PH valve and chromatographic equipment

Abstract

According to the PH valve and the chromatographic equipment, when the PH valve is in a detection position, the first end of a first liquid path is communicated with an outlet of an In connecting part, and the second end of the first liquid path is communicated with a second PH valve port; the first end of the second liquid path is communicated with the first PH valve port, and the second end of the second liquid path is communicated with an inlet of the Out connecting part; and at the bypass position, two ends of the third liquid path are respectively communicated with the outlet of the In connecting part and the inlet of the Out connecting part. According to the scheme, the defect that an existing system cannot be automatically switched and connected into a sensor can be overcome, and random switching of different external connection components can be achieved through one PH valve. According to the scheme, unnecessary operation in the experiment process is reduced, the analysis and preparation efficiency is improved, and meanwhile the cost is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatography equipment, in particular to a pH valve and a chromatography equipment. Background Art

[0002] The experiment of chromatography equipment is an analytical instrument that utilizes the differences in the physical and chemical properties of each component in a mixture. Each substance has a different distribution degree through the chromatography column, resulting in different flow rates to achieve separation. When analyzing a sample using chromatography equipment, it is necessary to detect and analyze the sample data through different sensors and components. And due to the special properties of the sensors (they cannot withstand high pressure and are consumable devices themselves), there is an operation of bypassing the sensor flow path during system operation.

[0003] However, when the existing chromatography equipment on the market needs to connect a chromatography column for an experiment, especially when the system needs to be cleaned after the experiment, the sensors can only be short-circuited manually, and the sensors are removed and placed in the protective liquid. The operation is very cumbersome and easily damages the sensors and wastes experimental time.

[0004] Therefore, how to solve the problem of unable to selectively access the pH sensor and back pressure valve during the experiment, and how to solve the problem of unable to quickly calibrate the sensor during the experiment have become important technical problems that need to be solved urgently by those skilled in the art. Content of the Utility Model

[0005] In view of this, the utility model provides a pH valve, which can solve the defect that the existing system cannot automatically switch to access the sensor, and can realize the arbitrary switching of different external components by using one pH valve.

[0006] To achieve the above object, the utility model provides the following technical solutions:

[0007] A pH valve for chromatography equipment, comprising: a fixed part and a moving part;

[0008] The fixed part is provided with a pH valve inlet, a pH valve outlet, a first pH valve port and a second pH valve port;

[0009] The inlet of the In connection part is used to communicate with the upstream liquid path of the pH valve in the chromatography equipment, and the outlet of the Out connection part is used to communicate with the downstream liquid path of the pH valve in the chromatography equipment;

[0010] The moving part is provided with a first liquid path, a second liquid path and a third liquid path;

[0011] The moving part can move relative to the fixed part to a detection position and a bypass position;

[0012] When in the detection position, the first end of the first liquid path is connected to the outlet of the In connection part, and the second end of the first liquid path is connected to the second PH valve port; the first end of the second liquid path is connected to the first PH valve port, and the second end of the second liquid path is connected to the inlet of the Out connection part;

[0013] When in the bypass position, the two ends of the third liquid path are respectively connected to the outlet of the In connection part and the inlet of the Out connection part.

[0014] In some embodiments, the fixing member and the moving member are coaxially arranged, and the moving member can rotate relative to the fixing member to the detection position and the bypass position.

[0015] In some embodiments, the fixing member and the moving member respectively have opposite first inner surface and second inner surface. The first inner surface is provided with a PH valve inlet, a PH valve outlet, a first PH valve port and a second PH valve port, and the second inner surface is provided with a first liquid path, a second liquid path and a third liquid path.

[0016] In some embodiments, the inlet of the In connection part and the inlet of the Out connection part are respectively arranged on the outer surface of the fixing member.

[0017] In some embodiments, the fixing member is further provided with a FrR port and a ToR port;

[0018] The moving member is further provided with a fourth liquid path;

[0019] The moving member can also move relative to the fixing member to the back pressure valve and the current limiting PH positions;

[0020] When in the back pressure position, the first end of the fourth liquid path is connected to the outlet of the In connection part, and the second end of the fourth liquid path is connected to the ToR port; the two ends of the third liquid path are respectively connected to the FrR port and the inlet of the Out connection part;

[0021] When passing through the back pressure valve and then through the PH sensor position, the second end of the fourth liquid path is connected to the outlet of the In connection part, and the first end of the fourth liquid path is connected to the ToR port; the first end of the second liquid path is connected to the FrR port, and the second end of the second liquid path is connected to the second PH valve port; the middle part of the first liquid path is connected to the first PH valve port, and the second end of the first liquid path is connected to the inlet of the Out connection part.

