Multifunctional blood glucose detector for detecting glycosylated hemoglobin

Abstract

The utility model discloses a multifunctional blood glucose detector for detecting glycosylated hemoglobin, which comprises a shell, a control panel, a screen, a battery pack and a multifunctional detection mechanism, the multifunctional detection mechanism is provided with an electrochemical detection assembly and a photochemical detection assembly which can be used for performing electrochemical detection and photochemical detection on the test strip respectively, and the screen, the battery pack and the multifunctional detection mechanism are electrically connected with the control panel respectively; a user can directly complete electrochemical detection and photochemical detection on one machine in sequence, the operation is convenient, the efficiency is high, and the detection accuracy of glycosylated hemoglobin can be improved by utilizing dual detection.

Description

Technical Field

[0001] The utility model relates to the technical field of blood glucose meters, in particular to the technical field of blood glucose detectors for detecting glycated hemoglobin.

Background Art

[0002] Blood glucose can enter cells by diffusion (without the participation of insulin) and combine with hemoglobin to form glycated hemoglobin (HbA1c). Since this binding process is slow and irreversible (it exists until red blood cells die), the glycated hemoglobin content in senescent red blood cells in the body is about 1.5 times higher than that in newly generated red blood cells. The proportion of glycated hemoglobin can reflect the average blood glucose level in the previous 1-2 months (the higher the glycated hemoglobin, the more blood glucose binds to hemoglobin, and the more severe the diabetes). It also avoids the daily fluctuations of blood glucose values (regardless of factors such as the patient's blood sampling time, whether fasting, and whether using insulin), so it has become an important means for monitoring the efficacy during the treatment of diabetes.

[0003] There are many methods for clinically measuring HbA1c. The more commonly used ones are HPLC method, enzyme method, latex immunoturbidimetry, etc. Among them, the HPLC method is widely used as the gold standard method for detecting glycated hemoglobin, but the cost is relatively high; the precision and accuracy of the enzyme method for detection are poor; latex immunoturbidimetry can be used in fully automatic biochemical analyzers, and the results are more accurate than the enzyme method, and the price is lower than the HPLC method, but its operation is relatively complex.

[0004] In order to simplify the detection process of HbA1c, the applicant once chose to respectively set an electrode group and an optical detection area on the test strip (a glycated hemoglobin detection test strip and its method for detecting glycated hemoglobin announced in the invention with the publication number of CN111521829B), so that the test strip can directly cooperate with the corresponding current detector and / or optical detector, and finally realize the rapid detection of HbA1c through electrochemical detection and / or photochemical detection. However, there is currently no instrument on the market that can cooperate with this test strip to complete electrochemical detection and photochemical detection integrally, resulting in the need to perform the two detections of HbA1c on two devices separately, and there is a problem that the operation process is relatively cumbersome. Therefore, there is still an urgent need in clinical practice to find a glycated hemoglobin detection instrument with simple operation, high speed and low manufacturing and use costs.

Content of the Utility Model

[0005] The purpose of the utility model is to solve the problems in the prior art, and propose a multifunctional blood glucose detector for detecting glycated hemoglobin, which can enable users to directly complete electrochemical detection and photochemical detection successively on one machine, not only with convenient operation and high efficiency, but also can improve the detection accuracy of glycated hemoglobin by using dual detection.

[0006] To achieve the above object, the present utility model provides a multifunctional blood glucose detector for detecting glycated hemoglobin, which includes a housing, a control board, a screen, a battery pack and a multifunctional detection mechanism. An insertion port for inserting a test strip is provided on the housing wall. The multifunctional detection mechanism has an electrochemical detection component and a photochemical detection component that can respectively perform electrochemical detection and photochemical detection on the test strip. The screen, the battery pack and the multifunctional detection mechanism are electrically connected to the control board respectively.

[0007] Preferably, the photochemical detection component includes a silicon photocell, an LED lamp and an outer cover. The outer cover can cooperate with the control board to jointly cover the silicon photocell and the LED lamp. The LED lamp can irradiate light towards the photochemical reaction area of the test strip, and the silicon photocell can receive the light reflected from the photochemical reaction area.

[0008] Preferably, a notch is provided at the position of the outer cover facing the silicon photocell, and a filter is installed at the notch.

[0009] Preferably, a separator is installed on the outer cover to separate the silicon photocell and the LED lamp.

[0010] Preferably, the silicon photocell and the LED lamp are respectively fixed on the control board, and a slot for inserting the separator is also provided on the surface of the control board.

[0011] Preferably, rubber rings and rubber cylinders that can respectively surround the outer edges of the silicon photocell and the LED lamp are provided on the outer cover.

