Plasma extraction device for biological sample library

Abstract

The plasma extraction device for the biological sample library relates to the technical field of plasma extraction and comprises a support, a movable plate and an extraction assembly, the extraction assembly comprises a separation cylinder, a supporting structure used for supporting the separation cylinder is arranged in the support, a first round hole is formed in the top of the separation cylinder, and a second round hole is formed in the bottom of the separation cylinder. A rotating sleeve is rotatably mounted in the round hole, a first transverse plate is fixed in the separation barrel, a second round hole coaxial with the rotating sleeve is formed in the top of the first transverse plate, a cylinder is movably arranged in the second round hole, and a round plate coaxial with the cylinder is fixed to the top end of the cylinder; a biological membrane is fixed between the circular plate and the rotating sleeve, and a connecting structure enabling the rotating sleeve and the circular plate to move synchronously is arranged between the rotating sleeve and the circular plate. According to the utility model, in the extraction process, the plasma and the separated object are respectively arranged at the bottom of the separation cylinder and in the sealed space formed by the biological membrane, so that the plasma and the separated object do not interfere with each other and are convenient to suck.

Description

Technical Field

[0001] The utility model relates to the technical field of plasma extraction, in particular to a plasma extraction device for a biological sample library. Background Technique

[0002] Blood is composed of plasma and blood cells suspended therein. The blood cells include red blood cells, white blood cells and platelets. Plasma is the liquid component of blood, which contains water, plasma proteins, electrolytes, nutrients, enzymes, hormones, cholesterol and other important components. For the plasma biological samples in the biological sample library, the drawn blood needs to be separated to obtain plasma samples. The extraction is generally achieved by applying centrifugal force or natural precipitation, so that the red blood cells settle to the bottom layer and the plasma is in the upper layer, thereby realizing the separation between plasma and red blood cells.

[0003] After retrieval, the Chinese patent with the authorization announcement number CN210774962U discloses a plasma extraction device for a biological sample library, which includes a frame and an extraction tank. The frame includes a base, a top plate and a support plate. The extraction tank includes a loading tube, an upper connection end, a lower connection end, an input tube and an output tube. The upper connection end and the lower connection end are respectively fixedly connected to the upper and lower side walls of the loading tube. The input tube and the output tube respectively penetrate and are fixedly connected to one side wall of the loading tube. The input tube is arranged above the output tube. A driving mechanism is arranged between the base and the lower connection end. Compared with the methods of natural precipitation and manually applying centrifugal force, this patent is more time-saving and labor-saving, improves the efficiency of plasma extraction, and compared with the method of applying centrifugal force through a centrifugal device, it not only has low cost and maintenance cost itself, but also can simply and conveniently separate and extract plasma, facilitate the installation and disassembly of the extraction tank, and improve the efficiency.

[0004] The above device still has the following deficiencies: The above device separates plasma and red blood cells into upper and lower layers by centrifugation. However, when sucking plasma, it is necessary to always pay attention to the suction volume. If the suction is too large, the red blood cell layer will be sucked, and the operation is rather troublesome. Content of the Utility Model

[0005] The utility model provides a plasma extraction device for a biological sample library, which has the advantage of being convenient for extracting and separating plasma, so as to solve the problem that when sucking plasma, it is necessary to always pay attention to the suction volume. If the suction is too large, the red blood cell layer will be sucked, and the operation is rather troublesome.

[0006] To achieve the purpose of extracting and separating plasma, the present utility model provides the following technical solutions: A plasma extraction device for a biological sample library, including a bracket, a moving plate, and an extraction component. The extraction component includes a separation cylinder. A support structure for supporting the separation cylinder is arranged inside the bracket. A first round hole is opened at the top of the separation cylinder, and a rotating sleeve is rotatably installed in the round hole. A first horizontal plate is fixed inside the separation cylinder. A second round hole coaxial with the rotating sleeve is opened at the top of the first horizontal plate, and a cylinder is movably arranged in the second round hole. A round plate coaxial with the cylinder is fixed at the top end of the cylinder. A biological membrane is jointly fixed between the round plate and the rotating sleeve. A connection structure for synchronously moving the two is arranged between the rotating sleeve and the round plate. The moving plate is located above the rotating sleeve. A third round hole is opened at the top of the moving plate, and a sleeve is rotatably installed in the third round hole. A driving mechanism for rotating the sleeve is arranged outside the moving plate. A lifting structure for moving the moving frame up and down is arranged inside the bracket. A plurality of spline blocks integrally formed with the rotating sleeve are arranged on the outer side of the rotating sleeve. A plurality of docking grooves adapted to the spline blocks are opened on the inner side wall of the sleeve.