[0022] In some embodiments, the fixing member is further provided with a W3 port and a Cal port;

[0023] The moving member is further provided with a fifth liquid path and a sixth liquid path;

[0024] The moving member can also move relative to the fixing member to the calibration position;

[0025] When in the calibration position, the two ends of the fifth liquid path are respectively connected to the Cal port and the first PH valve port, and the two ends of the sixth liquid path are respectively connected to the second PH valve port and the W3 port.

[0026] In some embodiments, the fourth liquid path is arranged radially along the moving part and is symmetric about the rotation center of the moving part;

[0027] The first liquid path and the second liquid path are located on one side of the fourth liquid path, and the third liquid path, the fifth liquid path and the sixth liquid path are located on the other side of the fourth liquid path.

[0028] In some embodiments, the distances from the PH valve inlet, the PH valve outlet, the FrR port second PH valve port and the ToR port to the center of the fixed part are all R;

[0029] The distances from the first PH valve port, the second PH valve port and the Cal port to the center of the fixed part are all r, and r < R;

[0030] The outer edge ends of the first liquid path, the second liquid path, the third liquid path, the fourth liquid path and the sixth liquid path are also all at a distance of R from the center of the moving part.

[0031] In some embodiments, the PH valve inlet, the PH valve outlet, the FrR port second PH valve port and the ToR port are arranged at equal intervals in the circumferential direction.

[0032] A chromatography device includes the PH valve as described above.

[0033] As can be seen from the above technical solutions, the PH valve provided by the present utility model can solve the defect that the existing system cannot automatically switch to access the sensor, and can realize the arbitrary switching of different external components by using one PH valve. This solution reduces unnecessary operations in the experiment process, improves the efficiency of analysis and preparation, and also reduces costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the technical solutions in the embodiments of the present utility model or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present utility model. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0035] Figure 1 It is a schematic structural diagram of the PH valve provided by the embodiment of the present utility model;

[0036] Figure 2 It is a schematic structural diagram of the PH valve provided by the embodiment of the present utility model;

[0037] Figure 3a It is a schematic structural diagram of the PH sensor provided by the embodiment of the present utility model;

[0038] Figure 3b It is a schematic structural diagram of the bypass provided by the embodiment of the present utility model;

[0039] Figure 3c Structural schematic diagram of the overcurrent limiter / back pressure valve provided by the embodiment of the present utility model;

[0040] Figure 3d Structural schematic diagram of the overcurrent limiter and then the PH sensor provided by the embodiment of the present utility model;

[0041] Figure 3e Structural schematic diagram of the PH calibration provided by the embodiment of the present utility model;

[0042] Figure 4 Structural schematic diagram of the fixing member provided by the embodiment of the present utility model;

[0043] Figure 5 Structural schematic diagram of one side of the PH valve provided by the embodiment of the present utility model;

[0044] Figure 6 Structural schematic diagram of the other side of the PH valve provided by the embodiment of the present utility model;

[0045] Figure 7 Another structural schematic diagram of the overcurrent limiter / back pressure valve provided by the embodiment of the utility model;

[0046] Figure 8 One structural schematic diagram of the moving member provided by the embodiment of the present utility model;

[0047] Figure 9 Another structural schematic diagram of the moving member provided by the embodiment of the present utility model;

[0048] Figure 10 Three - dimensional structural schematic diagram of the moving member provided by the embodiment of the present utility model.

[0049] Among them, 10 is the fixing member and 20 is the moving member;

[0050] 11 is the PH valve inlet, 12 is the PH valve outlet, 13 is the first PH valve port, 14 is the second PH valve port, 15 is the FrR port, 16 is the W3 port, 17 is the Cal port, and 18 is the ToR port;

[0051] 21 is the first liquid path, 22 is the second liquid path, 23 is the third liquid path, 24 is the fourth liquid path, 25 is the fifth liquid path, and 26 is the sixth liquid path;

[0052] 31 is the In connection part and 32 is the Out connection part. Detailed implementation manner

[0053] The following will clearly and completely describe the technical solutions in the embodiments of the present utility model with reference to the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0054] The PH valve provided in the embodiment of the present utility model is used for a chromatography device and includes a fixing member 10 and a moving member 20. Among them, the fixing member 10 is provided with a PH valve inlet 11, a PH valve outlet 12, a first PH valve port 13, a second PH valve port 14, an In connection part and an Out connection part. The In connection part is the input flow path of the previous-stage system, and the Out connection part is the output flow path interface. The inlet of the In connection part is used to communicate with the upstream liquid path of the PH valve in the chromatography device, and the outlet of the Out connection part is used to communicate with the downstream liquid path of the PH valve in the chromatography device. The moving member 20 is provided with a first liquid path 21, a second liquid path 22 and a third liquid path 23. The moving member 20 can move relative to the fixing member 10 to a detection position and a bypass position.

