Inner supporting device

Abstract

The utility model relates to experimental equipment, in particular to an inner support device for a long-acting preparation in-vitro release evaluation method, which can be arranged in a container and comprises a main body, an inner support and an outer support, the hanging part is connected with the main body and is used for being hung on the wall surface of the container; the mounting assembly comprises a mounting part which is connected with the main body and is used for mounting a sample; and the two ends of the connecting part are connected with the mounting part and the main body correspondingly, and the connecting part can be used for adjusting the distance between the main body and the mounting part. The inner supporting device can adapt to and be arranged in the container through the hanging part, and the distance between the mounting part and the main body can be adjusted through the connecting part, so that a sample can be arranged at a specified height in a medium in the container, and the in-vitro release evaluation requirements of different dosage forms of a long-acting preparation are met.

Description

Technical Field

[0001] This patent relates to the technical field of experimental equipment, and particularly to an internal support device. Background Art

[0002] With the continuous development of medical technology, the treatment demand for chronic diseases is increasing. Many chronic diseases require long-term medication. Ordinary short-acting drugs often fail to effectively control the condition due to missed doses, and patients' compliance is also poor with frequent medication. In contrast, long-acting preparations achieve continuous slow release after a single-dose administration by controlling drug release, changing from multiple daily administrations to once every few weeks, months or even years, significantly reducing the dosing frequency and maintaining the drug concentration at the optimal therapeutic level for a long time. It neither drops below the minimum therapeutic concentration resulting in reduced efficacy nor exceeds the threshold concentration causing safety problems, significantly improving the convenience and compliance of patients' medication.

[0003] Therefore, developing new long-acting preparations that can achieve single-dose administration and continuous drug release is of great significance for improving the treatment effect and the quality of life of patients.

[0004] In the process of developing long-acting preparations and monitoring the quality of marketed products, in vitro release tests are crucial for ensuring the safety and effectiveness of long-acting preparations. It can simulate the in vivo drug release process to a certain extent, predict the in vivo release behavior, thereby reducing the number of in vivo tests, helping researchers understand the drug release behavior of the preparation in a simulated in vivo environment, providing important information for the research and evaluation of the preparation, and promoting the research and development process of the product. At the same time, it is also one of the most important methods for controlling the quality of long-acting preparations.

[0005] There are various types of long-acting preparations, including microspheres, in-situ gels, implants, vaginal rings, and intrauterine devices, etc. And due to the different active pharmaceutical ingredients, doses, and drug release cycles contained in each preparation variety / specification, the current pharmacopoeias and regulatory guidelines of various countries have not clearly guided the release methods of long-acting preparations.

[0006] The shaking table method is the most widely used method in the in vitro release test of long-acting preparations currently. It places the preparation in a container containing a medium, keeps it at a constant temperature and closed, and samples regularly at a certain time to measure, so as to evaluate the drug release process in vivo. Compared with methods with fixed dissolution devices such as the flow-through cell method, paddle method / basket method, reciprocating cylinder method, etc., it is easy to select containers of different shapes and sizes and set different volumes of release media according to the different properties and characteristics of long-acting preparations, and is simple and easy to operate.

[0007] As described above, these long-acting preparations are diverse in type. Therefore, when using the shaking table method for experiments, some low-density long-acting preparations have sampling losses because they float on the medium; while some preparations may change their positions in the medium over time during the in vitro release study, and the unfixed position of the preparations in the medium may also be affected by different hydrodynamics, thus affecting the accuracy and reproducibility of the release results. Summary of the Invention

[0008] To solve or at least partially solve the above technical problems, the present patent provides an internal support device that can be disposed inside a container, comprising:

[0009] A main body;

[0010] A hanging component, connected to the main body and used for hanging on the wall surface of the container;

[0011] An installation assembly, comprising:

[0012] An installation component, connected to the main body and used for installing a sample;

[0013] A connecting component, with two ends respectively connected to the installation component and the main body, and the connecting component can be used to adjust the distance between the main body and the installation component.

[0014] Optionally, in the internal support device as described above, the connecting component comprises:

[0015] A telescopic component, with one end away from the main body connected to the installation component, and the telescopic component can change its own length under the action of an external force to change the height of the sample installed on the installation component inside the container.

[0016] Optionally, in the internal support device as described above, the telescopic component is a metal wire twisted into a spiral shape.

