Dissolving reaction kettle for producing ritonavir intermediate MTV-III

Abstract

The utility model discloses a dissolution reaction kettle for producing a ritonavir intermediate MTV-III, which is characterized in that a kettle cover is arranged on the upper surface of a kettle body, the lower part of a main shaft of a stirrer and a stirring paddle are movably arranged in the kettle body, a mixed liquid feeding hole and a water inlet are formed in the upper surface of the kettle cover, and an outer ring groove and an inner ring groove are formed in the lower surface of the kettle cover; an outer ring cover plate is arranged on the lower surface of the kettle cover and located at the outer ring groove, an inner ring cover plate is arranged on the lower surface of the kettle cover and located at the inner ring groove, the outer ring cover plate is provided with a plurality of discharging ports, and the inner ring cover plate is provided with a plurality of nozzles. On one hand, a mixed solution is evenly discharged through the outer ring groove, water is evenly discharged through the inner ring groove, and compared with installation of a water distributor, space is saved; and on the other hand, water is sprayed out through the nozzles, the outlet pressure is higher, the water can be quickly mixed and contacted with the mixed solution, and the dissolving effect is better.

Description

Technical Field

[0001] The utility model relates to the technical field of dissolution reaction kettles, in particular to a dissolution reaction kettle for the production of ritonavir intermediate MTV-III. Background Technique

[0002] Generally speaking, the process of mixing more than two substances to form a homogeneous phase of one state is called dissolution. Narrowly, dissolution refers to the process in which a liquid produces a physical or chemical reaction with a solid / liquid / or gas to make it into a homogeneous phase in a molecular state, which is called dissolution.

[0003] Ritonavir is a protease inhibitor mainly used for the treatment of HIV infection. Its mechanism of action is mainly to form a covalent complex with the active site of protease, block the proteolysis process, and thus interfere with virus replication. When producing ritonavir intermediate MTV-III {N-((N-methyl-N-((2-isopropyl-5-thiazolyl)methyl)methyl)amino)carbonyl-L-valine}, a condensation reaction is carried out with MTV-II, MTV-A, tetrahydrofuran, lithium hydroxide and water, followed by heat preservation and in-process control detection. Then, a water dissolution reaction will be carried out, followed by stripping tetrahydrofuran, adjusting the PH, extraction, combining the organic layers, drying and decolorizing, filtration, stripping toluene, dissolving and crystallizing with toluene and n-heptane, cooling, centrifuging, and drying to obtain ritonavir intermediate MTV-III.

[0004] Among them, a dissolution reaction kettle is used for the water dissolution reaction. At present, the mixed liquid inlet and the water inlet of the dissolution reaction kettle are respectively located on the upper surface of the kettle cover. First, the mixed liquid after the condensation of MTV-II, MTV-A, tetrahydrofuran, lithium hydroxide and water is added into the kettle body from the mixed liquid inlet, and then water is added into the kettle body through the water inlet, and a dissolution reaction is carried out by a stirring paddle. Since the water and the mixed liquid cannot be evenly added into the dissolution reaction kettle, the dissolution efficiency is reduced. In order to improve the uniformity of feeding, some dissolution reaction kettles install a water distributor under the kettle cover through a suspension, and this installation structure is relatively complex and occupies a large amount of space in the kettle body. Therefore, an improved technology is urgently needed to solve this problem existing in the prior art. Content of the Utility Model

[0005] The purpose of the present utility model is to provide a dissolution reactor for the production of ritonavir intermediate MTV-III. An outer ring groove and an inner ring groove are formed on the lower surface of the kettle cover. An outer ring cover plate is arranged at the position of the outer ring groove on the lower surface of the kettle cover, and an inner ring cover plate is arranged at the position of the inner ring groove on the lower surface of the kettle cover. The outer ring cover plate is provided with a plurality of material discharging ports, and the inner ring cover plate is provided with a plurality of nozzles. On the one hand, the mixed solution is evenly discharged through the outer ring groove, and water is evenly discharged through the inner ring groove, which saves space compared with installing a water distributor, does not require installing an additional hanging bracket, and has a lower cost at the same time. On the other hand, water is sprayed out through the nozzles, and the outlet pressure is greater, so that the water can quickly mix and contact with the mixed solution, and the dissolution effect is better, so as to solve the problems put forward in the above background technology.

