to the rotating shaft by the transmission component to drive its rotation.

[0006] Optionally, the driver is set as a servo motor, and the transmission component includes a worm gear coaxially connected to the lower end of the rotating shaft, and a worm fixedly connected to the output shaft of the driver and meshing with the worm gear. The power output by the servo motor is transmitted to the rotating shaft through the worm gear structure to drive its rotation, thereby realizing the rotation of the liquid supply mechanism.

[0007] Optionally, the driver is set as a servo motor, and the transmission component is set as a coupling. The coupling is fixedly connected to the output shaft of the driver and the rotating shaft respectively. The servo motor and the rotating shaft are directly connected through the coupling to drive the liquid supply mechanism.

[0008] Further, a bottom plate is connected to the rotating shaft, and the connecting frame is arranged on the bottom plate. The liquid supply mechanism further includes a machine box with a control system inside. The machine box is arranged on the bottom plate. The connecting frame and the machine box are supported by the bottom plate to improve the stability of the liquid supply mechanism during rotation. Specifically, the control system includes a driving device for driving the liquid supply pipe and a control device for controlling the switching valve group. The switching valve group is controlled by the control system to switch the connection or disconnection between the liquid supply pipe and the external syringe, and between the liquid supply pipe and the preparation mechanism. At the same time, the driving of the liquid supply pipe is realized through the control system, so that the liquid supply mechanism can extract the solution from the external syringe and pump it into the preparation mechanism for preparation.

[0009] Further, a partition is horizontally arranged at the bottom inside the box body. The driving component is arranged below the partition, and the liquid supply mechanism is arranged above the partition. The rotating shaft passes through the partition and is respectively connected to the driving component and the liquid supply mechanism at both ends. By separating the internal space of the box body with the partition, not only the cleanliness of the preparation area where the liquid supply mechanism is located is improved, reducing the pollution risk, but also the driving structure is prevented from being damaged due to the solution splashing into the driving component during use.

[0010] Furthermore, the preparation mechanism includes a chip rack fixedly arranged on the partition, a preparation chip detachably inserted into the chip rack, and a bracket arranged below the preparation chip and used for installing and accommodating a container for the product. Specifically, the preparation chip is respectively connected to the switching valve groups in the two groups of liquid supply mechanisms, so that the liquid supply pipe can convey the preparation solution to the preparation chip. By directly setting the chip rack and the preparation chip as a detachable structure, it is convenient to replace different specifications of preparation chips according to the process requirements. The bracket below the preparation chip is used for installing containers such as test tubes to facilitate the collection of the mixed and prepared products.

[0011] Further, the liquid supply mechanisms and the driving components on both sides of the preparation mechanism are symmetrically arranged, which not only facilitates the operation of personnel, but also makes it convenient to control the structural symmetry such as the pipeline length between the preparation mechanism and the liquid supply mechanism, and is convenient to control the preparation conditions.

[0012] Further, the operation port extends from the front of the box body to the top surface of the box body. The projection of the box door on the plane perpendicular to the left - right direction is in an L - shape and the upper end is rotatably connected to the top surface of the box body, which is convenient for the operator to install the external syringe from above or install or take the collection container from the front.

[0013] Further, an observation window is opened on the front of the box door, and a glass plate or a transparent acrylic plate is covered on the observation window, which is convenient for the operator to observe the preparation process.

[0014] Due to the application of the above technical solution, the present utility model has the following advantages compared with the prior art:

[0015] The multi-flux microfluidic control preparation instrument in the present utility model has a simple structure and is convenient to use. It not only realizes the preparation of multi-flux reagents through the preparation mechanism and the liquid supply mechanism, but also makes the structure of the preparation mechanism and the liquid supply mechanism reasonably set, and drives the liquid supply mechanism to rotate through the driving component and the rotating shaft, so that when the operator performs manual operations inside the box, it can provide enough operating space for the operator, prevent the operator from accidentally touching the various components on the liquid supply mechanism and the preparation mechanism, ensure the cleanliness inside the box, reduce the pollution risk, and at the same time reduce the operation difficulty of the operator and improve the use convenience. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Some specific embodiments of the present utility model will be described in detail hereinafter with reference to the accompanying drawings in an exemplary but not restrictive manner. The same reference numerals in the drawings denote the same or similar components or parts. Those skilled in the art should understand that these drawings are not necessarily drawn to scale. In the drawings:

[0017] Figure 1 is a schematic structural diagram of an embodiment of the present utility model Figure 1 ;

[0018] Figure 2 is Figure 1 the internal structure diagram of the illustrated embodiment;

[0019] Figure 3 is Figure 1 the schematic structural diagram of the multi-flux microfluidic control preparation instrument in the illustrated embodiment in the first working state;