[0012] Preferably, the electrochemical detection component includes a test strip holder and electrode contacts. The test strip holder is fixed on the control board, and electrode contacts are installed in the test strip cavity. The electrode contacts can contact the electrode group of the test strip in the electrochemical reaction area.

[0013] Preferably, a strip ejection mechanism is further included. The strip ejection mechanism is slidably connected to the housing and can push the test strip out of the housing.

[0014] Preferably, a slider that can slide along the test strip cavity is provided in the test strip holder. The strip ejection mechanism includes a base, a sliding button and a dial post. The dial post can penetrate the control board along the through groove and be inserted into the slider. The sliding button is slidably connected to the housing wall and is indirectly connected to the dial post through the base. A convex rib is also provided on the top surface of the base.

[0015] Preferably, the housing includes an upper shell, a lower shell, a battery cover and a panel. The upper shell and the lower shell can jointly clamp the control board. The panel is installed on the upper shell and can expose the screen. The battery cover and the lower shell can jointly cover the battery pack.

[0016] The beneficial effects of the present utility model:

[0017] 1) By combining an electrochemical detection component and a photochemical detection component that can perform electrochemical detection and photochemical detection into a multi-functional detection mechanism and placing it in a blood glucose meter, it can cooperate with a test strip having an electrochemical reaction area and a photochemical reaction area, enabling the user to directly complete electrochemical detection and photochemical detection successively on one machine. This not only makes the operation convenient and efficient, can improve the detection accuracy of glycated hemoglobin by using dual detection, but also can be applied to the electrochemical detection of blood glucose test strips, uric acid test strips, blood ketone test strips, etc.

[0018] 2) By using a test strip holder with electrode pins as the electrochemical detection component, a constant voltage can be applied to the electrode group located in the electrochemical reaction area, thereby using the potentiostatic method and detecting the content of glycated hemoglobin in the blood through the generated microcurrent. Additionally, a silicon photocell, an LED lamp, and an outer cover are jointly used to form the photochemical detection component, and the photochemical detection of glycated hemoglobin can be achieved by the light emission and reception between the LED lamp and the silicon photocell. The overall structure is simple and the cost is low.

[0019] 3) By adding a spacer that can be inserted into the control board along the through groove between the LED lamp and the silicon photocell, and respectively covering rubber rings and rubber cylinders around the LED lamp and the silicon photocell, the mutual cooperation between the spacer, rubber ring, and rubber cylinder can be used to jointly prevent the emitted light source from affecting the light reception of the receiver, thereby improving the measurement accuracy of the glycated hemoglobin content.

[0020] 4) By installing a filter on the outer cover opposite to the silicon photocell, the interfering wavelength bands can be filtered by the filter, thereby further improving the measurement accuracy of the glycated hemoglobin content.

[0021] The features and advantages of the present utility model will be described in detail through embodiments in conjunction with the accompanying drawings.

Description of the Drawings

[0022] Figure 1 is a three-dimensional structural schematic diagram of the multi-functional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0023] Figure 2 is the front view of the multi-functional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0024] Figure 3 is an exploded schematic diagram of the multi-functional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0025] Figure 4 is an assembly schematic diagram of the control board, screen, electrochemical detection component, silicon photocell, and LED lamp of the multi-functional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0026] Figure 5 It is an assembly schematic diagram of the outer cover and the filter of the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0027] Figure 6 It is a three-dimensional structural schematic diagram of the outer cover of the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0028] Figure 7 It is a three-dimensional structural schematic diagram of the strip ejection mechanism of the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model;

[0029] Figure 8 It is the front view of the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model when inserting a test strip;

[0030] Figure 9 It is the front view of the test strip used in conjunction with the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model.

[0031] In the figure: 1 - outer shell, 11 - upper shell, 12 - lower shell, 13 - battery cover, 14 - panel, 2 - control board, 21 - slot, 22 - through slot, 3 - screen, 4 - battery pack, 5 - strip ejection mechanism, 51 - base, 511 - rib, 52 - sliding button, 53 - dial post, 6 - multifunctional detection mechanism, 61 - electrochemical detection component, 611 - slider, 62 - photochemical detection component, 621 - silicon photocell, 622 - LED lamp, 623 - outer cover, 6231 - notch, 6232 - separator, 6233 - rubber ring, 6234 - rubber cylinder, 624 - filter, 7 - test strip, 71 - electrochemical reaction area, 72 - photochemical reaction area.