[0006] To achieve the above object, the present utility model provides the following technical solutions: A dissolution reactor for the production of ritonavir intermediate MTV-III, comprising a kettle body, a kettle cover, a driving motor, a stirrer main shaft, stirring paddles, an outer ring cover plate, an inner ring cover plate and nozzles. The kettle cover is arranged on the upper surface of the kettle body. A driving motor is arranged at the center position of the upper surface of the kettle cover through a motor base. The output shaft of the driving motor is connected to the top end of the stirrer main shaft through a coupling. The bottom of the stirrer main shaft is provided with stirring paddles. The lower part of the stirrer main shaft and the stirring paddles are both movably arranged in the kettle body. The bottom of the kettle body is provided with a discharge port. The upper surface of the kettle cover is provided with a mixed liquid inlet and a water inlet. The lower surface of the kettle cover is provided with an outer ring groove and an inner ring groove. The outer ring groove is communicated with the mixed liquid inlet, and the inner ring groove is communicated with the water inlet. The outer ring cover plate is arranged at the position of the outer ring groove on the lower surface of the kettle cover through bolts, and the inner ring cover plate is arranged at the position of the inner ring groove on the lower surface of the kettle cover through bolts. The outer ring cover plate is evenly provided with a plurality of through holes and material discharging ports are arranged at the positions of the through holes. The inner ring cover plate is evenly provided with a plurality of through holes and mounting seats are arranged at the positions of the through holes. Nozzles are installed at the mounting seats.

[0007] Preferably, in a dissolution reactor for the production of ritonavir intermediate MTV-III provided by the present utility model, a guide sleeve is arranged at the center position of the lower surface of the kettle cover, and the stirrer main shaft passes through the guide sleeve and is matched with the guide sleeve.

[0008] Preferably, in a dissolution reactor for the production of ritonavir intermediate MTV-III provided by the present utility model, sealing rubbers are compounded on the upper surfaces of the outer ring cover plate and the inner ring cover plate through adhesives.

[0009] Preferably, in a dissolution reactor for the production of ritonavir intermediate MTV-III provided by the present utility model, a plurality of support seats are evenly arranged on the outer surface of the kettle body.

[0010] Preferably, a dissolution reactor for the production of ritonavir intermediate MTV-III provided by the present utility model, wherein grooves are provided on both sides of the lower surface of the kettle cover and located in the outer ring groove and the inner ring groove, the outer ring cover plate is arranged in the groove of the outer ring groove, and the inner ring cover plate is arranged in the groove of the inner ring groove.

[0011] Preferably, a dissolution reactor for the production of ritonavir intermediate MTV-III provided by the present utility model, wherein a connecting sleeve is arranged at the middle position of the stirring paddle, and the bottom of the main shaft of the stirrer is connected to the connecting sleeve and fastened by bolts.

[0012] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0013] An outer ring groove and an inner ring groove are provided on the lower surface of the kettle cover. An outer ring cover plate is arranged at the outer ring groove on the lower surface of the kettle cover, and an inner ring cover plate is arranged at the inner ring groove on the lower surface of the kettle cover. A plurality of blanking ports are arranged on the outer ring cover plate, and a plurality of nozzles are arranged on the inner ring cover plate. On the one hand, the mixed solution is evenly fed through the outer ring groove, and water is evenly fed through the inner ring groove, saving space compared with installing a water distributor, without the need to install an additional hanging bracket, and the cost is also lower. On the other hand, water is sprayed out through the nozzles, and the outlet pressure is greater, enabling the water to quickly mix and contact with the mixed solution, and the dissolution effect is better. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 is a schematic structural diagram of the present utility model;

[0015] Figure 2 is Figure 1 an enlarged structural diagram of the marked A in the appendix;

[0016] Figure 3 is a schematic bottom view of the kettle cover.

[0017] In the figure: kettle body 1, kettle cover 2, drive motor 3, stirrer main shaft 4, stirring paddle 5, outer ring cover plate 6, inner ring cover plate 7, nozzle 8, motor base 9, discharge port 10, mixed liquid inlet 11, water inlet 12, outer ring groove 13, inner ring groove 14, blanking port 15, mounting seat 16, guide sleeve 17, sealing rubber 18, support seat 19, groove 20, connecting sleeve 21. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0018] The technical solutions of the present utility model will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model;

[0019] It should be noted that in the description of the present utility model, it should be noted that the orientation or positional relationship indicated by terms such as "inside", "outside", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc. is based on the orientation or positional relationship shown in the drawings. It is only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present utility model.

