Filtering device for lornoxicam preparation

Abstract

The utility model discloses a filtering device for lornoxicam preparation, relates to the field of lornoxicam preparation, and aims to solve the problems that raw material liquid needs to be subjected to decarburization and sterilization filtration in lornoxicam preparation in the prior art, and the existing filtering device is not provided with a sterilization mechanism, so that the raw material liquid needs to be subjected to decarburization and then is filtered, and the cost is high. The preparation efficiency is influenced. A liquid inlet pipe is fixedly arranged on one side of the upper end of the filtering device, the lower end of the liquid inlet pipe is connected with a sterilization box in the filtering device, overflow plates are fixedly connected to the middle and the two sides of the middle of the lower end face in the sterilization box, and two rectangular openings are formed between the upper end face of the sterilization box and the upper end face of the filtering device; supporting plates are arranged at the upper ends of the two rectangular openings, a plurality of ozone generators are fixedly connected to the lower ends of the supporting plates, and a filtering plate is fixedly connected to the middle of the interior of the filtering device.

Description

Technical Field

[0001] The utility model relates to the field of lornoxicam preparation, and particularly to a filtering device for lornoxicam preparation. Background Technique

[0002] Lornoxicam is the chloride of tenoxicam. Its effects are similar to those of piroxicam, having analgesic, anti-inflammatory and antipyretic effects. It can selectively inhibit COX-2, and its strength is slightly weaker than that of piroxicam. It activates the opioid neuropeptide system to exert a central analgesic effect. The antipyretic effect of this product is weak, and the required dose is 10 times that of the anti-inflammatory dose. Oral absorption is slow, and the peak blood concentration is reached in 24 hours. Food may reduce its absorption rate by 20% and delay its absorption rate. It is distributed throughout the body and also in synovial fluid.

[0003] For example, the application publication number is CN 115227655 A. The invention relates to a preparation method of injectable lornoxicam, including the following steps: weighing the prescription amounts of lornoxicam raw materials, tromethamine, mannitol and disodium edetate for standby; adding 85% of the total injection water volume to the liquid preparation tank, and successively adding disodium edetate and tromethamine to the liquid preparation tank, stirring to completely dissolve them, and then adding the prescription amount of lornoxicam raw materials; adding mannitol, stirring to completely dissolve it into a clear solution, adjusting the pH value of the liquid medicine to 8.0 - 9.0, and supplementing the injection water to the full volume; adding 0.1% (g / mL) of medicinal activated carbon based on the total amount of the liquid medicine, stirring and adsorbing at room temperature for 30 minutes, passing through carbon removal and the first sterilization filtration, after the intermediate inspection is qualified, filling and freeze-drying to obtain the finished product. The invention timely removes the methanol generated by the reaction through the way of distillation and condensation, and at the same time combines the addition of stabilizers to ensure the forward progress of the reaction, reduce the activation energy required for the reaction, and avoid the appearance of coking carbon phenomenon in the reaction. By combining macroporous adsorption resin to adsorb methanol, the reaction solvent can be recycled and the cost can be saved; and through the selection of solvents in the crude and refined processes, the crystallization time is minimized, and the yield and purity of the finished product are improved.

[0004] In the preparation of lornoxicam, the raw material liquid needs to be subjected to carbon removal and sterilization filtration. There is no sterilization mechanism on the existing filtering devices, so it is necessary to filter after the raw material liquid is decarbonized, which affects the preparation efficiency; therefore, there is an urgent need in the market to develop a filtering device for lornoxicam preparation to help people solve the existing problems. Content of the Utility Model

[0005] The purpose of the utility model is to provide a filtering device for lornoxicam preparation to solve the problem that in the preparation of lornoxicam, the raw material liquid needs to be subjected to carbon removal and sterilization filtration, and there is no sterilization mechanism on the existing filtering devices, so it is necessary to filter after the raw material liquid is decarbonized, which affects the preparation efficiency as mentioned in the above background technique.