[0055] When in the detection position, the first end of the first liquid path 21 communicates with the outlet of the In connection part, and the second end of the first liquid path 21 communicates with the second PH valve port 14. The first end of the second liquid path 22 communicates with the first PH valve port 13, and the second end of the second liquid path 22 communicates with the inlet of the Out connection part. Figure 3a It is a schematic structural diagram of the PH sensor provided in the embodiment of the present utility model. The upper right corner is the position for installing the PH sensor. The liquid passes through the PH sensor from the upstream liquid path of the PH valve in the chromatography device through the In connection part and then flows to the downstream liquid path of the PH valve in the chromatography device through the Out connection part.

[0056] When in the bypass position, both ends of the third liquid path 23 communicate with the outlet of the In connection part and the inlet of the Out connection part respectively. Figure 3b It is a schematic structural diagram of the bypass provided in the embodiment of the present utility model. The liquid flows from the upstream liquid path of the PH valve in the chromatography device through the In connection part and directly flows to the downstream liquid path of the PH valve in the chromatography device through the Out connection part.

[0057] It can be seen from the above technical solutions that the PH valve provided in the embodiment of the present utility model can solve the defect that the existing system cannot automatically switch to access the sensor, and can realize the arbitrary switching of different external components by using one PH valve. This solution reduces unnecessary operations in the experiment process, improves the efficiency of analysis and preparation, and also reduces the cost.

[0058] In some embodiments of this solution, the fixing member 10 and the moving member 20 are coaxially arranged, and the moving member 20 can rotate relative to the fixing member 10 to the detection position and the bypass position, and its structure is convenient for state switching.

[0059] In some embodiments of this solution, the fixing member 10 and the moving member 20 respectively have opposite first inner surfaces and second inner surfaces. The first inner surface is provided with a PH valve inlet 11, a PH valve outlet 12, a first PH valve port 13 and a second PH valve port 14, and its structure can be referred to Figure 4 as shown; the second inner surface is provided with a first liquid path 21, a second liquid path 22 and a third liquid path 23, and its structure can be referred to Figure 8 as shown.

[0060] In some embodiments of this solution, the inlets of the In connection part and the Out connection part are respectively arranged on the outer surface of the fixing member 10.

[0061] In some embodiments of this solution, the fixing member 10 is further provided with a FrR port 15 and a ToR port 18, and its structure can be referred to Figure 4 as shown;

[0062] The moving member 20 is further provided with a fourth liquid path 24, and its structure can be referred to Figure 8 as shown;

[0063] The moving member 20 can also move relative to the fixing member 10 to the back pressure valve and the current-limiting PH positions;

[0064] When in the back pressure position, the first end of the fourth liquid path 24 communicates with the outlet of the In connection part, and the second end of the fourth liquid path 24 communicates with the ToR port 18; both ends of the third liquid path 23 respectively communicate with the FrR port 15 and the inlet of the Out connection part; Figure 3c is a schematic structural diagram of the over-current limiter / back pressure valve provided by the embodiment of the present invention; liquid enters the ToR port 18 from the upstream liquid path of the PH valve in the chromatography device through the In connection part, then passes through the back pressure valve and enters the FrR port 15, and flows out through the Out connection part to the downstream liquid path of the PH valve in the chromatography device;

[0065] When passing through the back pressure valve and then the PH sensor position, the second end of the fourth liquid path 24 communicates with the outlet of the In connection part, and the first end of the fourth liquid path 24 communicates with the ToR port 18; the first end of the second liquid path 22 communicates with the FrR port 15, and the second end of the second liquid path 22 communicates with the second PH valve port 14; the middle of the first liquid path 21 communicates with the first PH valve port 13, and the second end of the first liquid path 21 communicates with the inlet of the Out connection part; Figure 3d is a schematic structural diagram of the over-current limiter passing through the PH sensor provided by the embodiment of the present invention; liquid enters the ToR port 18 from the upstream liquid path of the PH valve in the chromatography device through the In connection part, then enters the FrR port 15 through the back pressure valve and passes through the PH sensor, and finally flows out through the Out connection part to the downstream liquid path of the PH valve in the chromatography device. Through the above structural design, this solution can also realize the rapid switching between the back pressure function and the current-limiting PH function.