Detailed implementation manner

[0032] Refer to Figures 1 to 9 , the multifunctional blood glucose meter for detecting glycated hemoglobin of the present utility model includes an outer shell 1, a control board 2, a screen 3, a battery pack 4 and a multifunctional detection mechanism 6. An insertion port for the test strip 7 is provided on the shell wall of the outer shell 1. The multifunctional detection mechanism 6 has an electrochemical detection component 61 and a photochemical detection component 62 that can respectively perform electrochemical detection and photochemical detection on the test strip 7. The screen 3, the battery pack 4 and the multifunctional detection mechanism 6 are respectively electrically connected to the control board 2. Among them, the control board 2 is used to control the entire inspection operation of the instrument and is equipped with buttons (the buttons are exposed through the outer shell 1) for users to set; the screen 3 is used to interact with users to display the detection results and detection status; the battery pack 4 is used to supply power to the control board 2, the screen 3 and the multifunctional detection mechanism 6 respectively. In addition, the test strip 7 can also be selected as the glycated hemoglobin detection test strip proposed by the applicant in the invention with the publication number of CN111521829B.

[0033] The photochemical detection component 62 includes a silicon photocell 621, an LED lamp 622, and an outer cover 623. The outer cover 623 can cooperate with the control board 2 to cover the silicon photocell 621 and the LED lamp 622 together. The LED lamp 622 can irradiate light towards the photochemical reaction area 72 of the test strip 7, and the silicon photocell 621 can receive the light reflected from the photochemical reaction area 72.

[0034] A notch 6231 is provided at the part of the outer cover 623 facing the silicon photocell 621, and a filter 624 is installed at the notch 6231. The filter 624 installed on the outer cover 623 is used to filter out interfering bands, which can effectively improve the measurement accuracy.

[0035] An isolation sheet 6232 is installed on the outer cover 623 and separated between the silicon photocell 621 and the LED lamp 622. The isolation sheet 6232 separated between the silicon photocell 621 and the LED lamp 622 can effectively prevent the emission light source (LED lamp 622) from affecting the light reception of the receiver (silicon photocell 621), thereby improving the measurement accuracy.

[0036] The silicon photocell 621 and the LED lamp 622 are respectively fixed on the control board 2, and a slot 21 for inserting the isolation sheet 6232 is also provided on the surface of the control board 2. After the isolation sheet 6232 is inserted into the surface of the control board 2 along the slot 21, the installation stability and light isolation effect can be further improved.

[0037] Rubber rings 6233 and rubber cylinders 6234 are provided on the outer cover 623 and can respectively surround the outer edges of the silicon photocell 621 and the LED lamp 622. Among them, the rubber rings 6233 and the rubber cylinders 6234 can respectively wrap the silicon photocell 621 and the LED lamp 622, thereby assisting the isolation sheet 6232 to effectively prevent the light emitted by the LED lamp 622 from directly irradiating on the silicon photocell 621 and affecting the photochemical detection accuracy.

[0038] The electrochemical detection component 61 includes a test strip holder and electrode contact pins. The test strip holder is fixed on the control board 2 and the electrode contact pins are installed in the test strip cavity. The electrode contact pins can be in contact with the electrode group of the test strip 7 in the electrochemical reaction area 71. When in use, the test strip 7 can insert the electrochemical reaction area 71 into the test strip cavity, and the test strip holder can contact the test strip 7 through the electrode contact pins and transmit signals.

[0039] It further includes a strip ejection mechanism 5. The strip ejection mechanism 5 is slidably connected to the housing 1 and can eject the test strip 7 out of the housing 1.

[0040] A slider 611 that can slide along the test strip cavity is provided in the test strip holder. The strip ejection mechanism 5 includes a base 51, a sliding button 52, and a dial post 53. The dial post 53 can pass through the control board 2 along the through slot 22 and is inserted into the slider 611. The sliding button 52 is slidably connected to the shell wall of the outer shell 1 and is indirectly connected to the dial post 53 through the base 51. A convex rib 511 is further provided on the top surface of the base 51. When it is necessary to eject the test strip 7, the sliding button 52 can be pressed and slid, so that the test strip 7 can be driven to leave the outer shell 1 by means of the dial post 53 and the slider 611. In addition, the added convex rib 511 can reduce the contact area between the base 51 and the control board 2, thereby reducing the sliding friction resistance.

[0041] The outer shell 1 includes an upper shell 11, a lower shell 12, a battery cover 13, and a panel 14. The upper shell 11 and the lower shell 12 can jointly clamp the control board 2. The panel 14 is installed on the upper shell 11 and can expose the screen 3. The battery cover 13 and the lower shell 12 can jointly cover the battery pack 4. Among them, the upper shell 11 and the lower shell 12 are jointly used to fix and protect the control board 2; the battery cover 13 is used to cooperate with the lower shell 12 to fix and protect the battery pack 4; the panel 14 is used to cooperate with the upper shell 11 to fix and protect the screen 3.

