Chromatographic column easy to backwash and fill
By introducing cleaning and spraying mechanisms into the chromatographic column, the impurity filter cake problem caused by resin density is solved, and efficient cleaning effect is achieved, ensuring material purity and output rate.
Patent Information
- Application Number
- CN202421927672.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-09
- Publication Date
- 2025-06-27
- Estimated Expiration
- 2034-08-09
AI Technical Summary
During the cleaning process of existing chromatographic columns, the dense resin causes large particles to be unable to be completely cleaned, forming a filter cake and adhering to the inner wall, affecting the purity and output rate of subsequent materials.
A chromatographic column that is easy to backwash and fill is designed, including a cleaning mechanism and a spray mechanism. The scraper is driven to scrape the inner wall through the impeller, and the spray mechanism breaks the filter cake to achieve efficient cleaning of the chromatographic column.
Effectively remove filter cake impurities and large particle impurities on the inner wall of the chromatographic column, ensure material purity and output rate, and improve the cleaning efficiency and convenience of the chromatographic column.
Smart Images
Figure CN223026757U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of chromatographic columns, in particular to a chromatographic column that is easy to backwash and fill. Background Technique
[0002] The chromatographic column section is a key section on the fermentation production line. The most core part is the chromatographic resin. The operation of the chromatographic column not only affects the content of the fermentation product, but also affects the yield of the finished product.
[0003] When directly cleaning from top to bottom inside the chromatographic column, due to the relatively dense resin inside the chromatographic column, some large particle impurities cannot be discharged, a filter cake is formed above the resin, and impurities also adhere to the inner wall of the chromatographic column, resulting in the inability to clean the chromatographic column thoroughly.
[0004] Therefore, it is necessary to improve a chromatographic column that is easy to backwash and fill to solve the above problems. Content of the Utility Model
[0005] The purpose of the utility model is to provide a chromatographic column that is easy to backwash and fill to solve the problems put forward in the above background technique.
[0006] To achieve the above purpose, the utility model provides the following technical solution: a chromatographic column that is easy to backwash and fill, including a chromatographic column body, a cleaning mechanism is arranged inside the chromatographic column body, and a spraying mechanism is arranged inside the chromatographic column body;
[0007] The cleaning mechanism includes an installation component and a rotating component, and the rotating component is arranged inside the installation component.
[0008] Preferably, the installation component includes a threaded sleeve, the threaded sleeve is threadedly installed outside the chromatographic column body, an observation cover is fixedly installed at the top of the threaded sleeve, a first water inlet pipe is fixedly installed at the top of the observation cover, a feed pipe is fixedly installed at the top of the observation cover, a discharge pipe is fixedly installed at the bottom of the chromatographic column body, and a second water inlet pipe is fixedly installed on the right side of the discharge pipe. The observation cover is convenient for observing the separation situation inside the chromatographic column body.
[0009] Preferably, a threaded structure is arranged outside the top of the chromatographic column body, and the threaded sleeve is threadedly installed outside the threaded structure. The observation cover is of a conical structure, making the chromatographic column body convenient for observation.
[0010] Preferably, the rotating component includes a fixed bracket, the fixed bracket is fixedly installed inside the chromatographic column body, an impeller is rotatably installed at the top of the fixed bracket, a rotating frame is fixedly installed at the top of the impeller, and a scraping plate is fixedly installed at the top of the rotating frame, scraping off the filter cake impurities attached to the inner wall of the chromatographic column body to prevent the impurities from contaminating the materials that need to be chromatographed next time.
[0011] Preferably, four sets of scraping plates are provided and are circumferentially distributed around the center position of the rotating frame. The scraping plates are attached to the inner wall of the chromatographic column body and scrape the inner wall of the chromatographic column body.
[0012] Preferably, the spraying mechanism includes a rotating disk which is rotatably installed inside the observation cover. A spraying pipe is fixedly installed inside the rotating disk. Spraying holes are provided inside the spraying pipe. One end of the spraying pipe away from the rotating disk is fixedly installed with a spraying box. After the water is sprayed, the filter cake is broken up.
[0013] Preferably, a first water inlet pipe is rotatably installed inside the spraying box. Four sets of the spraying pipes and the spraying holes are provided and are circumferentially distributed around the center position of the spraying box, so that the rotating disk rotates inside the observation cover.