[0017] Optionally, in the internal support device as described above, the connecting component further comprises:

[0018] An adjusting component, the telescopic component is connected to the main body through the adjusting component and used for adjusting the length of the telescopic component.

[0019] Optionally, in the internal support device as described above, the installation component comprises:

[0020] An installation part, used for installing a sample;

[0021] A hanging part, the installation part is hung on the connecting component through the hanging part.

[0022] Optionally, in the internal support device as described above, the installation part is a chuck, and the hanging part comprises at least two clamping rods, with the end of each clamping rod connected to the chuck, and the installation component further comprises:

[0023] A tightening sleeve that sleeves the clamping rods of the hanging connection part together;

[0024] The clamping rods of the hanging connection part open on the side away from the main body and can be clamped under the restraint generated when the tightening sleeve moves towards the opening side.

[0025] Optionally, in the inner support device as described above, the main body further includes:

[0026] An elastic member that connects the main body and the hanging component, makes the hanging component tend to move away from the main body, and enables the main body to be supported on the inner wall of the container through the hanging component.

[0027] Optionally, in the inner support device as described above, the elastic member is a helical wire, and the elastic member supports on the inner wall of the container by its own elastic force.

[0028] Optionally, in the inner support device as described above, the hanging component includes:

[0029] A contact head that can be magnetically adsorbed;

[0030] A spring with both ends connected to the contact head and the main body respectively;

[0031] And, the main body includes:

[0032] A frame having a receiving groove and a central groove;

[0033] An electromagnet disposed in the central groove;

[0034] The electromagnet generates a magnetic force after being powered on to adsorb the hanging component on the frame and makes the spring received in the receiving groove.

[0035] Optionally, in the inner support device as described above, the elastic member is a spring, and at least 3 springs are set as a group to connect the hanging component and the main body.

[0036] Optionally, in the inner support device as described above, the outer wall of the hanging component away from the main body is an arc surface, and at least 3 hanging components are evenly distributed around the wall surface of the main body.

[0037] Compared with the existing documents, this patent has the following technical effects:

[0038] The connecting component can adjust the position of the sample installed on the mounting component relative to the main body, thereby adjusting the height position of the sample in the medium in the container, so as to control the influence of the depth of the sample in the medium on the sample dissolution rate; the tightening component can provide a continuous clamping force for the clamping part to clamp the continuously dissolving sample in the medium, so that the sample can be stably maintained in the original position; the hanging component can be hung on the inner wall of the container, can stably hold the main body in the container, and can adapt to containers of various sizes and models, making the application scenarios more extensive; the mounting component can be replaced with different styles to suit different types of samples. Brief Description of the Drawings

[0039] In order to more clearly illustrate the implementation manners of this patent, the relevant drawings will be briefly introduced below. It can be understood that the drawings in the following description are only used to illustrate some implementation manners of this patent, and those of ordinary skill in the art can also obtain many other technical features and connection relationships not mentioned in this text according to these drawings.

[0040] Figure 1 is a three-dimensional schematic diagram of an inner support device according to an implementation manner of this patent;

[0041] Figure 2 is a cross-sectional schematic diagram of an inner support device according to an implementation manner of this patent;

[0042] Figure 3 is an exploded schematic diagram of an inner support device according to an implementation manner of this patent;

[0043] Figure 4 is a three-dimensional schematic diagram of a mounting component according to an implementation manner of this patent;

[0044] Figure 5 is a three-dimensional schematic diagram of an inner support device with a spiral metal wire according to an implementation manner of this patent;

[0045] Figure 6 is a partial schematic diagram of an inner support device according to an implementation manner of this patent;

[0046] Figure 7 is a three-dimensional schematic diagram of an inner support device with a mesh box according to an implementation manner of this patent;

[0047] Figure 8 is a three-dimensional schematic diagram of a mounting component of a T-shaped ring according to an implementation manner of this patent;

[0048] Figure 9 is another three-dimensional schematic diagram of a mounting component of a T-shaped ring according to an implementation manner of this patent;

[0049] Figure 10 is a schematic diagram of the cooperation between a T-shaped protrusion and a T-shaped groove according to an implementation manner of this patent.