[0007] As a preferred technical solution of the present utility model, the support structure includes a spline ring. A spline groove adapted to the spline of the spline ring is opened at the outer bottom end of the separation cylinder. The spline groove of the separation cylinder is inserted into the spline ring. A plurality of columns are jointly fixed between the outer side of the spline ring and the bottom of the bracket.

[0008] As a preferred technical solution of the present utility model, the connection structure includes a second horizontal plate, a spline sleeve, and a spline column. Both ends of the second horizontal plate are fixed inside the rotating sleeve. One end of the spline sleeve is fixed on the second horizontal plate. One end of the spline column is coaxially fixed with the round plate. The other end of the spline column is slidably inserted into the spline sleeve through a spline.

[0009] As a preferred technical solution of the present utility model, the driving mechanism includes a servo motor. The housing of the servo motor is fixed on the moving plate. A transmission structure for transmission is arranged between the output shaft of the servo motor and the sleeve.

[0010] As a preferred technical solution of the present utility model, the transmission structure includes a first synchronous pulley, a second synchronous pulley, and a synchronous belt sleeved on the first synchronous pulley and the second synchronous pulley. The first synchronous pulley is coaxially fixed with the sleeve. The output shaft of the servo motor is coaxially fixed with the second synchronous pulley.

[0011] As a preferred technical solution of the present utility model, the lifting structure includes a plurality of electric push rods. The housing of each electric push rod is fixed on the top of the bracket. The telescopic end of each electric push rod is fixed on the moving plate.

[0012] As a preferred technical solution of the present utility model, an inclined and closed annular groove is provided on the outer side of the cylinder, a fixing block is fixed to the bottom of the first cross plate, a sliding column is rotatably installed on the outer side of the fixing block, and one end of the sliding column is slidably arranged in the annular groove.

[0013] As a preferred technical solution of the present utility model, a discharge pipe communicated with the separation cylinder is fixed to the bottom of the separation cylinder, and a valve is installed at one end of the discharge pipe.

[0014] Compared with the prior art, the present utility model provides a plasma extraction device for a biological sample library, and has the following beneficial effects:

[0015] 1. In the present utility model, during the extraction process, the plasma and the separated substances are respectively placed at the bottom of the separation cylinder and in the sealed space formed by the biological membrane, so that the two do not interfere with each other and are convenient for suction.

[0016] 2. In the present utility model, the centrifugation process is adopted for filtration. During centrifugal filtration, the biological membrane generates up and down fluctuations, so as to shake off the macromolecular substances attached to the biological membrane, make the plasma more easily pass through the biological membrane, and improve the extraction efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is the overall structural schematic diagram of the present utility model;

[0018] Figure 2 is the structural schematic diagram of the extraction component of the present utility model from the first perspective;

[0019] Figure 3 is the structural schematic diagram of the extraction component of the present utility model from the second perspective;

[0020] Figure 4 is the internal structural schematic diagram of the separation cylinder of the present utility model;

[0021] Figure 5 is Figure 4 the enlarged structural schematic diagram of part A of

[0022] Figure 6 is the three-dimensional structural schematic diagram of the casing of the present utility model;

[0023] Figure 7 is the three-dimensional structural schematic diagram of the support structure of the present utility model.

[0024] In the figure: 1. Bracket; 2. Electric push rod; 3. Moving plate; 4. Extraction component; 401. Separation cylinder; 402. First synchronous pulley; 403. Synchronous belt; 404. Second synchronous pulley; 405. Sheath; 406. Spline ring; 407. Discharge pipe; 408. Valve; 409. Servo motor; 410. Column; 411. First horizontal plate; 412. Circular plate; 413. Spline column; 414. Spline sleeve; 415. Second horizontal plate; 416. Rotating sleeve; 417. Spline block; 418. Fixed block; 419. Slide column; 420. Cylinder; 421. Ring groove; 422. Docking groove; 423. Biofilm. Detailed implementation manners

[0025] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0026] Please refer to Figures 1 - 7 , the present invention discloses a plasma extraction device for a biobank, including a bracket 1, a moving plate 3 and an extraction component 4. Here, the bracket 1 is made of metal, and metal is selected to improve the structural strength of the whole device.