[0020] Figure 4 is Figure 1 the schematic structural diagram of the multi-flux microfluidic control preparation instrument in the illustrated embodiment in the second working state;

[0021] The reference numerals are explained as follows:

[0022] 1. Box body; 11. Operation opening; 12. Box door; 121. Observation window; 13. Partition board; 2. Preparation mechanism; 21. Chip holder; 22. Preparation chip; 23. Bracket; 3. Liquid supply mechanism; 31. Connection frame; 32. Liquid supply pipe; 33. Switching valve group; 34. Bottom plate; 35. Machine box; 4. Driving component; 41. Rotating shaft; 42. Fixed seat; 43. Transmission component; 44. Driver. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0023] The technical solution of the present utility model will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present utility model, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative work fall within the protection scope of the present utility model.

[0024] In the description of the present utility model, it should be noted that the terms "front", "rear", "left", and "right" related to directions are defined according to the use direction of the preparation instrument. Specifically, when the preparation instrument is in normal use, the direction facing the person is "front", and vice versa is "rear"; when the person faces forward, the left side of the person is "left", and vice versa is "right". In addition, the technical features involved in different embodiments of the present utility model described below can be combined with each other as long as they do not conflict with each other.

[0025] Refer to the attached Figures 1-4 , in this embodiment of the multi-flux microfluidic control preparation instrument, it includes a box body 1 with an operation port 11 opened on the surface, a box door 12 covering the operation port 11, a preparation mechanism 2 arranged inside the box body 1, and a liquid supply mechanism 3.

[0026] There are two groups of liquid supply mechanisms 3, which are respectively rotatably arranged on the left and right sides of the preparation mechanism 2. The liquid supply mechanism 3 includes a connecting frame 31, a plurality of liquid supply pipes 32 arranged vertically and horizontally on the connecting frame 31, and a switching valve group 33 connected to the upper ends of the plurality of liquid supply pipes 32 and respectively communicating with the syringe cone head and the preparation mechanism 2. The connecting frame 31 is connected to a rotating shaft 41 rotatably arranged at the bottom of the box body 1 and with its axis arranged vertically. The rotating shaft 41 is connected with a driving component 4 for driving its rotation; the multi-flux microfluidic control preparation instrument has at least two working states. When it is in the first working state, as shown in the attached Figure 3 , the two groups of liquid supply mechanisms 3 approach each other, and the liquid supply pipes 32 in each group of liquid supply mechanisms 3 are arranged in the front-rear direction. When the multi-flux microfluidic control preparation instrument is in the second working state, as shown in the attached Figure 4As shown, the two liquid supply mechanisms 3 are opened relatively, and the liquid supply pipes 32 in each liquid supply mechanism 3 are arranged in the left-right direction. By arranging the liquid supply mechanisms 3 on both sides of the preparation mechanism 2 respectively, and arranging a plurality of liquid supply pipes 32 in the liquid supply mechanism 3, and controlling the input and output channels of the liquid supply pipes 32 through the switching valve group 33, so as to carry out the preparation of multiple preparation processes simultaneously to meet the high-throughput preparation requirements; at the same time, by arranging the rotating shaft 41 to connect the connecting frame in the liquid supply mechanism, the two liquid supply mechanisms 3 can be rotated to be relatively opened when the operator operates, so that the liquid supply mechanism 3 faces the operator, and the preparation mechanism 2 located between the two is exposed, which is convenient for the operator to load the syringe or take the collection container; and when the operator completes the loading or taking operation, the driving component 4 drives the two liquid supply mechanisms 3 to rotate to be relatively close to each other, which is convenient for normal preparation. By rotating the liquid supply mechanism 3, enough operation space is provided for the operator to prevent the operator from accidentally touching the various components on the liquid supply mechanism 3 and the preparation mechanism 2, ensuring the cleanliness inside the box body 1, reducing the pollution risk, and at the same time reducing the operation difficulty of the operator and improving the use convenience. The driving component 4 includes a fixed seat 42 fixedly arranged on the bottom surface of the box body 1, a transmission component 43 arranged in the fixed seat 42 and connected to the rotating shaft 41, and a driver 44 connected to the transmission component 43. The rotating shaft 41 is inserted into the fixed seat 42 and pivotally connected to the fixed seat 42. The driving component 4 is installed in the box body 1 through the fixed seat to provide support for the liquid supply mechanism 3, and then the power is provided by the driver 44, and the power provided by the driver 44 is transmitted to the rotating shaft 41 by the transmission component 43 to drive its rotation.