[0050] Explanation of Reference Numerals:

[0051] A, inner support device;

[0052] 1, main body;

[0053] 11, elastic member; 12, frame; 121, receiving groove; 122, central groove; 13, electromagnet; 14, receiving hole; 141, guiding structure;

[0054] 2, hanging component;

[0055] 21, abutting head; 22, spring;

[0056] 3, mounting assembly;

[0057] 31, mounting part; 311, mounting portion; 3112, chuck; 3113, mesh box; 312, hanging portion; 3121, clamping rod; 3122, T-shaped projection; 313, tightening sleeve;

[0058] 32, connecting part; 321, telescopic part; 3211, guiding groove; 322, adjusting part; 3221, adjusting sleeve; 3222, sleeved portion; 3223, through hole; 323, T-shaped groove;

[0059] 4, T-shaped ring. Detailed Implementation Modes

[0060] The present patent will be described in detail below with reference to the accompanying drawings.

[0061] Embodiment 1

[0062] The inventor of the present application found that fixing the long-acting preparation at a suitable position in the medium can improve the accuracy and reproducibility of the release result.

[0063] In view of this, the first embodiment of the present patent discloses an inner support device A, as shown in Figure 1 shown, the inner support device A is arranged in a container and includes:

[0064] Main body 1;

[0065] Hanging component 2, connected to the main body 1 and used for hanging on the wall surface of the container;

[0066] Mounting assembly 3, including:

[0067] Mounting part 31, connected to the main body 1 and used for mounting the sample;

[0068] Connecting part 32, with two ends respectively connected to the mounting part 31 and the main body 1, and the connecting part 32 can be used to adjust the distance between the main body 1 and the mounting part 31.

[0069] The main body 1 is located in the space in the container that does not contain the medium. When the medium is stored in the container, the main body 1 does not come into contact with the medium. The hanging component 2 can be hung on the inner wall or the mouth of the container to set the main body 1 connected to the hanging component 2 in the container. The installation assembly 3 includes an installation component 31 and a connecting component 32. Among them, the connecting component 32 is used to directly connect to the main body 1 and is used to install the sample. Both ends of the connecting component 32 are respectively connected to the installation component 31 and the main body 1, and the relative position between the connecting component 32 and the main body 1 can be adjusted by changing its own length or generating relative movement with the main body 1, etc., so as to adjust the position of the sample installed on the installation component 31 in the medium contained in the container.

[0070] The inner support device A arranged as above has the following technical effects:

[0071] 1. The connecting component 32 can adjust the position of the sample installed on the installation component 31 relative to the main body 1, and then adjust the height position of the sample in the medium in the container, so as to control the depth of the sample in the medium. By calibrating the depth, the correlation between the depth of the sample and the dissolution rate can be clarified;

[0072] 2. The tightening component can provide a continuous clamping force for the sample that is continuously dissolving in the medium by the installation part 311, so that the sample can be stably maintained in the original position;

[0073] 3. The hanging component 2 can be hung on the inner wall of the container, can stably hold the main body 1 in the container, and can adapt to containers of various sizes and models, making the application scenario of the inner support device A more extensive.

[0074] It is worth mentioning that the form in which the hanging component 2 is hung on the container wall can be diverse. According to the different shapes of the container, in some cases, the hanging component 2 can be hung on the opening of the container through the end hook structure, or can be hung on the container wall through cooperation with the components arranged on the container wall. In other cases, when the container needs to be closed, an elastic structure can be arranged between the main body 1 and the hanging component 2 to endow the hanging component 2 with elastic potential energy, so that the hanging component 2 tends to move away from the main body 1 and can abut against the inner wall of the container. By the way that the hanging component 2 abuts against the inner wall of the container, the main body 1 can be arranged in the container with a closed opening, and the structural requirements for the container itself are not high, and it has a wider applicability.

[0075] It should be noted that in some specific scenarios, when testing samples of long-acting contraceptive preparations, the container contains a medium for mimicking the intrauterine environment. The long-acting preparation achieves continuous slow release after a single-dose administration by controlling drug release. After a single administration, the administration time can last for weeks, months or even years. Therefore, when initially conducting observation experiments, it is necessary to select an installation component 3 of a suitable structural type to install the sample.

[0076] Accordingly, there are various different types of installation components 3 that can be replaced according to the differences in the installed samples. The installation component 3 is installed on the main body 1 through its connecting component 32, and the connection structure between the main body 1 and the connecting component 32 can be set as a detachable structure to replace different types of installation components 3.

