Polypeptide synthesizer equipment capable of carrying out PS solid-phase carrier

Abstract

The utility model discloses polypeptide synthesizer equipment capable of synthesizing a PS (Polystyrene) solid-phase carrier, relates to the technical field of polypeptide synthesizers, and aims to solve the problem that a transfer cavity is blocked by materials when synthesized and cleaned solids are transferred when the existing solid-phase carrier synthesizing equipment for polypeptide is used. The sand core funnel is installed below the tank body, the upper end of the sand core funnel penetrates through and extends into the lower portion of the tank body, the sand core funnel is detachably and rotatably connected with the tank body, a first inner cavity is formed in the upper portion of the interior of the sand core funnel, and a second inner cavity is formed in the lower portion of the interior of the sand core funnel. A discharging cavity is formed in the rotating valve mechanism, a sand core layer is arranged in the discharging cavity, the third inner cavity is installed on the front side of the interior of the rotating valve mechanism, a rotating block is arranged in the third inner cavity, and a center connecting shaft is arranged in the middle of the interior of the rotating block.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide synthesizers, and particularly relates to a polypeptide synthesizer device capable of performing polypeptide synthesis on a PS solid-phase carrier. Background Technique

[0002] Polypeptide is a bioactive substance related to various cell functions in organisms. Its molecular structure is between amino acids and proteins, and it is a compound formed by multiple amino acids combined by peptide bonds in a certain arrangement order. The solid-phase synthesis method has become the preferred method for polypeptide synthesis due to its convenient and rapid synthesis.

[0003] For example, the publication number is CN219682536U, and the Chinese authorized patent name is (a polypeptide synthesizer), which includes: a reaction tank, an upper cover, a lower cover and a box body. An upper fixing plate and a lower fixing plate are horizontally and fixedly arranged inside the box body. The upper cover and the lower cover are respectively rotatably connected to the upper fixing plate and the lower fixing plate. A motor box is arranged above the box body, and a first motor is arranged inside the motor box. A stirring rod is arranged inside the reaction tank, and stirring paddles fixedly connected to the stirring rod are respectively arranged in the middle and the lower part of the stirring rod. A filter plate is arranged in the middle of the lower cover, and a worm gear is fixedly connected below the lower cover. A worm is meshed on the right side of the worm gear, and one end of the worm extends to the fixing seat and is rotatably connected to the fixing seat; in this application, the reaction tank body and the stirring paddle can rotate in two different directions respectively, so that the reaction raw materials can be quickly and fully subjected to a synthesis reaction, the reaction rate is increased, and the stirring time is reduced.

[0004] However, when the existing solid-phase carrier synthesis equipment for polypeptides is in use, there is a problem that the transfer cavity is blocked by materials when transferring the synthesized and cleaned solids; therefore, it does not meet the existing requirements. For this reason, we propose a polypeptide synthesizer device capable of performing polypeptide synthesis on a PS solid-phase carrier. Content of the Utility Model

[0005] The purpose of the utility model is to provide a polypeptide synthesizer device capable of performing polypeptide synthesis on a PS solid-phase carrier, so as to solve the problem that when the existing solid-phase carrier synthesis equipment for polypeptides is in use, there is a problem that the transfer cavity is blocked by materials when transferring the synthesized and cleaned solids as mentioned in the above background technique.

[0006] To achieve the above purpose, the utility model provides the following technical solution: A polypeptide synthesizer device capable of performing polypeptide synthesis on a PS solid-phase carrier, including: an outer support mechanism and a rotary valve mechanism. A load-bearing bottom plate is arranged below the interior of the outer support mechanism, a sleeve ring is arranged above the interior of the outer support mechanism, and a can body is arranged above the load-bearing bottom plate and inside the sleeve ring;

[0007] It further includes:

[0008] A sand core funnel is installed below the can body. The upper end of the sand core funnel penetrates and extends into the interior below the can body. The sand core funnel is detachably and rotatably connected to the can body. A first inner cavity is provided above the interior of the sand core funnel, and a second inner cavity is provided below the interior of the sand core funnel. A blanking cavity is provided inside the rotary valve mechanism, and a sand core layer is provided inside the blanking cavity;

[0009] A third inner cavity is installed on the front side inside the rotary valve mechanism. A rotating block is provided inside the third inner cavity. A central connecting shaft is provided at the middle position inside the rotating block. A rotating handle is provided in front of the rotary valve mechanism. One end of the rotating handle penetrates and extends into the interior of the rotary valve mechanism. One end of the rotating handle is fixedly connected to one end of the central connecting shaft. Brush heads are provided above and below the outer wall of the rotating block, and one end of the brush head is fixedly connected to the outer wall of the rotating block.