[0014] Compared with the prior art, the present utility model provides a chromatographic column that is easy to backwash and fill, and has the following beneficial effects:
[0015] 1. For this chromatographic column that is easy to backwash and fill, during use, through the provided cleaning mechanism, when water flows through the impeller, the rotating frame is driven to rotate by the power of the water, and then the scraping plate is driven to rotate to scrape the inner wall of the chromatographic column body, scraping off the filter cake impurities attached to the inner wall of the chromatographic column body, preventing the impurities from contaminating the material to be chromatographed next time. At the same time, the inside of the chromatographic column body is cleaned, and the large particle impurities between the resin particles can also be reversely eluted out of the inside of the chromatographic column body, making it more convenient to use.
[0016] 2. For this chromatographic column that is easy to backwash and fill, during use, after water enters the spraying box, it flows out through the spraying pipe and is sprayed through the spraying holes, causing the rotating disk to rotate inside the observation cover. After the water is sprayed, the filter cake is broken up, which is convenient for subsequent cleaning. BRIEF DESCRIPTION OF THE DRAWINGS
[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model, the following will briefly introduce the drawings required for description in the embodiments. Obviously, the following drawings are only some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts:
[0018] Figure 1 It is a schematic external structure diagram of the present utility model;
[0019] Figure 2 It is a schematic sectional structure diagram of the present utility model;
[0020] Figure 3 It is an exploded structural diagram of the installation components of the present utility model;
[0021] Figure 4 This is a schematic diagram of the external structure of the rotating assembly of the present utility model;
[0022] Figure 5 This is a schematic diagram of the external structure of the spraying mechanism of the present utility model.
[0023] In the figure: 1, chromatographic column body; 2, cleaning mechanism; 21, installation component; 211, threaded sleeve; 212, observation cover; 213, feed pipe; 214, first water inlet pipe; 215, discharge pipe; 216, second water inlet pipe; 22, rotating assembly; 221, fixed bracket; 222, impeller; 223, rotating frame; 224, scraper; 3, spraying mechanism; 31, rotating disk; 32, spraying pipe; 33, spraying holes; 34, spraying box. Specific embodiments
[0024] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.
[0025] In the present utility model, unless otherwise clearly defined and limited, the terms "installation", "connection", "connection", "fixation" and other terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be the communication inside two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present utility model can be understood according to specific situations.
[0026] Embodiment 1:
[0027] Please refer to Figures 1-4 , the present utility model provides a technical solution: a chromatographic column that is easy to backwash and fill, including a chromatographic column body 1, a cleaning mechanism 2 is arranged inside the chromatographic column body 1, and a spraying mechanism 3 is arranged inside the chromatographic column body 1;
[0028] The cleaning mechanism 2 includes an installation component 21 and a rotating component 22, and the rotating component 22 is arranged inside the installation component 21.
[0029] Further, the installation component 21 includes a threaded sleeve 211, which is threadedly installed outside the chromatographic column body 1. A viewing cover 212 is fixedly installed at the top of the threaded sleeve 211. A first water inlet pipe 214 is fixedly installed at the top of the viewing cover 212. A feed pipe 213 is fixedly installed at the top of the viewing cover 212. A discharge pipe 215 is fixedly installed at the bottom of the chromatographic column body 1. A second water inlet pipe 216 is fixedly installed on the right side of the discharge pipe 215. The viewing cover 212 facilitates observing the separation situation inside the chromatographic column body 1.
[0030] Further, a threaded structure is provided outside the top of the chromatographic column body 1, and the threaded sleeve 211 is threadedly installed outside the threaded structure. The viewing cover 212 is of a conical structure, making it convenient to observe the chromatographic column body 1.
[0031] Further, the rotating component 22 includes a fixed bracket 221, which is fixedly installed inside the chromatographic column body 1. An impeller 222 is rotatably installed at the top of the fixed bracket 221. A rotating frame 223 is fixedly installed at the top of the impeller 222. A scraping plate 224 is fixedly installed at the top of the rotating frame 223, which scrapes off the filter cake impurities attached to the inner wall of the chromatographic column body 1 to prevent the impurities from contaminating the materials that need to undergo chromatography next time.
[0032] Further, four groups of scraping plates 224 are provided, and they are circumferentially distributed around the center position of the rotating frame 223. The scraping plates 224 are in contact with the inner wall of the chromatographic column body 1 to perform scraping operations on the inner wall of the chromatographic column body 1.