[0077] Optionally, the outer wall of the hanging component 2 of the inner support device A away from the main body 1 is an arc surface, and at least 3 hanging components 2 are evenly distributed around the wall surface of the main body 1. The outer wall of the hanging component 2 of the inner support device A away from the main body 1 is an arc surface, and at least 3 hanging components 2 are evenly distributed around the wall surface of the main body 1. Specifically, the shape of the main body 1 can be a cylinder, and multiple hanging components 2 can be arranged in a surrounding form on the side surface of the cylindrical main body 1. For example, when there are 3 hanging components 2, the hanging components 2 can be evenly surrounded on the side surface of the main body 1 at an interval of 120 degrees; when there are 6 hanging components 2, the 6 hanging components 2 can be evenly surrounded on the side surface of the main body 1 at an interval of 60 degrees, and so on. By the way of equiangular surrounding arrangement of multiple hanging components 2, after the hanging components 2 come into contact with the container, the main body 1 connected to the hanging components 2 can be more stably arranged in the space inside the container.

[0078] Embodiment 2

[0079] This embodiment discloses an inner support device A. This embodiment makes a further improvement on the first embodiment. The improvement lies in that the inner support device A also adds devices such as a telescopic component 321 and an adjusting component 322, so that the adjusting component 322 can adjust the height of the telescopic component 321. Specifically, referring to Figure 1 and Figure 2 as shown, the connecting component 32 of the inner support device A further includes:

[0080] A telescopic component 321, one end of the telescopic component 321 away from the main body 1 is connected to the mounting component 31, and the telescopic component 321 can change its own length under the action of an external force to change the height of the sample installed on the mounting component 31 in the container.

[0081] The telescopic member 321 can be disposed on the main body 1 near the medium in the container. The telescopic member 321 is adjustable relative to the main body 1. Specifically, the telescopic member 321 can perform a linear motion relative to the main body 1, or the telescopic member 321 can change its own length to adjust the height position of its end mounting member 31 relative to the main body 1, thereby adjusting the height position of the sample in the medium in the container.

[0082] By providing the telescopic member 321, the height of the sample in the container can be better adjusted, enabling the sample to perform a medicament release action at a preset height from the liquid level of the medium, reducing the influence of factors such as sample position changes and fluid factors at different heights on the accuracy of the release result, and improving reproducibility.

[0083] In some embodiments, when the telescopic member 321 can perform a linear motion based on the main body 1 to adjust the position of the mounting member 31 relative to the main body 1. For example, the telescopic member 321 can be an adjusting rod and can perform a linear motion relative to the main body 1 under the adjustment of an external force to change the distance between the mounting member 31 and the main body 1, thereby adjusting the depth of the sample in the medium.

[0084] See Figure 5 As shown, the telescopic member 321 of the inner support device A can also be a metal wire twisted into a spiral shape. That is to say, the telescopic member 321 can adopt a spiral-shaped plastic metal wire. The metal wire changes the height of the mounting member 31 relative to the main body 1 by changing its own length under the action of an external force, thereby changing the height of the sample in the medium. In addition, the metal wire can be used in cooperation with a fixing rod to fix the end of the metal wire at a specific height, thereby adjusting the height of the sample in the medium. The metal wire in a spiral shape is easy to change in length. The metal wire as the telescopic member 321 has the characteristics of simple structure and convenient disassembly and assembly.

[0085] Optionally, in some other embodiments, see Figure 3 As shown, the connecting member 32 of the inner support device A further includes:

[0086] An adjusting member 322. The telescopic member 321 is connected to the main body 1 through the adjusting member 322 and is used to adjust the length of the telescopic member 321.

[0087] The adjusting member 322 can be disposed on the main body 1 and is connected to the main body 1 and the telescopic member 321. By applying an external force to the adjusting member 322, the position of the telescopic member 321 relative to the main body 1 can be changed.

[0088] Specifically, the adjusting member 322 may be a deformable material. For example, it may be a metal sheet with a coating that does not react with the medium or sample. By changing the shape of the metal sheet, the position of the mounting member 31 relative to the main body 1 can be changed, so as to set the sample mounted on the mounting member 31 at an appropriate height in the medium. The deformable material can easily and quickly adjust the position between the mounting member 31 and the main body 1, and has strong universality for different containers.

[0089] Different from the way of changing its own length, in some other embodiments, the distance between the telescopic member 321 and the main body 1 can be changed by a transmission method.