[0010] Preferably, a blanking pipe is provided below the rotary valve mechanism, and the blanking pipe is fixedly connected to the lower part of the rotary valve mechanism. A discharge pipe is provided on the front side of the outer wall of the sand core funnel.

[0011] Preferably, a shielding piece is provided inside the lower end surface of the sand core funnel. The outer side of the shielding piece is integrally formed with the sand core funnel through a connecting rod body.

[0012] Preferably, the upper end of the can body penetrates inside the sleeve ring and is sleeved with the sleeve ring.

[0013] Preferably, a feeding end is provided above the can body, and a feeding pipe is provided above the feeding end.

[0014] Compared with the prior art, the beneficial effects of the present utility model are:

[0015] In the present utility model, through the rotary valve mechanism provided inside the sand core funnel, and the rotating block, central connecting shaft and brush head provided inside the rotary valve mechanism, the liquid flows down through the blanking cavity, and the sand core layer provided inside the blanking cavity retains the solid on the sand core layer. At the same time, the solid also enters the third inner cavity. When it is necessary to transfer the solid of the material, rotate the rotating handle, then the rotating handle drives the rotating block to rotate, forming a cavity with smooth blanking in the third inner cavity. At the same time, the brush head provided on the outer wall of the rotating block can effectively avoid the blockage of the internal solid and has a dredging effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 is a schematic diagram of the overall structure of the present utility model;

[0017] Figure 2 is a schematic diagram of the internal structure of the sand core funnel of the present utility model;

[0018] Figure 3 This is a front internal structural schematic diagram of the rotary valve mechanism of the present utility model;

[0019] Figure 4 This is a side internal structural schematic diagram of the rotary valve mechanism of the present utility model;

[0020] In the figure: 100, outer support mechanism; 101, load-bearing bottom plate; 102, sleeve ring; 200, can body; 201, feeding end; 20101, feeding pipeline; 202, sand core funnel; 20201, first inner cavity; 20202, second inner cavity; 20203, shielding piece; 20204, connecting rod body; 20205, sand core layer; 202051, blanking cavity; 203, rotary valve mechanism; 20301, third inner cavity; 20302, rotating block; 20303, central connecting shaft; 20304, brush head; 204, rotating handle; 205, blanking pipeline; 206, discharging pipeline. Specific embodiments

[0021] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments.

[0022] Embodiment 1

[0023] Please refer to Figures 1-4 , an embodiment provided by the present utility model: a polypeptide synthesizer device capable of performing PS solid-phase carriers, including: an outer support mechanism 100 and a rotary valve mechanism 203. A load-bearing bottom plate 101 is arranged below the interior of the outer support mechanism 100, a sleeve ring 102 is arranged above the interior of the outer support mechanism 100, and a can body 200 is arranged above the load-bearing bottom plate 101 and inside the sleeve ring 102;

[0024] It also includes:

[0025] A sand core funnel 202, which is installed below the can body 200. The upper end of the sand core funnel 202 penetrates and extends into the interior below the can body 200. The sand core funnel 202 is detachably and rotatably connected to the can body 200. A first inner cavity 20201 is arranged above the interior of the sand core funnel 202, a second inner cavity 20202 is arranged below the interior of the sand core funnel 202, a blanking cavity 202051 is arranged inside the rotary valve mechanism 203, and a sand core layer 20205 is arranged inside the blanking cavity 202051;

[0026] The third inner cavity 20301 is installed on the front side inside the rotary valve mechanism 203. A rotating block 20302 is arranged inside the third inner cavity 20301. A central connecting shaft 20303 is arranged at the middle position inside the rotating block 20302. A rotating handle 204 is arranged in front of the rotary valve mechanism 203. One end of the rotating handle 204 penetrates and extends inside the rotary valve mechanism 203. One end of the rotating handle 204 is fixedly connected to one end of the central connecting shaft 20303. Brush heads 20304 are arranged above and below the outer wall of the rotating block 20302, and one end of the brush head 20304 is fixedly connected to the outer wall of the rotating block 20302.

[0027] The liquid flows down through the blanking cavity 202051, and the sand core layer 20205 arranged inside the blanking cavity 202051 retains the solid on the sand core layer 20205. At the same time, the solid also enters the third inner cavity 20301. When it is necessary to transfer the solid of the material, twist the rotating handle 204, then the rotating handle 204 drives the rotating block 20302 to rotate, forming a cavity with unobstructed blanking in the third inner cavity 20301. At the same time, the brush heads 20304 arranged on the outer wall of the rotating block 20302 can effectively prevent the blockage of the internal solid and have a dredging effect.