[0066] In some embodiments of this solution, the fixing member 10 is further provided with a W3 port 16 and a Cal port 17, and its structure can be referred to Figure 4 as shown;

[0067] The moving member 20 is further provided with a fifth liquid path 25 and a sixth liquid path 26;

[0068] The moving member 20 can also move relative to the fixing member 10 to a calibration position;

[0069] When in the calibration position, both ends of the fifth liquid path 25 are respectively communicated with the Cal port 17 and the first PH valve port 13, and both ends of the sixth liquid path 26 are respectively communicated with the second PH valve port 14 and the W3 port 16; Figure 3e It is a schematic structural diagram of PH calibration provided by an embodiment of the present invention; the liquid enters from the upstream liquid path of the PH valve in the chromatography device through the Cal port 17 and flows out from the W3 port 16 to the downstream liquid path of the PH valve in the chromatography device. Through the above structural design of this solution, the rapid switching of the calibration function can also be realized.

[0070] In some embodiments of this solution, the fourth liquid path 24 is arranged along the radial direction of the moving member 20 and is symmetric about the rotation center of the moving member 20, and its structure can be referred to Figure 4 as shown;

[0071] The first liquid path 21 and the second liquid path 22 are located on one side of the fourth liquid path 24, and the third liquid path 23, the fifth liquid path 25 and the sixth liquid path 26 are located on the other side of the fourth liquid path 24.

[0072] In some embodiments of this solution, the distances from the PH valve inlet 11, the PH valve outlet 12, the FrR port 15, the second PH valve port 16 and the ToR port 18 to the center of the fixing member 10 are all R, and its structure can be referred to Figure 4 as shown;

[0073] The distances from the first PH valve port 13, the second PH valve port 14 and the Cal port 17 to the center of the fixing member 10 are all r, and r < R;

[0074] The outer edge ends of the first liquid path 21, the second liquid path 22, the third liquid path 23, the fourth liquid path 24 and the sixth liquid path 26 to the center of the moving member 20 are also all R, and its structure can be referred to Figure 9 as shown, D = 2R.

[0075] In some embodiments of this solution, the PH valve inlet 11, the PH valve outlet 12, the FrR port 15, the second PH valve port 16 and the ToR port 18 are arranged at equal intervals in the circumferential direction.

[0076] As Figure 4 - Figure 10As shown in the figure, the structure of the present utility model includes a stator (i.e., the fixed part 10) and a rotor (i.e., the moving part 20). The rotor is closely combined with the surface of the stator. During use, the rotor is connected to specific hole positions on the stator by rotation. Among them, there are many equally divided hole positions with equal circle radii on the surface of the stator, namely the PH valve inlet 11, the PH valve outlet 12, the FrR port 15, the second PH valve port 16, and the ToR port 18. Among them, the hole position at the center point is the inlet from the chromatography device to the PH valve, and the hole position at a distance of R5 from the circular part is the outlet of the PH valve. The rotor is composed of a straight groove (i.e., the fourth liquid path 24), a circular groove (i.e., the first liquid path 21), and internal channels (i.e., the second liquid path 22, the third liquid path 23, the fifth liquid path 25, and the sixth liquid path 26) on the surface. Each inlet and outlet of the PH valve are distributed on the stator surface at a distance of R5 from the center of the circle. By rotating the rotor to any hole position on the R5 radius, the functions of arbitrarily accessing sensors and backpressure valves can be achieved.

[0077] An embodiment of the present utility model also provides a chromatography device, including the PH valve as described above, which can be a protein purification instrument, a liquid chromatography instrument, etc., and does not require manual operations such as accessing sensors and backpressure valves.

[0078] In this specification, each embodiment is described in a progressive manner. The key point of each embodiment is to illustrate the differences from other embodiments. The same or similar parts among the embodiments can be referred to each other.

