Self-suction multi-runner dry biochemical multi-item detection device

Abstract

The utility model provides a self-suction multi-runner dry biochemical multi-item detection device. The self-suction multi-runner dry biochemical multi-item detection device comprises an upper cover layer, a runner layer, a lower permeable layer and a sample absorption layer which are sequentially arranged from top to bottom, the upper cover layer is provided with an upper cover layer air hole, the runner layer is provided with a sample suction runner, a runner layer air hole area and at least one shunting runner, the upper cover layer air hole is located behind the sample suction runner of the runner layer and in front of the shunting runner, and the diameter of the upper cover layer air hole is smaller than the width of the runner layer air hole area below the upper cover layer air hole; the lower permeable layer is provided with at least one infiltration hole at the top end of the shunting flow channel, and the sample absorption layer is tightly attached to the infiltration hole of the lower permeable layer. According to the utility model, a pipettor or a suction tube does not need to be additionally used for sample adding, bubbles can be eliminated in an automatic sample suction process, and flow is automatically cut off after a quantitative sample to be detected is sucked, so that the problems of sample pollution and inaccurate sample adding amount caused by sample adding by using the pipettor or the suction tube during detection can be solved, and the operation steps during detection are simplified.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical detection devices, in particular to a self-priming multi-channel dry biochemical multi-item detection device. Background Art

[0002] Existing dry biochemical test strips for quantitatively detecting biochemical indicators mostly require additional pipettes or straws to aspirate specimens and transfer them to the sample addition area of the test strip during specimen detection. There are detection errors caused by improper operations such as inaccurate sample addition volume, offset sample addition position, or multiple sample additions due to human factors, and there are also contamination problems caused by tips or straws.

[0003] Currently, dry chemical test strip detection methods are commonly used for quantitatively or qualitatively testing whether a certain component exists in a liquid sample, such as glucose, cholesterol, alanine aminotransferase, etc. in a blood sample. Dry biochemical test strips are divided into single-item and multi-item test strips according to the number of samples that can be measured at one time and the types of test indicators. The test method is to use a pipette or a quantitative straw to aspirate a specific amount of the specimen to be detected and drop it into the sample addition area of the test strip, and visually observe the result within a certain time or use a supporting instrument to test the result.

[0004] U.S. Patent No. US7087397B2 discloses a single-item test strip for measuring high-density lipoprotein cholesterol in blood. The device disclosed in this patent has an upper plate with a sample addition hole and a lower plate with a test window, and a test strip is tightly pressed between the upper plate and the lower plate. This detection device requires the use of a pipette or a sample addition tube, and only one item can be tested with one sample addition.

[0005] U.S. Patent No. US07494818B1 discloses a dry chemical detection device that can detect multiple items with one sample addition. It includes a sample addition hole and multiple test blocks, and a distribution layer between the sample addition hole and the multiple test blocks evenly distributes the dropped sample onto multiple reagent blocks, thereby realizing the function of completing multiple detection items with one sample addition. This detection device still requires the use of a pipette or a sample addition tube for sample addition.

[0006] Chinese Patent No. CN102680672A discloses a detection device, including an upper cover, a bottom plate combined with the upper cover, and a test strip located between the upper cover and the bottom plate. The upper cover is provided with a diversion structure on the lower surface, and a liquid transmission channel is formed between the sample addition hole of the upper cover, the diversion structure, the covering layer of the test strip, and the detection area, thereby realizing the test of multiple items with one sample addition. This detection device still requires the use of a pipette or a sample addition tube for sample addition.

[0007] A detection device capable of realizing automatic quantitative sampling is disclosed in a Chinese patent with the publication number CN106198950A. It includes a first cover plate and a second cover plate, and a controlled-volume sampling channel is provided on the first cover plate. The controlled-volume sampling channel includes a sampling port and a liquid outlet, and at least a section of capillary channel is included near the sampling port. There is a sampling platform on the first cover plate, and the sampling port is located at the center of the sampling platform. When sampling, the liquid sample enters the controlled-volume sampling channel inside the sampling port through the capillary channel near the sampling port. The volume of the controlled-volume sampling channel determines the volume of the sampled liquid. The design of this detection device is relatively complex, and a sampling platform and an additional capillary channel need to be added to the device. When sampling, the sample will leave residues in the sampling platform and the capillary channel, resulting in an increase in the actual sampling volume. It is difficult to perform multiple detections, and the operator cannot intuitively observe whether there is enough sample in the sampling channel.