[0090] Other structures are provided at the bottom of the hole. The main body 1 is provided with a receiving hole 14, and a guiding structure 141 is provided in the receiving hole 14. A guiding groove 3211 is provided on the telescopic member 321 and is matched with the guiding structure 141. The guiding structure 141 is used to enable the telescopic member 321 to perform a rotational motion along its own axis, and under the guiding action of the guiding structure 141, this rotational motion is converted into a linear motion of the telescopic member 321 along the axis direction of the receiving hole 14.

[0091] Specifically, the adjusting member 322 can be nested in the receiving hole 14 of the main body 1. The adjusting member 322 may include an adjusting sleeve 3221 and a socket part 3222. The socket part 3222 is arranged in the receiving hole 14 of the main body 1, and the adjusting sleeve 3221 is arranged at the end of the socket part 3222. Moreover, the dimension of the adjusting sleeve 3221 perpendicular to the axial direction may be larger than that of the main body 1 in contact therewith, so that the adjusting sleeve 3221 protrudes out of the main body 1, which is convenient for an external force to be applied to the adjusting sleeve 3221 and make it rotate. A through hole 3223 is provided along the rotation axis of the adjusting member 322, and threads are provided inside the through hole 3223. At the same time, the telescopic member 321 may be a rod arranged inside the adjusting member. Threads are provided along the circumferential surface of the rod and are matched with the threads inside the through hole 3223. When the adjusting member 322 rotates, the threads inside the through hole 3223 drive the threads of the telescopic member 321 in cooperation therewith to rotate, so that the telescopic member 321 can perform a linear motion along the axis direction of the through hole 3223.

[0092] Through the internal support device A arranged as above, the telescopic member 321 can directly move in a straight line direction to change the distance between the mounting member 31 and the main body 1, and further adjust the height position of the sample in the medium. The advantage of the screw drive method is that it can make the movement of the telescopic member 321 very stable, and can accurately control the distance, so that the height of the sample in the medium can be accurately calculated and controlled.

[0093] Embodiment 3

[0094] This embodiment discloses an internal support device A. This embodiment is a further improvement on the first embodiment. The improvement lies in that by adding a mounting part 311 and a suspension part 312, a method for mounting various types of samples is provided. Specifically, referring to Figure 3 and Figure 4 as shown, the mounting component 31 of the internal support device A includes:

[0095] A mounting part 311 for mounting samples;

[0096] A suspension part 312, and the mounting part 311 is suspended on the connecting component 32 through the suspension part 312.

[0097] The suspension part 312 is detachably connected to the connecting part. The mounting part 311 is arranged at the end of the suspension part 312, and samples can be mounted through the mounting part 311. Among them, the suspension part 312 can be detachably connected to the connecting component 32 by means of fitting groove structure cooperation or clamping with a fixture. The detachable connection is beneficial to replacing different types of mounting components 31 for different samples.

[0098] Specifically, referring to Figure 1 and Figure 2 as shown, when the disassembly and assembly part uses a fitting groove structure for cooperation, a T-shaped groove 323 can be opened on the connecting component 32, and a T-shaped protrusion 3122 matching the structure of the T-shaped groove 323 can be arranged on the suspension part 312. The T-shaped protrusion 3122 is sent into the T-shaped groove 323 to form a fit, realizing the replacement of the mounting component 31, and not affecting the original height of the sample relative to the main body 1, having the advantage of being easy to disassemble and assemble.

[0099] It is worth mentioning that the internal support device A can be used to test contraceptive samples, long-acting contraceptive preparation samples, including but not limited to O-shaped rings, T-shaped rings, Y-shaped rings, uterine-shaped rings, and fancy rings, etc. From Figure 8 and Figure 9 taking two T-shaped rings 4 as typical examples, different mounting methods can be adopted for different types of long-acting contraceptive preparation samples. When mounting closed rings such as O-shaped rings and Yuangong-shaped rings, the clamping method with a fixture can be used. When testing long-acting contraceptive preparation samples with rods such as T-shaped rings, Y-shaped rings, T-shaped rings, or fancy rings, the end of the rod part of the sample can be set as a T-shaped protrusion, which is matched with the T-shaped groove 323 opened on the connecting component 32, so that the mounting component 31 is detachably mounted on the connecting component 32, facilitating the replacement of different types of samples. As Figure 10As shown, the T-shaped protrusion 3122 slides into the opening on one side of the T-shaped groove 323 to form a T-shaped structure fit, so that the mounting component 31 is mounted on the connecting component 32. When it is necessary to replace the mounting component 31, the T-shaped protrusion 3122 is removed from the T-shaped groove to facilitate the installation of other types of connecting components 32.

