Medicine dispensing device for washing liquid used after tumor operation

Abstract

The utility model discloses a medicine dispensing device for washing liquid used after a tumor operation. The dispensing device comprises a base, and the base is provided with a first partition plate, a second partition plate and a third partition plate which are parallel from top to bottom; an mRNA preparation lotion bottle clamping assembly is arranged on the first partition plate; a planar ultrasonic probe, a planar amplitude-change pole and a transducer are arranged below the first partition plate; an ultrasonic generator is arranged on the second partition plate; a heat dissipation film is arranged below the second partition plate; a controller, a power supply module and an uninterruptible power supply are arranged on the third partition plate; a control panel of the controller is mounted on the outer wall of the left side, between the first partition plate and the third partition plate, of the base; heat dissipation through holes are formed in the outer wall of the right side, between the first partition plate and the second partition plate, of the base; and an external power line outlet is formed in the outer wall of the right side, between the second partition plate and the third partition plate, of the base.

Description

Technical Field

[0001] The utility model relates to the technical field of tumor treatment, in particular to a medicine dispensing device for a lotion after tumor surgery and its using method. Background Art

[0002] The lotion of in vitro synthesized mRNA preparation is gradually applied to the cleaning of tumor surgical wounds or in vivo surgical areas to assist in reducing the risk of cancer recurrence and metastasis after surgery as much as possible (1. Chinese invention patent, application number: 2023111836270, a mRNA preparation lotion for cleaning tumor surgical wounds or in vivo surgical areas; 2. Chinese invention patent, application number: 2023112807294, a novel lotion for cleaning tumor surgical wounds or in vivo surgical areas; 3. Chinese invention patent, application number: 202410628847.8, a mRNA preparation lotion bottle). Among them, Chinese invention patent 202410628847.8 provides a strong guarantee for the precise and safe use of mRNA preparation lotion by medical staff after tumor surgery.

[0003] However, since some cancer patients need to further dilute the mRNA preparation lotion with solutions such as normal saline before use after tumor surgery. During the dilution process, medical staff need to inject normal saline into the bottle containing the mRNA preparation lotion through a syringe, and then place the palms of both hands on both sides of the bottle and rotate the bottle repeatedly and evenly to promote the uniform mixing of the diluent. Obviously, due to the rotation speed of the mRNA preparation lotion bottle and its dispensing time being seriously affected by the subjective factors of medical staff, not only can the full mixing between normal saline and the mRNA preparation lotion not be ensured, but also medical staff cannot carry out other work during the process of rotating the mRNA preparation lotion bottle, which is time-consuming and laborious.

[0004] In view of this, the purpose of the utility model is to provide a medicine dispensing device for a lotion after tumor surgery, which mixes the normal saline diluent of the mRNA preparation lotion through dry-coupled ultrasonic oscillation, while reducing the physical labor workload of medical staff in dispensing medicine, and fully meeting the personalized customization needs of some cancer patients who need to further dilute the mRNA preparation lotion before use after tumor surgery. Content of the Utility Model

[0005] The technical problem to be solved by the utility model is to overcome the deficiencies of the existing operation technology for diluting the mRNA preparation lotion, and provide a medicine dispensing device for a lotion after tumor surgery that can overcome or partially solve the above problems. It can not only reduce the physical labor workload of medical staff in dispensing medicine, but also fully meet the personalized customization needs of some cancer patients who need to further dilute the mRNA preparation lotion before use after tumor surgery.

[0006] To achieve the above object, the technical solution of the present utility model is as follows:

[0007] A medicine dispensing device for a lotion after tumor surgery. The dispensing device includes a base, and the base is provided with a first partition, a second partition, and a third partition that are parallel from top to bottom; a mRNA preparation lotion bottle clamping assembly is arranged on the upper surface of the first partition. The bottle clamping assembly includes a vibration isolation pad, a support ring, a lotion bottle clamp, and a column. The vibration isolation pad is installed in the middle of the first partition, the support ring is installed on the vibration isolation pad, the column is fixedly installed in the column fixing hole positions provided on the first partition, and the end of the lotion bottle clamp without a spring clip is fixed in the lotion bottle clamp fixing hole positions provided on the column; a planar ultrasonic probe, a planar amplitude transformer, and a transducer are arranged under the first partition. The planar ultrasonic probe is adhesively installed under the first partition by mechanical connection, the planar amplitude transformer is adhesively installed under the planar ultrasonic probe by mechanical connection, and the transducer is adhesively installed under the planar amplitude transformer by mechanical connection; an ultrasonic generator is arranged on the upper surface of the second partition, and the ultrasonic generator is connected to the transducer through a high-frequency high-voltage cable; a heat dissipation film is arranged under the second partition; a controller, a power module, and an uninterruptible power supply are arranged on the upper surface of the third partition. The controller is connected to the ultrasonic generator through a signal cable, the controller is connected to the power module through a control cable, the power module is connected to the ultrasonic generator through a power cable, the power module is connected to the uninterruptible power supply through a power cable, and the uninterruptible power supply is connected to an external power cord; a control panel of the controller is installed on the left outer wall of the base between the first partition and the third partition. The control panel includes a display screen, buttons, and an alarm lamp, and the control panel is connected to the controller through a control cable; heat dissipation through holes are arranged on the right outer wall of the base between the first partition and the second partition; an external power cord outlet is arranged on the right outer wall of the base between the second partition and the third partition. Compared with the existing operation technical solution for diluting the current mRNA preparation lotion, the present utility model not only can reduce the physical labor workload of medicine dispensing for medical staff, but also can fully meet the personalized customization requirements of some cancer patients for further diluting the mRNA preparation lotion before use after tumor surgery.

[0008] According to the embodiments of the present utility model, the present utility model can be further optimized. The following is the technical solution formed after optimization:

[0009] In one preferred embodiment, for a medicine dispensing device for a lotion after tumor surgery, the material of the first partition is aluminum alloy that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming.

[0010] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the first partition is titanium alloy that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming.

[0011] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the first partition is stainless steel that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming.

[0012] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the first partition is glass fiber reinforced plastic that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming. The heat distortion temperature of the glass fiber reinforced plastic is greater than 100 degrees Celsius. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is thirty to seventy percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is thirty-one percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is thirty-five percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is forty percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is forty percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is forty-five percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is fifty percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is fifty-five percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is sixty percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is sixty-five percent. In one preferred embodiment, in the glass fiber reinforced plastic, the mass content of glass fiber is sixty-nine percent.

[0013] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the first partition is carbon fiber reinforced plastic that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming. The heat distortion temperature of the carbon fiber reinforced plastic is greater than 100 degrees Celsius. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 50% to 70%. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 51%. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 55%. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 60%. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 65%. In one preferred embodiment, in the carbon fiber reinforced plastic, the mass content of carbon fiber is 69%.

[0014] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the first partition is boron nitride that can not only effectively conduct ultrasonic waves through the partition but also prevent the partition from bending and deforming.

[0015] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the vibration isolation pad is fixed in the middle of the first partition by using an industrial-grade adhesive.

[0016] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the vibration isolation pad is fixed in the middle of the first partition by a mechanical fixing method using bolts or screws.

[0017] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the vibration isolation pad is fixed in the middle of the first partition by an embedded installation method of grooving in the middle of the first partition.

[0018] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the thickness of the vibration isolation pad is 1 - 20 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 2 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 3 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 4 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 5 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 6 - 10 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 11 - 15 millimeters. In one preferred embodiment, the thickness of the vibration isolation pad is 15 - 19 millimeters.