[0027] In an alternative embodiment, the driver 44 is set as a servo motor, and the transmission component 43 includes a worm gear coaxially connected to the lower end of the rotating shaft 41 and a worm gear meshed with the output shaft of the driver 44 and meshed with the worm gear (due to the display angle, the worm gear and worm in the drawing are blocked and not shown). The power output by the servo motor is transmitted to the rotating shaft 41 through the worm gear structure to drive its rotation, so as to realize the rotation of the liquid supply mechanism 3.

[0028] In another alternative embodiment, the driver 44 is set as a servo motor, and the transmission component 43 is set as a coupling. The coupling is fixedly connected to the output shaft of the driver 44 and the rotating shaft 41 respectively. The servo motor and the rotating shaft 41 are directly connected through the coupling to realize the driving of the liquid supply mechanism 3.

[0029] In a more preferred embodiment, a bottom plate 34 is connected to the rotating shaft 41, and the connecting frame 31 is arranged on the bottom plate 34. The liquid supply mechanism further includes a machine box 35 with a control system inside. The machine box 35 is arranged on the bottom plate 34. By means of the bottom plate 34, the connecting frame 31 and the machine box 35 are supported, improving the stability of the liquid supply mechanism 3 during rotation. Specifically, the control system includes a driving device for driving the liquid supply pipe 32 and a control device for controlling the switching valve group 33. The control system controls the switching valve group 33 to switch the connection or closing between the liquid supply pipe 32 and an external syringe, and between the liquid supply pipe 32 and the preparation mechanism 2. At the same time, the driving of the liquid supply pipe 32 is realized through the control system, so that the liquid supply mechanism 3 can extract the solution from an external syringe and pump it into the preparation mechanism 2 for preparation. Since the control system is not the inventive point of this application, its specific structure is not described here.

[0030] In a more preferred embodiment, a partition plate 13 is horizontally arranged at the bottom inside the box body 1. The driving assembly 4 is arranged below the partition plate 13, and the liquid supply mechanism 3 is arranged above the partition plate 13. The rotating shaft 41 penetrates through the partition plate 13 and is respectively connected to the driving assembly 4 and the liquid supply mechanism 3 at both ends. By separating the internal space of the box body 1 through the partition plate 13, not only the cleanliness of the preparation area where the liquid supply mechanism 3 is located is improved, reducing the pollution risk, but also the driving structure is prevented from being damaged due to the solution splashing into the driving assembly 4 during use.

[0031] In a more specific embodiment, the preparation mechanism 2 includes a chip rack 21 fixedly arranged on the partition plate 13, a preparation chip 22 detachably inserted into the chip rack 21, and a bracket 23 arranged below the preparation chip 22 and used for installing and accommodating a container for the product. Specifically, the preparation chip 22 is respectively connected to the switching valve groups 33 in the two groups of liquid supply mechanisms 3, so that the liquid supply pipe 32 can convey the preparation solution to the preparation chip 22. By directly setting the chip rack 21 and the preparation chip 22 as a detachable structure, it is convenient to replace different specifications of the preparation chip 22 according to process requirements. The bracket 23 below the preparation chip 22 is used for installing containers such as test tubes, facilitating the collection of the mixed and prepared product.

[0032] In a more preferred embodiment, the liquid supply mechanisms 3 and the driving assemblies 4 on both left and right sides of the preparation mechanism 2 are symmetrically arranged, which not only facilitates the operation of personnel, but also makes it easy to control the structural equivalence such as the pipeline length between the preparation mechanism 2 and the liquid supply mechanism 3, facilitating the control of the preparation conditions.

[0033] In a more preferred embodiment, the operation port 11 extends from the front of the box body 1 to the top surface of the box body 1. The projection of the box door 12 on the plane perpendicular to the left - right direction is in an L - shape and the upper end is rotatably connected to the top surface of the box body 1, facilitating the operator to install an external syringe from above or install or take a collection container from the front.

[0034] In a more preferred embodiment, an observation window 121 is provided on the front of the cabinet door 12, and a glass plate or a transparent acrylic plate is covered on the observation window 121, which is convenient for the operator to observe the preparation process.

[0035] Due to the application of the above technical solution, the present utility model has the following advantages compared with the prior art:

[0036] The multi-flux microfluidic preparation instrument in the present utility model has a simple structure and is convenient to use. It not only realizes the preparation of multi-flux reagents through the preparation mechanism and the liquid supply mechanism, but also reasonably sets the structures of the preparation mechanism and the liquid supply mechanism, and drives the liquid supply mechanism to rotate through the driving component and the rotating shaft, so that when the operator performs manual operations inside the cabinet, sufficient operating space can be provided for the operator, preventing the operator from accidentally touching the various components on the liquid supply mechanism and the preparation mechanism, ensuring the cleanliness inside the cabinet, reducing the pollution risk, and at the same time reducing the operation difficulty of the operator and improving the use convenience.