[0006] To achieve the above object, the present utility model provides the following technical solutions: A filtering device for the preparation of lornoxicam, including a filtering device. One side of the upper end of the filtering device is fixedly provided with a liquid inlet pipe. The lower end of the liquid inlet pipe is connected to a sterilization box inside the filtering device. In the middle and on both sides of the lower end surface inside the sterilization box, overflow plates are fixedly connected. Between the upper end surface of the sterilization box and the upper end surface of the filtering device, two rectangular openings are provided. On the upper ends of the two rectangular openings, support plates are provided. The lower ends of the support plates are fixedly connected with a plurality of ozone generators. In the middle of the filtering device, a filter plate is fixedly connected. In the middle of the upper end of the filter plate, a rotating member is rotatably connected. On the rotating member, a plurality of arc-shaped scraping rods are fixedly connected.

[0007] Preferably, the ozone generators on the two support plates respectively pass through the two rectangular openings and extend between two adjacent overflow plates.

[0008] Preferably, a water outlet is provided at the lower end of one side of the sterilization box.

[0009] Preferably, a transmission box is fixedly provided in the middle of the lower end of the filter plate. The lower end of the rotating member is fixedly connected with a rotating shaft. The lower end of the rotating shaft extends into the transmission box and is fixedly connected with a first bevel gear.

[0010] Preferably, a fixed pipe is fixedly connected between one side of the transmission box and the inner end face of the filtering device. A transmission shaft is arranged inside the fixed pipe. One end of the transmission shaft extends into the transmission box and is fixedly connected with a second bevel gear.

[0011] Preferably, the second bevel gear is meshed with the tooth part of the first bevel gear. A driving device for driving the transmission shaft to rotate is fixedly connected to one side of the filtering device. A motor is fixedly arranged inside the driving device. The other end of the transmission shaft extends into the driving device and is fixedly connected with the output shaft of the motor.

[0012] Preferably, a slag discharge port is provided at the rear end of the filtering device. A cover is connected to the outside of the slag discharge port in an openable manner. An outlet pipe is provided at the lower end of the filtering device.

[0013] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0014] 1. In this utility model, through the setting of the sterilization box, the lower end of the liquid inlet pipe is connected to the sterilization box inside the filtering device. The raw material liquid is added into the sterilization box through the liquid inlet pipe. The raw material liquid overflows from one side to the other side inside the sterilization box. When the raw material liquid overflows, the raw material liquid is sterilized by a plurality of ozone generators. The sterilized raw material liquid falls from the water outlet onto the upper end of the filter plate inside the filtering device. The raw material liquid is filtered by the filter plate, realizing the continuous sterilization and filtration of the raw material liquid in the preparation process of lornoxicam, and improving the preparation efficiency.

[0015] 2. In this utility model, through the arrangement of the overflow plates, the middle part and both sides of the lower end surface inside the sterilization tank are fixedly connected with overflow plates. The inside of the sterilization tank is divided by three overflow plates, so that the raw material liquid overflows from one side to the other side inside the sterilization tank, increasing the retention time of the raw material liquid inside the sterilization tank and improving the sterilization effect of the ozone generator on the raw material liquid.

[0016] 3. In this utility model, through the arrangement of the arc-shaped scraping rods, a plurality of arc-shaped scraping rods are fixedly connected to the rotating member. The rotating member is rotated by the motor, so that the arc-shaped scraping rods rotate and continuously scrape the upper end surface of the filter plate to prevent the filter residue of the raw material liquid from blocking the filter plate. A slag discharge port is arranged at the rear end of the filtering device, and a cover is openably connected to the outside of the slag discharge port. When the arc-shaped scraping rods scrape the filter residue on the upper end surface of the filter plate, the filter residue will be pushed outward by the arc part. After the raw material liquid is filtered, the cover is opened, and the filter residue is pushed by the arc-shaped scraping rods to move to the slag discharge port, and then the filter residue can be discharged, which is convenient for cleaning the filter residue. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is the front view of a filtering device for the preparation of lornoxicam according to the present utility model;

[0018] Figure 2 is the main sectional view of the present utility model;

[0019] Figure 3 is the side sectional view of the present utility model;

[0020] Figure 4 is the enlarged detail view of part A of the present utility model.

[0021] In the figure: 1. Filtering device; 101. Liquid inlet pipe; 102. Rectangular opening; 103. Filter plate; 104. Slag discharge port; 105. Cover; 106. Liquid outlet pipe; 2. Sterilization tank; 201. Overflow plate; 202. Water inlet; 3. Support plate; 301. C-shaped pull rod; 302. Ozone generator; 4. Rotating member; 401. Arc-shaped scraping rod; 402. Rotating shaft; 403. First bevel gear; 5. Transmission box; 501. Fixed pipe; 502. Transmission shaft; 503. Second bevel gear; 6. Driving device; 601. Motor. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0022] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments.