[0027] As a further solution of this embodiment, the above extraction component 4 includes a separation cylinder 401. A support structure for supporting the separation cylinder 401 is arranged in the bracket 1. A first round hole is opened at the top of the separation cylinder 401, and a rotating sleeve 416 is rotatably installed in the round hole. A first horizontal plate 411 is fixed inside the separation cylinder 401. A second round hole coaxially arranged with the rotating sleeve 416 is opened at the top of the first horizontal plate 411, and a cylinder 420 is movably arranged in the second round hole. A circular plate 412 coaxially arranged with it is fixed at the top of the cylinder 420. A biofilm 423 is jointly fixed between the circular plate 412 and the rotating sleeve 416. Inside the closed space surrounded by this biofilm 423, blood is poured into the rotating sleeve 416, and the blood flows into the closed space surrounded by the biofilm 423 and waits for the extraction operation. Here, the biofilm 423 is further explained. The biofilm 423 refers to a semi-permeable membrane with a filtering function. During the plasma extraction process, a blood filtering membrane is generally selected. The plasma in the blood can pass through the biofilm 423, but the macromolecules in the blood cannot pass through the biofilm 423.

[0028] A connecting structure is provided between the rotating sleeve 416 and the circular plate 412 to enable the synchronous movement of the rotating sleeve 416 and the circular plate 412. The moving plate 3 is arranged above the rotating sleeve 416. A third circular hole is formed in the top of the moving plate 3, and a sleeve housing 405 is rotatably installed in the third circular hole. A driving mechanism is arranged on the outer side of the moving plate 3 and is connected to the sleeve housing 405. The driving mechanism can enable the sleeve housing 405 to rotate axially in the third circular hole. A lifting structure is arranged in the bracket 1 and is connected to the moving plate 3. The lifting structure is used to control the height of the moving plate 3 in the bracket 1. A plurality of spline blocks 417 integrally formed with the rotating sleeve 416 are arranged on the outer side of the rotating sleeve 416. A plurality of docking grooves 422 adapted to the spline blocks 417 are formed in the inner side wall of the sleeve housing 405. When the lifting structure moves the moving plate 3 towards the rotating sleeve 416, the sleeve housing 405 on the moving plate 3 is sleeved on the rotating sleeve 416, and at the same time, the spline blocks 417 on the rotating sleeve 416 are inserted into the docking grooves 422 in the sleeve housing 405. When the driving mechanism rotates the sleeve housing 405, the sleeve housing 405 and the rotating sleeve 416 can rotate synchronously.

[0029] Specifically, in combination with the attached Figure 7 , the support structure includes a spline ring 406. A spline groove adapted to the spline of the spline ring 406 is formed at the outer bottom end of the separation cylinder 401. The spline groove of the separation cylinder 401 is inserted into the spline ring 406, and a plurality of columns 410 are fixedly connected between the outer side of the spline ring 406 and the bottom of the bracket 1.

[0030] As can be seen from the above description, the spline groove of the separation cylinder 401 is inserted into the spline ring 406, which facilitates the disassembly of the separation cylinder 401.

[0031] Specifically, in combination with the attached Figure 4 , the connecting structure includes a second cross plate 415, a spline sleeve 414, and a spline column 413. Both ends of the second cross plate 415 are fixed in the rotating sleeve 416. One end of the spline sleeve 414 is fixed on the second cross plate 415. One end of the spline column 413 is coaxially fixed with the circular plate 412, and the other end of the spline column 413 is slidably inserted into the spline sleeve 414 through a spline.

[0032] As can be seen from the above description, when the rotating sleeve 416 rotates, the rotating sleeve 416 drives the spline sleeve 414 to rotate through the second cross plate 415, and the rotating sleeve 416 drives the circular plate 412 to rotate through the spline column 413.