[0019] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the hardness of the vibration isolation pad is between 1 and 70 A. In one preferred embodiment, the hardness of the vibration isolation pad is 2 - 5 A. In one preferred embodiment, the hardness of the vibration isolation pad is 6 - 10 A. In one preferred embodiment, the hardness of the vibration isolation pad is 11 - 15 A. In one preferred embodiment, the hardness of the vibration isolation pad is 16 - 20 A. In one preferred embodiment, the hardness of the vibration isolation pad is 21 - 25 A. In one preferred embodiment, the hardness of the vibration isolation pad is 26 - 30 A. In one preferred embodiment, the hardness of the vibration isolation pad is 31 - 40 A. In one preferred embodiment, the hardness of the vibration isolation pad is 41 - 50 A. In one preferred embodiment, the hardness of the vibration isolation pad is 51 - 60 A. In one preferred embodiment, the hardness of the vibration isolation pad is 61 - 69 A.

[0020] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the vibration isolation pad is natural rubber.

[0021] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the vibration isolation pad is silica gel and polyurethane.

[0022] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the material of the vibration isolation pad is polyurethane.

[0023] In one of the preferred embodiments, a dispensing device for washing liquid after tumor surgery, the vibration isolation pad is a multi-layer structure. In one of the preferred embodiments, the multi-layer structure is a rubber layer, a foam layer, a metal plate layer, a foam layer, and a rubber layer from top to bottom, and the multi-layer structure uses a high-strength adhesive or a hot pressing process to tightly bond the layers together. In one of the preferred embodiments, the multi-layer structure is a rubber layer, a foam layer, an air layer, and a rubber layer from top to bottom, and the multi-layer structure uses a cold pressing agent or a hot pressing process to tightly bond the layers together. In one of the preferred embodiments, the multi-layer structure is a rubber layer, a spring layer, a silicone layer, and a rubber layer from top to bottom, and the multi-layer structure uses a cold pressing agent or a hot pressing process to tightly bond the layers together. In one of the preferred embodiments, the multi-layer structure is a polyurethane layer, a spring layer, a silicone layer, and a polyurethane layer from top to bottom, and the multi-layer structure uses a cold pressing agent or a hot pressing process to tightly bond the layers together. Among them, the thickness of the rubber layer is 0.5-10 mm, the thickness of the foam layer is 1-20 mm, and the thickness of the metal plate is 0.1-2 mm. Furthermore, the rubber material is made of wear-resistant and aging-resistant nitrile rubber or silicone or natural rubber, the foam material is high-density polyurethane foam or ethylene-vinyl acetate copolymer foam, the metal plate is aluminum alloy or stainless steel, and the adhesive is a high-strength and durable industrial adhesive.

[0024] In one of the preferred embodiments, a dispensing device for washing liquid after tumor surgery, the bottom of the vibration isolation pad has a texture or a non-slip surface.

[0025] In one of the preferred embodiments, a dispensing device for washing solution after tumor surgery, the support ring is fixed to the vibration isolation pad with a high-strength adhesive, and the adhesive is a high-strength, durable industrial adhesive with a tensile strength greater than 20 MPa, a shear strength greater than 24 MPa, an operating temperature greater than 100 degrees Celsius, and excellent chemical resistance.

[0026] In one of the preferred embodiments, a dispensing device for washing liquid after tumor surgery, the support ring is fixed to the vibration isolation pad by bolts and nuts, and both the support ring and the vibration isolation pad are provided with reserved holes for fixing.

[0027] In one of the preferred embodiments, in a dispensing device for washing liquid after tumor surgery, the support ring is fixed to the vibration isolation pad by physical interlocking, and the vibration isolation pad has a reserved embedding groove or hole.

[0028] In one of the preferred embodiments, a dispensing device for washing liquid after tumor surgery, the support ring is fixed to the vibration isolation pad by welding, the support ring is a metal support ring, and the vibration isolation pad is a vibration isolation pad with a metal insert or a metal vibration isolation pad.

[0029] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is rubber.

[0030] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is silica gel.

[0031] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is polyurethane.

[0032] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is polytetrafluoroethylene.

[0033] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is stainless steel.

[0034] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the material of the support ring is aluminum alloy.

[0035] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the support ring is annular, and the ring diameter of the support ring adopts an adjustable design with multiple gear slots, which is convenient for quick adjustment according to the bottle diameter to adapt to lotion bottles of different sizes.

[0036] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the column is fixedly installed on the column fixing hole positions provided on the first partition by bolts.

[0037] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the column is fixedly installed on the column fixing hole positions provided on the first partition by buckles.

[0038] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the height of the column is adjustable.

[0039] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the column is marked with scales.

[0040] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the column is provided with lotion bottle clip fixing hole positions, and the lotion bottle clip is fixed by bolts, screws or buckles.

[0041] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the lotion bottle clip fixing hole positions provided on the column are of a multi-hole design to adapt to the installation requirements at different positions.

[0042] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the material of the column is stainless steel.

[0043] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the material of the column is aluminum alloy.

[0044] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the lotion bottle clip not fixed at one end of the column is a spring clip.

[0045] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the lotion bottle clip not fixed at one end of the column is a screw clip, and the clamping force is adjusted by rotation.

[0046] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the material of the lotion bottle clip is aluminum alloy.

[0047] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, wherein the material of the lotion bottle clip is stainless steel.

[0048] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar ultrasonic probe and the first partition is a threaded connection, and a rubber or silicone gasket is used at the threaded connection.

[0049] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar ultrasonic probe and the first partition is a flange connection. The flange is welded or fixed on the probe and the partition, and the flange of the probe is connected to the flange of the partition with bolts, and a polytetrafluoroethylene or metal gasket is used.

[0050] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar ultrasonic probe and the first partition is a spring snap or a rotary locking structure, and a safety lock is added.

[0051] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the frequency of the planar ultrasonic probe is 20 KHz - 4 MHz.

[0052] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the planar ultrasonic probe is Olympus Panametrics V601, and the frequency is 20 kHz.

[0053] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the planar ultrasonic probe has a model of Airmar Technology Corporation T50-R and a frequency of 50 kHz.

[0054] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the planar ultrasonic probe has a model of Ultran Group UTS-1000 and a frequency of 100 kHz.

[0055] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the planar ultrasonic probe has a model of Olympus V601-RB and a frequency of 1 MHz.

[0056] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the planar ultrasonic probe has a model of GE Inspection Technologies Krautkramer SONOSCAN II and a frequency of 2.25 MHz.

[0057] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar horn and the planar ultrasonic probe is a threaded connection, and a locknut or a lock washer is used to prevent the thread from loosening.

[0058] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar horn and the planar ultrasonic probe is a flange connection. A flange is machined at the connection part between the planar horn and the planar ultrasonic probe, and the flange is fixedly connected by bolts and nuts, and washers are used.

[0059] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar horn and the planar ultrasonic probe is a keyway connection. Corresponding keyways are machined at the connection part between the planar horn and the planar ultrasonic probe, and the planar horn and the planar ultrasonic probe are fixed by bolts or nuts.

[0060] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the planar horn and the planar ultrasonic probe is a welding connection. Appropriate welding methods are used to weld at the connection part between the planar horn and the planar ultrasonic probe. In one preferred embodiment, the welding method is TIG welding. In one preferred embodiment, the welding method is laser welding.

[0061] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the mechanical connection between the planar horn and the planar ultrasonic probe is a clamping connection. The planar horn and the planar ultrasonic probe are placed in a suitable fixture, and the fixture is fastened by bolts or nuts.

[0062] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the frequency of the planar horn is 20 KHz - 4 MHz.