[0037] The above embodiments are only used to illustrate the technical concept and characteristics of the present utility model, and their purpose is to enable those who are familiar with this technology to understand the content of the present utility model and implement it accordingly. It cannot be used to limit the protection scope of the present utility model. All equivalent changes or modifications made according to the spirit of the present utility model should be covered within the protection scope of the present utility model.

Claims

1. A multi-flux microfluidic preparation instrument, comprising a box (1) with an operation port (11) on its surface, a box door (12) covering the operation port (11), a preparation mechanism (2) and a liquid supply mechanism (3) arranged inside the box (1), characterized in that: The liquid supply mechanism (3) has two groups and is rotatably arranged on the left and right sides of the preparation mechanism (2). The liquid supply mechanism (3) comprises a connecting frame (31), a plurality of liquid supply pipes (32) arranged vertically and arranged in a horizontal direction on the connecting frame (31), and a switching valve group (33) connected to the upper ends of the plurality of liquid supply pipes (32) and respectively connected to the syringe cone head and the preparation mechanism (2). The connecting frame (31) is rotatably arranged at the bottom of the box body (1) and the axis line is arranged in the vertical direction. The rotating shaft (41) is connected to a driving assembly (4) for driving the rotating shaft (41); the multi-flux microfluidic control device has at least two working states; when it is in a first working state, the two groups of liquid supply mechanisms (3) are close to each other, and the liquid supply tubes (32) in each group of liquid supply mechanisms (3) are arranged in a front-to-back direction; when the multi-flux microfluidic control device is in a second working state, the two groups of liquid supply mechanisms (3) are relatively open, and the liquid supply tubes (32) in each group of liquid supply mechanisms (3) are arranged in a left-to-right direction.

2. The multi-flux microfluidic control device according to claim 1, characterized in that: The driving assembly (4) comprises a fixing seat (42) fixedly arranged on the bottom surface of the box body (1), a transmission assembly (43) arranged in the fixing seat (42) and connected to the rotating shaft (41), and a driver (44) connected to the transmission assembly (43); the rotating shaft (41) is inserted into the fixing seat (42) and is pivotally connected to the fixing seat (42).

3. The multi-flux microfluidic control apparatus according to claim 2, characterized in that: The driver (44) is configured as a servo motor, and the transmission assembly (43) comprises a worm wheel coaxially connected to the lower end of the rotating shaft (41), and a worm fixedly connected to the output shaft of the driver (44) and meshing with the worm wheel.

4. The multi-flux microfluidic control apparatus according to claim 2, characterized in that: The driver (44) is configured as a servo motor, the transmission assembly (43) is configured as a coupling, and the coupling is respectively fixedly connected to an output shaft of the driver (44) and the rotating shaft (41).

5. The multi-flux microfluidic control apparatus according to claim 1, characterized in that: The rotating shaft (41) is connected to a bottom plate (34), the connecting frame (31) is arranged on the bottom plate (34), and the liquid supply mechanism further comprises a machine box (35) with a control system arranged therein, the machine box (35) being arranged on the bottom plate (34).

6. The multi-flux microfluidic control apparatus according to claim 1, characterized in that: A partition (13) is horizontally arranged at the bottom of the box body (1), the drive assembly (4) is arranged below the partition (13), the liquid supply mechanism (3) is arranged above the partition (13), and the rotating shaft (41) passes through the partition (13) and has two ends respectively connected to the drive assembly (4) and the liquid supply mechanism (3).

7. The multi-flux microfluidic control apparatus according to claim 6, characterized in that: The preparation mechanism (2) comprises a chip rack (21) fixedly mounted on the partition (13), a preparation chip (22) detachably inserted on the chip rack (21), and a bracket (23) disposed below the preparation chip (22) and used for mounting a container for accommodating a product.

8. The multi-flux microfluidic control apparatus according to claim 1, characterized in that: The liquid supply mechanism (3) and the driving assembly (4) on the left and right sides of the preparation mechanism (2) are symmetrically arranged.

9. The multi-flux microfluidic control apparatus according to claim 1, characterized in that: The operating port (11) extends from the front of the box body (1) to the top surface of the box body (1); the projection of the box door (12) on a plane perpendicular to the left-right direction is L-shaped and the upper end is rotatably connected to the top surface of the box body (1).

10. The multi-flux microfluidic control apparatus according to claim 1, characterized in that: An observation window (121) is provided in front of the box door (12), and a glass plate or a transparent acrylic plate is provided on the observation window (121).

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