[0008] A detection device is disclosed in a Chinese patent with the publication number CN206788183U. It includes a liquid suction upper cover, a bottom plate combined with the upper cover, and a test strip located between the upper cover and the bottom plate. The test strip can have one or more detection areas. When there are multiple detection areas, there is a covering layer connecting the multiple detection areas; the liquid suction upper cover includes an upper surface, a lower surface, and microfluidic channels penetrating the upper and lower surfaces. The sample outlet hole on the lower surface of the upper cover is opposite to the covering layer of the test strip; a liquid transmission channel is formed among the sample inlet hole, the microfluidic channels, the sample outlet hole on the upper cover, the covering layer of the test strip, and the said detection areas. To achieve multiple detections with this detection device, it depends on the liquid reaching the covering layer of the test strip and then diffusing through the covering layer to reach the detection areas. Since the diffusion layer has both diffusion and infiltration functions, the detection areas near the sample outlet hole on the lower surface of the upper cover will preferentially have more liquid infiltrating into this detection area. The amount of liquid specimen obtained by the detection areas far from the sample outlet hole of the upper cover is less than that near the sample outlet hole, resulting in uneven distribution of the sample volume among the detection areas in the case of multiple detection areas. In addition, after this detection device aspirates a quantitative liquid specimen, if the sample suction port of the device is not removed from the liquid sample in time, it will continuously aspirate the sample, causing too much sample to reach the detection areas and affecting the detection results. If air is mixed into the sample suction pipeline during the sample suction process, it will cause inaccurate sample suction volume. Utility Model Content

[0009] The purpose of the present utility model is to solve the above technical problems, and provide a self-aspirating multi-channel dry biochemical multi-detection device, which does not require additional use of a pipette or a straw for sampling, can exclude air bubbles during the automatic sampling process, and automatically cuts off the flow after aspirating a quantitative specimen to be detected. It can solve the problems of specimen contamination and inaccurate sampling volume caused by using a pipette or a straw for sampling during detection, and simplify the operation steps during detection.

[0010] To achieve the above purpose, the present utility model adopts the following technical solutions:

[0011] Self-priming multi-channel dry biochemical multi-detection device, comprising: an upper cover layer, a flow channel layer, a lower permeable layer and a sample absorption layer, the upper cover layer, the flow channel layer, the lower permeable layer and the sample absorption layer are arranged in sequence from top to bottom; the upper cover layer is provided with at least one upper cover layer air hole, the flow channel layer is provided with a sample suction flow channel, a flow channel layer air hole area and at least one shunt flow channel, the upper cover layer air hole is located after the sample suction flow channel and before the shunt flow channel of the flow channel layer, the diameter of the upper cover layer air hole is smaller than the width of the flow channel layer air hole area below the upper cover layer air hole, the lower permeable layer is provided with at least one infiltration hole at the top of the shunt flow channel, the diameter of the infiltration hole is smaller than the width of the shunt flow channel above the infiltration hole, and the sample absorption layer is closely attached to the infiltration hole of the lower permeable layer.

[0012] As a preferred technical solution, the sample absorption layer includes a dry reagent test block fixing and supporting layer and at least one dry reagent test block, the dry reagent test block is fixedly supported on the dry reagent test block fixing and supporting layer, and each dry reagent test block is closely attached to the infiltration hole corresponding to the lower permeable layer.

[0013] As a preferred technical solution, the shunt flow channel is a stepped flow channel, and the terminals of the stepped flow channels correspond to the infiltration holes of the lower permeable layer.

[0014] As a preferred technical solution, the upper cover layer, the flow channel layer and the lower permeable layer are separately arranged, at least one of the surfaces where the upper cover layer, the flow channel layer and the lower permeable layer are attached is a hydrophilic surface, the flow channel layer is a single-layer double-sided adhesive material, or the flow channel layer is a combination of multi-layer single-sided adhesive materials and double-sided adhesive materials.

[0015] As a preferred technical solution, the upper cover layer and the flow channel layer are integrally arranged.

[0016] As a preferred technical solution, the thickness of the lower permeable layer is between 0.01 and 0.3 mm.

[0017] After adopting the above technical solutions, the utility model has the following advantages:

[0018] 1 When the front sample suction port of the self-priming multi-channel dry biochemical multi-detection device contacts the liquid sample to be detected, the sample will be automatically sucked into the sample suction flow channel under the capillary action of the device flow channel, and the bubbles generated during the sample suction process can be discharged through the upper cover layer air hole, realizing the function of removing bubbles.

[0019] When the front sample suction port of the self-priming multi-channel dry biochemical multi-item detection device contacts the liquid sample to be detected, the sample will be automatically sucked into the sampling flow channel under the capillary action of the device flow channel and flow to each shunt flow channel, and then penetrate into the sample absorption layer through each infiltration hole of the lower penetration layer of the shunt flow channel. Since each detection area has a corresponding shunt flow channel and infiltration hole, the problem of uneven distribution of the sample volume in each detection area in the case of multiple detection areas is solved.