[0023] Please refer to Figures 1-4, An embodiment provided by the present utility model: A filtering device for the preparation of lornoxicam, including a filtering device 1. One side of the upper end of the filtering device 1 is fixedly provided with a liquid inlet pipe 101. The lower end of the liquid inlet pipe 101 is connected to a sterilization box 2 inside the filtering device 1. In the middle and on both sides of the lower end face inside the sterilization box 2, overflow plates 201 are fixedly connected. Between the upper end face of the sterilization box 2 and the upper end face of the filtering device 1, there are two rectangular openings 102. On the upper ends of the two rectangular openings 102, there are support plates 3. The lower end of the support plate 3 is fixedly connected with a plurality of ozone generators 302. In the middle of the inside of the filtering device 1, a filter plate 103 is fixedly connected. In the middle of the upper end of the filter plate 103, a rotating member 4 is rotatably connected. On the rotating member 4, a plurality of arc-shaped scraping rods 401 are fixedly connected.

[0024] Further, the ozone generators 302 on the two support plates 3 respectively pass through the two rectangular openings 102 and extend between two adjacent overflow plates 201. The raw material liquid is added into the inside of the sterilization box 2 through the liquid inlet pipe 101. The inside of the sterilization box 2 is separated by three overflow plates 201, so that the raw material liquid overflows from one side to the other side inside the sterilization box 2, increasing the retention time of the raw material liquid inside the sterilization box 2. When the raw material liquid overflows, the raw material liquid is sterilized by a plurality of ozone generators 302.

[0025] Further, a water outlet 202 is provided at the lower end of one side of the sterilization box 2. The sterilized raw material liquid falls from the water outlet 202 onto the upper end of the filter plate 103 inside the filtering device 1, and the raw material liquid is filtered by the filter plate 103.

[0026] Further, a transmission box 5 is fixedly provided in the middle of the lower end of the filter plate 103. The lower end of the rotating member 4 is fixedly connected with a rotating shaft 402. The lower end of the rotating shaft 402 extends into the inside of the transmission box 5 and is fixedly connected with a first bevel gear 403.

[0027] Further, between one side of the transmission box 5 and the inner end face of the filtering device 1, a fixed pipe 501 is fixedly connected. Inside the fixed pipe 501, a transmission shaft 502 is provided. One end of the transmission shaft 502 extends into the inside of the transmission box 5 and is fixedly connected with a second bevel gear 503.

[0028] Further, the second bevel gear 503 is in meshing connection with the tooth part of the first bevel gear 403. A driving device 6 for driving the transmission shaft 502 to rotate is fixedly connected to one side of the filtering device 1. Inside the driving device 6, a motor 601 is fixedly provided. The other end of the transmission shaft 502 extends into the inside of the driving device 6 and is fixedly connected with the output shaft of the motor 601. The rotating member 4 is driven to rotate by the motor 601, so that the arc-shaped scraping rods 401 rotate, continuously scraping the upper end face of the filter plate 103 to prevent the filter residue of the raw material liquid from blocking the filter plate 103.

[0029] Further, a slag discharge port 104 is provided at the rear end of the filtering device 1. A cover 105 is connected to the outside of the slag discharge port 104 in an openable manner. A liquid outlet pipe 106 is provided at the lower end of the filtering device 1. When the arc-shaped scraping rod 401 scrapes the filter residue on the upper surface of the filter plate 103, the filter residue will be pushed outward by the arc-shaped part. When the raw material liquid filtration is completed, the cover 105 is opened, and the filter residue is pushed to the slag discharge port 104 by the arc-shaped scraping rod 401, and then the filter residue can be discharged.