[0063] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the model of the planar horn is Olympus NDT Rexo™ 6400, and the frequency is 20 kHz.

[0064] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the model of the planar horn is GE Inspection Technologies Krautkramer SONOSCAN DCM™, and the frequency is 50 kHz.

[0065] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the model of the planar horn is Sonatest Ltd. Dryscan™ D50 with 100 kHz capability, and the frequency is 100 kHz.

[0066] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the model of the planar horn is Olympus V305-SU, and the frequency is 1 MHz.

[0067] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the model of the planar horn is GE P / N 113-262-043, and the frequency is 2.25 MHz.

[0068] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the mechanical connection between the transducer and the planar horn is a threaded connection, and a locknut or a lock washer is used to prevent the thread from loosening.

[0069] In one preferred embodiment, a dispensing device for a lotion used after tumor surgery, the mechanical connection between the transducer and the planar horn is a flange connection. A flange is machined at the connection part between the transducer and the planar horn, and the flange is fixedly connected by bolts and nuts, and washers are used.

[0070] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the transducer and the planar horn is a keyway connection. Corresponding keyways are machined at the connection part between the transducer and the planar horn, and the planar horn and the planar ultrasonic probe are fixed by bolts or nuts.

[0071] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the transducer and the planar horn is a welding connection. Appropriate welding methods are used for welding at the connection part between the transducer and the planar horn. In one preferred embodiment, the welding method is TIG welding. In one preferred embodiment, the welding method is laser welding.

[0072] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the mechanical connection between the transducer and the planar horn is a clamping connection. The transducer and the planar horn are placed in a suitable fixture, and the fixture is fastened by bolts or nuts.

[0073] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the frequency of the transducer is 20 KHz - 4 MHz.

[0074] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the transducer is Branson 502 and the frequency is 20 kHz.

[0075] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the transducer is Olympus V1011 and the frequency is 50 kHz.

[0076] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the transducer is PiezoData PS110A1 100 kHz and the frequency is 100 kHz.

[0077] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the transducer is Kaijo 1 MHz and the frequency is 1 MHz.

[0078] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the transducer is Danatronics DCK-250 2.25 MHz and the frequency is 2.25 MHz.

[0079] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, a heat dissipation film is pasted under the second partition board, and the heat dissipation film is used to ensure the stable operation of the ultrasonic generator and extend its service life.

[0080] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the heat dissipation film is a graphite heat dissipation film.

[0081] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the heat dissipation film is a silica gel heat dissipation film.

[0082] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the heat dissipation film is a phase change material (PCM) heat dissipation film.

[0083] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the heat dissipation film is an aluminum foil heat dissipation film.

[0084] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the frequency of the ultrasonic generator is 20KHz - 4MHz, and the power is 10W - 2400W. The ultrasonic generator body is equipped with a power sensor and a temperature sensor. The power sensor is installed in the circuit of the ultrasonic generator to monitor its power consumption, which helps to detect abnormal conditions such as power overload or other faults. The temperature sensor is installed near the shell or key components of the ultrasonic generator to monitor the working temperature of the device. Because too high temperature may cause device damage or reduce the service life. The signals of the sensors are transmitted to the controller via signal cables, and the controller monitors according to preset thresholds. If the values detected by the sensors exceed the set thresholds, the controller will trigger the alarm system to notify the operator to take measures.

[0085] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the ultrasonic generator is Olympus 5077PR, the frequency is 20KHz, and the power is 200W.

[0086] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the ultrasonic generator is Kaijo Phenix Hyper, the frequency is 50KHz, and the power is 300W.

[0087] In one preferred embodiment, a dispensing device for a lotion after tumor surgery, the model of the ultrasonic generator is Kaijo Phenix Hyper, the frequency is 100KHz, and the power is 400W.

[0088] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the ultrasonic generator has a model number of Avitech AU, a frequency of 1 MHz, and a power of 800 W.

[0089] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the ultrasonic generator has a model number of Avitech AU, a frequency of 2.25 MHz, and a power of 1200 W.

[0090] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the controller is a programmable logic controller (PLC), a distributed control system controller (DCS), an embedded controller or an intelligent controller.

[0091] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the controller has a model number of Siemens S7-1200 PLC, and the PLC program described in ladder diagram (LAD) language is as follows:

[0092] ;

[0093] The program explanation is as follows: (1) Startup logic: When the startup button is pressed, the PLC will output a startup signal to start the ultrasonic generator; (2) Stop logic: When the stop button is pressed, the PLC will output a stop signal to stop the ultrasonic generator; (3) Reset logic: When the reset button is pressed, the PLC will clear the alarm signal and reset the alarm status; (4) Monitoring logic: Monitor the power signal and temperature signal. When the power exceeds 210 W or the temperature exceeds 50 °C, trigger the alarm light; (5) Display logic: Periodically refresh the display screen to display the current system status and alarm information; (6) The power threshold and temperature threshold in the code can be adjusted according to the power and temperature requirements of different ultrasonic generators.

[0094] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the controller has a model number of Emerson DeltaV, and the DCS program described in ladder diagram logic is as follows:

[0095] ;

[0096] The program explanation is as follows: (1) Start button logic: When X0 (start button) is pressed, Y0 (start ultrasonic generator) and Y1 (output start signal) are triggered; (2) Stop button logic: When X1 (stop button) is pressed, Y2 (stop ultrasonic generator) and Y3 (output stop signal) are triggered; (3) Reset button logic: When X2 (reset button) is pressed, Y4 (reset alarm status) and Y5 (clear alarm signal) are triggered; (4) Power signal alarm logic: When X3 (power signal) exceeds the threshold of 210, Y6 (trigger alarm light) is triggered; (5) Temperature signal alarm logic: When X4 (temperature signal) exceeds the threshold of 50, Y7 (trigger alarm light) is triggered; (6) Display screen refresh logic: When X5 (display screen update signal) is triggered, Y10 (refresh display content) is triggered; (7) The power threshold and temperature threshold in the code can be adjusted according to the power and temperature requirements of different ultrasonic generators.

[0097] In one preferred embodiment, a medicine dispensing device for the lotion after tumor surgery, the model of the controller is Raspberry Pi, and the embedded controller program described in Python is:

[0098] ;

[0099] The program explanation is as follows: (1) Pin definition: Define all GPIO pins to be used; (2) Set pin mode: Pull-up resistors are used for input pins to ensure that the pins remain high when the button is not pressed; (3) Output pins are used to control the ultrasonic generator, output signals, and alarm lights; (4) Initialize pin status: The initial status of all output pins is set to low level (off state); (5) Button check function check_buttons: Check the status of each button and perform corresponding operations if pressed; (6) Trigger the alarm light according to the sensor signal status; (7) Call the update_display function when the display update button is pressed; (8) Main loop: Continuously check the button status and refresh it every 0.1 second; (9) Clean up: Catch the keyboard interrupt (Ctrl+C) and clean up the GPIO pin status when the program exits; (9) The power threshold and temperature threshold in the code can be adjusted according to the power and temperature requirements of different ultrasonic generators.

[0100] In one preferred embodiment, a medicine dispensing device for the lotion after tumor surgery, the controller is an intelligent controller, and the intelligent control program described in the LabVIEW block diagram is:

[0101] ;

[0102] The program explanation is as follows: (1) Start and stop buttons: Connect the start button and stop button to the "Case Structure", and set the corresponding output signals according to the button status; (2) Reset button: Connect the reset button to the "Case Structure", and clear the alarm signal according to the button status; (3) Alarm logic: Connect the power signal and temperature signal to the "greater than" comparison function, and the comparison result triggers the alarm light through the "Or" function; (4) Display logic: Connect the system status information to the "Concatenate Strings" function to update the display screen content; (5) The power threshold and temperature threshold in the code can be adjusted according to the power and temperature requirements of different ultrasonic generators.