[0020] When the front sample suction port of the self-priming multi-channel dry biochemical multi-item detection device contacts the liquid sample to be detected, the sample will be automatically sucked into the sampling flow channel under the capillary action of the device flow channel and flow to the shunt flow channel, and then penetrate into the sample absorption layer through the infiltration hole of the lower penetration layer. When the sample reaches the dry reagent test block in the absorption layer, since the liquid absorption speed of the dry reagent test block is faster than the liquid transmission speed of the shunt flow channel, air will enter the flow channel layer through the air holes in the upper cover layer and then enter the shunt flow channel at the rear end, causing the capillary action in the sampling flow channel given by the shunt flow channel to disappear, thereby achieving the automatic cut-off function of the sample suction port to stop sucking the liquid sample.

[0021] 4. For the self-priming multi-channel dry biochemical multi-item detection device of the present utility model, different reactants can be pre-treated in the fixed support layers of each dry reagent test block. After automatically sucking the sample, since each shunt flow channel is independent, there will be no cross-contamination between different dry reagent test blocks. In addition, the width and length of the shunt flow channel can be calculated and designed according to the actual sample demand of each item to be detected, so simultaneous detection of multiple detection items with different sample demands can be realized.

[0022] 5. The self-priming multi-channel dry biochemical multi-item detection device of the present utility model can achieve different stepped designs by controlling the cross-sectional area of different regions of the shunt flow channel, so as to change the capillary force received by the liquid sample at different positions in the flow channel space composed of the upper cover layer, the flow channel layer and the lower penetration layer, thereby controlling the flow speed of the liquid specimen in the shunt flow channel, so as to achieve the purpose of still reaching the sample absorption layer simultaneously under the condition that the lengths of each shunt flow channel are different. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 is a structural schematic diagram of the self-priming multi-channel dry biochemical multi-item detection device;

[0024] Figure 2 is a structural schematic diagram of the upper cover layer;

[0025] Figure 3 is a structural schematic diagram of the upper flow channel layer in this embodiment;

[0026] Figure 4 is a structural schematic diagram of the lower flow channel layer in this embodiment;

[0027] Figure 5 It is a schematic structural diagram of the lower permeable layer;

[0028] Figure 6 It is a schematic structural diagram of the sample absorption layer;

[0029] Figure 7 It is a sectional view of a self - suction multi - channel dry biochemical multi - detection device. Detailed implementation manners

[0030] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the protection scope of the present utility model.

[0031] As Figure 1-7 shown, a self - suction multi - channel dry biochemical multi - detection device includes: an upper cover layer 1, a flow channel layer 2, a lower permeable layer 3, and a sample absorption layer 4, which are arranged in sequence from top to bottom.

[0032] In this embodiment, the upper cover layer 1 and the flow channel layer 2 are separately provided. The upper cover layer 1 is made of transparent plastic material, and the surface of the upper cover layer 1 that fits with the flow channel layer 2 is a hydrophilic surface. The flow channel layer 1 is a single - layer double - sided adhesive material, or the flow channel layer 2 is a combination of multi - layer single - sided adhesive materials and double - sided adhesive materials.

[0033] In another implementation manner, the upper cover layer 1 and the flow channel layer 2 are integrally provided plastic materials. The upper cover layer 1 and the flow channel layer 2 are transparent hydrophilic materials, or the surfaces of the upper cover layer 1 and the flow channel layer 2 adjacent to the lower permeable layer 3 are treated hydrophilically.

[0034] The upper cover layer 1 is provided with upper cover layer air holes 101. The flow channel layer 2 is provided with a sample suction flow channel 201, a flow channel layer air hole area 202, and at least one shunt flow channel 203. The upper cover layer air holes 101 are located after the sample suction flow channel 201 and before the shunt flow channel 203 of the flow channel layer 2. The diameter of the upper cover layer air holes 101 is smaller than the width of the flow channel layer air hole area 202 located below the upper cover layer air holes 101. The upper cover layer air holes 101 can be one or more, and the shape of the upper cover layer air holes 101 can be various shapes formed by closing lines.

[0035] The shunt flow channels 203 can be one or more, and the width, length, and thickness of the shunt flow channels 203 are calculated and determined according to the actual sample demand of the sample to be detected. The shunt flow channels 203 can be stepped flow channels, and the terminals of the stepped flow channels 203 correspond to the infiltration holes 301 of the lower permeable layer 3. By controlling the cross-sectional area of different stepped regions of the shunt flow channels 203, the capillary force acting on the sample at different positions in the liquid flow channel composed of the upper cover layer 1, the flow channel layer 2, and the lower permeable layer 3 is controlled.