[0100] Obviously, the above contraceptive samples are only an example of the embodiments of this patent. The inner support device A can of course also be used to test samples with non-contraceptive properties, such as samples for slow-release drugs during the treatment of intrauterine diseases.

[0101] Optionally, referring to Figure 3 and Figure 4 As shown, the installation part 311 of the inner support device A is a chuck 3112, and the suspension part 312 includes at least two clamping rods 3121. The end of each clamping rod 3121 is connected to the chuck 3112. Moreover, the mounting component 31 further includes:

[0102] A tightening sleeve 313 that sleeves the clamping rods 3121 of the suspension part 312 together;

[0103] The clamping rods 3121 of the suspension part 312 open on the side away from the main body 1 and can be clamped under the constraint generated when the tightening sleeve 313 moves towards the opening side.

[0104] In this embodiment, at least two clamping rods 3121 can be provided on the suspension part 312. The tightening sleeve 313 sleeves the clamping rods 3121 together, and the clamping rods 3121 are mutually closed or dispersed by moving along the direction of the clamping rods 3121, so that the end chuck 3112 clamps or removes the sample. Such a setting has a good clamping effect on small samples and can provide a continuous clamping force.

[0105] Specifically, when two clamping rods 3121 are provided, the clamping surfaces of the two chucks 3112 face each other. The two clamping rods 3121 can be gradually opened in the direction away from the main body 1, and the opening angle between the two clamping rods 3121 can be within 0 to 45 degrees. When the tightening sleeve 313 gradually approaches the sample from the side of the clamping rods 3121 away from the sample, under the tightening action of the tightening sleeve 313, the two clamping rods 3121 gradually approach each other, driving the end chucks 3112 to approach each other, contacting the sample and clamping the sample; when the tightening sleeve 313 continues to approach the sample, the sample bears a certain pressure and can fix the sample. It is worth mentioning that the contact surface between the chuck 3112 and the sample can be provided with textures to increase the friction between the chuck 3112 and the sample.

[0106] In some embodiments, the contact mode of the chuck 3112 with the sample can be changed according to the shape of the sample to reduce the influence of the chuck 3112 or the clamping action on the dissolution rate of the sample. For example, when the sample is cylindrical, the paired chucks 3112 can be set to conform to the curved surface shape of the side of the cylindrical sample to wrap the side of the sample to improve stability.

[0107] In addition, considering that a part of the sample is affected by the fixture and is difficult to contact with the medium in the container, a plurality of holes can be opened in the chuck 3112 to allow the medium to pass through the holes and contact the sample, reducing the influence of the chuck 3112 on the dissolution rate of the medium.

[0108] See Figure 7 As shown, considering that some low-density long-acting preparations may float on the medium, there may be sampling losses. Moreover, the change in density during the release of the preparation in the medium may diverge into fragments, and these fragments may float up and be affected by the drug release density at different heights in the medium.

[0109] Therefore, in an alternative embodiment, the mounting portion 311 can also be set as a net cage 3113, and the sample is arranged in the net cage 3113, and the medium can fully contact the sample through the mesh holes of the net cage. With this setting, most of the samples can always remain at the height where the net cage 3113 is located during the release process, minimizing the influence caused by the floating of the sample fragments in the medium.

[0110] In addition, a tray 3114 can be installed on the net cage 3113 to receive the undissolved samples that fall off from the net cage 3113 or the insoluble residues that leak out from the mesh holes of the net cage 3113. The tray 3114 can be arranged deeper in the medium than the net cage 3113, and the bottom surface of the tray 3114 can cover the bottom surface of the net cage 3113 so that the vertical projection of the net cage 3113 can completely fall within the bottom surface of the tray 3114. Setting the tray 3114 can receive the samples that have not been completely dissolved and leaked out from the net cage 3113, preventing the samples from sinking to the bottom and ensuring the accuracy of the experimental results.