[0103] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the power supply module is Mean Well.

[0104] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the power supply module is TDK-Lambda.

[0105] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the power supply module is Vicor VTM.

[0106] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the power supply module is XP Power.

[0107] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the uninterruptible power supply is CyberPower.

[0108] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the uninterruptible power supply is Eaton 5P.

[0109] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the uninterruptible power supply is APC Smart-UPS.

[0110] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the control panel is Olympus Epoch 6LT, and the power supply is a lithium-ion battery.

[0111] In one preferred embodiment, a dispensing device for postoperative tumor lotion, the model of the control panel is GE Inspection Technologies USM Go+, and the power supply is a rechargeable lithium-ion battery.

[0112] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the control panel is of the model Sonatest Sitescan D-70, and the power supply is a large-capacity lithium battery.

[0113] In one of the preferred embodiments, a dispensing device for a lotion after tumor surgery, the control panel is of the model Krautkramer USM 36, and the power supply is a lithium-ion battery.

[0114] A method for manufacturing a dispensing device for a lotion after tumor surgery includes the following steps:

[0115] First step, configure the first partition, the second partition, and the third partition parallel to each other from top to bottom on the base to construct the base; second step, attach and install the planar ultrasonic probe under the first partition through a flange connection; third step, attach and install the planar horn under the planar ultrasonic probe through a flange connection; fourth step, attach and install the transducer under the planar horn through a flange connection; fifth step, paste a heat dissipation film under the second partition; sixth step, install the ultrasonic generator on the second partition, and connect the ultrasonic generator and the transducer through a high-frequency high-voltage cable; seventh step, install the controller, the power module, and the uninterruptible power supply in sequence on the third partition, connect the controller and the ultrasonic generator through a signal cable, connect the power module and the ultrasonic generator through a power cable, connect the controller and the power module through a control cable, connect the power module and the uninterruptible power supply through a power cable, and connect the uninterruptible power supply and the external power cord; eighth step, install the control panel on the left outer wall between the first partition and the third partition of the base, and connect the display screen, the start button, the stop button, the reset button, and the alarm light on the control panel to the corresponding pins or terminals on the controller through a control cable; ninth step, install an outer wall with heat dissipation through holes on the right side between the first partition and the second partition of the base; tenth step, install an outer wall with an external power cord outlet on the right side between the second partition and the third partition of the base; eleventh step, install the front outer wall and the rear outer wall on the front and rear sides respectively between the first partition and the third partition of the base; twelfth step, install the vibration isolation pad in the middle of the first partition, and then install the support ring on the vibration isolation pad; thirteenth step, fixedly install the fixed connection part of the column on the column fixing hole position provided on the first partition; fourteenth step, fix one end of the lotion bottle clip without a spring clip on one of the lotion bottle clip fixing hole positions provided on the column to make a dispensing device for a lotion after tumor surgery.

[0116] Working principle of a medicine dispensing device for a lotion after tumor surgery: The ultrasonic transducer converts electrical energy into mechanical energy, generates ultrasonic waves through high-frequency vibration, and transmits the generated ultrasonic waves into the lotion bottle through the ultrasonic dry coupling medium material of the first partition, via the vibration isolation pad and the support ring. The mRNA preparation lotion diluted with physiological saline is mixed evenly by means of ultrasonic oscillation. Among them, the ultrasonic generator generates high-frequency high-voltage electrical signals to drive the ultrasonic transducer to work; the transducer converts the electrical signals into mechanical vibrations (ultrasonic waves); the horn adjusts the amplitude of the ultrasonic waves, amplifying or reducing the vibration amplitude; the planar ultrasonic probe evenly transmits the ultrasonic energy transmitted from the horn to the dry coupling medium material, the vibration isolation pad and the support ring. Among them, the vibration isolation pad is used to reduce the vibration transmitted to other components of the medicine dispensing device, ensuring that the vibration is mainly conducted into the lotion bottle rather than diffused to other parts of the medicine dispensing device; while, the support ring is used to fix and support the lotion bottle, ensuring that the lotion bottle does not displace or tilt under vibration, enabling the ultrasonic energy to be evenly conducted into the lotion bottle, ensuring that the liquid in the entire bottle can be subjected to uniform ultrasonic action. The synergistic effect of the vibration isolation pad and the support ring ensures that the diluted mRNA preparation lotion can be evenly mixed under dry coupling ultrasonic vibration, thus achieving the desired effect.

[0117] Usage method of a medicine dispensing device for a lotion after tumor surgery, including the following steps:

[0118] Step 1: Inject the required amount of normal saline into the mRNA preparation washing solution bottle; Step 2: Place the mRNA preparation washing solution bottle filled with normal saline into the support ring, and then further fix the washing solution bottle by adjustment using the washing solution bottle clamp; Step 3: Connect to the mains power through the external power cord, and turn on the start switch on the control panel to start the medicine dispensing device; Step 4: After dispensing medicine for a period of time, press the off switch on the control panel to turn off the medicine dispensing device; Step 5: For the washing solution bottle taken from the medicine dispensing device, use an ultrasonic transmission device to nondestructively detect the liquid at different positions of the washing solution bottle. By analyzing the difference in ultrasonic amplitude changes, judge the homogeneity of the mixture of the mRNA preparation washing solution and normal saline; if not evenly mixed, repeat the work in Steps 2 to 5; Step 6: Directly use the prepared mRNA preparation washing solution for clinical use. The ultrasonic transmission detection technology is a nondestructive detection method and is widely used in the uniformity detection of various liquids. For detecting the homogeneity of the washing solution at different positions in the washing solution bottle, the basic principle of ultrasonic transmission detection is as follows: First, an ultrasonic transmitter (usually a piezoelectric crystal) converts an electrical signal into an ultrasonic pulse and transmits it into the washing solution; Second, when the ultrasonic wave propagates in the washing solution, it will be affected by the density, viscosity and other physical properties of the washing solution. If the washing solution is homogeneous, the ultrasonic wave will propagate in the medium at a constant speed; if there is inhomogeneity, the ultrasonic wave propagation speed will change, resulting in a change in the transmitted waveform; Third, an ultrasonic receiver (also usually a piezoelectric crystal) receives the ultrasonic signal passing through the washing solution and converts it back into an electrical signal; Fourth, the received electrical signal is processed by an electronic circuit to analyze the changes in the time, amplitude and frequency spectrum of the ultrasonic signal at different positions in the washing solution bottle. Based on these changes, judge the homogeneity of the washing solution at different positions.

[0119] Compared with the prior art, the beneficial effects of the present utility model are:

[0120] (1) It fills the gap in the medicine dispensing device that uses dry-coupled ultrasonic oscillation to mix the mRNA preparation washing solution at home and abroad;

[0121] (2) It provides medical staff with a medicine dispensing method that uses dry-coupled ultrasonic oscillation to mix the mRNA preparation washing solution, which can reduce the workload of medical staff in medicine dispensing while improving the standardized operation of mRNA preparation washing solution dispensing;

[0122] (3) It fully meets the personalized customization needs of some cancer patients who need to further dilute the mRNA preparation washing solution with solutions such as normal saline after tumor surgery before use. Description of the Drawings

[0123] Figure 1 It is a cross-sectional view of a medicine dispensing device for the washing solution after tumor surgery in Example 1.

[0124] Figure 2The enlarged cross-sectional view of the second partition of the medicine dispensing device for the postoperative lotion for tumors in Example 1.