[0036] The lower permeable layer 3 is provided with at least one infiltration hole 301 at the top of the shunt flow channel 203. The diameter of the infiltration hole 301 is smaller than the width of the shunt flow channel 203 above the infiltration hole 301, and the sample absorption layer is closely attached to the infiltration hole 301 of the lower permeable layer 3. The lower permeable layer 3 is a single-layer single-sided adhesive, single-sided hot melt adhesive, single-sided UV adhesive, or a plastic sheet without coating, and its thickness is between 0.01 and 0.3 mm. The infiltration holes 301 can be one or more, and the shape of the infiltration holes 301 can be various shapes formed by closing lines.

[0037] In one embodiment, the dry test reagent block 401 in the sample absorption layer 4 can be composed of a single-layer material or a multi-layer material. The side that fits with the infiltration hole 301 is a hydrophilic and permeable material, preferably one of mesh cloth, polyester film, fiberglass, and filter paper materials. The dry test reagent block 401 in the sample absorption layer 4 is integrally attached to all the infiltration holes 301 of the lower permeable layer 3.

[0038] In this embodiment, the sample absorption layer 4 includes a dry reagent test block fixing and supporting layer 402 and at least one dry reagent test block 401. The dry reagent test block 401 is fixedly supported on the dry reagent test block fixing and supporting layer 402, and each dry reagent test block 401 is closely attached to the infiltration hole 301 corresponding to the lower permeable layer 3. The liquid flow channel composed of the upper cover layer 1, the flow channel layer 2, and the lower permeable layer 3 shunts the sample to be detected to one or more dry reagent test blocks 401 to achieve the purpose of single or multiple detections. When setting the dry reagent test blocks 401 in the sample absorption layer 4, the dry reagent test blocks 401 can be set to different thicknesses to balance the thickness differences caused by different thicknesses of the dry reagent test blocks 401 for different detection items.

[0039] The self-priming multi-channel dry biochemical multi-detection device of this embodiment is mainly applied to photochemical dry biochemical detection and uses the principle of photocolorimetry to measure a specific chemical component in body fluid. For example, in a multi-item lipid test, the device transports a quantitative amount of blood to different dry reagent test blocks 401 for reaction, and the purpose of quantitative detection is achieved by detecting the degree of change in the reaction color of the dry reagent test blocks 401 by an instrument.

[0040] For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above-mentioned exemplary embodiments, and the present utility model can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present utility model. Any reference signs in the claims should not be construed as limiting the claims involved.

[0041] In addition, it should be understood that although this specification is described in terms of embodiments, not every embodiment only contains an independent technical solution. This narrative way of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A self-priming multi-channel dry biochemical multi-item detection device, characterized in that: include: An upper cover layer, a flow channel layer, a lower permeation layer and a sample absorption layer, wherein the upper cover layer, the flow channel layer, the lower permeation layer and the sample absorption layer are arranged in sequence from top to bottom; the upper cover layer is provided with at least one upper cover layer pore, the flow channel layer is provided with a sample suction flow channel, a flow channel layer pore area and at least one diversion flow channel, the upper cover layer pore is located after the sample suction flow channel of the flow channel layer and before the diversion flow channel, the diameter of the upper cover layer pore is smaller than the width of the flow channel layer pore area below the upper cover layer pore, the lower permeation layer is provided with at least one lower infiltration hole at the top of the diversion flow channel, the diameter of the lower infiltration hole is smaller than the width of the diversion flow channel above the lower infiltration hole, and the sample absorption layer is tightly fitted with the lower infiltration hole of the lower permeation layer.

2. The self-priming multi-channel dry biochemical multi-item detection device according to claim 1 is characterized in that: The sample absorption layer includes a dry reagent test block fixing support layer and at least one dry reagent test block, the dry reagent test block is fixedly supported on the dry reagent test block fixing support layer, and each dry reagent test block is tightly fitted with the corresponding lower permeation hole of the lower permeation layer.

3. The self-priming multi-channel dry biochemical multi-item detection device according to claim 1, characterized in that: The diversion flow channel is a stepped flow channel, and the terminal end of the stepped flow channel corresponds to each lower infiltration hole of the lower permeation layer.

4. The self-priming multi-channel dry biochemical multi-item detection device according to claim 1 or 3, characterized in that: The upper cover layer, the flow channel layer and the lower permeation layer are arranged separately, at least one of the surfaces where the upper cover layer, the flow channel layer and the lower permeation layer are bonded is a hydrophilic surface, the flow channel layer is a single-layer double-sided adhesive material, or the flow channel layer is a combination of multiple layers of single-sided adhesive material and double-sided adhesive material.

5. The self-priming multi-channel dry biochemical multi-item detection device according to claim 1, characterized in that: The upper cover layer and the flow channel layer are integrally arranged.

6. The self-priming multi-channel dry biochemical multi-item detection device according to claim 1, characterized in that: The thickness of the lower permeable layer is between 0.01 and 0.3 mm.

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