[0111] Embodiment 4

[0112] This embodiment discloses an internal support device A. This embodiment makes a further improvement to the first embodiment. The improvement lies in that the additional structure of the main body 1 enables the main body 1 to be hung on the container through a retractable metal disc. Specifically, see Figure 5 As shown, the main body 1 of the internal support device A further includes:

[0113] An elastic member 11, which connects the main body 1 and the hanging member 2, makes the hanging member 2 tend to move away from the main body 1, and enables the main body 1 to be supported on the inner wall of the container through the hanging member 2.

[0114] Optionally, refer to Figure 5 As shown, the elastic member 11 of the inner support device A is a helical wire. The elastic member 11 acts through its own elastic force to support the hanging member 2 on the inner wall of the container.

[0115] In this embodiment, the helical wire starts from the center of the circle and extends in a direction away from the center of the circle. Each turn of the wire has a certain gap with the inner turn of the wire adjacent to it. The gap distance between two adjacent turns of the wire can be changed by an external force to form a helical wire with a compressible radius, that is, a metal disk is formed. The outermost circle of the metal disk is connected to the hanging member 2. Its working principle is that the metal disk changes its radius under the influence of an external force until it can adapt to the inner diameter of the container wall. Then it is placed in the container and the external force is removed, so that the hanging member 2 connected to the outermost circle of the wire is hung on the container wall to place the main body 1 in the container. For example, when the radius of the metal disk in the natural state is smaller than the inner wall of the container, an external force can be applied to expand the metal disk, and the main body 1 can be hung in the container through the hanging member 2 at the outermost circle of the metal disk; on the contrary, when the radius of the metal disk in the natural state is larger than the inner wall of the container, an external force can be applied to reduce the radius of the metal disk, and the main body can be hung in the container through the hanging member 2.

[0116] The structure of the helical wire is relatively simple. The radius of the metal disk can be directly adjusted by hand to be hung in the container through the hanging member 2. It is convenient to use, has strong adaptability to various types of containers, and is easy to disassemble and assemble.

[0117] Embodiment Five

[0118] This embodiment also discloses an inner support device A. This embodiment makes a further improvement on the first embodiment. The improvement lies in that the main body 1 can be arranged in the container by magnetically attracting and controlling the hanging member 2. Specifically, refer to Figure 6 As shown, the hanging member 2 of the inner support device A includes:

[0119] A contact head 21 that can be magnetically adsorbed;

[0120] A spring 22, with both ends of the spring 22 connected to the contact head 21 and the main body 1 respectively;

[0121] And, the main body 1 includes:

[0122] A frame 12 having a receiving groove 121 and a central groove 122;

[0123] An electromagnet 13, with the electromagnet 13 arranged in the central groove 122;

[0124] After the electromagnet 13 is powered on, it generates a magnetic force to adsorb the hanging component 2 on the frame 12 and accommodate the spring 22 in the accommodation groove 121.

[0125] In order to enable the inner support device A to be hung inside the bottle, in this embodiment, the hanging component 2 may include a butt joint 21 and a spring 22. The butt joint 21 tends to move away from the main body 1 under the driving force of the elastic potential energy of the spring 22. The frame 12 of the main body 1 has an accommodation groove 121 for accommodating the butt joint 21 and a central groove 122 for accommodating the spring 22. The accommodation groove 121 is directly communicated with the outside of the main body 1, and the central groove 122 is connected to the accommodation groove 121 and is arranged inside the main body 1.

[0126] When the electromagnet 13 is powered on, it generates a magnetic force to adsorb the butt joint 21 in the accommodation groove 121 on the frame 12 and accommodate the spring 22 in the central groove 122; when the electromagnet 13 is powered off, the magnetic force disappears, and the butt joint 21 expands outward from the main body 1 under the action of the elastic potential energy of the spring 22 and abuts against the inner wall of the container wall or the container lid. With the above settings, when there are multiple hanging components 2, the hanging components 2 can be adsorbed by energizing the electromagnet 13, which is convenient for removing the hanging components 2, and when powered off, the hanging components 2 can expand outward synchronously, making them abut against the inner wall of the container, so that the inner support device A can be permanently fixed in the container under the action of the elastic force of the spring 22.

[0127] In an alternative embodiment, a silica gel or rubber material layer can be added to the contact surface of the butt joint 21 for clamping the sample to increase the frictional force between the butt joint 21 and the container during abutment.