[0125] Figure 3 The enlarged cross-sectional view of the column of the medicine dispensing device for the postoperative lotion for tumors in Example 1.

[0126] Figure 4 The cross-sectional view of the control panel of the medicine dispensing device for the postoperative lotion for tumors in Example 1.

[0127] Figure 5 The outer wall cross-sectional view (upper) of the right side where heat dissipation through holes are installed between the first partition and the second partition of the base in Example 1 and the outer wall cross-sectional view (lower) of the right side where heat dissipation through holes are installed between the first partition and the second partition.

[0128] Figure 6 The front outer wall (left) and the rear outer wall (right) between the first partition and the third partition of the base in Example 1. Detailed implementation mode

[0129] The present utility model will be described in detail below with reference to the drawings and in combination with embodiments. It should be noted that, without conflict, the embodiments and features in the embodiments of the present utility model can be combined with each other. For the convenience of narration, words such as "upper", "lower", "left", and "right" hereinafter only indicate the same directions as the upper, lower, left, and right of the drawings themselves, and do not limit the structure. The embodiments of the present utility model are only for explaining the present invention and are not for limiting the present utility model, and the embodiments of the present utility model are not limited to the embodiments given in the specification. The embodiments without specific experimental conditions or operation conditions are made according to conventional conditions or according to the conditions recommended by the material suppliers. In addition, it should be understood that one or more method steps mentioned in the present utility model do not exclude the existence of other method steps before and after the combined steps or the insertion of other method steps between these clearly mentioned steps, unless otherwise stated; it should also be understood that the combined connection relationships mentioned in the present utility model do not exclude the existence of other connections before and after the combination or the insertion of other connections between these two clearly mentioned connections, unless otherwise stated. Moreover, unless otherwise stated, the numbers of each method step are only convenient tools for identifying each method step, rather than limiting the arrangement order of each method step or the scope in which the present utility model can be implemented. The change or adjustment of their relative relationships, without substantial change in technical content, should also be regarded as the scope in which the present utility model can be implemented. In the following embodiments, the reagents, materials, and instruments used, if not specifically stated, can be obtained commercially.

[0130] The base 1, the first partition 2, the second partition 3, the third partition 4, the planar ultrasonic probe 5, the planar horn 6, the transducer 7, the ultrasonic generator 8, the high-frequency high-voltage cable 9, the controller 10, the power module 11, the uninterruptible power supply 12, the signal cable 13, the power cable 14, the control cable 15, the power cable 16, the external power cord 17, the control panel 18, the control cable 19, the vibration isolation pad 20, the support ring 21, the column fixing hole position 22, the column 23, the washing liquid bottle clip 24, the spring clip 25 at one end of the washing liquid bottle clip, the heat dissipation film 26, the fixing hole position 27 at one end of the washing liquid bottle clip, the column fixed connection part 28, the display screen 29, the start button 30, the stop button 31, the reset button 32, the alarm lamp 33, the outer wall 34, the outer wall 35, the heat dissipation through hole 36, the outer wall 37, the external power cord outlet 38, the outer wall 39 and the outer wall 40 of the present utility model and other components are all common standard parts or components known to those skilled in the art. Their structures and principles can all be known by those skilled in the art through technical manuals or obtained through conventional experimental methods.

[0131] Embodiment 1

[0132] A medicine dispensing device for the washing liquid after tumor surgery, as shown in the attached Figure 1 - attached Figure 6 figure. The main components of the medicine dispensing device are: the base 1, the first partition 2, the second partition 3, the third partition 4, the planar ultrasonic probe 5, the planar horn 6, the transducer 7, the ultrasonic generator 8, the high-frequency high-voltage cable 9, the controller 10, the power module 11, the uninterruptible power supply 12, the signal cable 13, the power cable 14, the control cable 15, the power cable 16, the external power cord 17, the control panel 18, the control cable 19, the vibration isolation pad 20, the support ring 21, the column fixing hole position 22, the column 23, the washing liquid bottle clip 24, the spring clip 25 at one end of the washing liquid bottle clip, the heat dissipation film 26, the fixing hole position 27 at one end of the washing liquid bottle clip, the column fixed connection part 28, the display screen 29, the start button 30, the stop button 31, the reset button 32, the alarm lamp 33, the outer wall 34, the outer wall 35, the heat dissipation through hole 36, the outer wall 37, the external power cord outlet 38, the outer wall 39 and the outer wall 40;

[0133] In Embodiment 1, the material of the first partition 2 is boron nitride that can not only effectively conduct ultrasonic waves by the partition but also prevent the partition from bending and deforming;

[0134] In Embodiment 1, the vibration isolation pad 20 is fixed in the middle of the first partition 2 by mechanical fixing using bolts; the thickness of the vibration isolation pad 20 is 1 mm, the hardness of the vibration isolation pad 20 is 20A, the material of the vibration isolation pad 20 is polyurethane; the bottom of the vibration isolation pad 20 has patterns;

[0135] In Example 1, the support ring 21 is fixed to the vibration isolation pad 20 by bolts. Reserved holes for fixation are provided on both the support ring 21 and the vibration isolation pad 20. The material of the support ring 21 is silica gel. The support ring 21 is annular, and the ring diameter of the support ring 21 is designed with multiple gears of card slots, which can be quickly adjusted according to the diameter of the bottle to adapt to lotion bottles of different sizes.

[0136] In Example 1, the column 23 is fixedly installed on the column fixing hole position 22 provided on the first partition by bolts. The height of the column 23 is adjustable, the column 23 is marked with scales, the column 23 is provided with a lotion bottle clamp fixing hole position 27 and is designed with multiple holes, and the material of the column 23 is stainless steel.

[0137] In Example 1, one end of the lotion bottle clamp 24 that is not fixed to the lotion bottle clamp fixing hole position 27 provided on the column 23 is a spring clamp. The material of the lotion bottle clamp 24 is aluminum alloy, and it is fixed to the lotion bottle clamp fixing hole position 27 provided on the column 23 by bolts.

[0138] In Example 1, the mechanical connection between the planar ultrasonic probe 5 and the first partition 2 is a flange connection. The flange is welded on the planar ultrasonic probe 5 and the first partition 2. The flange of the planar ultrasonic probe 5 is connected to the flange of the first partition 2 by bolts and nuts, and a metal gasket is used. The model of the planar ultrasonic probe 5 is Olympus Panametrics V601, and the frequency is 20 kHz.

[0139] In Example 1, the mechanical connection between the planar horn 6 and the planar ultrasonic probe 5 is a flange connection. The flange is welded on the planar ultrasonic probe 5 and the planar horn 6. The flange of the planar horn 6 is connected to the flange of the planar ultrasonic probe 5 by bolts and nuts, and a metal gasket is used. The model of the planar horn 6 is Olympus NDT Rexo™ 6400, and the frequency is 20 kHz.

[0140] In Example 1, the mechanical connection between the transducer 7 and the planar horn 6 is a flange connection. The flange is welded on the transducer 7 and the planar horn 6. The flange of the transducer 7 is connected to the flange of the planar horn 6 by bolts and nuts, and a metal gasket is used. The model of the transducer 7 is Branson 502, and the frequency is 20 kHz.

[0141] In Example 1, the model of the ultrasonic generator 8 is Olympus 5077PR, the frequency is 20 kHz, and the power is 200 W. The heat dissipation film 26 is a phase change material (PCM) heat dissipation film.

[0142] In Embodiment 1, the model of the controller 10 is Siemens S7-1200 PLC, the model of the power supply module 11 is MeanWell, the model of the uninterruptible power supply 12 is APC Smart-UPS, and the model of the control panel is Olympus Epoch 6LT.