[0030] Working principle: During use, a liquid inlet pipe 101 is fixedly provided on one side of the upper end of the filtering device 1. The lower end of the liquid inlet pipe 101 is connected to a sterilization tank inside the filtering device 1. The raw material liquid is added into the sterilization tank 2 through the liquid inlet pipe 101. The sterilization tank 2 is separated by three overflow plates 201, so that the raw material liquid overflows from one side to the other side inside the sterilization tank 2, increasing the retention time of the raw material liquid inside the sterilization tank 2. When the raw material liquid overflows, the raw material liquid is sterilized by a plurality of ozone generators 302. The sterilized raw material liquid falls from the water inlet 202 onto the upper end of the filter plate 103 inside the filtering device 1. The raw material liquid is filtered by the filter plate 103. The filtered raw material liquid is discharged from the liquid outlet pipe 106 at the lower end of the filtering device 1. A rotating member 4 is rotatably connected to the middle of the upper end of the filter plate 103. A plurality of arc-shaped scraping rods 401 are fixedly connected to the rotating member 4. The rotating member 4 is driven to rotate by a motor 601, so that the arc-shaped scraping rods 401 rotate and continuously scrape the upper surface of the filter plate 103 to prevent the filter residue of the raw material liquid from blocking the filter plate 103. A slag discharge port 104 is provided at the rear end of the filtering device 1. A cover 105 is connected to the outside of the slag discharge port 104 in an openable manner. When the arc-shaped scraping rod 401 scrapes the filter residue on the upper surface of the filter plate 103, the filter residue will be pushed outward by the arc-shaped part. When the raw material liquid filtration is completed, the cover 105 is opened, and the filter residue is pushed to the slag discharge port 104 by the arc-shaped scraping rod 401, and then the filter residue can be discharged.

[0031] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above-described exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, in any aspect, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be included in the present invention. Any reference signs in the claims should not be regarded as limiting the claimed rights.

Claims

1. A filtering device for the preparation of lornoxicam, comprising a filtering device (1), characterized in that: One side of the upper end of the filtering device (1) is fixedly provided with a liquid inlet pipe (101). The lower end of the liquid inlet pipe (101) is connected to a sterilization box (2) inside the filtering device (1). In the middle and on both sides of the lower end face inside the sterilization box (2), overflow plates (201) are fixedly connected. Between the upper end face of the sterilization box (2) and the upper end face of the filtering device (1), two rectangular openings (102) are provided. At the upper ends of the two rectangular openings (102), support plates (3) are provided. The lower end of the support plate (3) is fixedly connected with a plurality of ozone generators (302). In the middle of the inside of the filtering device (1), a filter plate (103) is fixedly connected. In the middle of the upper end of the filter plate (103), a rotating member (4) is rotatably connected. A plurality of arc-shaped scraping rods (401) are fixedly connected to the rotating member (4).

2. The filtration device for the preparation of lornoxicam according to claim 1, characterized in that: The ozone generators (302) on the two support plates (3) respectively pass through the two rectangular openings (102) and extend between two adjacent overflow plates (201).

3. A filtering device for the preparation of lornoxicam according to claim 1, characterized in that: One side of the lower end of the sterilization box (2) is provided with a water outlet (202).

4. A filtering device for the preparation of lornoxicam according to claim 1, characterized in that: In the middle of the lower end of the filter plate (103), a transmission box (5) is fixedly provided. The lower end of the rotating member (4) is fixedly connected with a rotating shaft (402). The lower end of the rotating shaft (402) extends into the transmission box (5) and is fixedly connected with a first bevel gear (403).

5. A filtering device for the preparation of lornoxicam according to claim 4, characterized in that: Between one side of the transmission box (5) and the inner end face of the filtering device (1), a fixed pipe (501) is fixedly connected. Inside the fixed pipe (501), a transmission shaft (502) is provided. One end of the transmission shaft (502) extends into the transmission box (5) and is fixedly connected with a second bevel gear (503).

6. The filtration device for preparing lornoxicam according to claim 5, wherein: The second bevel gear (503) is meshed with the tooth part of the first bevel gear (403). On one side of the filtering device (1), a driving device (6) for driving the transmission shaft (502) to rotate is fixedly connected. Inside the driving device (6), a motor (601) is fixedly provided. The other end of the transmission shaft (502) extends into the driving device (6) and is fixedly connected with the output shaft of the motor (601).

7. A filtering device for the preparation of lornoxicam according to claim 1, characterized in that: At the rear end of the filtering device (1), a slag discharge port (104) is provided. A cover (105) is connected to the outside of the slag discharge port (104) in an openable manner. At the lower end of the filtering device (1), a liquid outlet pipe (106) is provided.

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