[0033] Embodiment 2:
[0034] Please refer to Figure 5 , and in combination with Embodiment 1, it is further obtained that the spraying mechanism 3 includes a rotating disk 31, which is rotatably installed inside the viewing cover 212. A spraying pipe 32 is fixedly installed inside the rotating disk 31. Spraying holes 33 are provided inside the spraying pipe 32. One end of the spraying pipe 32 away from the rotating disk 31 is fixedly installed with a spraying box 34. After the water is sprayed, the filter cake is broken up.
[0035] Further, a first water inlet pipe 214 is rotatably installed inside the spraying box 34. Four groups of both the spraying pipes 32 and the spraying holes 33 are provided, and they are circumferentially distributed around the center position of the spraying box 34, enabling the rotating disk 31 to perform a rotating operation inside the viewing cover 212.
[0036] In the actual operation process, when this device is in use, the material is introduced into the interior of the chromatographic column body 1 through the feed pipe 213 for chromatographic separation operation. After the chromatographic separation operation is completed, the feeding operation is stopped, and water is introduced into the interior of the chromatographic column body 1 through the first water inlet pipe 214. After the water enters the spray box 34, it flows out through the spray pipe 32, and after being sprayed through the spray holes 33, the rotating disk 31 rotates inside the observation cover 212. After the water is sprayed, the filter cake is broken up, and then water is introduced into the interior of the chromatographic column body 1 through the second water inlet pipe 216. The water flow passes through the impeller 222, and the rotation of the rotating frame 223 is driven by the power of the water, thereby driving the rotation of the scraper 224 to scrape the inner wall of the chromatographic column body 1, scraping off the filter cake impurities attached to the inner wall of the chromatographic column body 1, preventing the impurities from contaminating the material that needs to be chromatographed next time, and at the same time cleaning the interior of the chromatographic column body 1. Also, the large particle impurities between the resin particles can be eluted in the reverse direction out of the interior of the chromatographic column body 1, making it more convenient to use.
[0037] It should be noted that in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the said element.
Claims
1. A chromatographic column that is easy to backwash, comprising a chromatographic column body (1), characterized in that: A cleaning mechanism (2) is provided inside the chromatographic column body (1), and a spraying mechanism (3) is provided inside the chromatographic column body (1); The cleaning mechanism (2) comprises a mounting assembly (21) and a rotating assembly (22), wherein the rotating assembly (22) is arranged inside the mounting assembly (21); The mounting assembly (21) comprises a threaded sleeve (211), the threaded sleeve (211) being threadedly mounted on the outside of the chromatographic column body (1), an observation cover (212) being fixedly mounted on the top of the threaded sleeve (211), a water inlet pipe 1 (214) being fixedly mounted on the top of the observation cover (212), a feed pipe (213) being fixedly mounted on the top of the observation cover (212), a discharge pipe (215) being fixedly mounted on the bottom of the chromatographic column body (1), and a water inlet pipe 2 (216) being fixedly mounted on the right side of the discharge pipe (215); The rotating assembly (22) comprises a fixed bracket (221), the fixed bracket (221) is fixedly mounted inside the chromatographic column body (1), an impeller (222) is rotatably mounted on the top of the fixed bracket (221), a rotating frame (223) is fixedly mounted on the top of the impeller (222), and a scraper (224) is fixedly mounted on the top of the rotating frame (223); The spray mechanism (3) comprises a rotating disk (31), the rotating disk (31) being rotatably mounted inside the observation cover (212), a spray pipe (32) being fixedly mounted inside the rotating disk (31), a spray hole (33) being arranged inside the spray pipe (32), and a spray box (34) being fixedly mounted on one end of the spray pipe (32) away from the rotating disk (31).
2. A chromatographic column that is easily backwashed according to claim 1, characterized in that: A threaded structure is provided on the outside of the top of the chromatography column body (1), and the threaded sleeve (211) is threadedly mounted on the outside of the threaded structure; the observation cover (212) is a conical structure.
3. A chromatographic column that is easily backwashed according to claim 1, characterized in that: Four groups of scrapers (224) are provided and distributed in a circle at the center of the rotating frame (223), and the scrapers (224) are in contact with the inner wall of the chromatography column body (1).
4. The chromatographic column easily backwashed according to claim 1, characterized in that: A water inlet pipe (214) is rotatably mounted inside the spray box (34), and four groups of spray pipes (32) and spray holes (33) are provided and are distributed in a circle at the center of the spray box (34).