[0020] Please refer to Figures 1-3, the present utility model provides a technical solution: a dissolution reactor for the production of ritonavir intermediate MTV-III, including a reactor body 1, a reactor cover 2, a driving motor 3, a stirrer main shaft 4, a stirring paddle 5, an outer ring cover plate 6, an inner ring cover plate 7 and a nozzle 8. The upper surface of the reactor body 1 is provided with a reactor cover 2. At the center position of the upper surface of the reactor cover 2, a driving motor 3 is provided through a motor base 9. The output shaft of the driving motor 3 is connected to the top end of the stirrer main shaft 4 through a coupling. The bottom of the stirrer main shaft 4 is installed with a stirring paddle 5. A connecting sleeve 21 is arranged at the middle position of the stirring paddle 5. The bottom of the stirrer main shaft 4 is connected to the connecting sleeve 21 and fastened by bolts to achieve the connection and disassembly of the stirrer main shaft 4 and the stirring paddle 5. The lower part of the stirrer main shaft 4 and the stirring paddle 5 are both movably arranged in the reactor body 1. A guide sleeve 17 is arranged at the center position of the lower surface of the reactor cover 2. The stirrer main shaft 4 passes through the guide sleeve 17 and cooperates with the guide sleeve 17. Through the guiding and limiting of the guide sleeve 17, the stability of the stirrer main shaft 4 is ensured, thereby ensuring the stability of the stirring paddle 5 during rotation. The bottom of the reactor body 1 is provided with a discharge port 10. The upper surface of the reactor cover 2 is provided with a mixed liquid inlet 11 and a water inlet 12. An outer ring groove 13 and an inner ring groove 14 are opened on the lower surface of the reactor cover 2. The outer ring groove 13 communicates with the mixed liquid inlet 11, and the inner ring groove 14 communicates with the water inlet 12. An outer ring cover plate 6 is provided at the lower surface of the reactor cover 2 and located at the outer ring groove 13 through bolts. An inner ring cover plate 7 is provided at the lower surface of the reactor cover 2 and located at the inner ring groove 14 through bolts. Grooves 20 are opened on both sides of the outer ring groove 13 and the inner ring groove 14 on the lower surface of the reactor cover 2. The outer ring cover plate 6 is arranged in the groove 20 of the outer ring groove 13, and the inner ring cover plate 7 is arranged in the groove 20 of the inner ring groove 14. By opening grooves 20 on both sides of the outer ring groove 13 and the inner ring groove 14, the stability after the installation of the outer ring cover plate 6 and the inner ring cover plate 7 is ensured, and loosening will not occur. Sealing rubbers 18 are compounded on the upper surfaces of the outer ring cover plate 6 and the inner ring cover plate 7 to ensure the sealing performance when the outer ring cover plate 6 is installed at the outer ring groove 13 and the inner ring cover plate 7 is installed at the inner ring groove 14, especially the sealing performance at the inner ring cover plate 7, thereby ensuring the water outlet pressure. A plurality of through holes are evenly opened on the outer ring cover plate 6, and a blanking port 15 is arranged at the through holes. A plurality of through holes are evenly opened on the inner ring cover plate 7, and mounting seats 16 are arranged at the through holes. Nozzles 8 are installed at the mounting seats 16. A plurality of support seats 19 are evenly arranged on the outer surface of the reactor body 1 to achieve the overall support and fixation.

[0021] Installation method and working principle: First, place the outer ring cover plate 6 in the groove 20 of the outer ring groove 13 on the lower surface of the kettle cover 2. The outer ring groove 13 is blocked by the outer ring cover plate 6. Then place the inner ring cover plate 7 in the groove 20 of the inner ring groove 14 on the lower surface of the kettle cover 2. The inner ring groove 14 is blocked by the inner ring cover plate 7. Subsequently, install the nozzle 8 at each mounting seat 16 of the inner ring cover plate 7. Then pass the main shaft 4 of the stirrer through the guide sleeve on the lower surface of the kettle cover 2 and connect it to the output shaft of the driving motor 3 through a coupling. Then connect the stirring paddle 5 to the bottom of the main shaft 4 of the stirrer through a connecting sleeve 21. After lifting the kettle cover 2 by a hoisting device, place the stirring paddle 5 into the kettle body 1 and install the kettle cover 2 on the upper surface of the kettle body 1 through bolts to complete the installation. The kettle body 1 is supported on the platform by the support seat 19. During use, perform a condensation reaction on MTV-II, MTV-A, tetrahydrofuran, lithium hydroxide and water to obtain a mixed solution. Then, after heat preservation reaction and in-process detection, send it into the outer ring groove 13 from the mixed liquid inlet 11. Add water into the inner ring groove 14 from the water inlet 12. The mixed solution uniformly enters the kettle body 1 through the material discharge port 15 of the outer ring cover plate 6. The water is sprayed into the kettle body 1 at a high speed through the nozzle 8 of the inner ring cover plate 7 and mixes with the mixed solution. At the same time, start the driving motor 3. The driving motor 3 drives the main shaft 4 of the stirrer to rotate, thereby driving the stirring paddle 5 to rotate to achieve full mixing and dissolution of the mixed solution and water. The dissolved mixed solution is discharged from the discharge port 10 and enters the subsequent stripping kettle. The structure of the present utility model is reasonable. The lower surface of the kettle cover 2 is provided with an outer ring groove 13 and an inner ring groove 14. An outer ring cover plate 6 is provided at the position of the outer ring groove 13 on the lower surface of the kettle cover 2. An inner ring cover plate 7 is provided at the position of the inner ring groove 14 on the lower surface of the kettle cover 2. The outer ring cover plate 6 is provided with a plurality of material discharge ports 15. The inner ring cover plate 7 is provided with a plurality of nozzles 8. On the one hand, the mixed solution is uniformly discharged through the outer ring groove 13, and water is uniformly discharged through the inner ring groove 14, saving space compared with installing a water distributor, without the need to install an additional hanger, and the cost is also lower. On the other hand, the water is sprayed out through the nozzle 8 with greater pressure, enabling the water to quickly mix and contact with the mixed solution, and the dissolution effect is better.