[0033] Specifically, in combination with the attached Figure 2 and Figure 3, The driving mechanism includes a servo motor 409. The housing of the servo motor 409 is fixed on the moving plate 3. A transmission structure for transmission is provided between the output shaft of the servo motor 409 and the sleeve 405. The transmission structure includes a first synchronous pulley 402, a second synchronous pulley 404, and a synchronous belt 403 sleeved on the first synchronous pulley 402 and the second synchronous pulley 404. Here, it is supplemented that the diameter of the first synchronous pulley 402 is smaller than that of the second synchronous pulley 404. The first synchronous pulley 402 is coaxially fixed with the sleeve 405, and the output shaft of the servo motor 409 is coaxially fixed with the second synchronous pulley 404.

[0034] As can be seen from the above description, the servo motor 409 drives the second synchronous pulley 404 to rotate through the output shaft. The first synchronous pulley 402 and the second synchronous pulley 404 rotate synchronously through the synchronous belt 403, and the first synchronous pulley 402 drives the sleeve 405 to rotate.

[0035] Specifically, in combination with the attached Figure 1 , The lifting structure includes a plurality of electric push rods 2. The housing of the electric push rod 2 is fixed on the top of the bracket 1, and the telescopic end of each electric push rod 2 is fixed on the moving plate 3. Here, the electric push rod 2 is supplemented. The electric push rod 2 is of a threaded type, so that the electric push rod 2 has self-locking property.

[0036] Specifically, in combination with the attached Figure 5 , An inclined and closed annular groove 421 is formed on the outer side of the cylinder 420. A fixed block 418 is fixed at the bottom of the first cross plate 411. A sliding column 419 is rotatably installed on the outer side of the fixed block 418, and one end of the sliding column 419 is slidably arranged in the annular groove 421.

[0037] As can be seen from the above description, when the circular plate 412 rotates, the cylinder 420 on the circular plate 412 rotates synchronously. The sliding column 419 slides along the annular groove 421 on the cylinder 420. Thus, it can be seen that the cylinder 420 moves up and down, and the cylinder 420 drives the circular plate 412 to move up and down. At this time, the biofilm 423 on the circular plate 412 fluctuates, so as to shake off the macromolecular substances attached to the biofilm 423, making it easier for the plasma to pass through the biofilm 423 and improving the extraction efficiency.

[0038] Specifically, a discharge pipe 407 communicated with the separation cylinder 401 is fixed at the bottom of the separation cylinder 401. A valve 408 is installed at one end of the discharge pipe 407. After the separation is completed, the valve 408 is opened, and the plasma flows out from the bottom of the separation cylinder 401.

[0039] Working principle and usage process of the present utility model: When in use, pour blood into the rotating sleeve 416, and the blood flows into the enclosed space surrounded by the biological membrane 423. Each electric push rod 2 extends synchronously, causing the moving plate 3 to move downward. The housing 405 is sleeved on the rotating sleeve 416. At this time, the spline block 417 on the rotating sleeve 416 is inserted into the docking groove 422 in the housing 405. The servo motor 409 drives the second synchronous wheel 404 to rotate through the output shaft. The first synchronous wheel 402 and the second synchronous wheel 404 rotate synchronously through the synchronous belt 403. The first synchronous wheel 402 drives the housing 405 to rotate, the housing 405 drives the rotating sleeve 416 to rotate, the rotating sleeve 416 drives the spline sleeve 414 to rotate through the second cross plate 415, and the rotating sleeve 416 drives the circular plate 412 to rotate through the spline column 413. The plasma in the blood permeates through the biological membrane 423 under the centrifugal force. The plasma and the separated substances are respectively placed at the bottom of the separation cylinder 401 and in the sealed space formed by the biological membrane 423, so that the two do not interfere with each other and are convenient for suction. When the circular plate 412 rotates, the cylinder 420 on the circular plate 412 rotates synchronously. The sliding column 419 slides along the annular groove 421 on the cylinder 420. It can be seen therefrom that the cylinder 420 moves up and down, and the cylinder 420 drives the circular plate 412 to move up and down. At this time, the biological membrane 423 on the circular plate 412 fluctuates, so as to shake off the macromolecular substances attached to the biological membrane 423, making it easier for the plasma to pass through the biological membrane 423 and improving the extraction efficiency.