[0079] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present utility model. Various modifications to these embodiments will be obvious to those skilled in the art. The general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present utility model. Therefore, the present utility model will not be limited to these embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A PH valve for a chromatography device, characterized in that, Comprising: A fixing member (10) and a moving member (20); The fixing member (10) is provided with a PH valve inlet (11), a PH valve outlet (12), a first PH valve port (13), a second PH valve port (14), an In connection portion and an Out connection portion; The inlet of the In connection portion is used to communicate with the upstream liquid path of the PH valve in the chromatography device, and the outlet of the Out connection portion is used to communicate with the downstream liquid path of the PH valve in the chromatography device; The moving member (20) is provided with a first liquid path (21), a second liquid path (22) and a third liquid path (23); The moving member (20) can move relative to the fixing member (10) to a detection position and a bypass position; At the detection position, the first end of the first liquid path (21) communicates with the outlet of the In connection portion, and the second end of the first liquid path (21) communicates with the second PH valve port (14); the first end of the second liquid path (22) communicates with the first PH valve port (13), and the second end of the second liquid path (22) communicates with the inlet of the Out connection portion; At the bypass position, both ends of the third liquid path (23) communicate with the outlet of the In connection portion and the inlet of the Out connection portion respectively.

2. The PH valve according to claim 1, characterized in that, The fixing member (10) and the moving member (20) are coaxially arranged, and the moving member (20) can rotate relative to the fixing member (10) to the detection position and the bypass position.

3. The PH valve according to claim 2, characterized in that, The fixing member (10) and the moving member (20) respectively have opposite first inner surfaces and second inner surfaces. The first inner surface is provided with a PH valve inlet (11), a PH valve outlet (12), a first PH valve port (13) and a second PH valve port (14), and the second inner surface is provided with a first liquid path (21), a second liquid path (22) and a third liquid path (23).

4. The PH valve according to claim 3, characterized in that, The inlet of the In connection portion and the inlet of the Out connection portion are respectively arranged on the outer surface of the fixing member (10).

5. The PH valve according to claim 3, characterized in that, The fixing member (10) is further provided with a FrR port (15) and a ToR port (18); The moving member (20) is further provided with a fourth liquid path (24); The moving member (20) can further move relative to the fixing member (10) to an anti-pressure valve and a current-limiting PH position; At the anti-pressure position, the first end of the fourth liquid path (24) communicates with the outlet of the In connection portion, and the second end of the fourth liquid path (24) communicates with the ToR port (18); both ends of the third liquid path (23) communicate with the FrR port (15) and the inlet of the Out connection portion respectively; At the position of passing through the anti-pressure valve and then the PH sensor, the second end of the fourth liquid path (24) communicates with the outlet of the In connection portion, and the first end of the fourth liquid path (24) communicates with the ToR port (18); the first end of the second liquid path (22) communicates with the FrR port (15), and the second end of the second liquid path (22) communicates with the second PH valve port (14); the middle of the first liquid path (21) communicates with the first PH valve port (13), and the second end of the first liquid path (21) communicates with the inlet of the Out connection portion.

6. The PH valve according to claim 5, wherein, The fixing member (10) is further provided with a W3 port (16) and a Cal port (17); The moving member (20) is further provided with a fifth liquid path (25) and a sixth liquid path (26); The moving member (20) can further move relative to the fixing member (10) to a calibration position; When in the calibration position, the two ends of the fifth liquid path (25) are respectively connected to the Cal port (17) and the first PH valve port (13), and the two ends of the sixth liquid path (26) are respectively connected to the second PH valve port (14) and the W3 port (16).

7. The PH valve according to claim 6, wherein The fourth liquid path (24) is arranged along the radial direction of the moving part (20) and is symmetric about the rotation center of the moving part (20); The first liquid path (21) and the second liquid path (22) are located on one side of the fourth liquid path (24), and the third liquid path (23), the fifth liquid path (25) and the sixth liquid path (26) are located on the other side of the fourth liquid path (24).

8. The PH valve according to claim 7, characterized in that, The distances from the PH valve inlet (11), the PH valve outlet (12), the FrR port (15), the second PH valve port (14) and the ToR port (18) to the center of the fixing part (10) are all R; The distances from the first PH valve port (13), the second PH valve port (14) and the Cal port (17) to the center of the fixing part (10) are all r, and r < R; The distances from the outer edge ends of the first liquid path (21), the second liquid path (22), the third liquid path (23), the fourth liquid path (24) and the sixth liquid path (26) to the center of the moving part (20) are also all R.

9. The PH valve according to claim 7, characterized in that, The PH valve inlet (11), the PH valve outlet (12), the FrR port (15), the second PH valve port (14) and the ToR port (18) are arranged at equal intervals in the circumferential direction.

10. A chromatography device, characterized in that, Comprising the PH valve according to any one of claims 1-9.

Images