[0022] For those parts not detailed in the present utility model, they are all well-known technologies to those skilled in the art.

[0023] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solutions of the present utility model rather than to limit them. Although the present utility model has been described in detail with reference to the embodiments, those of ordinary skill in the art should understand that the technical solutions of the present utility model can be modified and equivalently replaced without departing from the spirit and scope of the technical solutions of the present utility model, and they should all be covered within the scope of the claims of the present utility model.

Claims

1. A dissolution reactor for the production of ritonavir intermediate MTV-III, characterized in that: It includes a kettle body (1), a kettle cover (2), a driving motor (3), a stirrer main shaft (4), a stirring paddle (5), an outer ring cover plate (6), an inner ring cover plate (7) and a nozzle (8). The upper surface of the kettle body (1) is provided with a kettle cover (2). At the center position of the upper surface of the kettle cover (2), a driving motor (3) is provided through a motor base (9). The output shaft of the driving motor (3) is connected to the top end of the stirrer main shaft (4) through a coupling. The bottom of the stirrer main shaft (4) is installed with a stirring paddle (5). The lower part of the stirrer main shaft (4) and the stirring paddle (5) are both movably arranged in the kettle body (1). The bottom of the kettle body (1) is provided with a discharge port (10). The upper surface of the kettle cover (2) is provided with a mixed liquid inlet (11) and a water inlet (12). The lower surface of the kettle cover (2) is provided with an outer ring groove (13) and an inner ring groove (14). The outer ring groove (13) is communicated with the mixed liquid inlet (11). The inner ring groove (14) is communicated with the water inlet (12). An outer ring cover plate (6) is provided at the lower surface of the kettle cover (2) and located at the outer ring groove (13) through bolts. An inner ring cover plate (7) is provided at the lower surface of the kettle cover (2) and located at the inner ring groove (14) through bolts. The outer ring cover plate (6) is evenly provided with a plurality of through holes and a blanking port (15) is provided at the through holes. The inner ring cover plate (7) is evenly provided with a plurality of through holes and a mounting seat (16) is provided at each through hole. Nozzles (8) are installed at the mounting seats (16).

2. The dissolution reactor for producing ritonavir intermediate MTV-III according to claim 1, wherein: A guide sleeve (17) is provided at the center position of the lower surface of the kettle cover (2). The stirrer main shaft (4) passes through the guide sleeve (17) and cooperates with the guide sleeve (17).

3. A dissolving reactor for the production of ritonavir intermediate MTV-III according to claim 1, characterized in that: Sealing rubbers (18) are compounded on the upper surfaces of the outer ring cover plate (6) and the inner ring cover plate (7) through adhesives.

4. A dissolving reactor for the production of ritonavir intermediate MTV-III according to claim 1, characterized in that: A plurality of support seats (19) are evenly arranged on the outer surface of the kettle body (1).

5. A dissolution reactor for the production of ritonavir intermediate MTV-III according to claim 1, characterized in that: Grooves (20) are provided on both sides of the outer ring groove (13) and the inner ring groove (14) at the lower surface of the kettle cover (2). The outer ring cover plate (6) is arranged in the groove (20) of the outer ring groove (13). The inner ring cover plate (7) is arranged in the groove (20) of the inner ring groove (14).

6. The dissolution reactor for the production of ritonavir intermediate MTV-III according to claim 1, wherein: A connecting sleeve (21) is provided at the middle position of the stirring paddle (5). The bottom of the stirrer main shaft (4) is connected to the connecting sleeve (21) and fastened by bolts.

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