[0040] It should be noted that in this article, terms such as "including", "comprising" or any other variant thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not explicitly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "including one..." does not exclude the existence of another identical element in the process, method, article or device including the said element.

[0041] Although the embodiments of the present utility model have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present utility model. The scope of the present utility model is defined by the appended claims and their equivalents.

Claims

1. A plasma extraction device for a biobank, comprising a bracket (1), a moving plate (3) and an extraction component (4), characterized in that: The extraction component (4) includes a separation cylinder (401). A support structure for supporting the separation cylinder (401) is arranged inside the bracket (1). A first round hole is formed at the top of the separation cylinder (401), and a rotating sleeve (416) is rotatably installed in the round hole. A first horizontal plate (411) is fixed inside the separation cylinder (401). A second round hole coaxial with the rotating sleeve (416) is formed at the top of the first horizontal plate (411), and a cylinder (420) is movably arranged in the second round hole. A round plate (412) coaxial with the cylinder (420) is fixed at the top end of the cylinder (420). A biological membrane (423) is jointly fixed between the round plate (412) and the rotating sleeve (416). A connection structure for synchronously moving the two is arranged between the rotating sleeve (416) and the round plate (412). The moving plate (3) is located above the rotating sleeve (416). A third round hole is formed at the top of the moving plate (3), and a sleeve housing (405) is rotatably installed in the third round hole. A driving mechanism for rotating the sleeve housing (405) is arranged outside the moving plate (3). A lifting structure for moving the moving frame up and down is arranged inside the bracket (1). A plurality of spline blocks (417) integrally formed with the rotating sleeve (416) are arranged on the outer side of the rotating sleeve (416). A plurality of docking grooves (422) adapted to the spline blocks (417) are formed on the inner side wall of the sleeve housing (405).

2. The plasma extraction device for a biobank according to claim 1, characterized in that: The support structure includes a spline ring (406). A spline groove adapted to the spline of the spline ring (406) is formed at the outer bottom end of the separation cylinder (401). The spline groove of the separation cylinder (401) is inserted into the spline ring (406). A plurality of columns (410) are jointly fixed between the outer side of the spline ring (406) and the bottom of the bracket (1).

3. The plasma extraction device for a biobank according to claim 1, characterized in that: The connection structure includes a second horizontal plate (415), a spline sleeve (414), and a spline column (413). Both ends of the second horizontal plate (415) are fixed inside the rotating sleeve (416). One end of the spline sleeve (414) is fixed on the second horizontal plate (415). One end of the spline column (413) is coaxially fixed with the round plate (412). The other end of the spline column (413) is slidably inserted into the spline sleeve (414) through a spline.

4. A plasma extraction device for a biorepository according to claim 3, wherein: The driving mechanism includes a servo motor (409). The housing of the servo motor (409) is fixed on the moving plate (3). A transmission structure for transmission is arranged between the output shaft of the servo motor (409) and the sleeve housing (405).

5. The plasma extraction device for a biobank according to claim 4, characterized in that: The transmission structure includes a first synchronous pulley (402), a second synchronous pulley (404), and a synchronous belt (403) sleeved on the first synchronous pulley (402) and the second synchronous pulley (404). The first synchronous pulley (402) is coaxially fixed with the sleeve housing (405). The output shaft of the servo motor (409) is coaxially fixed with the second synchronous pulley (404).

6. The plasma extraction device for a biobank according to claim 5, wherein: The lifting structure includes a plurality of electric push rods (2), the outer shell of the electric push rod (2) is fixed to the top of the bracket (1), and the telescopic end of each electric push rod (2) is fixed to the moving plate (3).

7. The plasma extraction device for a biobank according to claim 1, wherein: An inclined and closed annular groove (421) is formed on the outer side of the cylinder (420), a fixing block (418) is fixed to the bottom of the first horizontal plate (411), a sliding column (419) is rotatably installed on the outer side of the fixing block (418), and one end of the sliding column (419) is slidably arranged in the annular groove (421).

8. A plasma extraction device for a biobank according to claim 1, characterized in that: A discharge pipe (407) communicated with the separation cylinder (401) is fixed to the bottom of the separation cylinder (401), and a valve (408) is installed at one end of the discharge pipe (407).

Images