[0128] Considering that the release experiment generally has a long cycle, when using the spring 22 to push the butt joint 21 to fix the hanging component 2, after a long experimental cycle, the hanging component 2 may be difficult to remove due to the adhesion between the butt joint 21 and the container wall, or the hanging component 2 may also be difficult to remove or even damage the container due to the too strong elastic force of the spring 22. Accordingly, the inner support device A can be more conveniently removed through the electromagnet 13 in this embodiment. Only by energizing the electromagnet 13 can the magnetic suction force of the electromagnet 13 attract each butt joint 21, disengage from the container wall, and be adsorbed in the accommodation groove 121 to disengage from the container. The operation is convenient; the inner support device A does not require continuous power supply during the entire use process and is only powered on when removed. Therefore, the inner support device A has the advantage of being able to be continuously used for a long time.

[0129] Optionally, the elastic member 11 of the inner support device A is a spring 22, and at least 3 springs 22 are set as a group to connect the hanging component 2 and the main body 1.

[0130] In order to more stably arrange the inner support device A in the container, at least three springs 22 can be set as a group, and each group of springs 22 is correspondingly connected between a hanging component 2 and the main body 1. A group of springs 22 are compressed simultaneously, and the multiple compressed springs 22 can provide stronger elastic potential energy. Under the elastic force of the multiple springs 22, the hanging component 2 exerts a stronger force on the inner wall of the container, and the abutting effect is more reliable. Therefore, by arranging multiple springs 22, the inner support device A can be more stably fixed in the container.

[0131] Finally, it should be noted that those of ordinary skill in the art can understand that, in order to enable readers to better understand this patent, many technical details are proposed in the embodiments of this patent. However, even without these technical details and various changes and modifications based on the above embodiments, the technical solutions required to be protected by the claims of this patent can be basically achieved. Therefore, in practical applications, various changes can be made to the above embodiments in terms of form and details without departing from the spirit and scope of this patent.

Claims

1. An internal support device, characterized in that, The inner support device can be arranged inside the container and is used for hoisting samples, and includes: A main body; A hanging component, connected to the main body and used for hanging on the wall surface of the container; An installation assembly, including: An installation component, connected to the main body and used for installing the sample; A connecting component, with two ends respectively connected to the installation component and the main body, and the connecting component can be used to adjust the distance between the main body and the installation component.

2. The inner support device according to claim 1, characterized in that, The connecting component includes: A telescopic component, with one end away from the main body connected to the installation component, and the telescopic component can change its own length under the action of an external force to change the height of the sample installed on the installation component inside the container.

3. The inner support device according to claim 2, characterized in that, The telescopic component is a metal wire twisted into a spiral shape.

4. The inner support device according to claim 2, wherein, The connecting component further includes: An adjusting component, through which the telescopic component is connected to the main body and used for adjusting the length of the telescopic component.

5. The inner support device according to claim 1, wherein The installation component includes: A mounting part, which is used for mounting the sample; A suspension part, and the mounting part is suspended on the connecting component through the suspension part.

6. The inner support device according to claim 5, characterized in that, The mounting part is a chuck, and the suspension part includes at least two clamping rods. The end of each clamping rod is connected to the chuck. Moreover, the installation component further includes: A tightening sleeve, which sleeves the clamping rods of the suspension part together; The clamping rods of the suspension part open on the side away from the main body and can be clamped under the restraint generated when the tightening sleeve moves towards the opening side.

7. The inner support device according to claim 1, characterized in that, The main body further includes: An elastic component, connecting the main body and the hanging component, making the hanging component tend to move away from the main body, and enabling the main body to be supported on the inner wall of the container through the hanging component.

8. The inner support device according to claim 7, characterized in that The elastic component is a spiral metal wire, and the elastic component supports on the inner wall of the container through its own elastic force.

9. The inner support device according to claim 1, characterized in that, The hanging component includes: A contact head, which can be magnetically adsorbed; A spring, with two ends respectively connected to the contact head and the main body; Moreover, the main body includes: A frame, having a receiving groove and a central groove; An electromagnet, which is arranged in the central groove; After being electrified, the electromagnet generates a magnetic force to adsorb the hanging component on the frame and makes the spring be received in the receiving groove.

10. The inner support device according to claim 8, characterized in that, The elastic component is a spring, and at least 3 such springs are set as a group to connect the hanging component and the main body.

11. The inner support device according to claim 1, characterized in that, The outer wall of the hanging component away from the main body is an arc surface, and at least 3 such hanging components are evenly distributed around the wall surface of the main body.

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