[0143] A method for manufacturing a medicine dispensing device for a post-operative tumor lotion, comprising the following steps:

[0144] First step, configure the first partition 2, the second partition 3, and the third partition 4 that are parallel from top to bottom on the base 1 to construct the base 1; second step, fit and install the planar ultrasonic probe 5 under the first partition 2 through flange connection; third step, fit and install the planar horn 6 under the planar ultrasonic probe 5 through flange connection; fourth step, fit and install the transducer 7 under the planar horn 6 through flange connection; fifth step, paste the heat dissipation film 26 under the second partition 3; sixth step, install the ultrasonic generator 8 on the second partition 2, and connect the ultrasonic generator to the transducer 7 through the high-frequency high-voltage cable 9; seventh step, install the controller 10, the power supply module 11, and the uninterruptible power supply 12 in sequence on the third partition 4, connect the controller 10 to the ultrasonic generator 8 through the signal cable 13, connect the power supply module 11 to the ultrasonic generator 8 through the power cable 14, connect the controller 10 to the power supply module 11 through the control cable 15, connect the power supply module 11 to the uninterruptible power supply 12 through the power cable 16, and connect the uninterruptible power supply 12 to the external power supply line 17; eighth step, install the control panel 18 on the left outer wall 34 between the first partition 3 and the third partition 4 of the base 1, and connect the display screen 29, the start button 30, the stop button 31, the reset button 32, and the alarm lamp 33 on the control panel 18 to the corresponding pins or terminals on the controller 10 through the control cable 19; ninth step, install the outer wall 35 with heat dissipation through holes 36 on the right side between the first partition 2 and the second partition 3 of the base 1; tenth step, install the outer wall 37 with an external power supply line outlet 38 on the right side between the second partition and the third partition of the base; eleventh step, install the front outer wall 39 and the rear outer wall 40 on the front and rear sides respectively between the first partition and the third partition of the base; twelfth step, install the vibration isolation pad 20 in the middle of the first partition 2, and then install the support ring 21 on the vibration isolation pad 20; thirteenth step, fixedly install the fixed connection part 28 of the column 23 on the column fixed hole position 22 provided on the first partition; fourteenth step, fix one end of the lotion bottle clip 24 without a spring clip on one of the lotion bottle clip fixed hole positions 27 provided on the column to make a medicine dispensing device for a post-operative tumor lotion.

[0145] A method for using a medicine dispensing device for a post-operative tumor lotion, comprising the following steps:

[0146] Step 1: Inject the required amount of normal saline into the mRNA preparation washing solution bottle; Step 2: Place the mRNA preparation washing solution bottle filled with normal saline into the support ring 21, and then further fix the washing solution bottle by adjusting with the washing solution bottle clamp 25; Step 3: Connect to the mains power through the external power cord 17, and press the start button 30 on the control panel 18 to start the medicine dispensing device; Step 4: After dispensing medicine for a period of time, press the stop button 31 on the control panel 18 to turn off the medicine dispensing device; Step 5: For the washing solution bottle taken from the medicine dispensing device, use an ultrasonic transmission device to judge the homogeneity of the mixture of the mRNA preparation washing solution and normal saline by analyzing the change in ultrasonic amplitude at different positions of the washing solution bottle; If not evenly mixed, repeat the work in Steps 2 to 5; Step 6: Directly use the prepared mRNA preparation washing solution for clinical use.

[0147] Example 2

[0148] The medicine dispensing device for the washing solution after tumor surgery in Example 1 of the present utility model evaluates the mixing homogeneity effect of diluting the mRNA preparation with normal saline according to the following process: First step, mark 3 different positions at the top, middle, and bottom of the washing solution bottle to be tested for ultrasonic transmission detection from the bottle mouth to the bottle bottom; Second step, fix the ultrasonic transmitter and receiver of the ultrasonic transmission detector (Olympus Epoch650) on both sides of the marked positions to be tested on the washing solution bottle respectively, ensuring the distance and parallel relative position between them; Second step, the transmitter emits ultrasonic pulses, which pass through the bottle wall and the washing solution of the washing solution bottle and reach the receiver. The receiver receives the transmitted ultrasonic signal and converts it into an electrical signal; Third step, repeat the steps of the first step and the second step to perform ultrasonic transmission detection on the remaining 2 different positions of the washing solution bottle to be tested; Fourth step, by analyzing and comparing the arrival time, amplitude change, and frequency spectrum of the transmitted waves at 3 different positions from the bottle mouth to the bottle bottom of the washing solution bottle to be tested and the standard mRNA preparation washing solution bottle with known homogeneous mixing, obtain the propagation speed, energy attenuation, and possibility of the existence of fine particles or bubbles of the ultrasonic wave in the washing solution at 3 different positions from the bottle mouth to the bottle bottom of the washing solution bottle to be tested, and draw a conclusion on whether the mixture of diluting the mRNA preparation with normal saline is homogeneous;

[0149] The mixing effect of the mRNA preparation lotion and normal saline in the drug dispensing device for postoperative tumors in Example 1 of the present utility model was detected according to Table 1-6 below, and the results are shown in Table 1-6. Each position was measured in parallel 3 times. As shown in the results of Table 1-6, the coefficient of variation of the measurement results of the mRNA preparation lotion and normal saline was less than 15%, meeting the repeatability requirements and intermediate precision requirements for the mixing effect measurement. Among them, the volumes of the mRNA preparation lotion bottles were 5 ml, 10 ml, 20 ml, 50 ml, 100 ml, and 250 ml respectively. The arrival time difference, amplitude change, spectral overlap degree, and density of the transmitted wave in Table 1-6 are the ratio values of the arrival time, amplitude ratio value, and spectral ratio value of the transmitted wave at corresponding different positions from the bottle mouth to the bottom of the bottle of a known uniformly mixed standard mRNA preparation lotion bottle;

[0150] ; ; ; ; ; .

[0151] Example 3

[0152] The average values and coefficients of variation of the parallel detection results of 3 different positions of the mRNA preparation lotion and normal saline mixed measurement by the drug dispensing device for postoperative tumors composed of 4 different specifications of components produced according to the manufacturing method of the drug dispensing device for postoperative tumors in Example 1 of the present utility model were summarized, and the results are shown in Table 7-12. As shown in the results of Table 7-12, the coefficients of variation of the mixing effect measurement results were all less than 15%, meeting the repeatability requirements and intermediate precision requirements for the mixing effect measurement. This shows the reliability of the manufacturing method of the drug dispensing device for postoperative tumors in Example 1 of the present utility model. In addition, the drug dispensing device product for postoperative tumors produced according to the manufacturing method of the drug dispensing device for postoperative tumors in Example 1 of the present utility model can meet the requirement of uniform mixing of the mRNA preparation lotion and normal saline. In other words, the drug dispensing device for postoperative tumors of the present utility model can meet the personalized customization needs of different patients for the mRNA preparation lotion for tumor surgical wounds or in-vivo surgical area cleaning, and realize the precise and safe operation and use of the mRNA preparation lotion;