[0042] During use, the electrochemical detection component 61 and the photochemical detection component 62 of the multi-functional detection mechanism 6 can be used to perform electrochemical detection and photochemical detection on the test strip 7 respectively, and the specific steps are as follows:

[0043] a) Electrochemical detection: First, insert the test strip 7 into the outer shell 1 along the socket, then drop the blood of the test subject at the electrochemical reaction area 71. Next, the electrochemical detection component 61 applies a constant voltage to the electrode group located at the electrochemical reaction area 71 through the electrode pins built in the test strip holder, so as to detect the content of glycated hemoglobin in the blood by using the potentiostatic method and through the generated microcurrent;

[0044] b) Photochemical detection: First, aspirate 150 - 250 μL of the eluent and wash the blood at the electrochemical reaction area 71 to the photochemical reaction area 72. Subsequently, the control board 2 controls the LED lamp 622 to emit light and irradiate the light on the photochemical reaction area 72. Then, using the color of the glycated hemoglobin itself, the reflected light of the photochemical reaction area 72 is irradiated on the silicon photocell 621 after being filtered by the filter 624, and the silicon photocell 621 can detect the reflectance under the condition of 415 nm to obtain the content of glycated hemoglobin in the blood.

[0045] The above embodiments are illustrative of the present invention, not limiting the present invention. Any simply transformed scheme of the present invention belongs to the protection scope of the present invention.

Claims

1. A multi-functional blood glucose detector for detecting glycated hemoglobin, characterized in that: It includes a housing (1), a control board (2), a screen (3), a battery pack (4) and a multi-functional detection mechanism (6). An insertion port for the test strip (7) is provided on the wall of the housing (1). The multi-functional detection mechanism (6) has an electrochemical detection component (61) and a photochemical detection component (62) that can respectively perform electrochemical detection and photochemical detection on the test strip (7). The screen (3), the battery pack (4) and the multi-functional detection mechanism (6) are respectively electrically connected to the control board (2).

2. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 1, characterized in that: The photochemical detection component (62) includes a silicon photocell (621), an LED lamp (622) and a housing (623). The housing (623) can cooperate with the control board (2) to jointly cover the silicon photocell (621) and the LED lamp (622). The LED lamp (622) can irradiate light towards the photochemical reaction area (72) of the test strip (7), and the silicon photocell (621) can receive the light reflected from the photochemical reaction area (72).

3. The multi-functional blood glucose detector for detecting glycated hemoglobin according to claim 2, characterized in that: A notch (6231) is provided at the part of the housing (623) facing the silicon photocell (621), and a filter (624) is installed at the notch (6231).

4. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 2, wherein: An isolation sheet (6232) that separates the silicon photocell (621) from the LED lamp (622) is installed on the housing (623).

5. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 4, characterized in that: The silicon photocell (621) and the LED lamp (622) are respectively fixed on the control board (2), and a slot (21) for inserting the isolation sheet (6232) is also provided on the surface of the control board (2).

6. The multi-functional blood glucose detector for detecting glycated hemoglobin according to claim 5, characterized in that: Rubber rings (6233) and rubber cylinders (6234) that can respectively surround the outer edges of the silicon photocell (621) and the LED lamp (622) are provided on the housing (623).

7. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 1, characterized in that: The electrochemical detection component (61) includes a test strip holder and electrode pins. The test strip holder is fixed on the control board (2), and electrode pins are installed in the test strip cavity. The electrode pins can be in contact with the electrode group of the test strip (7) in the electrochemical reaction area (71).

8. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 7, characterized in that: It also includes a strip ejection mechanism (5). The strip ejection mechanism (5) is slidably connected to the housing (1) and can eject the test strip (7) out of the housing (1).

9. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 8, wherein: A slider (611) that can slide along the test strip cavity is provided in the test strip holder. The strip ejection mechanism (5) includes a base (51), a sliding button (52) and a dial post (53). The dial post (53) can pass through the control board (2) along the through groove (22) and be inserted into the slider (611). The sliding button (52) is slidably connected to the wall of the housing (1) and is indirectly connected to the dial post (53) through the base (51). A convex rib (511) is also provided on the top surface of the base (51).

10. The multifunctional blood glucose detector for detecting glycated hemoglobin according to claim 1, characterized in that: The housing (1) includes an upper shell (11), a lower shell (12), a battery cover (13) and a panel (14). The upper shell (11) and the lower shell (12) can jointly clamp the control board (2). The panel (14) is installed on the upper shell (11) and can expose the screen (3). The battery cover (13) and the lower shell (12) can jointly cover the battery pack (4).

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