[0028] Embodiment 2

[0029] Please refer to Figure 1 and Figure 2 A blanking pipe 205 is arranged below the rotary valve mechanism 203, and the blanking pipe 205 is fixedly connected to the lower part of the rotary valve mechanism 203. A discharge pipe 206 is arranged on the front side of the outer wall of the sand core funnel 202. A shielding piece 20203 is arranged inside the lower end surface of the sand funnel 202. The outer circumference of the shielding piece 20203 is integrally formed with the sand core funnel 202 through a connecting rod body 20204. The upper end of the can body 200 penetrates inside the sleeve ring 102 and is sleeved and connected with the sleeve ring 102. An upper feeding end 201 is arranged above the can body 200, and a feeding pipe 20101 is arranged above the upper feeding end 201.

[0030] The load-bearing bottom plate 101 and the sleeve ring 102 below the can body 200 can effectively provide a stable and reliable connection method for the placement and fixation of the can body 200. At the same time, it is convenient for disassembly operation when taking it.

[0031] Working principle: The sand core funnel 202 is rotatably and detachably connected to the lower end of the can body 200. The can body can perform polypeptide synthesis operations on the materials inside. After synthesis and cleaning, the liquid flows down through the blanking cavity 202051, while the sand core layer 20205 provided inside the blanking cavity 202051 retains the solids on the sand core layer 20205. At the same time, the solids also enter the third inner cavity 20301. When it is necessary to transfer the solids of the materials, turn the rotation handle 204, then the rotation handle 204 drives the rotating block 20302 to rotate, forming a cavity with unobstructed blanking in the third inner cavity 20301. At the same time, the brush heads 20304 provided on the outer wall of the rotating block 20302 can effectively prevent the blockage of the internal solids and have a dredging effect on them.

[0032] For those skilled in the art, it is obvious that the present utility model is not limited to the details of the above exemplary embodiments, and can be implemented in other specific forms without departing from the spirit or basic characteristics of the present utility model. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present utility model is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present utility model. Any reference signs in the claims should not be regarded as limiting the claimed rights.

Claims

1. A polypeptide synthesizer device capable of performing PS solid-phase carriers, comprising an outer support mechanism (100) and a rotary valve mechanism (203). A load-bearing bottom plate (101) is provided below the interior of the outer support mechanism (100), and a sleeve ring (102) is provided above the interior of the outer support mechanism (100). A can body (200) is provided above the load-bearing bottom plate (101) and inside the sleeve ring (102). It is characterized in that: It further includes: A fritted funnel (202), which is installed below the can body (200). The upper end of the fritted funnel (202) penetrates and extends to the interior below the can body (200). The fritted funnel (202) is detachably and rotatably connected to the can body (200). A first inner cavity (20201) is provided above the interior of the fritted funnel (202), and a second inner cavity (20202) is provided below the interior of the fritted funnel (202). A material discharge cavity (202051) is provided inside the rotary valve mechanism (203), and a fritted layer (20205) is provided inside the material discharge cavity (202051). A third inner cavity (20301), which is installed on the front side inside the rotary valve mechanism (203). A rotating block (20302) is provided inside the third inner cavity (20301). A central connecting shaft (20303) is provided at the middle position inside the rotating block (20302). A rotating handle (204) is provided in front of the rotary valve mechanism (203). One end of the rotating handle (204) penetrates and extends to the interior of the rotary valve mechanism (203). One end of the rotating handle (204) is fixedly connected to one end of the central connecting shaft (20303). Brush heads (20304) are provided above and below the outer wall of the rotating block (20302), and one end of the brush head (20304) is fixedly connected to the outer wall of the rotating block (20302).

2. The polypeptide synthesizer device for PS solid phase carriers according to claim 1, wherein: A material discharge pipe (205) is provided below the rotary valve mechanism (203), and the material discharge pipe (205) is fixedly connected to the lower part of the rotary valve mechanism (203). A discharge pipe (206) is provided on the front side of the outer wall of the fritted funnel (202).

3. The polypeptide synthesizer device capable of performing PS solid-phase carrier according to claim 1, wherein: A shielding piece (20203) is provided inside the lower end surface of the fritted funnel (202). The outer side of the shielding piece (20203) is integrally formed with the fritted funnel (202) through a connecting rod body (20204).

4. A polypeptide synthesizer device for PS solid-phase carriers according to claim 1, characterized in that: The upper end of the can body (200) penetrates inside the sleeve ring (102) and is sleeved with the sleeve ring (102).

5. The polypeptide synthesizer device capable of performing PS solid-phase carrier according to claim 1, characterized in that: An upper feeding end (201) is provided above the can body (200), and a feeding pipe (20101) is provided above the upper feeding end (201).

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