[0153] Among them: The specifications of Product 1 are as follows: The material of the first partition 2 is boron nitride; the vibration isolation pad 20 is fixed in the middle of the first partition 2 by mechanical fixing using bolts; the thickness of the vibration isolation pad 20 is 1 mm, the hardness of the vibration isolation pad 20 is 20A, and the material of the vibration isolation pad 20 is polyurethane; the bottom of the vibration isolation pad 20 has patterns; the support ring 21 is fixed on the vibration isolation pad 20 by bolts, and both the support ring 21 and the vibration isolation pad 20 are provided with reserved holes for fixing; the material of the support ring 21 is silica gel, the support ring 21 is annular, and the ring diameter of the support ring 21 is designed with multi-gear card slots, which can be quickly adjusted according to the bottle diameter to adapt to lotion bottles of different sizes; the column 23 is fixed on the column fixing hole position 22 provided on the first partition by bolts, the height of the column 23 is adjustable, the column 23 is marked with scales, the column 23 is provided with a lotion bottle clip fixing hole position 27 and is a multi-hole design, and the material of the column 23 is stainless steel; one end of the lotion bottle clip 24 that is not fixed on the column 23 where the lotion bottle clip fixing hole position 27 is provided is a spring clip, the material of the lotion bottle clip 24 is aluminum alloy, and the lotion bottle clip 24 is fixed on the column 23 where the lotion bottle clip fixing hole position 27 is provided by bolts; the mechanical connection between the planar ultrasonic probe 5 and the first partition 2 is a flange connection, the flange is welded on the planar ultrasonic probe 5 and the first partition 2, and the flange of the planar ultrasonic probe 5 is connected to the flange of the first partition 2 by bolts and nuts, and a metal gasket is used; the model of the planar ultrasonic probe 5 is Olympus Panametrics V601, and the frequency is 20 kHz; the mechanical connection between the planar horn 6 and the planar ultrasonic probe 5 is a flange connection, the flange is welded on the planar ultrasonic probe 5 and the planar horn 6, and the flange of the planar horn 6 is connected to the flange of the planar ultrasonic probe 5 by bolts and nuts, and a metal gasket is used; the model of the planar horn 6 is Olympus NDT Rexo™ 6400, and the frequency is 20 kHz; the mechanical connection between the transducer 7 and the planar horn 6 is a flange connection, the flange is welded on the transducer 7 and the planar horn 6, and the flange of the transducer 7 is connected to the flange of the planar horn 6 by bolts and nuts, and a metal gasket is used; the model of the transducer 7 is Branson 502, and the frequency is 20 kHz; the model of the ultrasonic generator 8 is Olympus 5077PR, the frequency is 20KHz, and the power is 200W; the heat dissipation film 26 is a phase change material (PCM) heat dissipation film; the model of the controller 10 is Siemens S7-1200 PLC, the model of the power supply module 11 is Mean Well, the model of the uninterruptible power supply 12 is APC Smart-UPS, and the model of the control panel is Olympus Epoch 6LT;

[0154] The specifications of product 2 are as follows: the material of the first partition 2 is stainless steel; the vibration isolation pad 20 is fixed in the middle of the first partition 2 by mechanical fixing using epoxy resin adhesive; the thickness of the vibration isolation pad 20 is 1.25 mm, the hardness of the vibration isolation pad 20 is 10A, and the material of the vibration isolation pad 20 is natural rubber; the bottom of the vibration isolation pad 20 has texture; the support ring 21 is fixed to the vibration isolation pad 20 by epoxy resin adhesive, the material of the support ring 21 is rubber, the support ring 21 is annular, and the ring diameter of the support ring 21 is a multi-speed card slot design, which can be quickly adjusted according to the diameter of the bottle to adapt to different sizes of lotion bottles; the column 23 is fixed to the column fixing hole 22 provided on the first partition by a buckle, the height of the column 23 is adjustable, and the column 23 is marked with an engraved The column 23 is provided with a lotion bottle clamp fixing hole 27 and is of porous design. The material of the column 23 is aluminum alloy; the end of the lotion bottle clamp 24 not fixed to the column 23 with the lotion bottle clamp fixing hole 27 is a spiral clamp. The material of the lotion bottle clamp 24 is aluminum alloy, and the column 23 is fixed with the lotion bottle clamp fixing hole 27 by a buckle; the mechanical connection between the planar ultrasonic probe 5 and the first partition 2 is a threaded connection, and a rubber gasket is used at the threaded connection; the model of the planar ultrasonic probe 5 is Airmar Technology Corporation T50-R, with a frequency of 50 kHz; the mechanical connection between the plane horn 6 and the plane ultrasonic probe 5 is a threaded connection, and a rubber gasket is used at the threaded connection; the model of the plane horn 6 is GEInspection Technologies Krautkramer SONOSCAN DCM™, with a frequency of 50 kHz; the mechanical connection between the transducer 7 and the plane horn 6 is a threaded connection, and a rubber gasket is used at the threaded connection; the model of the transducer 7 is OlympusV1011, with a frequency of 50 kHz; the model of the ultrasonic generator 8 is Kaijo Phenix Hyper, with a frequency of 50KHz and a power of 300W; the heat dissipation film 26 is a silicone heat dissipation film; the model of the controller 10 is Emerson DeltaV, the model of the power module 11 is TDK-Lambda, the model of the uninterruptible power supply 12 is Eaton 5P, and the model of the control panel is Sonatest Sitescan D-70;

[0155] The specifications of Product 3 are as follows: The material of the first partition 2 is aluminum alloy; the vibration isolation pad 20 is fixed in the middle of the first partition 2 by an embedded installation method with a groove cut in the middle of the first partition 2; the thickness of the vibration isolation pad 20 is 1 mm, the hardness of the vibration isolation pad 20 is 24A, and the material of the vibration isolation pad 20 is a composite material of silica gel and polyurethane; the bottom of the vibration isolation pad 20 has a non-slip surface; the support ring 21 is fixed on the vibration isolation pad 20 by a reserved embedded groove in a physical fitting manner; the material of the support ring 21 is polyurethane, the support ring 21 is annular, and the ring diameter of the support ring 21 is designed with multiple gear slots and can be quickly adjusted according to the bottle diameter to adapt to lotion bottles of different sizes; the column 23 is fixedly installed on the column fixing hole positions 22 provided on the first partition by bolts, the height of the column 23 is adjustable, the column 23 is marked with scales, the column 23 is provided with lotion bottle clip fixing hole positions 27 and is designed with multiple holes, and the material of the column 23 is stainless steel; one end of the lotion bottle clip 24 that is not fixed on the column 23 where the lotion bottle clip fixing hole positions 27 are provided is a spring clip, the material of the lotion bottle clip 24 is aluminum alloy, and the lotion bottle clip 24 is fixed on the column 23 where the lotion bottle clip fixing hole positions 27 are provided by bolts; the mechanical connection between the planar ultrasonic probe 5 and the first partition 2 is a rotary locking structure; the model of the planar ultrasonic probe 5 is Ultran Group UTS-1000, and the frequency is 100 kHz; the mechanical connection between the planar horn 6 and the planar ultrasonic probe 5 is a keyway connection, and the planar horn 6 and the planar ultrasonic probe 5 are fixed by bolts or nuts; the model of the planar horn 6 is Sonatest Ltd. Dryscan™ D50 with 100 kHz capability, and the frequency is 100 kHz; the mechanical connection between the transducer 7 and the planar horn 6 is a keyway connection, and the transducer 7 and the planar horn 6 are fixed by bolts or nuts; the model of the transducer 7 is PiezoData PS110A1 100 kHz, and the frequency is 100 kHz; the model of the ultrasonic generator 8 is Kaijo PhenixHyper, the frequency is 100KHz, and the power is 400W; the heat dissipation film 26 is a graphite heat dissipation film; the model of the controller 10 is RaspberryPi, the model of the power module 11 is Vicor VTM, the model of the uninterruptible power supply 12 is CyberPower, and the model of the control panel is Krautkramer USM 36;

[0156] The specifications of Product 4 are as follows: The material of the first partition 2 is carbon fiber reinforced plastic; the vibration isolation pad 20 is fixed in the middle of the first partition 2 by mechanical fixation using bolts; the thickness of the vibration isolation pad 20 is 2 mm, the hardness of the vibration isolation pad 20 is 34A, and the vibration isolation pad 20 is composed of a multi-layer structural composite material consisting of a rubber layer, a foam layer, a metal plate layer, a foam layer, and a rubber layer; the bottom of the vibration isolation pad 20 has patterns; the support ring 21 is fixed on the vibration isolation pad 20 by bolts, and both the support ring 21 and the vibration isolation pad 20 are provided with reserved holes for fixation; the material of the support ring 21 is silica gel, the support ring 21 is annular, and the ring diameter of the support ring 21 is designed with multi-gear card slots, which can be quickly adjusted according to the diameter of the bottle to adapt to lotion bottles of different sizes; the column 23 is fixedly installed on the column fixing hole position 22 provided on the first partition by bolts, the height of the column 23 is adjustable, the column 23 is marked with scales, the column 23 is provided with a lotion bottle clip fixing hole position 27 and is a multi-hole design, and the material of the column 23 is stainless steel; one end of the lotion bottle clip 24 that is not fixed on the column 23 where the lotion bottle clip fixing hole position 27 is provided is a spring clip, the material of the lotion bottle clip 24 is stainless steel, and it is fixed to the column 23 where the lotion bottle clip fixing hole position 27 is provided by bolts; the mechanical connection between the planar ultrasonic probe 5 and the first partition 2 is a flange connection, the flange is welded on the planar ultrasonic probe 5 and the first partition 2, and the flange of the planar ultrasonic probe 5 is connected to the flange of the first partition 2 by bolts and nuts, and a metal gasket is used; the model of the planar ultrasonic probe 5 is Olympus V601-RB, and the frequency is 1 MHz; the mechanical connection between the planar horn 6 and the planar ultrasonic probe 5 is a flange connection, the flange is welded on the planar ultrasonic probe 5 and the planar horn 6, and the flange of the planar horn 6 is connected to the flange of the planar ultrasonic probe 5 by bolts and nuts, and a metal gasket is used; the model of the planar horn 6 is Olympus V305-SU, and the frequency is 1 MHz; the mechanical connection between the transducer 7 and the planar horn 6 is a flange connection, the flange is welded on the transducer 7 and the planar horn 6, and the flange of the transducer 7 is connected to the flange of the planar horn 6 by bolts and nuts, and a metal gasket is used; the model of the transducer 7 is Kaijo 1 MHz, and the frequency is 1 MHz; the model of the ultrasonic generator 8 is Avitech AU, the frequency is 1 MHz, and the power is 800 W; the heat dissipation film 26 is an aluminum foil heat dissipation film; the model of the controller 10 is the LabVIEW control system, the model of the power supply module 11 is XP Power, the model of the uninterruptible power supply 12 is APC Smart-UPS, and the model of the control panel is GE InspectionTechnologies USM Go+;

[0157] ; ; ; ; ; 。

[0158] Example 4

[0159] The dispensing device for the lotion after tumor surgery in Example 1 of the present utility model was used to compare the mixing results of the mRNA preparation lotion and normal saline with directly using ultrasonic cleaning equipment (Elma, Germany), ultrasonic cleaning machine case (Telsonic, Switzerland), and ultrasonic cleaning system (Branson, USA). The results showed that the mixing uniformity of the four was the same. However, compared with the ultrasonic cleaning equipment (Elma, Germany), ultrasonic cleaning machine case (Telsonic, Switzerland), and ultrasonic cleaning system (Branson, USA), the operation time required for the mixing uniformity of the mRNA preparation lotion and normal saline <mRNA preparation lotion (135 ml) and normal saline (15 ml) in a 250-ml lotion bottle> was shortened by 15 minutes, 18 minutes, and 20 minutes respectively, greatly improving the dispensing efficiency of diluting the mRNA preparation lotion with normal saline. In addition, the process of drying the lotion bottle when taken out of the water was also omitted.

[0160] The content clarified in the above embodiments should be understood that these embodiments are only used to illustrate the present utility model more clearly, rather than to limit the scope of the present utility model. After reading the present utility model, various equivalent forms of modification of these embodiments by those skilled in the art all fall within the scope defined by the appended claims of the present utility model.

Claims

1. A dispensing device for a lotion used after tumor surgery, characterized in that, The dispensing device includes a base, and the base is provided with a first partition, a second partition, and a third partition that are parallel from top to bottom; on the first partition, there is an mRNA preparation washing solution bottle clamping assembly, and the bottle clamping assembly includes a vibration isolation pad, a support ring, a washing solution bottle clamp, and a column. The vibration isolation pad is installed in the middle of the first partition, the support ring is installed on the vibration isolation pad, the column is fixedly installed at the column fixing hole positions provided on the first partition, and the end of the washing solution bottle clamp without a spring clip is fixed at the washing solution bottle clamp fixing hole positions provided on the column; below the first partition, there are a planar ultrasonic probe, a planar horn, and a transducer. The planar ultrasonic probe is adhesively installed on the lower surface of the first partition by mechanical connection, the planar horn is adhesively installed on the lower surface of the planar ultrasonic probe by mechanical connection, and the transducer is adhesively installed on the lower surface of the planar horn by mechanical connection; on the second partition, there is an ultrasonic generator, and the ultrasonic generator is connected to the transducer through a high-frequency high-voltage cable; below the second partition, there is a heat dissipation film; on the third partition, there are a controller, a power module, and an uninterruptible power supply. The controller is connected to the ultrasonic generator through a signal cable, the controller is connected to the power module through a control cable, the power module is connected to the ultrasonic generator through a power cable, the power module is connected to the uninterruptible power supply through a power cable, and the uninterruptible power supply is connected to an external power cord; on the left outer wall of the base between the first partition and the third partition, there is a control panel of the controller, and the control panel includes a display screen, buttons, and an alarm lamp. The control panel is connected to the controller through a control cable; on the right outer wall of the base between the first partition and the second partition, there are heat dissipation through holes; on the right outer wall of the base between the second partition and the third partition, there is an external power cord outlet.

2. The dispensing device for the lotion used after tumor surgery according to claim 1, wherein, The material of the first partition is aluminum alloy, titanium alloy, stainless steel, glass fiber reinforced plastic, carbon fiber reinforced plastic, or boron nitride.

3. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The thickness of the vibration isolation pad is 1 - 20 millimeters, the hardness of the vibration isolation pad is 1 - 70A, and the bottom of the vibration isolation pad has patterns or is a non-slip surface.

4. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The support ring is annular, and the ring diameter of the support ring adopts an adjustable design with multi-gear slots.

5. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The height of the column is adjustable, and the column is marked with scales.

6. The dispensing device for the lotion used after tumor surgery according to claim 1, wherein, The mechanical connection between the planar ultrasonic probe and the first partition is a threaded connection, a flange connection, a spring buckle, or a rotary locking structure.

7. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The mechanical connection between the planar horn and the planar ultrasonic probe is a threaded connection, a flange connection, a keyway connection, a welded connection, or a clamping connection.

8. The dispensing device for the lotion used after tumor surgery according to claim 1, wherein, The mechanical connection between the transducer and the planar horn is a threaded connection, a flange connection, a keyway connection, a welded connection, or a clamping connection.

9. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The heat dissipation film pasted on the lower surface of the second partition is a graphite heat dissipation film, a silicone heat dissipation film, a phase change material heat dissipation film, or an aluminum foil heat dissipation film.

10. The dispensing device for the lotion used after tumor surgery according to claim 1, characterized in that, The controller is a programmable logic controller, a distributed control system controller, an embedded controller or an intelligent controller.

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